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P60827

- C1QT8_HUMAN

UniProt

P60827 - C1QT8_HUMAN

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Protein

Complement C1q tumor necrosis factor-related protein 8

Gene

C1QTNF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 8
Alternative name(s):
C1q/TNF-related protein 8
Short name:
CTRP8
Gene namesi
Name:C1QTNF8
ORF Names:UNQ5829/PRO19648
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:31374. C1QTNF8.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 252235Complement C1q tumor necrosis factor-related protein 8PRO_0000003541Add
BLAST

Post-translational modificationi

No N-glycosylation.

Proteomic databases

PaxDbiP60827.
PRIDEiP60827.

Expressioni

Tissue specificityi

Expressed predominantly in lung and testis.1 Publication

Gene expression databases

BgeeiP60827.
CleanExiHS_C1QTNF8.
GenevestigatoriP60827.

Organism-specific databases

HPAiHPA056438.

Interactioni

Subunit structurei

Homotrimer. Forms heteromeric complexes with C1QL1.

Structurei

3D structure databases

ProteinModelPortaliP60827.
SMRiP60827. Positions 136-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 11143Collagen-likeAdd
BLAST
Domaini112 – 252141C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG44388.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000101544.
HOVERGENiHBG108220.
InParanoidiP60827.
OMAiHGDLYIT.
OrthoDBiEOG71CFMS.
PhylomeDBiP60827.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60827-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG
60 70 80 90 100
DLWRGLPRVR PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG
110 120 130 140 150
QKGQVGPPGA ACRRAYAAFS VGRREGLHSS DHFQAVPFDT ELVNLDGAFD
160 170 180 190 200
LAAGRFLCTV PGVYFLSLNV HTWNYKETYL HIMLNRRPAA VLYAQPSERS
210 220 230 240 250
VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI YGEHGDLYIT FSGHLVKPAA

EL
Length:252
Mass (Da):27,685
Last modified:March 2, 2010 - v2
Checksum:i42F987B300C9C1BC
GO

Sequence cautioni

The sequence AAQ89191.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome.
The sequence ACJ46463.1 differs from that shown. Reason: Contains a 30 bp insertion which does not match the genome.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ422561 mRNA. Translation: ACJ46463.1. Sequence problems.
AY358832 mRNA. Translation: AAQ89191.1. Sequence problems.
AC009041 Genomic DNA. No translation available.
AL031713 Genomic DNA. No translation available.
CCDSiCCDS32358.1.
RefSeqiNP_997302.2. NM_207419.3.
UniGeneiHs.527853.

Genome annotation databases

EnsembliENST00000328449; ENSP00000330426; ENSG00000184471.
GeneIDi390664.
KEGGihsa:390664.
UCSCiuc010uuw.1. human.

Polymorphism databases

DMDMi290457629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ422561 mRNA. Translation: ACJ46463.1 . Sequence problems.
AY358832 mRNA. Translation: AAQ89191.1 . Sequence problems.
AC009041 Genomic DNA. No translation available.
AL031713 Genomic DNA. No translation available.
CCDSi CCDS32358.1.
RefSeqi NP_997302.2. NM_207419.3.
UniGenei Hs.527853.

3D structure databases

ProteinModelPortali P60827.
SMRi P60827. Positions 136-249.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 290457629.

Proteomic databases

PaxDbi P60827.
PRIDEi P60827.

Protocols and materials databases

DNASUi 390664.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328449 ; ENSP00000330426 ; ENSG00000184471 .
GeneIDi 390664.
KEGGi hsa:390664.
UCSCi uc010uuw.1. human.

Organism-specific databases

CTDi 390664.
GeneCardsi GC16M001138.
H-InvDB HIX0038589.
HGNCi HGNC:31374. C1QTNF8.
HPAi HPA056438.
MIMi 614147. gene.
neXtProti NX_P60827.
PharmGKBi PA134914298.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44388.
GeneTreei ENSGT00760000118830.
HOGENOMi HOG000101544.
HOVERGENi HBG108220.
InParanoidi P60827.
OMAi HGDLYIT.
OrthoDBi EOG71CFMS.
PhylomeDBi P60827.
TreeFami TF329591.

Miscellaneous databases

GenomeRNAii 390664.
NextBioi 103975.
PROi P60827.
SOURCEi Search...

Gene expression databases

Bgeei P60827.
CleanExi HS_C1QTNF8.
Genevestigatori P60827.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members."
    Peterson J.M., Wei Z., Wong G.W.
    Biochem. Biophys. Res. Commun. 388:360-365(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH C1QL1, TISSUE SPECIFICITY.
    Tissue: Hippocampus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiC1QT8_HUMAN
AccessioniPrimary (citable) accession number: P60827
Secondary accession number(s): B7U178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 2, 2010
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3