P60827 (C1QT8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Complement C1q tumor necrosis factor-related protein 8

Alternative name(s):
C1q/TNF-related protein 8
Short name=CTRP8

Gene names

Name:	C1QTNF8
ORF Names:	UNQ5829/PRO19648

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homotrimer. Forms heteromeric complexes with C1QL1.
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed predominantly in lung and testis. Ref.1
Post-translational modification	No N-glycosylation.
Sequence similarities	Contains 1 C1q domain. Contains 1 collagen-like domain.
Sequence caution	The sequence AAQ89191.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome. The sequence ACJ46463.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome.

Ontologies

Keywords
Cellular component	Secreted
Domain	Collagen Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	collagen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 252	235	Complement C1q tumor necrosis factor-related protein 8		PRO_0000003541
Regions
	Domain	69 – 111	43	Collagen-like
	Domain	112 – 252	141	C1q

Sequences

	Sequence		Length	Mass (Da)
	P60827 [UniParc]. Last modified March 2, 2010. Version 2. Checksum: 42F987B300C9C1BC	FASTA	252	27,685
	10 20 30 40 50 60 MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG DLWRGLPRVR 70 80 90 100 110 120 PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG QKGQVGPPGA ACRRAYAAFS 130 140 150 160 170 180 VGRREGLHSS DHFQAVPFDT ELVNLDGAFD LAAGRFLCTV PGVYFLSLNV HTWNYKETYL 190 200 210 220 230 240 HIMLNRRPAA VLYAQPSERS VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI YGEHGDLYIT 250 FSGHLVKPAA EL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members." Peterson J.M., Wei Z., Wong G.W. Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed: 19666007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY. Tissue: Hippocampus.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FJ422561 mRNA. Translation: ACJ46463.1. Sequence problems. AY358832 mRNA. Translation: AAQ89191.1. Sequence problems. AC009041 Genomic DNA. No translation available. AL031713 Genomic DNA. No translation available.
IPI	IPI00410242.
RefSeq	NP_997302.2. NM_207419.3.
UniGene	Hs.527853.
3D structure databases
ProteinModelPortal	P60827.
SMR	P60827. Positions 73-107, 116-248.
ModBase	Search...
Polymorphism databases
DMDM	290457629.
Proteomic databases
PRIDE	P60827.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328449; ENSP00000330426; ENSG00000184471. ENST00000420278; ENSP00000394735; ENSG00000184471.
GeneID	390664.
KEGG	hsa:390664.
UCSC	uc002ckr.1. human.
Organism-specific databases
CTD	390664.
GeneCards	GC16M001138.
H-InvDB	HIX0038589.
HGNC	HGNC:31374. C1QTNF8.
MIM	614147. gene.
neXtProt	NX_P60827.
PharmGKB	PA134914298.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12536.
GeneTree	ENSGT00560000076704.
HOGENOM	HBG444750.
HOVERGEN	HBG108220.
InParanoid	P60827.
OMA	AYAAFSV.
OrthoDB	EOG4229KQ.
PhylomeDB	P60827.
Gene expression databases
Bgee	P60827.
CleanEx	HS_C1QTNF8.
Genevestigator	P60827.
Family and domain databases
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	103975.
SOURCE	Search...

Entry information

Entry name

C1QT8_HUMAN

Accession

Primary (citable) accession number: P60827
Secondary accession number(s): B7U178

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 2, 2010
Last modified:	January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.