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P60773

- NXS1_NAJPH

UniProt

P60773 - NXS1_NAJPH

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Protein
Short neurotoxin 1
Gene
N/A
Organism
Naja philippinensis (Philippine cobra)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to the muscular nicotinic acetylcholine receptor.

GO - Biological processi

  1. modification of morphology or physiology of other organism Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Short neurotoxin 1
Short name:
NTX I
OrganismiNaja philippinensis (Philippine cobra)
Taxonomic identifieri8659 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

GO - Cellular componenti

  1. other organism postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.05 mg/kg by intravenous injection.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Short neurotoxin 1
PRO_0000093609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 23 By similarity
Disulfide bondi17 ↔ 40 By similarity
Disulfide bondi42 ↔ 53 By similarity
Disulfide bondi54 ↔ 59 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP60773.
SMRiP60773. Positions 1-61.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

InterProiIPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view]
PfamiPF00087. Toxin_1. 1 hit.
[Graphical view]
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60773-1 [UniParc]FASTAAdd to Basket

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LECHNQQSSQ APTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVK   50
LNCCRTDRCN N 61
Length:61
Mass (Da):6,873
Last modified:July 21, 1986 - v1
Checksum:i74A0EA75BE568961
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551R → T in minor component.

Sequence databases

PIRiA91768. N1NJ1P.
B94448. N1NJ2P.

Cross-referencesi

Sequence databases

PIRi A91768. N1NJ1P.
B94448. N1NJ2P.

3D structure databases

ProteinModelPortali P60773.
SMRi P60773. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006553.

Family and domain databases

InterProi IPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view ]
Pfami PF00087. Toxin_1. 1 hit.
[Graphical view ]
PROSITEi PS00272. SNAKE_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The major lethal neurotoxin of the venom of Naja naja philippinensis. Purification, physical and chemical properties, partial amino acid sequence."
    Hauert J., Maire M., Sussmann A., Bargetzi J.-P.
    Int. J. Pept. Protein Res. 6:201-222(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (MAJOR COMPONENT).
    Tissue: Venom.
  2. Hauert J.
    Thesis (1977), University of Geneva, Switzerland
    Cited for: PROTEIN SEQUENCE (MINOR COMPONENT).
    Tissue: Venom.

Entry informationi

Entry nameiNXS1_NAJPH
AccessioniPrimary (citable) accession number: P60773
Secondary accession number(s): P01428
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 24, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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