ID RL4_ECOLI Reviewed; 201 AA. AC P60723; P02388; Q2M6Y4; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 27-MAR-2024, entry version 197. DE RecName: Full=Large ribosomal subunit protein uL4 {ECO:0000303|PubMed:24524803}; DE AltName: Full=50S ribosomal protein L4; GN Name=rplD; Synonyms=eryA; OrderedLocusNames=b3319, JW3281; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP PROTEIN SEQUENCE, AND SUBUNIT. RA Kimura M., Wittmann-Liebold B.; RT "The primary structure of protein L4 from the large subunit of the RT Escherichia coli ribosome."; RL FEBS Lett. 121:317-322(1980). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3892488; DOI=10.1093/nar/13.12.4521; RA Zurawski G., Zurawski S.M.; RT "Structure of the Escherichia coli S10 ribosomal protein operon."; RL Nucleic Acids Res. 13:4521-4526(1985). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [5] RP PROTEIN SEQUENCE OF 1-12. RC STRAIN=K12 / EMG2; RX PubMed=9298646; DOI=10.1002/elps.1150180807; RA Link A.J., Robison K., Church G.M.; RT "Comparing the predicted and observed properties of proteins encoded in the RT genome of Escherichia coli K-12."; RL Electrophoresis 18:1259-1313(1997). RN [6] RP PROTEIN SEQUENCE OF 26-50, SUBUNIT, AND CROSS-LINKING TO RRNA. RC STRAIN=MRE-600; RX PubMed=7556101; DOI=10.1002/j.1460-2075.1995.tb00137.x; RA Urlaub H., Kruft V., Bischof O., Mueller E.-C., Wittmann-Liebold B.; RT "Protein-rRNA binding features and their structural and functional RT implications in ribosomes as determined by cross-linking studies."; RL EMBO J. 14:4578-4588(1995). RN [7] RP CROSS-LINKING TO 23S RRNA. RC STRAIN=MRE-600; RX PubMed=6170935; DOI=10.1093/nar/9.17.4285; RA Wower I., Wower J., Meinke M., Brimacombe R.; RT "The use of 2-iminothiolane as an RNA-protein cross-linking agent in RT Escherichia coli ribosomes, and the localisation on 23S RNA of sites cross- RT linked to proteins L4, L6, L21, L23, L27 and L29."; RL Nucleic Acids Res. 9:4285-4302(1981). RN [8] RP IDENTIFICATION BY 2D-GEL. RX PubMed=9298644; DOI=10.1002/elps.1150180805; RA VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.; RT "Escherichia coli proteome analysis using the gene-protein database."; RL Electrophoresis 18:1243-1251(1997). RN [9] RP NOMENCLATURE. RX PubMed=24524803; DOI=10.1016/j.sbi.2014.01.002; RA Ban N., Beckmann R., Cate J.H.D., Dinman J.D., Dragon F., Ellis S.R., RA Lafontaine D.L.J., Lindahl L., Liljas A., Lipton J.M., McAlear M.A., RA Moore P.B., Noller H.F., Ortega J., Panse V.G., Ramakrishnan V., RA Spahn C.M.T., Steitz T.A., Tchorzewski M., Tollervey D., Warren A.J., RA Williamson J.R., Wilson D., Yonath A., Yusupov M.; RT "A new system for naming ribosomal proteins."; RL