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Protein

Leucine zipper putative tumor suppressor 1

Gene

Lzts1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 1
Alternative name(s):
F37/Esophageal cancer-related gene-coding leucine-zipper motif
Fez1
Gene namesi
Name:Lzts1
Synonyms:Fez1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2684762. Lzts1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 599598Leucine zipper putative tumor suppressor 1PRO_0000182972Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Post-translational modificationi

Phorphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP60853.
MaxQBiP60853.
PaxDbiP60853.
PRIDEiP60853.

PTM databases

iPTMnetiP60853.
PhosphoSiteiP60853.

Expressioni

Gene expression databases

BgeeiP60853.
CleanExiMM_LZTS1.
GenevisibleiP60853. MM.

Interactioni

Subunit structurei

Binds EEF1G, TLK2 and CDK1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039397.

Structurei

3D structure databases

ProteinModelPortaliP60853.
SMRiP60853. Positions 263-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili256 – 572317Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the LZTS family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiP60853.
OMAiGMELKTQ.
OrthoDBiEOG7F7W8K.
TreeFamiTF331420.

Family and domain databases

InterProiIPR033293. LZTS1.
[Graphical view]
PANTHERiPTHR19354:SF5. PTHR19354:SF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS
60 70 80 90 100
GRGKSSSKMG KSEDFFYIKV SQKARGSHRP DYTALSSGDI GGQTGVDFDP
110 120 130 140 150
ATPPKLMPFS NQLEMSSDKG AVRPTAFKPV LPRSGAILHS SPESTSHQLH
160 170 180 190 200
PMPPDKPKEQ ELKPGLCSGA LSDSGRNSMS SLPTHSTTSS YQLDPLVTPV
210 220 230 240 250
GPTSRFGGSA HNITQGIILQ DSNMMSLKAL SFSDGGSKLA HPGKADKGAS
260 270 280 290 300
CVRSPLSTDE CTIQELEQKL LQRETALQKL QRSFDEKEFA SGQTFEERPR
310 320 330 340 350
RTRDELECLE PKSKLKPPSQ KSQRTQQVLQ LQVLQLQQEK RQLRQELESL
360 370 380 390 400
MKEQDLLETK LRSYEREKTN FAPALEETQW EVCQKSGEIS LLKQQLKESQ
410 420 430 440 450
LEVNTKASEI LSLKAQLKDT RGKLDGMELK TQDLESALRT KGLELEVCEN
460 470 480 490 500
ELQRKKNEAE LLREKVNLLE QELMELRAQA ALHPAPLGPP GVGLTFSEDI
510 520 530 540 550
PALQRELDRL RAELKEERQG HDQMSSGFQH ERLVWKEEKE KVIQYQRQLQ
560 570 580 590
QSYLAMYQRN QRLEKALQQL ARGDGPGEPF EIDLEGADIP YEDIIATEI
Length:599
Mass (Da):67,290
Last modified:July 27, 2011 - v3
Checksum:i7B77A3BCF249E817
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901I → M in AAQ14349 (PubMed:10097140).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288601 mRNA. Translation: AAQ14349.1.
BC139350 mRNA. Translation: AAI39351.1.
BC139352 mRNA. Translation: AAI39353.1.
CCDSiCCDS22345.1.
RefSeqiNP_955396.2. NM_199364.2.
XP_006509669.1. XM_006509606.1.
XP_006509670.1. XM_006509607.2.
XP_006509671.1. XM_006509608.2.
UniGeneiMm.409446.
Mm.479807.

Genome annotation databases

EnsembliENSMUST00000037049; ENSMUSP00000039397; ENSMUSG00000036306.
ENSMUST00000185176; ENSMUSP00000139117; ENSMUSG00000036306.
GeneIDi211134.
KEGGimmu:211134.
UCSCiuc009lxa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288601 mRNA. Translation: AAQ14349.1.
BC139350 mRNA. Translation: AAI39351.1.
BC139352 mRNA. Translation: AAI39353.1.
CCDSiCCDS22345.1.
RefSeqiNP_955396.2. NM_199364.2.
XP_006509669.1. XM_006509606.1.
XP_006509670.1. XM_006509607.2.
XP_006509671.1. XM_006509608.2.
UniGeneiMm.409446.
Mm.479807.

3D structure databases

ProteinModelPortaliP60853.
SMRiP60853. Positions 263-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039397.

PTM databases

iPTMnetiP60853.
PhosphoSiteiP60853.

Proteomic databases

EPDiP60853.
MaxQBiP60853.
PaxDbiP60853.
PRIDEiP60853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037049; ENSMUSP00000039397; ENSMUSG00000036306.
ENSMUST00000185176; ENSMUSP00000139117; ENSMUSG00000036306.
GeneIDi211134.
KEGGimmu:211134.
UCSCiuc009lxa.1. mouse.

Organism-specific databases

CTDi11178.
MGIiMGI:2684762. Lzts1.

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiP60853.
OMAiGMELKTQ.
OrthoDBiEOG7F7W8K.
TreeFamiTF331420.

Miscellaneous databases

NextBioi373144.
PROiP60853.
SOURCEiSearch...

Gene expression databases

BgeeiP60853.
CleanExiMM_LZTS1.
GenevisibleiP60853. MM.

Family and domain databases

InterProiIPR033293. LZTS1.
[Graphical view]
PANTHERiPTHR19354:SF5. PTHR19354:SF5. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors."
    Ishii H., Baffa R., Numata S., Murakumo Y., Rattan S., Inoue H., Mori M., Fidanza V., Alder H., Croce C.M.
    Proc. Natl. Acad. Sci. U.S.A. 96:3928-3933(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLZTS1_MOUSE
AccessioniPrimary (citable) accession number: P60853
Secondary accession number(s): B2RTI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.