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P60781

- RNP3_METMP

UniProt

P60781 - RNP3_METMP

Protein

Ribonuclease P protein component 3

Gene

rnp3

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.1 PublicationUniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

    Kineticsi

    kcat 10 min(-1) in absence of L7Ae, 63 min(-1) in presence of L7Ae. Kinetic parameters determined at 37 degrees Celsius.

    1. KM=2.6 µM for pre-tRNA-Tyr in the absence of L7Ae1 Publication
    2. KM=0.044 µM for pre-tRNA-Tyr in the presence of L7Ae1 Publication

    Temperature dependencei

    Optimum temperature is 36-38 degrees Celsius in the absence of L7Ae, 48-50 degrees Celsius in presence of L7Ae.1 Publication

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB

    GO - Biological processi

    1. RNA phosphodiester bond hydrolysis Source: GOC
    2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    3. tRNA 5'-leader removal Source: UniProtKB

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Enzyme and pathway databases

    BioCyciMMAR267377:GJ77-457-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein component 3UniRule annotation (EC:3.1.26.5UniRule annotation)
    Short name:
    RNase P component 3UniRule annotation
    Alternative name(s):
    Rpp30UniRule annotation
    Gene namesi
    Name:rnp3UniRule annotation
    Ordered Locus Names:MMP0430
    OrganismiMethanococcus maripaludis (strain S2 / LL)
    Taxonomic identifieri267377 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000590: Chromosome

    Subcellular locationi

    Cytoplasm 1 PublicationUniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. ribonuclease P complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Ribonuclease P protein component 3PRO_0000140042Add
    BLAST

    Interactioni

    Subunit structurei

    Consists of a catalytic RNA component and at least 5 protein subunits.1 Publication

    Protein-protein interaction databases

    DIPiDIP-59366N.
    STRINGi267377.MMP0430.

    Structurei

    3D structure databases

    ProteinModelPortaliP60781.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic/archaeal RNase P protein component 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1603.
    HOGENOMiHOG000296348.
    KOiK03539.
    OMAiVAIELNF.

    Family and domain databases

    HAMAPiMF_00756. RNase_P_3.
    InterProiIPR016195. Pol/histidinol_Pase-like.
    IPR023539. RNase_P_comp-3_arc.
    IPR002738. RNase_P_p30.
    [Graphical view]
    PfamiPF01876. RNase_P_p30. 1 hit.
    [Graphical view]
    SUPFAMiSSF89550. SSF89550. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P60781-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEGIFDINH VFDEEGIKTL KRFGWDGSVA VQNHNEYSEE KINTAVEYGE    50
    NCEFKVYSGV KISTKNQNEM EKAVKKYRNK VDILLVEGGD VKINRRVLEM 100
    NDVDILSTPE LNRMDNGLDH ILARLGSTNR VAVELNFGNL LKSKNYDRSK 150
    ILWAFQRNLK LSKKYDTPVV ISSGANDIYG IKAPGDLRGF LNTVADPLYS 200
    KKIIETTSKI IDYRLYLKNK NVLMPGLEIV EE 232
    Length:232
    Mass (Da):26,452
    Last modified:April 13, 2004 - v1
    Checksum:i1BE3FFFB9096C7EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF29986.1.
    RefSeqiNP_987550.1. NC_005791.1.
    WP_011170374.1. NC_005791.1.

    Genome annotation databases

    EnsemblBacteriaiCAF29986; CAF29986; MMP0430.
    GeneIDi2762077.
    KEGGimmp:MMP0430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF29986.1 .
    RefSeqi NP_987550.1. NC_005791.1.
    WP_011170374.1. NC_005791.1.

    3D structure databases

    ProteinModelPortali P60781.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59366N.
    STRINGi 267377.MMP0430.

    Protocols and materials databases

    DNASUi 2762077.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF29986 ; CAF29986 ; MMP0430 .
    GeneIDi 2762077.
    KEGGi mmp:MMP0430.

    Phylogenomic databases

    eggNOGi COG1603.
    HOGENOMi HOG000296348.
    KOi K03539.
    OMAi VAIELNF.

    Enzyme and pathway databases

    BioCyci MMAR267377:GJ77-457-MONOMER.

    Family and domain databases

    HAMAPi MF_00756. RNase_P_3.
    InterProi IPR016195. Pol/histidinol_Pase-like.
    IPR023539. RNase_P_comp-3_arc.
    IPR002738. RNase_P_p30.
    [Graphical view ]
    Pfami PF01876. RNase_P_p30. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89550. SSF89550. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S2 / LL.
    2. Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, SUBCELLULAR LOCATION.
      Strain: S2 / LL.

    Entry informationi

    Entry nameiRNP3_METMP
    AccessioniPrimary (citable) accession number: P60781
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3