Curr. Opin. Struct. Biol. 24:165-169(2014). RN [10] RP CHARACTERIZATION OF AN ERYTHROMYCIN-RESISTANT VARIANT. RC STRAIN=N282; RX PubMed=4589347; DOI=10.1007/bf00333665; RA Wittmann H.G., Stoffler G., Apirion D., Rosen L., Tanaka K., Tamaki M., RA Takata R., Dekio S., Otaka E.; RT "Biochemical and genetic studies on two different types of erythromycin RT resistant mutants of Escherichia coli with altered ribosomal proteins."; RL Mol. Gen. Genet. 127:175-189(1973). RN [11] RP ASSEMBLY MAP OF THE 50S SUBUNIT, AND SUBUNIT. RC STRAIN=K12; RX PubMed=3298242; DOI=10.1016/s0021-9258(18)47489-3; RA Herold M., Nierhaus K.H.; RT "Incorporation of six additional proteins to complete the assembly map of RT the 50 S subunit from Escherichia coli ribosomes."; RL J. Biol. Chem. 262:8826-8833(1987). RN [12] RP FUNCTION IN TRANSCRIPTION/TRANSLATION REGULATION. RC STRAIN=K12 / LL308; RX PubMed=2442760; DOI=10.1073/pnas.84.18.6516; RA Freedman L.P., Zengel J.M., Archer R.H., Lindahl L.; RT "Autogenous control of the S10 ribosomal protein operon of Escherichia RT coli: genetic dissection of transcriptional and posttranscriptional RT regulation."; RL Proc. Natl. Acad. Sci. U.S.A. 84:6516-6520(1987). RN [13] RP MECHANISM OF TRANSCRIPTIONAL REGULATION. RC STRAIN=K12 / LL308; RX PubMed=1692593; DOI=10.1016/s0022-2836(05)80122-6; RA Zengel J.M., Lindahl L.; RT "Escherichia coli ribosomal protein L4 stimulates transcription termination RT at a specific site in the leader of the S10 operon independent of L4- RT mediated inhibition of translation."; RL J. Mol. Biol. 213:67-78(1990). RN [14] RP REQUIREMENT FOR NUSA IN TRANSCRIPTION TERMINATION CONTROL. RX PubMed=2157208; DOI=10.1073/pnas.87.7.2675; RA Zengel J.M., Lindahl L.; RT "Ribosomal protein L4 stimulates in vitro termination of transcription at a RT NusA-dependent terminator in the S10 operon leader."; RL Proc. Natl. Acad. Sci. U.S.A. 87:2675-2679(1990). RN [15] RP IDENTIFICATION OF CHANGES IN AN ERYTHROMYCIN-RESISTANT VARIANT. RC STRAIN=N282; RX PubMed=7928988; DOI=10.1128/jb.176.20.6192-6198.1994; RA Chittum H.S., Champney W.S.; RT "Ribosomal protein gene sequence changes in erythromycin-resistant mutants RT of Escherichia coli."; RL J. Bacteriol. 176:6192-6198(1994). RN [16] RP ERYTHROMYCIN AND RIBOSOME ASSEMBLY. RC STRAIN=N282, and SK901; RX PubMed=7766155; DOI=10.1007/bf00295501; RA Chittum H.S., Champney W.S.; RT "Erythromycin inhibits the assembly of the large ribosomal subunit in RT growing Escherichia coli cells."; RL Curr. Microbiol. 