Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P60827 (C1QT8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C1q tumor necrosis factor-related protein 8
Alternative name(s):
C1q/TNF-related protein 8
Short name=CTRP8
Gene names
Name:C1QTNF8
ORF Names:UNQ5829/PRO19648
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homotrimer. Forms heteromeric complexes with C1QL1.

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed predominantly in lung and testis. Ref.1

Post-translational modification

No N-glycosylation.

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

Sequence caution

The sequence AAQ89191.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome.

The sequence ACJ46463.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome.

Ontologies

Keywords
   Cellular componentSecreted
   DomainCollagen
Signal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcollagen

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 252235Complement C1q tumor necrosis factor-related protein 8
PRO_0000003541

Regions

Domain69 – 11143Collagen-like
Domain112 – 252141C1q

Sequences

Sequence LengthMass (Da)Tools
P60827 [UniParc].

Last modified March 2, 2010. Version 2.
Checksum: 42F987B300C9C1BC

FASTA25227,685
        10         20         30         40         50         60 
MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG DLWRGLPRVR 

        70         80         90        100        110        120 
PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG QKGQVGPPGA ACRRAYAAFS 

       130        140        150        160        170        180 
VGRREGLHSS DHFQAVPFDT ELVNLDGAFD LAAGRFLCTV PGVYFLSLNV HTWNYKETYL 

       190        200        210        220        230        240 
HIMLNRRPAA VLYAQPSERS VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI YGEHGDLYIT 

       250 
FSGHLVKPAA EL 

« Hide

References

« Hide 'large scale' references
[1]"CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
Peterson J.M., Wei Z., Wong G.W.
Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY.
Tissue: Hippocampus.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FJ422561 mRNA. Translation: ACJ46463.1. Sequence problems.
AY358832 mRNA. Translation: AAQ89191.1. Sequence problems.
AC009041 Genomic DNA. No translation available.
AL031713 Genomic DNA. No translation available.
RefSeqNP_997302.2. NM_207419.3.
UniGeneHs.527853.

3D structure databases

ProteinModelPortalP60827.
SMRP60827. Positions 45-250.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM290457629.

Proteomic databases

PaxDbP60827.
PRIDEP60827.

Protocols and materials databases

DNASU390664.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328449; ENSP00000330426; ENSG00000184471.
GeneID390664.
KEGGhsa:390664.
UCSCuc010uuw.1. human.

Organism-specific databases

CTD390664.
GeneCardsGC16M001138.
H-InvDBHIX0038589.
HGNCHGNC:31374. C1QTNF8.
HPAHPA056438.
MIM614147. gene.
neXtProtNX_P60827.
PharmGKBPA134914298.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44388.
HOGENOMHOG000101544.
HOVERGENHBG108220.
InParanoidP60827.
OMAHGDLYIT.
OrthoDBEOG71CFMS.
PhylomeDBP60827.
TreeFamTF329591.

Gene expression databases

BgeeP60827.
CleanExHS_C1QTNF8.
GenevestigatorP60827.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi390664.
NextBio103975.
PROP60827.
SOURCESearch...

Entry information

Entry nameC1QT8_HUMAN
AccessionPrimary (citable) accession number: P60827
Secondary accession number(s): B7U178
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 2, 2010
Last modified: March 19, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM