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P60852

- ZP1_HUMAN

UniProt

P60852 - ZP1_HUMAN

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Protein

Zona pellucida sperm-binding protein 1

Gene

ZP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

GO - Biological processi

  1. binding of sperm to zona pellucida Source: Reactome
  2. multicellular organism reproduction Source: Reactome
  3. single fertilization Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Fertilization

Enzyme and pathway databases

ReactomeiREACT_163933. Interaction With The Zona Pellucida.

Protein family/group databases

MEROPSiS01.969.

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida sperm-binding protein 1
Alternative name(s):
Zona pellucida glycoprotein 1
Short name:
Zp-1
Cleaved into the following chain:
Gene namesi
Name:ZP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13187. ZP1.

Subcellular locationi

Chain Processed zona pellucida sperm-binding protein 1 : Secretedextracellular spaceextracellular matrix
Note: The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 601576ExtracellularSequence AnalysisAdd
BLAST
Transmembranei602 – 62221HelicalSequence AnalysisAdd
BLAST
Topological domaini623 – 63816CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. Golgi apparatus Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
  5. proteinaceous extracellular matrix Source: UniProtKB-KW
  6. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Oocyte maturation defect (OOMD) [MIM:615774]: An infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi615774. phenotype.
Orphaneti404466. Female infertility due to zona pellucida defect.
PharmGKBiPA37755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 553528Zona pellucida sperm-binding protein 1PRO_0000041677Add
BLAST
Chaini26 – ?Processed zona pellucida sperm-binding protein 1PRO_0000304553
Propeptidei554 – 63885Removed in mature formBy similarityPRO_0000041678Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...)By similarity
Disulfide bondi236 ↔ 261PROSITE-ProRule annotation
Disulfide bondi245 ↔ 260PROSITE-ProRule annotation
Disulfide bondi255 ↔ 270PROSITE-ProRule annotation
Glycosylationi379 – 3791N-linked (GlcNAc...)By similarity
Disulfide bondi457 ↔ 478PROSITE-ProRule annotation
Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60852.
PRIDEiP60852.

PTM databases

PhosphoSiteiP60852.

Expressioni

Tissue specificityi

Oocytes.

Gene expression databases

BgeeiP60852.
CleanExiHS_ZP1.
ExpressionAtlasiP60852. baseline and differential.
GenevestigatoriP60852.

Organism-specific databases

HPAiHPA044523.

Interactioni

Subunit structurei

Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000278853.

Structurei

3D structure databases

ProteinModelPortaliP60852.
SMRiP60852. Positions 233-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 27441P-typePROSITE-ProRule annotationAdd
BLAST
Domaini279 – 553275ZPPROSITE-ProRule annotationAdd
BLAST

Domaini

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Sequence similaritiesi

Belongs to the ZP domain family. ZPB subfamily.Curated
Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39535.
HOGENOMiHOG000118071.
HOVERGENiHBG036289.
InParanoidiP60852.
OMAiGCHVLEK.
OrthoDBiEOG7D2FDC.
PhylomeDBiP60852.
TreeFamiTF332794.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60852-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL
60 70 80 90 100
LVFPRPGQTL RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG
110 120 130 140 150
CHVLEKDGRF HLRVFMEAVL PNGRVDVAQD ATLICPKPDP SRTLDSQLAP
160 170 180 190 200
PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP SPLDPGHSSV HPTPALPSPG
210 220 230 240 250
PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS GHLPCIVRRT
260 270 280 290 300
SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI
310 320 330 340 350
TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL
360 370 380 390 400
VSGIHIQKGP QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT
410 420 430 440 450
QPGPLRLELR IAKDETFSSY YGEDDYPIVR LLREPVHVEV RLLQRTDPNL
460 470 480 490 500
VLLLHQCWGA PSANPFQQPQ WPILSDGCPF KGDSYRTQMV ALDGATPFQS
510 520 530 540 550
HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE TCSTACSTGT
560 570 580 590 600
TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR
610 620 630
PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ
Length:638
Mass (Da):70,049
Last modified:April 13, 2004 - v1
Checksum:i052107CCFFEDFF21
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581T → I.
Corresponds to variant rs489172 [ dbSNP | Ensembl ].
VAR_052996

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004126 Genomic DNA. No translation available.
CCDSiCCDS31572.1.
RefSeqiNP_997224.2. NM_207341.3.
UniGeneiHs.172130.

Genome annotation databases

EnsembliENST00000278853; ENSP00000278853; ENSG00000149506.
GeneIDi22917.
KEGGihsa:22917.
UCSCiuc001nqd.3. human.

Polymorphism databases

DMDMi46397079.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004126 Genomic DNA. No translation available.
CCDSi CCDS31572.1.
RefSeqi NP_997224.2. NM_207341.3.
UniGenei Hs.172130.

3D structure databases

ProteinModelPortali P60852.
SMRi P60852. Positions 233-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000278853.

Protein family/group databases

MEROPSi S01.969.

PTM databases

PhosphoSitei P60852.

Polymorphism databases

DMDMi 46397079.

Proteomic databases

PaxDbi P60852.
PRIDEi P60852.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278853 ; ENSP00000278853 ; ENSG00000149506 .
GeneIDi 22917.
KEGGi hsa:22917.
UCSCi uc001nqd.3. human.

Organism-specific databases

CTDi 22917.
GeneCardsi GC11P060635.
H-InvDB HIX0035993.
HGNCi HGNC:13187. ZP1.
HPAi HPA044523.
MIMi 195000. gene.
615774. phenotype.
neXtProti NX_P60852.
Orphaneti 404466. Female infertility due to zona pellucida defect.
PharmGKBi PA37755.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39535.
HOGENOMi HOG000118071.
HOVERGENi HBG036289.
InParanoidi P60852.
OMAi GCHVLEK.
OrthoDBi EOG7D2FDC.
PhylomeDBi P60852.
TreeFami TF332794.

Enzyme and pathway databases

Reactomei REACT_163933. Interaction With The Zona Pellucida.

Miscellaneous databases

GenomeRNAii 22917.
NextBioi 43609.
PROi P60852.
SOURCEi Search...

Gene expression databases

Bgeei P60852.
CleanExi HS_ZP1.
ExpressionAtlasi P60852. baseline and differential.
Genevestigatori P60852.

Family and domain databases

Gene3Di 4.10.110.10. 1 hit.
InterProi IPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
PRINTSi PR00023. ZPELLUCIDA.
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
SUPFAMi SSF57492. SSF57492. 1 hit.
PROSITEi PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?"
    Hughes D.C., Barratt C.L.
    Biochim. Biophys. Acta 1447:303-306(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: INVOLVEMENT IN OOMD.

Entry informationi

Entry nameiZP1_HUMAN
AccessioniPrimary (citable) accession number: P60852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3