30:273-279(1995). RN [17] RP REQUIREMENT FOR RNA-BINDING, MUTAGENESIS OF 40-ARG--ARG-88; RP 67-ARG--GLY-103; 93-SER--TYR-101; THR-131; LEU-134; ALA-160; VAL-167 AND RP 171-ASP--ALA-201, AND REGULATION-DEFECTIVE MUTANTS. RC STRAIN=K12 / LL308; RX PubMed=8846294; RA Li X., Lindahl L., Zengel J.M.; RT "Ribosomal protein L4 from Escherichia coli utilizes nonidentical RT determinants for its structural and regulatory functions."; RL RNA 2:24-37(1996). RN [18] RP ABILITY TO REGULATE S10 OPERON EXPRESSION IN OTHER BACTERIA. RC STRAIN=K12 / LL308; RX PubMed=10498727; DOI=10.1128/jb.181.19.6124-6132.1999; RA Allen T., Shen P., Samsel L., Liu R., Lindahl L., Zengel J.M.; RT "Phylogenetic analysis of L4-mediated autogenous control of the S10 RT ribosomal protein operon."; RL J. Bacteriol. 181:6124-6132(1999). RN [19] RP REQUIREMENT FOR RIBOSOME ASSEMBLY, AND S10 OPERON REGULATION. RC STRAIN=K12 / LL308; RX PubMed=13130133; DOI=10.1261/rna.5400703; RA Zengel J.M., Jerauld A., Walker A., Wahl M.C., Lindahl L.; RT "The extended loops of ribosomal proteins L4 and L22 are not required for RT ribosome assembly or L4-mediated autogenous control."; RL RNA 9:1188-1197(2003). RN [20] RP MASS SPECTROMETRY, AND SUBUNIT. RC STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290; RX PubMed=10094780; DOI=10.1006/abio.1998.3077; RA Arnold R.J., Reilly J.P.; RT "Observation of Escherichia coli ribosomal proteins and their RT posttranslational modifications by mass spectrometry."; RL Anal. Biochem. 269:105-112(1999). RN [21] RP STRUCTURE BY ELECTRON MICROSCOPY (11.50 ANGSTROMS), AND SUBUNIT. RC STRAIN=MRE-600; RX PubMed=12809609; DOI=10.1016/s0092-8674(03)00427-6; RA Gao H., Sengupta J., Valle M., Korostelev A., Eswar N., Stagg S.M., RA Van Roey P., Agrawal R.K., Harvey S.C., Sali A., Chapman M.S., Frank J.; RT "Study of the structural dynamics of the E. coli 70S ribosome using real- RT space refinement."; RL Cell 113:789-801(2003). RN [22] RP STRUCTURE BY ELECTRON MICROSCOPY (17.8 ANGSTROMS), SUBUNIT, AND EFFECT OF RP THE ERYTHROMYCIN-RESISTANT VARIANT ON THE POLYPEPTIDE EXIT TUNNEL. RC STRAIN=N282; RX PubMed=11511371; DOI=10.1016/s1097-2765(01)00293-3; RA Gabashvili I.S., Gregory S.T., Valle M., Grassucci R., Worbs M., Wahl M.C., RA Dahlberg A.E., Frank J.; RT "The polypeptide tunnel system in the ribosome and its gating in RT erythromycin resistance mutants of L4 and L22."; RL Mol. Cell 8:181-188(2001). RN [23] RP X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 2 DIFFERENT RIBOSOME STRUCTURES, RP AND SUBUNIT. RC STRAIN=MRE-600; RX PubMed=16272117; DOI=10.1126/science.1117230; RA Schuwirth B.S., Borovinskaya M.A., Hau C.W., Zhang W., Vila-Sanjurjo A., RA Holton J.M., Cate J.H.D.; RT "Structures of the bacterial ribosome at 3.5 A resolution."; RL Science 310:827-834(2005). RN [24] RP STRUCTURE BY ELECTRON MICROSCOPY (3.80 