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P60852

- ZP1_HUMAN

UniProt

P60852 - ZP1_HUMAN

Protein

Zona pellucida sperm-binding protein 1

Gene

ZP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

    GO - Biological processi

    1. binding of sperm to zona pellucida Source: Reactome
    2. multicellular organism reproduction Source: Reactome
    3. single fertilization Source: Reactome

    Keywords - Biological processi

    Fertilization

    Enzyme and pathway databases

    ReactomeiREACT_163933. Interaction With The Zona Pellucida.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zona pellucida sperm-binding protein 1
    Alternative name(s):
    Zona pellucida glycoprotein 1
    Short name:
    Zp-1
    Cleaved into the following chain:
    Gene namesi
    Name:ZP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13187. ZP1.

    Subcellular locationi

    Chain Processed zona pellucida sperm-binding protein 1 : Secretedextracellular spaceextracellular matrix
    Note: The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. Golgi apparatus Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
    6. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Extracellular matrix, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37755.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 553528Zona pellucida sperm-binding protein 1PRO_0000041677Add
    BLAST
    Chaini26 – ?Processed zona pellucida sperm-binding protein 1PRO_0000304553
    Propeptidei554 – 63885Removed in mature formBy similarityPRO_0000041678Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi76 – 761N-linked (GlcNAc...)By similarity
    Disulfide bondi236 ↔ 261PROSITE-ProRule annotation
    Disulfide bondi245 ↔ 260PROSITE-ProRule annotation
    Disulfide bondi255 ↔ 270PROSITE-ProRule annotation
    Glycosylationi379 – 3791N-linked (GlcNAc...)By similarity
    Disulfide bondi457 ↔ 478PROSITE-ProRule annotation
    Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
    O-glycosylated.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP60852.
    PRIDEiP60852.

    PTM databases

    PhosphoSiteiP60852.

    Expressioni

    Tissue specificityi

    Oocytes.

    Gene expression databases

    BgeeiP60852.
    CleanExiHS_ZP1.
    GenevestigatoriP60852.

    Organism-specific databases

    HPAiHPA044523.

    Interactioni

    Subunit structurei

    Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000278853.

    Structurei

    3D structure databases

    ProteinModelPortaliP60852.
    SMRiP60852. Positions 233-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 601576ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini623 – 63816CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei602 – 62221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini234 – 27441P-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini279 – 553275ZPPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

    Sequence similaritiesi

    Belongs to the ZP domain family. ZPB subfamily.Curated
    Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation
    Contains 1 ZP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39535.
    HOGENOMiHOG000118071.
    HOVERGENiHBG036289.
    InParanoidiP60852.
    OMAiGCHVLEK.
    OrthoDBiEOG7D2FDC.
    PhylomeDBiP60852.
    TreeFamiTF332794.

    Family and domain databases

    Gene3Di4.10.110.10. 1 hit.
    InterProiIPR000519. P_trefoil.
    IPR017957. P_trefoil_CS.
    IPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]
    PRINTSiPR00023. ZPELLUCIDA.
    SMARTiSM00241. ZP. 1 hit.
    [Graphical view]
    SUPFAMiSSF57492. SSF57492. 1 hit.
    PROSITEiPS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    PS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60852-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL    50
    LVFPRPGQTL RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG 100
    CHVLEKDGRF HLRVFMEAVL PNGRVDVAQD ATLICPKPDP SRTLDSQLAP 150
    PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP SPLDPGHSSV HPTPALPSPG 200
    PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS GHLPCIVRRT 250
    SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI 300
    TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL 350
    VSGIHIQKGP QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT 400
    QPGPLRLELR IAKDETFSSY YGEDDYPIVR LLREPVHVEV RLLQRTDPNL 450
    VLLLHQCWGA PSANPFQQPQ WPILSDGCPF KGDSYRTQMV ALDGATPFQS 500
    HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE TCSTACSTGT 550
    TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR 600
    PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ 638
    Length:638
    Mass (Da):70,049
    Last modified:April 13, 2004 - v1
    Checksum:i052107CCFFEDFF21
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1581T → I.
    Corresponds to variant rs489172 [ dbSNP | Ensembl ].
    VAR_052996

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004126 Genomic DNA. No translation available.
    CCDSiCCDS31572.1.
    RefSeqiNP_997224.2. NM_207341.3.
    UniGeneiHs.172130.

    Genome annotation databases

    EnsembliENST00000278853; ENSP00000278853; ENSG00000149506.
    GeneIDi22917.
    KEGGihsa:22917.
    UCSCiuc001nqd.3. human.

    Polymorphism databases

    DMDMi46397079.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004126 Genomic DNA. No translation available.
    CCDSi CCDS31572.1.
    RefSeqi NP_997224.2. NM_207341.3.
    UniGenei Hs.172130.

    3D structure databases

    ProteinModelPortali P60852.
    SMRi P60852. Positions 233-286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000278853.

    PTM databases

    PhosphoSitei P60852.

    Polymorphism databases

    DMDMi 46397079.

    Proteomic databases

    PaxDbi P60852.
    PRIDEi P60852.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278853 ; ENSP00000278853 ; ENSG00000149506 .
    GeneIDi 22917.
    KEGGi hsa:22917.
    UCSCi uc001nqd.3. human.

    Organism-specific databases

    CTDi 22917.
    GeneCardsi GC11P060635.
    H-InvDB HIX0035993.
    HGNCi HGNC:13187. ZP1.
    HPAi HPA044523.
    MIMi 195000. gene.
    neXtProti NX_P60852.
    PharmGKBi PA37755.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39535.
    HOGENOMi HOG000118071.
    HOVERGENi HBG036289.
    InParanoidi P60852.
    OMAi GCHVLEK.
    OrthoDBi EOG7D2FDC.
    PhylomeDBi P60852.
    TreeFami TF332794.

    Enzyme and pathway databases

    Reactomei REACT_163933. Interaction With The Zona Pellucida.

    Miscellaneous databases

    GenomeRNAii 22917.
    NextBioi 43609.
    PROi P60852.
    SOURCEi Search...

    Gene expression databases

    Bgeei P60852.
    CleanExi HS_ZP1.
    Genevestigatori P60852.

    Family and domain databases

    Gene3Di 4.10.110.10. 1 hit.
    InterProi IPR000519. P_trefoil.
    IPR017957. P_trefoil_CS.
    IPR001507. ZP_dom.
    IPR017977. ZP_dom_CS.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    PRINTSi PR00023. ZPELLUCIDA.
    SMARTi SM00241. ZP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57492. SSF57492. 1 hit.
    PROSITEi PS00025. P_TREFOIL_1. 1 hit.
    PS51448. P_TREFOIL_2. 1 hit.
    PS00682. ZP_1. 1 hit.
    PS51034. ZP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?"
      Hughes D.C., Barratt C.L.
      Biochim. Biophys. Acta 1447:303-306(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiZP1_HUMAN
    AccessioniPrimary (citable) accession number: P60852
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3