Reviewed, UniProtKB/Swiss-Prot P60819 (SELD_METJA)

Names and origin

Protein names

Recommended name:
    Selenide, water dikinase
    EC=2.7.9.3
Alternative name(s):
    Selenophosphate synthetase
    Selenium donor protein

Gene names

Name:	selD
Ordered Locus Names:	MJ1591

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity.
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate. HAMAP MF_00625
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the selenophosphate synthetase 1 family. Class I subfamily.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	ATP-binding Magnesium Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP selenide, water dikinase activity Inferred from electronic annotation. Source: HAMAP selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Selenide, water dikinase HAMAP MF_00625		PRO_0000127645
Regions
	Nucleotide binding	249 – 255	7	ATP Potential
Sites
	Active site	19	1	Potential
	Site	22	1	Important for catalytic activity By similarity
Amino acid modifications
	Non-standard residue	19	1	Selenocysteine Probable

Sequences

	Sequence		Length	Mass (Da)
	P60819-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 93B43EB552563680	FASTA	349	38,040
	10 20 30 40 50 60 MERGNEKIKL TELVKLHGUA CKLPSTELEF LVKGIVTDDD LLDKNILVGL GDDASIIKRN 70 80 90 100 110 120 GLVIAKTVDV FTPIVDDPYI QGKIAACNST SDIYAMGLLD IVGVLAIVGI PEKLPIHVVR 130 140 150 160 170 180 EMLKGFQDFC RENKTTIVGG HTILNPWPLI GGAVTGVGRE EEVLTKAGVK VGDVLILTKP 190 200 210 220 230 240 LGTQTAMALS RIPEEFKDLI SITEEERDYI INKAIEIMTT SNRYALKALR KAEERVGDKI 250 260 270 280 290 300 ANALTDITGF GILGHSNEMA KNSNVLIEIN LLPCIKRTPE LSRLFGHALL DGYGAETAGG 310 320 330 340 LLISAKEEYK DNLIDELEKA KCYAFEVGRV VKKGEGKAVL SKDVKVIEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
[2]	"Selenoprotein synthesis in archaea: identification of an mRNA element of Methanococcus jannaschii probably directing selenocysteine insertion." Wilting R., Schorling S., Persson B.C., Boeck A. J. Mol. Biol. 266:637-641(1997) [PubMed: 9102456] [Abstract] Cited for: PROBABLE SELENOCYSTEINE AT SEC-19.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L77117 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus MJ1591 in contig L77117_GR.
TIGR	MJ1591.
Phylogenomic databases
HOGENOM	P60819.
OMA	MDSCVIP.
Enzyme and pathway databases
BRENDA	2.7.9.3. 256362.
Family and domain databases
HAMAP	MF_00625. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004536. SelD. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
TIGRFAMs	TIGR00476. selD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SELD_METJA

Accession

Primary (citable) accession number: P60819

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)