ANGSTROMS) OF TNAC-STALLED 50S RP RIBOSOMAL SUBUNIT, AND SUBUNIT. RC STRAIN=K12 / A19 / KC6; RX PubMed=25310980; DOI=10.1016/j.celrep.2014.09.011; RA Bischoff L., Berninghausen O., Beckmann R.; RT "Molecular basis for the ribosome functioning as an L-tryptophan sensor."; RL Cell Rep. 9:469-475(2014). RN [25] RP STRUCTURE BY ELECTRON MICROSCOPY (5.5 ANGSTROMS) OF 50S RIBOSOMAL SUBUNIT RP IN COMPLEX WITH OBGE AND GMP-PNP, AND SUBUNIT. RX PubMed=24844575; DOI=10.1371/journal.pbio.1001866; RA Feng B., Mandava C.S., Guo Q., Wang J., Cao W., Li N., Zhang Y., Zhang Y., RA Wang Z., Wu J., Sanyal S., Lei J., Gao N.; RT "Structural and functional insights into the mode of action of a RT universally conserved Obg GTPase."; RL PLoS Biol. 12:E1001866-E1001866(2014). RN [26] RP STRUCTURE BY ELECTRON MICROSCOPY (3.0 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX RP WITH ARFA AND RF2, AND SUBUNIT. RX PubMed=27906160; DOI=10.1038/nature20822; RA Ma C., Kurita D., Li N., Chen Y., Himeno H., Gao N.; RT "Mechanistic insights into the alternative translation termination by ArfA RT and RF2."; RL Nature 541:550-553(2017). RN [27] RP STRUCTURE BY ELECTRON MICROSCOPY (3.1 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX RP WITH ARFA AND RF2, AND SUBUNIT. RX PubMed=27906161; DOI=10.1038/nature20821; RA Huter P., Mueller C., Beckert B., Arenz S., Berninghausen O., Beckmann R., RA Wilson D.N.; RT "Structural basis for ArfA-RF2-mediated translation termination on mRNAs RT lacking stop codons."; RL Nature 541:546-549(2017). RN [28] RP STRUCTURE BY ELECTRON MICROSCOPY (2.97 ANGSTROMS) OF 70S RIBOSOME IN RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT. RX PubMed=27934701; DOI=10.1126/science.aai9127; RA James N.R., Brown A., Gordiyenko Y., Ramakrishnan V.; RT "Translational termination without a stop codon."; RL Science 354:1437-1440(2016). RN [29] RP STRUCTURE BY ELECTRON MICROSCOPY (3.52 ANGSTROMS) OF 70S RIBOSOME IN RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT. RX PubMed=28077875; DOI=10.1038/nature21053; RA Zeng F., Chen Y., Remis J., Shekhar M., Phillips J.C., Tajkhorshid E., RA Jin H.; RT "Structural basis of co-translational quality control by ArfA and RF2 bound RT to ribosome."; RL Nature 541:554-557(2017). RN [30] {ECO:0000312|PDB:7O19, ECO:0000312|PDB:7O1A, ECO:0000312|PDB:7O1C} RP STRUCTURE BY ELECTRON MICROSCOPY (2.40 ANGSTROMS) IN TNAC-STALLED RIBOSOME RP WITH L-TRYPTOPHAN WITH OR WITHOUT RELEASE FACTOR 2, AND SUBUNIT RP RRNA-BINDING. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=34504068; DOI=10.1038/s41467-021-25663-8; RA van der Stel A.X., Gordon E.R., Sengupta A., Martinez A.K., Klepacki D., RA Perry T.N., Herrero Del Valle A., Vazquez-Laslop N., Sachs M.S., RA Cruz-Vera L.R., Innis C.A.; RT "Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome RT stalling."; RL Nat. Commun. 