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Protein

Zona pellucida sperm-binding protein 1

Gene

ZP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

GO - Biological processi

Keywordsi

Biological processFertilization

Enzyme and pathway databases

ReactomeiR-HSA-1300644 Interaction With The Zona Pellucida

Protein family/group databases

MEROPSiS01.969

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida sperm-binding protein 1
Alternative name(s):
Zona pellucida glycoprotein 1
Short name:
Zp-1
Cleaved into the following chain:
Gene namesi
Name:ZP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149506.10
HGNCiHGNC:13187 ZP1
MIMi195000 gene
neXtProtiNX_P60852

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 601ExtracellularSequence analysisAdd BLAST576
Transmembranei602 – 622HelicalSequence analysisAdd BLAST21
Topological domaini623 – 638CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Oocyte maturation defect 1 (OOMD1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa.
See also OMIM:615774

Organism-specific databases

DisGeNETi22917
MalaCardsiZP1
MIMi615774 phenotype
OpenTargetsiENSG00000149506
Orphaneti404466 Female infertility due to zona pellucida defect
PharmGKBiPA37755

Polymorphism and mutation databases

BioMutaiZP1
DMDMi46397079

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000004167726 – 553Zona pellucida sperm-binding protein 1Add BLAST528
ChainiPRO_000030455326 – ?Processed zona pellucida sperm-binding protein 1
PropeptideiPRO_0000041678554 – 638Removed in mature formBy similarityAdd BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi236 ↔ 261PROSITE-ProRule annotation
Disulfide bondi245 ↔ 260PROSITE-ProRule annotation
Disulfide bondi255 ↔ 270PROSITE-ProRule annotation
Glycosylationi379N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi457 ↔ 478PROSITE-ProRule annotation
Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60852
PeptideAtlasiP60852
PRIDEiP60852

PTM databases

iPTMnetiP60852
PhosphoSitePlusiP60852

Expressioni

Tissue specificityi

Oocytes.

Gene expression databases

BgeeiENSG00000149506
CleanExiHS_ZP1
ExpressionAtlasiP60852 baseline and differential
GenevisibleiP60852 HS

Interactioni

Subunit structurei

Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity). Interacts with ZP3 (PubMed:28886344).By similarity1 Publication

Protein-protein interaction databases

BioGridi116579, 1 interactor
STRINGi9606.ENSP00000278853

Structurei

3D structure databases

ProteinModelPortaliP60852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 274P-typePROSITE-ProRule annotationAdd BLAST41
Domaini279 – 553ZPPROSITE-ProRule annotationAdd BLAST275

Domaini

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Sequence similaritiesi

Belongs to the ZP domain family. ZPB subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE4J Eukaryota
ENOG4111H75 LUCA
GeneTreeiENSGT00530000063096
HOGENOMiHOG000118071
HOVERGENiHBG036289
InParanoidiP60852
KOiK19926
OMAiFCSASAC
OrthoDBiEOG091G0UNU
PhylomeDBiP60852
TreeFamiTF332794

Family and domain databases

CDDicd00111 Trefoil, 1 hit
InterProiView protein in InterPro
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00018 PD, 1 hit
SM00241 ZP, 1 hit
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL
60 70 80 90 100
LVFPRPGQTL RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG
110 120 130 140 150
CHVLEKDGRF HLRVFMEAVL PNGRVDVAQD ATLICPKPDP SRTLDSQLAP
160 170 180 190 200
PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP SPLDPGHSSV HPTPALPSPG
210 220 230 240 250
PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS GHLPCIVRRT
260 270 280 290 300
SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI
310 320 330 340 350
TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL
360 370 380 390 400
VSGIHIQKGP QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT
410 420 430 440 450
QPGPLRLELR IAKDETFSSY YGEDDYPIVR LLREPVHVEV RLLQRTDPNL
460 470 480 490 500
VLLLHQCWGA PSANPFQQPQ WPILSDGCPF KGDSYRTQMV ALDGATPFQS
510 520 530 540 550
HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE TCSTACSTGT
560 570 580 590 600
TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR
610 620 630
PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ
Length:638
Mass (Da):70,049
Last modified:April 13, 2004 - v1
Checksum:i052107CCFFEDFF21
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052996158T → I. Corresponds to variant dbSNP:rs489172Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004126 Genomic DNA No translation available.
CCDSiCCDS31572.1
RefSeqiNP_997224.2, NM_207341.3
UniGeneiHs.172130

Genome annotation databases

EnsembliENST00000278853; ENSP00000278853; ENSG00000149506
GeneIDi22917
KEGGihsa:22917

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZP1_HUMAN
AccessioniPrimary (citable) accession number: P60852
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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