Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MAM domain-containing glycosylphosphatidylinositol anchor protein 2

Gene

Mdga2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell-cell interactions.By similarity

GO - Biological processi

  • pattern specification process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
Alternative name(s):
MAM domain-containing protein 1
Gene namesi
Name:Mdga2
Synonyms:Mamdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2444706. Mdga2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 924899MAM domain-containing glycosylphosphatidylinositol anchor protein 2PRO_0000014860Add
BLAST
Propeptidei925 – 94925Removed in mature formSequence analysisPRO_0000292044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 110PROSITE-ProRule annotation
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi159 ↔ 216PROSITE-ProRule annotation
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi264 ↔ 310PROSITE-ProRule annotation
Disulfide bondi359 ↔ 417PROSITE-ProRule annotation
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi465 ↔ 515PROSITE-ProRule annotation
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence analysis
Disulfide bondi561 ↔ 611PROSITE-ProRule annotation
Glycosylationi610 – 6101N-linked (GlcNAc...)Sequence analysis
Glycosylationi703 – 7031N-linked (GlcNAc...)Sequence analysis
Lipidationi924 – 9241GPI-anchor amidated aspartateSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP60755.
PaxDbiP60755.
PRIDEiP60755.

PTM databases

iPTMnetiP60755.
PhosphoSiteiP60755.
SwissPalmiP60755.

Expressioni

Gene expression databases

BgeeiP60755.
ExpressionAtlasiP60755. baseline and differential.
GenevisibleiP60755. MM.

Interactioni

Subunit structurei

Interacts (through the Ig-like domains) with NLGN2.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046761.

Structurei

3D structure databases

ProteinModelPortaliP60755.
SMRiP60755. Positions 13-618, 741-914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 127101Ig-like 1Add
BLAST
Domaini134 – 23299Ig-like 2Add
BLAST
Domaini242 – 32887Ig-like 3Add
BLAST
Domaini340 – 43697Ig-like 4Add
BLAST
Domaini442 – 53392Ig-like 5Add
BLAST
Domaini540 – 62788Ig-like 6Add
BLAST
Domaini638 – 738101Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Domaini739 – 914176MAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IF9B. Eukaryota.
ENOG410XPYU. LUCA.
GeneTreeiENSGT00720000108445.
HOGENOMiHOG000015243.
HOVERGENiHBG052403.
InParanoidiP60755.
PhylomeDBiP60755.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000998. MAM_dom.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00629. MAM. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 6 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVYGLVWL LTVLLEGISG QGVYAPPTVR IVHSGLACNI EEERYSERVY
60 70 80 90 100
TIREGETLEL TCLVTGHPRP QIRWTKTAGS ASDRFQDSSV FNETLRITNI
110 120 130 140 150
QRHQGGRYYC KAENGLGSPA IKSIRVDVYY LDDPVVTVHQ SIGEAKEQFY
160 170 180 190 200
YERTVFLRCV ANSNPPVRYS WRRGQEVLLQ GSDKGVEIYE PFFTQGETKI
210 220 230 240 250
LKLKNLRPQD YANYSCIASV RNVCNIPDKM VSFRLSNKTA SPSIKLLVDD
260 270 280 290 300
PIVVNPGEAI TLVCVTTGGE PTPSLTWVRS FGTLPEKIVL NGGTLTIPAI
310 320 330 340 350
TSDDAGTYSC IANNNVGNPA KKSTNIIVRA LKKGRFWITP DPYHKDDNIQ
360 370 380 390 400
IGREVKISCQ VEAVPSEELT FSWFKNGRPL RSSERMVITQ TDPDVSPGTT
410 420 430 440 450
NLDIIDLKFT DFGTYTCVAS LKGGGISDIS IDVNISSSTV PPNLTVPQEK
460 470 480 490 500
SPLVTREGDT IELQCQVTGK PKPIILWSRA DKEVAMPDGT MQMESYDGTL
510 520 530 540 550
RIVNVSREMS GMYRCQTSQY NGFNVKPREA LVQLIVQYPP AVEPAFLEIR
560 570 580 590 600
QGQDRSVTMS CRVLRAYPIR VLTYEWRLGN KLLRTGQFDS QEYTEYPLKS
610 620 630 640 650
LSNENYGVYN CSIINEAGAG RCSFLVTGKA YAPEFYYDTY NPVWQNRHRV
660 670 680 690 700
YSYSLQWTQM NPDAVDRIVA YRLGIRQAGQ QRWWEQEIKI NGNIQKGELI
710 720 730 740 750
TYNLTELIKP EAYEVRLTPL TKFGEGDSTI RVIKYTGEFH CGFEDGNICL
760 770 780 790 800
FTQDDTDNFD WTKQSTATRN TKYTPNTGPS ADRSGSKEGF YMYIETSRPR
810 820 830 840 850
LEGEKARLLS PVFSIAPKNP YGPTNSAYCF SFFYHMYGQH IGVLNVYLRL
860 870 880 890 900
KGQTTIENPL WSSSGNKGQR WNEAHVNIYP ITSFQLIFEG IRGPGIEGDI
910 920 930 940
AIDDVSIAEG ECAKQDLPTK NSVDGAVGIL VHIWLFPVII LISILSPRR
Length:949
Mass (Da):106,689
Last modified:April 13, 2004 - v1
Checksum:i10205A40D4DB379A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY371925 mRNA. Translation: AAQ75751.1.
CCDSiCCDS25945.1.
RefSeqiNP_996893.3. NM_207010.2.
UniGeneiMm.227680.