12:5340-5340(2021). RN [31] {ECO:0000312|PDB:7OIZ, ECO:0000312|PDB:7OJ0, ECO:0000312|PDB:7P3K} RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS) IN TNAC-STALLED RIBOSOME RP WITH AND WITHOUT L-TRYPTOPHAN AND RELEASE FACTOR 2. RC STRAIN=K12; RX PubMed=34403461; DOI=10.1093/nar/gkab665; RA Su T., Kudva R., Becker T., Buschauer R., Komar T., Berninghausen O., RA von Heijne G., Cheng J., Beckmann R.; RT "Structural basis of L-tryptophan-dependent inhibition of release factor 2 RT by the TnaC arrest peptide."; RL Nucleic Acids Res. 49:9539-9547(2021). CC -!- FUNCTION: One of the primary rRNA binding proteins, this protein CC initially binds near the 5'-end of the 23S rRNA (PubMed:3298242). It is CC important during the early stages of 50S assembly (PubMed:3298242). It CC makes multiple contacts with different domains of the 23S rRNA in the CC assembled 50S subunit and ribosome (PubMed:7556101, PubMed:6170935). CC {ECO:0000269|PubMed:13130133, ECO:0000269|PubMed:2442760, CC ECO:0000269|PubMed:3298242, ECO:0000269|PubMed:6170935, CC ECO:0000269|PubMed:7556101}. CC -!- FUNCTION: Protein uL4 is a both a transcriptional repressor and a CC translational repressor protein; these two functions are independent of CC each other. It regulates transcription of the S10 operon (to which uL4 CC belongs) by causing premature termination of transcription within the CC S10 leader; termination absolutely requires the NusA protein. uL4 CC controls the translation of the S10 operon by binding to its mRNA. The CC regions of uL4 that control regulation (residues 131-210) are different CC from those required for ribosome assembly (residues 89-103). CC {ECO:0000269|PubMed:13130133, ECO:0000269|PubMed:1692593, CC ECO:0000269|PubMed:2157208, ECO:0000269|PubMed:2442760}. CC -!- FUNCTION: Forms part of the polypeptide exit tunnel. CC {ECO:0000269|PubMed:11511371, ECO:0000269|PubMed:2442760, CC ECO:0000269|PubMed:34403461, ECO:0000269|PubMed:34504068}. CC -!- FUNCTION: Can regulate expression from Citrobacter freundii, CC Haemophilus influenzae, Morganella morganii, Salmonella typhimurium, CC Serratia marcescens, Vibrio cholerae and Yersinia enterocolitica (but CC not Pseudomonas aeruginosa) S10 leaders in vitro. CC {ECO:0000269|PubMed:10498727}. CC -!