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P60827

- C1QT8_HUMAN

UniProt

P60827 - C1QT8_HUMAN

Protein

Complement C1q tumor necrosis factor-related protein 8

Gene

C1QTNF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (02 Mar 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 8
    Alternative name(s):
    C1q/TNF-related protein 8
    Short name:
    CTRP8
    Gene namesi
    Name:C1QTNF8
    ORF Names:UNQ5829/PRO19648
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:31374. C1QTNF8.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914298.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 252235Complement C1q tumor necrosis factor-related protein 8PRO_0000003541Add
    BLAST

    Post-translational modificationi

    No N-glycosylation.

    Proteomic databases

    PaxDbiP60827.
    PRIDEiP60827.

    Expressioni

    Tissue specificityi

    Expressed predominantly in lung and testis.1 Publication

    Gene expression databases

    BgeeiP60827.
    CleanExiHS_C1QTNF8.
    GenevestigatoriP60827.

    Organism-specific databases

    HPAiHPA056438.

    Interactioni

    Subunit structurei

    Homotrimer. Forms heteromeric complexes with C1QL1.

    Structurei

    3D structure databases

    ProteinModelPortaliP60827.
    SMRiP60827. Positions 136-249.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 11143Collagen-likeAdd
    BLAST
    Domaini112 – 252141C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG44388.
    HOGENOMiHOG000101544.
    HOVERGENiHBG108220.
    InParanoidiP60827.
    OMAiHGDLYIT.
    OrthoDBiEOG71CFMS.
    PhylomeDBiP60827.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60827-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG    50
    DLWRGLPRVR PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG 100
    QKGQVGPPGA ACRRAYAAFS VGRREGLHSS DHFQAVPFDT ELVNLDGAFD 150
    LAAGRFLCTV PGVYFLSLNV HTWNYKETYL HIMLNRRPAA VLYAQPSERS 200
    VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI YGEHGDLYIT FSGHLVKPAA 250
    EL 252
    Length:252
    Mass (Da):27,685
    Last modified:March 2, 2010 - v2
    Checksum:i42F987B300C9C1BC
    GO

    Sequence cautioni

    The sequence AAQ89191.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome.
    The sequence ACJ46463.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ422561 mRNA. Translation: ACJ46463.1. Sequence problems.
    AY358832 mRNA. Translation: AAQ89191.1. Sequence problems.
    AC009041 Genomic DNA. No translation available.
    AL031713 Genomic DNA. No translation available.
    CCDSiCCDS32358.1.
    RefSeqiNP_997302.2. NM_207419.3.
    UniGeneiHs.527853.

    Genome annotation databases

    EnsembliENST00000328449; ENSP00000330426; ENSG00000184471.
    GeneIDi390664.
    KEGGihsa:390664.
    UCSCiuc010uuw.1. human.

    Polymorphism databases

    DMDMi290457629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ422561 mRNA. Translation: ACJ46463.1 . Sequence problems.
    AY358832 mRNA. Translation: AAQ89191.1 . Sequence problems.
    AC009041 Genomic DNA. No translation available.
    AL031713 Genomic DNA. No translation available.
    CCDSi CCDS32358.1.
    RefSeqi NP_997302.2. NM_207419.3.
    UniGenei Hs.527853.

    3D structure databases

    ProteinModelPortali P60827.
    SMRi P60827. Positions 136-249.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 290457629.

    Proteomic databases

    PaxDbi P60827.
    PRIDEi P60827.

    Protocols and materials databases

    DNASUi 390664.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328449 ; ENSP00000330426 ; ENSG00000184471 .
    GeneIDi 390664.
    KEGGi hsa:390664.
    UCSCi uc010uuw.1. human.

    Organism-specific databases

    CTDi 390664.
    GeneCardsi GC16M001138.
    H-InvDB HIX0038589.
    HGNCi HGNC:31374. C1QTNF8.
    HPAi HPA056438.
    MIMi 614147. gene.
    neXtProti NX_P60827.
    PharmGKBi PA134914298.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44388.
    HOGENOMi HOG000101544.
    HOVERGENi HBG108220.
    InParanoidi P60827.
    OMAi HGDLYIT.
    OrthoDBi EOG71CFMS.
    PhylomeDBi P60827.
    TreeFami TF329591.

    Miscellaneous databases

    GenomeRNAii 390664.
    NextBioi 103975.
    PROi P60827.
    SOURCEi Search...

    Gene expression databases

    Bgeei P60827.
    CleanExi HS_C1QTNF8.
    Genevestigatori P60827.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
      Peterson J.M., Wei Z., Wong G.W.
      Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY.
      Tissue: Hippocampus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiC1QT8_HUMAN
    AccessioniPrimary (citable) accession number: P60827
    Secondary accession number(s): B7U178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3