Genome annotation databases

EnsembliENSMUST00000178814; ENSMUSP00000137608; ENSMUSG00000034912.
GeneIDi320772.
KEGGimmu:320772.
UCSCiuc007nrl.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY371925 mRNA. Translation: AAQ75751.1.
CCDSiCCDS25945.1.
RefSeqiNP_996893.3. NM_207010.2.
UniGeneiMm.227680.

3D structure databases

ProteinModelPortaliP60755.
SMRiP60755. Positions 13-618, 741-914.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046761.

PTM databases

iPTMnetiP60755.
PhosphoSiteiP60755.
SwissPalmiP60755.

Proteomic databases

MaxQBiP60755.
PaxDbiP60755.
PRIDEiP60755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000178814; ENSMUSP00000137608; ENSMUSG00000034912.
GeneIDi320772.
KEGGimmu:320772.
UCSCiuc007nrl.3. mouse.

Organism-specific databases

CTDi161357.
MGIiMGI:2444706. Mdga2.

Phylogenomic databases

eggNOGiENOG410IF9B. Eukaryota.
ENOG410XPYU. LUCA.
GeneTreeiENSGT00720000108445.
HOGENOMiHOG000015243.
HOVERGENiHBG052403.
InParanoidiP60755.
PhylomeDBiP60755.

Miscellaneous databases

ChiTaRSiMdga2. mouse.
PROiP60755.
SOURCEiSearch...

Gene expression databases

BgeeiP60755.
ExpressionAtlasiP60755. baseline and differential.
GenevisibleiP60755. MM.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000998. MAM_dom.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00629. MAM. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 6 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Wu S.L., Liu S.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development."
    Pettem K.L., Yokomaku D., Takahashi H., Ge Y., Craig A.M.
    J. Cell Biol. 200:321-336(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NLGN2.
  4. "MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development."
    Lee K., Kim Y., Lee S.-J., Qiang Y., Lee D., Lee H.W., Kim H., Je H.S., Suedhof T.C., Ko J.
    Proc. Natl. Acad. Sci. U.S.A. 110:336-341(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NLGN2.

Entry informationi

Entry nameiMDGA2_MOUSE
AccessioniPrimary (citable) accession number: P60755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.