- SUBUNIT: Part of the 50S ribosomal subunit (Ref.1, PubMed:7556101, CC PubMed:3298242, PubMed:10094780, PubMed:12809609, PubMed:11511371, CC PubMed:16272117, PubMed:25310980, PubMed:24844575, PubMed:27934701, CC PubMed:27906160, PubMed:27906161, PubMed:34504068, PubMed:34403461). In CC TnaC-stalled ribosomes forms part of the binding pocket for L-Trp with CC the leader peptide and uL22 (PubMed:34504068, PubMed:34403461). CC {ECO:0000269|PubMed:10094780, ECO:0000269|PubMed:11511371, CC ECO:0000269|PubMed:12809609, ECO:0000269|PubMed:16272117, CC ECO:0000269|PubMed:24844575, ECO:0000269|PubMed:25310980, CC ECO:0000269|PubMed:27906160, ECO:0000269|PubMed:27906161, CC ECO:0000269|PubMed:27934701, ECO:0000269|PubMed:3298242, CC ECO:0000269|PubMed:34403461, ECO:0000269|PubMed:34504068, CC ECO:0000269|PubMed:7556101, ECO:0000269|Ref.1}. CC -!- INTERACTION: CC P60723; P0A6I6: coaD; NbExp=2; IntAct=EBI-545597, EBI-553173; CC P60723; P0A6K3: def; NbExp=4; IntAct=EBI-545597, EBI-548913; CC -!- MASS SPECTROMETRY: Mass=22086.2; Method=MALDI; CC Evidence={ECO:0000269|PubMed:10094780}; CC -!- MISCELLANEOUS: The erythromycin sensitive allele is dominant over the CC resistant allele. CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X02613; CAA26461.1; -; Genomic_DNA. DR EMBL; U18997; AAA58116.1; -; Genomic_DNA. DR EMBL; U00096; AAC76344.1; -; Genomic_DNA. DR EMBL; AP009048; BAE77972.1; -; Genomic_DNA. DR PIR; C23129; R5EC4. DR RefSeq; NP_417778.1; NC_000913.3. DR RefSeq; WP_000424395.1; NZ_STEB01000038.1. DR PDB; 2J28; EM; 8.00 A; E=1-201. DR PDB; 2RDO; EM; 9.10 A; E=1-201. DR PDB; 3BBX; EM; 10.00 A; E=1-201. DR PDB; 3J5L; EM; 6.60 A; E=1-201. DR PDB; 3J7Z; EM; 3.90 A; E=1-201. DR PDB; 3J8G; EM; 5.00 A; E=1-201. DR PDB; 3J9Y; EM; 3.90 A; E=1-201. DR PDB; 3J9Z; EM; 3.60 A; L6=1-201. DR PDB; 3JA1; EM; 3.60 A; LF=1-201. DR PDB; 3JBU; EM; 3.64 A; e=1-201. DR PDB; 3JBV; EM; 3.32 A; e=1-201. DR PDB; 3JCD; EM; 3.70 A; E=1-201. DR PDB; 3JCE; EM; 3.20 A; E=1-201. DR PDB; 3JCJ; EM; 3.70 A; D=1-201. DR PDB; 3JCN; EM; 4.60 A; E=1-201. DR PDB; 4CSU; EM; 5.50 A; E=1-201. DR PDB; 4U1U; X-ray; 2.95 A; BE/DE=1-201. DR PDB; 4U1V; X-ray; 3.00 A; BE/DE=1-201. DR PDB; 4U20; X-ray; 2.90 A; BE/DE=1-201. DR PDB; 4U24; X-ray; 2.90 A; BE/DE=1-201. DR PDB; 4U25; X-ray; 2.90 A; BE/DE=1-201. DR PDB; 4U26; X-ray; 2.80 A; BE/DE=1-201. DR PDB; 4U27; X-ray; 2.80 A; BE/DE=1-201. DR PDB; 4UY8; EM; 3.80 A; E=1-201. DR PDB; 4V47; EM; 12.30 A; AC=1-201. DR PDB; 4V48; EM; 11.50 A; AC=1-201. DR PDB; 4V4H; X-ray; 3.46 A; BE/DE=1-201. DR PDB; 4V4Q; X-ray; 3.46 A; BE/DE=1-201. DR PDB; 4V4V; EM; 15.00 A; BC=1-198. DR PDB; 4V4W; EM; 15.00 A; BC=1-198. DR PDB; 4V50; X-ray; 3.22 A; BE/DE=1-201. DR PDB; 4V52; X-ray; 3.21 A; BE/DE=1-201. DR PDB; 4V53; X-ray; 3.54 A; BE/DE=1-201. DR PDB; 4V54; X-ray; 3.30 A; BE/DE=1-201. DR PDB; 4V55; X-ray; 4.00 A; BE/DE=1-201. DR PDB; 4V56; X-ray; 3.93 A; BE/DE=1-201. DR PDB; 4V57; X-ray; 3.50 A; BE/DE=1-201. DR