Reviewed, UniProtKB/Swiss-Prot P60827 (C1QT8_HUMAN)

Names and origin

Protein names

Recommended name:
    Complement C1q tumor necrosis factor-related protein 8

Gene names

Name:	C1QTNF8
ORF Names:	UNQ5829/PRO19648

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	SecretedPotential.
Sequence similarities	Contains 1 C1q domain. Contains 1 collagen-like domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Collagen Signal
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 262	245	Complement C1q tumor necrosis factor-related protein 8		PRO_0000003541
Regions
	Domain	69 – 111	43	Collagen-like
	Domain	122 – 262	141	C1q

Sequences

	Sequence		Length	Mass (Da)
	P60827-1 [UniParc]. Last modified April 13, 2004. Version 1. Checksum: DE086CB72488ADAD	FASTA	262	28,764
	10 20 30 40 50 60 MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG DLWRGLPRVR 70 80 90 100 110 120 PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG QKGQVGPPGA ACRRAYAAFS 130 140 150 160 170 180 VGRRAYAAFS VGRREGLHSS DHFQAVPFDT ELVNLDGAFD LAAGRFLCTV PGVYFLSLNV 190 200 210 220 230 240 HTWNYKETYL HIMLNRRPAA VLYAQPSERS VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI 250 260 YGEHGDLYIT FSGHLVKPAA EL

References

[1]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY358832 mRNA. Translation: AAQ89191.1.
RefSeq	NP_997302.2.
UniGene	Hs.527853
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000184471. Homo sapiens. [Contig view]
GeneID	390664.
KEGG	hsa:390664.
Organism-specific databases
H-InvDB	HIX0038589.
HGNC	HGNC:31374. C1QTNF8.
PharmGKB	PA134914298.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P60827.
HOVERGEN	P60827.
Gene expression databases
CleanEx	HS_C1QTNF8.
Family and domain databases
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like. [Graphical view]
Gene3D	G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	103975.

Entry information

Entry name

C1QT8_HUMAN

Accession

Primary (citable) accession number: P60827

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	November 4, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)