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P60852

- ZP1_HUMAN

UniProt

P60852 - ZP1_HUMAN

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Protein
Zona pellucida sperm-binding protein 1
Gene
ZP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

GO - Biological processi

  1. binding of sperm to zona pellucida Source: Reactome
  2. multicellular organism reproduction Source: Reactome
  3. single fertilization Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Fertilization

Enzyme and pathway databases

ReactomeiREACT_163933. Interaction With The Zona Pellucida.

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida sperm-binding protein 1
Alternative name(s):
Zona pellucida glycoprotein 1
Short name:
Zp-1
Cleaved into the following chain:
Gene namesi
Name:ZP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13187. ZP1.

Subcellular locationi

Chain Processed zona pellucida sperm-binding protein 1 : Secretedextracellular spaceextracellular matrix
Note: The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 601576Extracellular Reviewed prediction
Add
BLAST
Transmembranei602 – 62221Helical; Reviewed prediction
Add
BLAST
Topological domaini623 – 63816Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. extracellular region Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
  6. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 553528Zona pellucida sperm-binding protein 1
PRO_0000041677Add
BLAST
Chaini26 – ?Processed zona pellucida sperm-binding protein 1PRO_0000304553
Propeptidei554 – 63885Removed in mature form By similarity
PRO_0000041678Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...) By similarity
Disulfide bondi236 ↔ 261 By similarity
Disulfide bondi245 ↔ 260 By similarity
Disulfide bondi255 ↔ 270 By similarity
Glycosylationi379 – 3791N-linked (GlcNAc...) By similarity
Disulfide bondi457 ↔ 478 By similarity
Glycosylationi561 – 5611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi596 – 5961N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
O-glycosylated By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60852.
PRIDEiP60852.

PTM databases

PhosphoSiteiP60852.

Expressioni

Tissue specificityi

Oocytes.

Gene expression databases

BgeeiP60852.
CleanExiHS_ZP1.
GenevestigatoriP60852.

Organism-specific databases

HPAiHPA044523.

Interactioni

Subunit structurei

Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000278853.

Structurei

3D structure databases

ProteinModelPortaliP60852.
SMRiP60852. Positions 233-286.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 27441P-type
Add
BLAST
Domaini279 – 553275ZP
Add
BLAST

Domaini

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Sequence similaritiesi

Contains 1 ZP domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39535.
HOGENOMiHOG000118071.
HOVERGENiHBG036289.
InParanoidiP60852.
OMAiGCHVLEK.
OrthoDBiEOG7D2FDC.
PhylomeDBiP60852.
TreeFamiTF332794.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60852-1 [UniParc]FASTAAdd to Basket

« Hide

MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL    50
LVFPRPGQTL RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG 100
CHVLEKDGRF HLRVFMEAVL PNGRVDVAQD ATLICPKPDP SRTLDSQLAP 150
PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP SPLDPGHSSV HPTPALPSPG 200
PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS GHLPCIVRRT 250
SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI 300
TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL 350
VSGIHIQKGP QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT 400
QPGPLRLELR IAKDETFSSY YGEDDYPIVR LLREPVHVEV RLLQRTDPNL 450
VLLLHQCWGA PSANPFQQPQ WPILSDGCPF KGDSYRTQMV ALDGATPFQS 500
HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE TCSTACSTGT 550
TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR 600
PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ 638
Length:638
Mass (Da):70,049
Last modified:April 13, 2004 - v1
Checksum:i052107CCFFEDFF21
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581T → I.
Corresponds to variant rs489172 [ dbSNP | Ensembl ].
VAR_052996

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004126 Genomic DNA. No translation available.
CCDSiCCDS31572.1.
RefSeqiNP_997224.2. NM_207341.3.
UniGeneiHs.172130.

Genome annotation databases

EnsembliENST00000278853; ENSP00000278853; ENSG00000149506.
GeneIDi22917.
KEGGihsa:22917.
UCSCiuc001nqd.3. human.

Polymorphism databases

DMDMi46397079.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004126 Genomic DNA. No translation available.
CCDSi CCDS31572.1.
RefSeqi NP_997224.2. NM_207341.3.
UniGenei Hs.172130.

3D structure databases

ProteinModelPortali P60852.
SMRi P60852. Positions 233-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000278853.

PTM databases

PhosphoSitei P60852.

Polymorphism databases

DMDMi 46397079.

Proteomic databases

PaxDbi P60852.
PRIDEi P60852.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278853 ; ENSP00000278853 ; ENSG00000149506 .
GeneIDi 22917.
KEGGi hsa:22917.
UCSCi uc001nqd.3. human.

Organism-specific databases

CTDi 22917.
GeneCardsi GC11P060635.
H-InvDB HIX0035993.
HGNCi HGNC:13187. ZP1.
HPAi HPA044523.
MIMi 195000. gene.
neXtProti NX_P60852.
PharmGKBi PA37755.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39535.
HOGENOMi HOG000118071.
HOVERGENi HBG036289.
InParanoidi P60852.
OMAi GCHVLEK.
OrthoDBi EOG7D2FDC.
PhylomeDBi P60852.
TreeFami TF332794.

Enzyme and pathway databases

Reactomei REACT_163933. Interaction With The Zona Pellucida.

Miscellaneous databases

GenomeRNAii 22917.
NextBioi 43609.
PROi P60852.
SOURCEi Search...

Gene expression databases

Bgeei P60852.
CleanExi HS_ZP1.
Genevestigatori P60852.

Family and domain databases

Gene3Di 4.10.110.10. 1 hit.
InterProi IPR000519. P_trefoil.
IPR017957. P_trefoil_CS.
IPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
PRINTSi PR00023. ZPELLUCIDA.
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
SUPFAMi SSF57492. SSF57492. 1 hit.
PROSITEi PS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
PS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?"
    Hughes D.C., Barratt C.L.
    Biochim. Biophys. Acta 1447:303-306(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZP1_HUMAN
AccessioniPrimary (citable) accession number: P60852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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