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Protein

Protein TsgA

Gene

tsgA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • response to selenite ion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:YHFC-MONOMER.
ECOL316407:JW3327-MONOMER.

Protein family/group databases

TCDBi2.A.1.7.14. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TsgA
Gene namesi
Name:tsgA
Synonyms:gutS, yhfC, yhfH
Ordered Locus Names:b3364, JW3327
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11262. tsgA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 5019PeriplasmicSequence analysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Topological domaini72 – 776CytoplasmicSequence analysis
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Topological domaini99 – 1002PeriplasmicSequence analysis
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Topological domaini122 – 13312CytoplasmicSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 1617PeriplasmicSequence analysis
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Topological domaini183 – 20523CytoplasmicSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 24418PeriplasmicSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 2727CytoplasmicSequence analysis
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST
Topological domaini294 – 2963PeriplasmicSequence analysis
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Topological domaini318 – 33114CytoplasmicSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Topological domaini353 – 3608PeriplasmicSequence analysis
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Topological domaini382 – 39312CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Protein TsgAPRO_0000206494Add
BLAST

Proteomic databases

PaxDbiP60778.

Expressioni

Inductioni

By selenite or tellurite. Maximal expression was detected at concentrations of 10.0 and 0.5 micrograms/ml for sodium selenite and sodium tellurite, respectively.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261086. 9 interactions.
STRINGi511145.b3364.

Structurei

3D structure databases

ProteinModelPortaliP60778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106DTQ. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000290517.
InParanoidiP60778.
KOiK06141.
OMAiRFGFVLM.
OrthoDBiEOG67T5G4.
PhylomeDBiP60778.

Family and domain databases

HAMAPiMF_01044. MFS_TsgA.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023528. MFS_TsgA.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSNRIKLT WISFLSYALT GALVIVTGMV MGNIADYFNL PVSSMSNTFT
60 70 80 90 100
FLNAGILISI FLNAWLMEIV PLKTQLRFGF LLMVLAVAGL MFSHSLALFS
110 120 130 140 150
AAMFILGVVS GITMSIGTFL VTQMYEGRQR GSRLLFTDSF FSMAGMIFPM
160 170 180 190 200
IAAFLLARSI EWYWVYACIG LVYVAIFILT FGCEFPALGK HAPKTDAPVE
210 220 230 240 250
KEKWGIGVLF LSVAALCYIL GQLGFISWVP EYAKGLGMSL NDAGTLVSNF
260 270 280 290 300
WMSYMVGMWA FSFILRFFDL QRILTVLAGL AAILMYVFNT GTPAHMAWSI
310 320 330 340 350
LALGFFSSAI YTTIITLGSQ QTKVPSPKLV NFVLTCGTIG TMLTFVVTGP
360 370 380 390
IVEHSGPQAA LLTANGLYAV VFVMCFLLGF VSRHRQHNTL TSH
Length:393
Mass (Da):43,166
Last modified:April 13, 2004 - v1
Checksum:i75445C6136809691
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58161.1.
U00096 Genomic DNA. Translation: AAC76389.1.
AP009048 Genomic DNA. Translation: BAE77926.1.
M28363 Genomic DNA. Translation: AAA23771.2.
X14202 Genomic DNA. No translation available.
PIRiG65130.
RefSeqiNP_417823.1. NC_000913.3.
WP_000185247.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76389; AAC76389; b3364.
BAE77926; BAE77926; BAE77926.
GeneIDi947869.
KEGGiecj:JW3327.
eco:b3364.
PATRICi32122162. VBIEscCol129921_3458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58161.1.
U00096 Genomic DNA. Translation: AAC76389.1.
AP009048 Genomic DNA. Translation: BAE77926.1.
M28363 Genomic DNA. Translation: AAA23771.2.
X14202 Genomic DNA. No translation available.
PIRiG65130.
RefSeqiNP_417823.1. NC_000913.3.
WP_000185247.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP60778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261086. 9 interactions.
STRINGi511145.b3364.

Protein family/group databases

TCDBi2.A.1.7.14. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP60778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76389; AAC76389; b3364.
BAE77926; BAE77926; BAE77926.
GeneIDi947869.
KEGGiecj:JW3327.
eco:b3364.
PATRICi32122162. VBIEscCol129921_3458.

Organism-specific databases

EchoBASEiEB1242.
EcoGeneiEG11262. tsgA.

Phylogenomic databases

eggNOGiENOG4106DTQ. Bacteria.
COG0477. LUCA.
HOGENOMiHOG000290517.
InParanoidiP60778.
KOiK06141.
OMAiRFGFVLM.
OrthoDBiEOG67T5G4.
PhylomeDBiP60778.

Enzyme and pathway databases

BioCyciEcoCyc:YHFC-MONOMER.
ECOL316407:JW3327-MONOMER.

Miscellaneous databases

PROiP60778.

Family and domain databases

HAMAPiMF_01044. MFS_TsgA.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023528. MFS_TsgA.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Nucleotide sequences of fic and fic-1 genes involved in cell filamentation induced by cyclic AMP in Escherichia coli."
    Kawamukai M., Matsuda H., Fujii W., Utsumi R., Komano T.
    J. Bacteriol. 171:4525-4529(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-107.
  4. "Cloning of binding sequences for the Escherichia coli transcription activators, FNR and CRP: location of bases involved in discrimination between FNR and CRP."
    Bell A.I., Gaston K.L., Cole J.A., Busby S.J.W.
    Nucleic Acids Res. 17:3865-3874(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 347-393.
    Strain: K12.
  5. "Nucleotide sequence, organisation and structural analysis of the products of genes in the nirB-cysG region of the Escherichia coli K-12 chromosome."
    Peakman T., Crouzet J., Mayaux J.F., Busby S.J.W., Mohan S., Harborne N., Wootton J., Nicolson R., Cole J.A.
    Eur. J. Biochem. 191:315-323(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 347-393.
    Strain: K12.
  6. "A novel selenite- and tellurite-inducible gene in Escherichia coli."
    Guzzo J., Dubow M.S.
    Appl. Environ. Microbiol. 66:4972-4978(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiTSGA_ECOLI
AccessioniPrimary (citable) accession number: P60778
Secondary accession number(s): P21229, P37612, Q2M730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: February 17, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.