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P60852 (ZP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zona pellucida sperm-binding protein 1
Alternative name(s):
Zona pellucida glycoprotein 1
Short name=Zp-1

Cleaved into the following chain:

  1. Processed zona pellucida sperm-binding protein 1
Gene names
Name:ZP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

Subunit structure

Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers By similarity.

Subcellular location

Processed zona pellucida sperm-binding protein 1: Secretedextracellular spaceextracellular matrix. Note: The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Oocytes.

Domain

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Post-translational modification

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.

O-glycosylated By similarity.

Sequence similarities

Belongs to the ZP domain family. ZPB subfamily.

Contains 1 P-type (trefoil) domain.

Contains 1 ZP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 553528Zona pellucida sperm-binding protein 1
PRO_0000041677
Chain26 – ?Processed zona pellucida sperm-binding protein 1PRO_0000304553
Propeptide554 – 63885Removed in mature form By similarity
PRO_0000041678

Regions

Topological domain26 – 601576Extracellular Potential
Transmembrane602 – 62221Helical; Potential
Topological domain623 – 63816Cytoplasmic Potential
Domain234 – 27441P-type
Domain279 – 553275ZP

Amino acid modifications

Glycosylation761N-linked (GlcNAc...) By similarity
Glycosylation3791N-linked (GlcNAc...) By similarity
Glycosylation5611N-linked (GlcNAc...) Potential
Glycosylation5961N-linked (GlcNAc...) Potential
Disulfide bond236 ↔ 261 By similarity
Disulfide bond245 ↔ 260 By similarity
Disulfide bond255 ↔ 270 By similarity
Disulfide bond457 ↔ 478 By similarity

Natural variations

Natural variant1581T → I.
Corresponds to variant rs489172 [ dbSNP | Ensembl ].
VAR_052996

Sequences

Sequence LengthMass (Da)Tools
P60852 [UniParc].

Last modified April 13, 2004. Version 1.
Checksum: 052107CCFFEDFF21

FASTA63870,049
        10         20         30         40         50         60 
MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL LVFPRPGQTL 

        70         80         90        100        110        120 
RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG CHVLEKDGRF HLRVFMEAVL 

       130        140        150        160        170        180 
PNGRVDVAQD ATLICPKPDP SRTLDSQLAP PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP 

       190        200        210        220        230        240 
SPLDPGHSSV HPTPALPSPG PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS 

       250        260        270        280        290        300 
GHLPCIVRRT SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI 

       310        320        330        340        350        360 
TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL VSGIHIQKGP 

       370        380        390        400        410        420 
QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT QPGPLRLELR IAKDETFSSY 

       430        440        450        460        470        480 
YGEDDYPIVR LLREPVHVEV RLLQRTDPNL VLLLHQCWGA PSANPFQQPQ WPILSDGCPF 

       490        500        510        520        530        540 
KGDSYRTQMV ALDGATPFQS HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE 

       550        560        570        580        590        600 
TCSTACSTGT TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR 

       610        620        630 
PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?"
Hughes D.C., Barratt C.L.
Biochim. Biophys. Acta 1447:303-306(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004126 Genomic DNA. No translation available.
CCDSCCDS31572.1.
RefSeqNP_997224.2. NM_207341.3.
UniGeneHs.172130.

3D structure databases

ProteinModelPortalP60852.
SMRP60852. Positions 233-286.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000278853.

PTM databases

PhosphoSiteP60852.

Polymorphism databases

DMDM46397079.

Proteomic databases

PaxDbP60852.
PRIDEP60852.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278853; ENSP00000278853; ENSG00000149506.
GeneID22917.
KEGGhsa:22917.
UCSCuc001nqd.3. human.

Organism-specific databases

CTD22917.
GeneCardsGC11P060635.
H-InvDBHIX0035993.
HGNCHGNC:13187. ZP1.
HPAHPA044523.
MIM195000. gene.
neXtProtNX_P60852.
PharmGKBPA37755.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39535.
HOGENOMHOG000118071.
HOVERGENHBG036289.
InParanoidP60852.
OMAGCHVLEK.
OrthoDBEOG7D2FDC.
PhylomeDBP60852.
TreeFamTF332794.

Enzyme and pathway databases

ReactomeREACT_163848. Reproduction.

Gene expression databases

BgeeP60852.
CleanExHS_ZP1.
GenevestigatorP60852.

Family and domain databases

Gene3D4.10.110.10. 1 hit.
InterProIPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSPR00023. ZPELLUCIDA.
SMARTSM00241. ZP. 1 hit.
[Graphical view]
SUPFAMSSF57492. SSF57492. 1 hit.
PROSITEPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi22917.
NextBio43609.
PROP60852.
SOURCESearch...

Entry information

Entry nameZP1_HUMAN
AccessionPrimary (citable) accession number: P60852
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM