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P60773

- NXS1_NAJPH

UniProt

P60773 - NXS1_NAJPH

Protein

Short neurotoxin 1

Gene
N/A
Organism
Naja philippinensis (Philippine cobra)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to the muscular nicotinic acetylcholine receptor.

    GO - Biological processi

    1. modification of morphology or physiology of other organism Source: InterPro

    Keywords - Molecular functioni

    Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short neurotoxin 1
    Short name:
    NTX I
    OrganismiNaja philippinensis (Philippine cobra)
    Taxonomic identifieri8659 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

    Subcellular locationi

    GO - Cellular componenti

    1. other organism postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Toxic dosei

    LD50 is 0.05 mg/kg by intravenous injection.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6161Short neurotoxin 1PRO_0000093609Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 23By similarity
    Disulfide bondi17 ↔ 40By similarity
    Disulfide bondi42 ↔ 53By similarity
    Disulfide bondi54 ↔ 59By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP60773.
    SMRiP60773. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG006553.

    Family and domain databases

    InterProiIPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view]
    PfamiPF00087. Toxin_1. 1 hit.
    [Graphical view]
    PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60773-1 [UniParc]FASTAAdd to Basket

    « Hide

    LECHNQQSSQ APTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVK   50
    LNCCRTDRCN N 61
    Length:61
    Mass (Da):6,873
    Last modified:July 21, 1986 - v1
    Checksum:i74A0EA75BE568961
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551R → T in minor component.

    Sequence databases

    PIRiA91768. N1NJ1P.
    B94448. N1NJ2P.

    Cross-referencesi

    Sequence databases

    PIRi A91768. N1NJ1P.
    B94448. N1NJ2P.

    3D structure databases

    ProteinModelPortali P60773.
    SMRi P60773. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006553.

    Family and domain databases

    InterProi IPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view ]
    Pfami PF00087. Toxin_1. 1 hit.
    [Graphical view ]
    PROSITEi PS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The major lethal neurotoxin of the venom of Naja naja philippinensis. Purification, physical and chemical properties, partial amino acid sequence."
      Hauert J., Maire M., Sussmann A., Bargetzi J.-P.
      Int. J. Pept. Protein Res. 6:201-222(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (MAJOR COMPONENT).
      Tissue: Venom.
    2. Hauert J.
      Thesis (1977), University of Geneva, Switzerland
      Cited for: PROTEIN SEQUENCE (MINOR COMPONENT).
      Tissue: Venom.

    Entry informationi

    Entry nameiNXS1_NAJPH
    AccessioniPrimary (citable) accession number: P60773
    Secondary accession number(s): P01428
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3