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P60773 (NXS1_NAJPH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 24, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short neurotoxin 1

Short name=NTX I
OrganismNaja philippinensis (Philippine cobra)
Taxonomic identifier8659 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to the muscular nicotinic acetylcholine receptor.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Toxic dose

LD50 is 0.05 mg/kg by intravenous injection.

Sequence similarities

Belongs to the snake three-finger toxin family. Type I alpha-neurotoxin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Short neurotoxin 1
PRO_0000093609

Amino acid modifications

Disulfide bond3 ↔ 23 By similarity
Disulfide bond17 ↔ 40 By similarity
Disulfide bond42 ↔ 53 By similarity
Disulfide bond54 ↔ 59 By similarity

Natural variations

Natural variant551R → T in minor component.

Sequences

Sequence LengthMass (Da)Tools
P60773 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 74A0EA75BE568961

FASTA616,873
        10         20         30         40         50         60 
LECHNQQSSQ APTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVK LNCCRTDRCN 


N 

« Hide

References

[1]"The major lethal neurotoxin of the venom of Naja naja philippinensis. Purification, physical and chemical properties, partial amino acid sequence."
Hauert J., Maire M., Sussmann A., Bargetzi J.-P.
Int. J. Pept. Protein Res. 6:201-222(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (MAJOR COMPONENT).
Tissue: Venom.
[2]Hauert J.
Thesis (1977), University of Geneva, Switzerland
Cited for: PROTEIN SEQUENCE (MINOR COMPONENT).
Tissue: Venom.

Cross-references

Sequence databases

PIRN1NJ1P. A91768.
N1NJ2P. B94448.

3D structure databases

ProteinModelPortalP60773.
SMRP60773. Positions 1-61.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006553.

Family and domain databases

InterProIPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view]
PfamPF00087. Toxin_1. 1 hit.
[Graphical view]
PROSITEPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNXS1_NAJPH
AccessionPrimary (citable) accession number: P60773
Secondary accession number(s): P01428
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 24, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families