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Protein

DNA/RNA-binding protein Alba 1

Gene

albA1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. May be involved in DNA compaction. May bind rRNA and mRNA, playing a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA condensation

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA/RNA-binding protein Alba 1
Alternative name(s):
Sso10b
Gene namesi
Name:albA1
Synonyms:sso10b
Ordered Locus Names:SSO0962
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16K → A or V: Unable to repress transcription. 1 Publication1
Mutagenesisi17K → A or V: Unable to repress transcription. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001517122 – 97DNA/RNA-binding protein Alba 1Add BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei17N6-acetyllysine1 Publication1

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase increases its DNA-binding affinity, thereby repressing transcription. Regulation of DNA-based activities is therefore achieved at the chromatin level.1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-48444N.
STRINGi273057.SSO0962.

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Helixi19 – 31Combined sources13
Beta strandi36 – 42Combined sources7
Helixi45 – 59Combined sources15
Turni62 – 64Combined sources3
Beta strandi65 – 79Combined sources15
Beta strandi84 – 96Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0XX-ray2.60A/B1-97[»]
1H0YX-ray2.80A1-97[»]
2BKYX-ray1.70A/B1-97[»]
4R3LX-ray1.84B2-7[»]
ProteinModelPortaliP60849.
SMRiP60849.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60849.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiarCOG01753. Archaea.
COG1581. LUCA.
HOGENOMiHOG000105803.
InParanoidiP60849.
KOiK03622.
OMAiYVIATVM.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
HAMAPiMF_01122. AlbA. 1 hit.
InterProiIPR013795. DNA/RNA-bd_Alba.
IPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
PIRSFiPIRSF028732. Alba. 1 hit.
SUPFAMiSSF82704. SSF82704. 1 hit.
TIGRFAMsiTIGR00285. TIGR00285. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGTPTPSN VVLIGKKPVM NYVLAALTLL NQGVSEIVIK ARGRAISKAV
60 70 80 90
DTVEIVRNRF LPDKIEIKEI RVGSQVVTSQ DGRQSRVSTI EIAIRKK
Length:97
Mass (Da):10,585
Last modified:January 23, 2007 - v2
Checksum:i22C1BC9CCDB6B013
GO

Sequence cautioni

The sequence AAK41236 differs from that shown. Reason: Erroneous initiation.Curated

Mass spectrometryi

Molecular mass is 10538 Da from positions 2 - 97. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298830 Genomic DNA. Translation: CAC12668.1.
AE006641 Genomic DNA. Translation: AAK41236.1. Different initiation.
PIRiE90247.
RefSeqiWP_009992406.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41236; AAK41236; SSO0962.
GeneIDi8761191.
KEGGisso:SSO0962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298830 Genomic DNA. Translation: CAC12668.1.
AE006641 Genomic DNA. Translation: AAK41236.1. Different initiation.
PIRiE90247.
RefSeqiWP_009992406.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0XX-ray2.60A/B1-97[»]
1H0YX-ray2.80A1-97[»]
2BKYX-ray1.70A/B1-97[»]
4R3LX-ray1.84B2-7[»]
ProteinModelPortaliP60849.
SMRiP60849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48444N.
STRINGi273057.SSO0962.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41236; AAK41236; SSO0962.
GeneIDi8761191.
KEGGisso:SSO0962.

Phylogenomic databases

eggNOGiarCOG01753. Archaea.
COG1581. LUCA.
HOGENOMiHOG000105803.
InParanoidiP60849.
KOiK03622.
OMAiYVIATVM.

Miscellaneous databases

EvolutionaryTraceiP60849.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
HAMAPiMF_01122. AlbA. 1 hit.
InterProiIPR013795. DNA/RNA-bd_Alba.
IPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
PIRSFiPIRSF028732. Alba. 1 hit.
SUPFAMiSSF82704. SSF82704. 1 hit.
TIGRFAMsiTIGR00285. TIGR00285. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALBA1_SULSO
AccessioniPrimary (citable) accession number: P60849
Secondary accession number(s): P74761, Q97ZF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.