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Protein

Probable glycerol-3-phosphate acyltransferase

Gene

plsY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO4 (Probable).1 Publication

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.1 Publication
Acyl-[acyl-carrier-protein] + sn-glycerol 3-phosphate = [acyl-carrier-protein] + 1-acyl-sn-glycerol 3-phosphate.1 Publication

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG11674-MONOMER
UniPathwayiUPA00085

Protein family/group databases

TCDBi9.B.31.1.1 the plsy/yqih (plsy) family

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate acyltransferase
Alternative name(s):
G3P acyltransferase (EC:2.3.1.15, EC:2.3.1.n5)
Short name:
GPAT
Lysophosphatidic acid synthase
Short name:
LPA synthase
Gene namesi
Name:plsY
Synonyms:ygiH
Ordered Locus Names:b3059, JW3031
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11674 plsY

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3PeriplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 52CytoplasmicSequence analysisAdd BLAST28
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 80PeriplasmicSequence analysis7
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 111CytoplasmicSequence analysis10
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 137PeriplasmicSequence analysis5
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 205CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001883681 – 205Probable glycerol-3-phosphate acyltransferaseAdd BLAST205

Proteomic databases

PaxDbiP60782
PRIDEiP60782

Interactioni

Subunit structurei

Probably interacts with PlsX.By similarity

Protein-protein interaction databases

BioGridi4259257, 299 interactors
IntActiP60782, 1 interactor
STRINGi316385.ECDH10B_3234

Structurei

3D structure databases

ProteinModelPortaliP60782
SMRiP60782
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PlsY family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105K7Z Bacteria
COG0344 LUCA
HOGENOMiHOG000283806
InParanoidiP60782
KOiK08591
OMAiHSQYPKI
PhylomeDBiP60782

Family and domain databases

HAMAPiMF_01043 PlsY, 1 hit
InterProiView protein in InterPro
IPR003811 G3P_acylTferase_PlsY
PANTHERiPTHR30309 PTHR30309, 1 hit
PfamiView protein in Pfam
PF02660 G3P_acyltransf, 1 hit
SMARTiView protein in SMART
SM01207 G3P_acyltransf, 1 hit
TIGRFAMsiTIGR00023 TIGR00023, 1 hit

Sequencei

Sequence statusi: Complete.

P60782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAIAPGMIL IAYLCGSISS AILVCRLCGL PDPRTSGSGN PGATNVLRIG
60 70 80 90 100
GKGAAVAVLI FDVLKGMLPV WGAYELGVSP FWLGLIAIAA CLGHIWPVFF
110 120 130 140 150
GFKGGKGVAT AFGAIAPIGW DLTGVMAGTW LLTVLLSGYS SLGAIVSALI
160 170 180 190 200
APFYVWWFKP QFTFPVSMLS CLILLRHHDN IQRLWRRQET KIWTKFKRKR

EKDPE
Length:205
Mass (Da):22,193
Last modified:April 13, 2004 - v1
Checksum:i13066C8FBA2543E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28379 Genomic DNA Translation: AAA89139.1
U00096 Genomic DNA Translation: AAC76095.1
AP009048 Genomic DNA Translation: BAE77110.1
L12966 Genomic DNA No translation available.
PIRiA65094
RefSeqiNP_417531.1, NC_000913.3
WP_001272796.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76095; AAC76095; b3059
BAE77110; BAE77110; BAE77110
GeneIDi947561
KEGGiecj:JW3031
eco:b3059
PATRICifig|1411691.4.peg.3672

Similar proteinsi

Entry informationi

Entry nameiPLSY_ECOLI
AccessioniPrimary (citable) accession number: P60782
Secondary accession number(s): P31056, Q2M9E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health