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Protein

Complement C1q tumor necrosis factor-related protein 8

Gene

C1QTNF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 8
Alternative name(s):
C1q/TNF-related protein 8
Short name:
CTRP8
Gene namesi
Name:C1QTNF8
ORF Names:UNQ5829/PRO19648
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:31374. C1QTNF8.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 252235Complement C1q tumor necrosis factor-related protein 8PRO_0000003541Add
BLAST

Post-translational modificationi

No N-glycosylation.

Proteomic databases

PaxDbiP60827.
PRIDEiP60827.

Expressioni

Tissue specificityi

Expressed predominantly in lung and testis.1 Publication

Gene expression databases

BgeeiP60827.
CleanExiHS_C1QTNF8.
GenevestigatoriP60827.

Organism-specific databases

HPAiHPA056438.

Interactioni

Subunit structurei

Homotrimer. Forms heteromeric complexes with C1QL1.

Structurei

3D structure databases

ProteinModelPortaliP60827.
SMRiP60827. Positions 83-109, 136-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 11143Collagen-likeAdd
BLAST
Domaini112 – 252141C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG44388.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000101544.
HOVERGENiHBG108220.
InParanoidiP60827.
OMAiAIYGEHG.
OrthoDBiEOG71CFMS.
PhylomeDBiP60827.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG
60 70 80 90 100
DLWRGLPRVR PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG
110 120 130 140 150
QKGQVGPPGA ACRRAYAAFS VGRREGLHSS DHFQAVPFDT ELVNLDGAFD
160 170 180 190 200
LAAGRFLCTV PGVYFLSLNV HTWNYKETYL HIMLNRRPAA VLYAQPSERS
210 220 230 240 250
VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI YGEHGDLYIT FSGHLVKPAA

EL
Length:252
Mass (Da):27,685
Last modified:March 1, 2010 - v2
Checksum:i42F987B300C9C1BC
GO

Sequence cautioni

The sequence AAQ89191.1 differs from that shown.Contains a 30 bp insertion which does not match the genome.Curated
The sequence ACJ46463.1 differs from that shown.Contains a 30 bp insertion which does not match the genome.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ422561 mRNA. Translation: ACJ46463.1. Sequence problems.
AY358832 mRNA. Translation: AAQ89191.1. Sequence problems.
AC009041 Genomic DNA. No translation available.
AL031713 Genomic DNA. No translation available.
CCDSiCCDS32358.1.
RefSeqiNP_997302.2. NM_207419.3.
UniGeneiHs.527853.

Genome annotation databases

EnsembliENST00000328449; ENSP00000330426; ENSG00000184471.
GeneIDi390664.
KEGGihsa:390664.
UCSCiuc010uuw.1. human.

Polymorphism databases

DMDMi290457629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ422561 mRNA. Translation: ACJ46463.1. Sequence problems.
AY358832 mRNA. Translation: AAQ89191.1. Sequence problems.
AC009041 Genomic DNA. No translation available.
AL031713 Genomic DNA. No translation available.
CCDSiCCDS32358.1.
RefSeqiNP_997302.2. NM_207419.3.
UniGeneiHs.527853.

3D structure databases

ProteinModelPortaliP60827.
SMRiP60827. Positions 83-109, 136-249.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi290457629.

Proteomic databases

PaxDbiP60827.
PRIDEiP60827.

Protocols and materials databases

DNASUi390664.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328449; ENSP00000330426; ENSG00000184471.
GeneIDi390664.
KEGGihsa:390664.
UCSCiuc010uuw.1. human.

Organism-specific databases

CTDi390664.
GeneCardsiGC16M001138.
H-InvDBHIX0038589.
HGNCiHGNC:31374. C1QTNF8.
HPAiHPA056438.
MIMi614147. gene.
neXtProtiNX_P60827.
PharmGKBiPA134914298.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44388.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000101544.
HOVERGENiHBG108220.
InParanoidiP60827.
OMAiAIYGEHG.
OrthoDBiEOG71CFMS.
PhylomeDBiP60827.
TreeFamiTF329591.

Miscellaneous databases

GenomeRNAii390664.
NextBioi103975.
PROiP60827.
SOURCEiSearch...

Gene expression databases

BgeeiP60827.
CleanExiHS_C1QTNF8.
GenevestigatoriP60827.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
    Peterson J.M., Wei Z., Wong G.W.
    Biochem. Biophys. Res. Commun. 388:360-365(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY.
    Tissue: Hippocampus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiC1QT8_HUMAN
AccessioniPrimary (citable) accession number: P60827
Secondary accession number(s): B7U178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2004
Last sequence update: March 1, 2010
Last modified: January 6, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.