PDB; 4V5B; X-ray; 3.74 A; AE/CE=1-201. DR PDB; 4V5H; EM; 5.80 A; BE=1-201. DR PDB; 4V5Y; X-ray; 4.45 A; BE/DE=1-201. DR PDB; 4V64; X-ray; 3.50 A; BE/DE=1-201. DR PDB; 4V65; EM; 9.00 A; B1=1-201. DR PDB; 4V66; EM; 9.00 A; B1=1-201. DR PDB; 4V69; EM; 6.70 A; BE=1-201. DR PDB; 4V6C; X-ray; 3.19 A; BE/DE=1-201. DR PDB; 4V6D; X-ray; 3.81 A; BE/DE=1-201. DR PDB; 4V6E; X-ray; 3.71 A; BE/DE=1-201. DR PDB; 4V6K; EM; 8.25 A; AF=1-201. DR PDB; 4V6L; EM; 13.20 A; BF=1-201. DR PDB; 4V6M; EM; 7.10 A; BE=1-201. DR PDB; 4V6N; EM; 12.10 A; AF=1-201. DR PDB; 4V6O; EM; 14.70 A; BF=1-201. DR PDB; 4V6P; EM; 13.50 A; BF=1-201. DR PDB; 4V6Q; EM; 11.50 A; BF=1-201. DR PDB; 4V6R; EM; 11.50 A; BF=1-201. DR PDB; 4V6S; EM; 13.10 A; AF=1-201. DR PDB; 4V6T; EM; 8.30 A; BE=1-201. DR PDB; 4V6V; EM; 9.80 A; BF=1-201. DR PDB; 4V6Y; EM; 12.00 A; BE=1-201. DR PDB; 4V6Z; EM; 12.00 A; BE=1-201. DR PDB; 4V70; EM; 17.00 A; BE=1-201. DR PDB; 4V71; EM; 20.00 A; BE=1-201. DR PDB; 4V72; EM; 13.00 A; BE=1-201. DR PDB; 4V73; EM; 15.00 A; BE=1-201. DR PDB; 4V74; EM; 17.00 A; BE=1-201. DR PDB; 4V75; EM; 12.00 A; BE=1-201. DR PDB; 4V76; EM; 17.00 A; BE=1-201. DR PDB; 4V77; EM; 17.00 A; BE=1-201. DR PDB; 4V78; EM; 20.00 A; BE=1-201. DR PDB; 4V79; EM; 15.00 A; BE=1-201. DR PDB; 4V7A; EM; 9.00 A; BE=1-201. DR PDB; 4V7B; EM; 6.80 A; BE=1-201. DR PDB; 4V7C; EM; 7.60 A; BF=1-201. DR PDB; 4V7D; EM; 7.60 A; AF=1-201. DR PDB; 4V7I; EM; 9.60 A; AE=1-201. DR PDB; 4V7S; X-ray; 3.25 A; BE/DE=1-201. DR PDB; 4V7T; X-ray; 3.19 A; BE/DE=1-201. DR PDB; 4V7U; X-ray; 3.10 A; BE/DE=1-201. DR PDB; 4V7V; X-ray; 3.29 A; BE/DE=1-201. DR PDB; 4V85; X-ray; 3.20 A; BE=1-201. DR PDB; 4V89; X-ray; 3.70 A; BE=1-201. DR PDB; 4V9C; X-ray; 3.30 A; BE/DE=1-201. DR PDB; 4V9D; X-ray; 3.00 A; CE/DE=1-201. DR PDB; 4V9O; X-ray; 2.90 A; AE/CE/EE/GE=1-201. DR PDB; 4V9P; X-ray; 2.90 A; AE/CE/EE/GE=1-201. DR PDB; 4WF1; X-ray; 3.09 A; BE/DE=1-201. DR PDB; 4WOI; X-ray; 3.00 A; BE/CE=1-201. DR PDB; 4WWW; X-ray; 3.10 A; RE/YE=1-201. DR PDB; 4YBB; X-ray; 2.10 A; CE/DE=1-201. DR PDB; 5ADY; EM; 4.50 A; E=1-201. DR PDB; 5AFI; EM; 2.90 A; E=1-201. DR PDB; 5AKA; EM; 5.70 A; E=1-201. DR PDB; 5GAD; EM; 3.70 A; E=1-201. DR PDB; 5GAE; EM; 3.33 A; E=1-201. DR PDB; 5GAF; EM; 4.30 A; E=1-201. DR PDB; 5GAG; EM; 3.80 A; E=1-201. DR PDB; 5GAH; EM; 3.80 A; E=1-201. DR PDB; 5H5U; EM; 3.00 A; E=1-201. DR PDB; 5IQR; EM; 3.00 A; D=1-201. DR PDB; 5IT8; X-ray; 3.12 A; CE/DE=1-201. DR PDB; 5J5B; X-ray; 2.80 A; CE/DE=1-201. DR PDB; 5J7L; X-ray; 3.00 A; CE/DE=1-201. DR PDB; 5J88; X-ray; 3.32 A; CE/DE=1-201. DR PDB; 5J8A; X-ray; 3.10 A; CE/DE=1-201. DR PDB; 5J91; X-ray; 2.96 A; CE/DE=1-201. DR PDB; 5JC9; X-ray; 3.03 A; CE/DE=1-201. DR PDB; 5JTE; EM; 3.60 