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P60773

- 3S11_NAJPH

UniProt

P60773 - 3S11_NAJPH

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Protein

Short neurotoxin 1

Gene
N/A
Organism
Naja philippinensis (Philippine cobra)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.By similarity

GO - Biological processi

  1. modification of morphology or physiology of other organism Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Short neurotoxin 1
Short name:
NTX I
OrganismiNaja philippinensis (Philippine cobra)
Taxonomic identifieri8659 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. other organism postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.05 mg/kg by intravenous injection.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Short neurotoxin 1PRO_0000093609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 23By similarity
Disulfide bondi17 ↔ 40By similarity
Disulfide bondi42 ↔ 53By similarity
Disulfide bondi54 ↔ 59By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP60773.
SMRiP60773. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

InterProiIPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view]
PfamiPF00087. Toxin_1. 1 hit.
[Graphical view]
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60773-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LECHNQQSSQ APTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVK
60
LNCCRTDRCN N
Length:61
Mass (Da):6,873
Last modified:July 21, 1986 - v1
Checksum:i74A0EA75BE568961
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551R → T in minor component.

Sequence databases

PIRiA91768. N1NJ1P.
B94448. N1NJ2P.

Cross-referencesi

Sequence databases

PIRi A91768. N1NJ1P.
B94448. N1NJ2P.

3D structure databases

ProteinModelPortali P60773.
SMRi P60773. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006553.

Family and domain databases

InterProi IPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view ]
Pfami PF00087. Toxin_1. 1 hit.
[Graphical view ]
PROSITEi PS00272. SNAKE_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The major lethal neurotoxin of the venom of Naja naja philippinensis. Purification, physical and chemical properties, partial amino acid sequence."
    Hauert J., Maire M., Sussmann A., Bargetzi J.-P.
    Int. J. Pept. Protein Res. 6:201-222(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (MAJOR COMPONENT), SUBCELLULAR LOCATION.
    Tissue: Venom.
  2. Hauert J.
    Thesis (1977), University of Geneva, Switzerland
    Cited for: PROTEIN SEQUENCE (MINOR COMPONENT).
    Tissue: Venom.

Entry informationi

Entry namei3S11_NAJPH
AccessioniPrimary (citable) accession number: P60773
Secondary accession number(s): P01428
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 7, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.