A; BE=1-201. DR PDB; 5JU8; EM; 3.60 A; BE=1-201. DR PDB; 5KCR; EM; 3.60 A; 1F=1-201. DR PDB; 5KCS; EM; 3.90 A; 1F=1-201. DR PDB; 5KPS; EM; 3.90 A; D=1-201. DR PDB; 5KPV; EM; 4.10 A; C=1-201. DR PDB; 5KPW; EM; 3.90 A; C=1-201. DR PDB; 5KPX; EM; 3.90 A; C=1-201. DR PDB; 5L3P; EM; 3.70 A; F=1-201. DR PDB; 5LZA; EM; 3.60 A; E=1-201. DR PDB; 5LZB; EM; 5.30 A; E=1-201. DR PDB; 5LZC; EM; 4.80 A; E=1-201. DR PDB; 5LZD; EM; 3.40 A; E=1-201. DR PDB; 5LZE; EM; 3.50 A; E=1-201. DR PDB; 5LZF; EM; 4.60 A; E=1-201. DR PDB; 5MDV; EM; 2.97 A; D=1-201. DR PDB; 5MDW; EM; 3.06 A; D=1-201. DR PDB; 5MDY; EM; 3.35 A; D=1-201. DR PDB; 5MDZ; EM; 3.10 A; D=1-201. DR PDB; 5MGP; EM; 3.10 A; E=1-201. DR PDB; 5NCO; EM; 4.80 A; E=1-201. DR PDB; 5NP6; EM; 3.60 A; c=1-201. DR PDB; 5NWY; EM; 2.93 A; R=1-201. DR PDB; 5O2R; EM; 3.40 A; E=1-201. DR PDB; 5U4I; EM; 3.50 A; E=1-201. DR PDB; 5U9F; EM; 3.20 A; 06=1-201. DR PDB; 5U9G; EM; 3.20 A; 06=1-201. DR PDB; 5UYK; EM; 3.90 A; 06=1-201. DR PDB; 5UYL; EM; 3.60 A; 06=1-201. DR PDB; 5UYM; EM; 3.20 A; 06=1-201. DR PDB; 5UYN; EM; 4.00 A; 06=1-201. DR PDB; 5UYP; EM; 3.90 A; 06=1-201. DR PDB; 5UYQ; EM; 3.80 A; 06=1-201. DR PDB; 5WDT; EM; 3.00 A; E=2-201. DR PDB; 5WE4; EM; 3.10 A; E=2-201. DR PDB; 5WE6; EM; 3.40 A; E=2-201. DR PDB; 5WF0; EM; 3.60 A; E=2-201. DR PDB; 5WFK; EM; 3.40 A; E=2-201. DR PDB; 5WFS; EM; 3.00 A; E=2-201. DR PDB; 6BU8; EM; 3.50 A; 06=1-201. DR PDB; 6BY1; X-ray; 3.94 A; CE/DE=21-201. DR PDB; 6C4I; EM; 3.24 A; E=1-201. DR PDB; 6DNC; EM; 3.70 A; H=1-201. DR PDB; 6ENF; EM; 3.20 A; E=1-201. DR PDB; 6ENJ; EM; 3.70 A; E=1-201. DR PDB; 6ENU; EM; 3.10 A; E=1-201. DR PDB; 6GBZ; EM; 3.80 A; E=1-201. DR PDB; 6GC0; EM; 3.80 A; E=1-201. DR PDB; 6GC4; EM; 4.30 A; E=1-201. DR PDB; 6GC6; EM; 4.30 A; E=1-201. DR PDB; 6GC7; EM; 4.30 A; E=1-201. DR PDB; 6GC8; EM; 3.80 A; E=1-201. DR PDB; 6GWT; EM; 3.80 A; E=1-201. DR PDB; 6GXM; EM; 3.80 A; E=1-201. DR PDB; 6GXN; EM; 3.90 A; E=1-201. DR PDB; 6GXO; EM; 3.90 A; E=1-201. DR PDB; 6GXP; EM; 4.40 A; E=1-201. DR PDB; 6H4N; EM; 3.00 A; E=1-201. DR PDB; 6H58; EM; 7.90 A; E/EE=1-201. DR PDB; 6HRM; EM; 2.96 A; D=1-201. DR PDB; 6I0Y; EM; 3.20 A; E=1-201. DR PDB; 6I7V; X-ray; 2.90 A; CE/DE=1-201. DR PDB; 6O9J; EM; 3.90 A; E=1-201. DR PDB; 6O9K; EM; 4.00 A; E=1-201. DR PDB; 6OFX; EM; 3.30 A; d=1-201. DR PDB; 6OG7; EM; 3.30 A; d=1-201. DR PDB; 6OGF; EM; 3.90 A; d=1-201. DR PDB; 6OGG; EM; 4.20 A; d=1-201. DR PDB; 6OGI; EM; 3.40 A; d=1-201. DR PDB; 6OM6; EM; 3.10 A; D=1-201. DR PDB; 6ORE; EM; 2.90 A; D=1-201. DR PDB; 6ORL; EM; 3.50 A; D=1-201. DR PDB; 6OSK; EM; 3.60 A; D=1-201. DR PDB; 6OSQ; EM; 3.50 A; D=1-201. DR PDB; 6OST; EM; 4.20 A; D=1-201. DR PDB; 6OT3; EM; 3.90 A; D=1-201. DR PDB; 6OUO; EM; 3.70 A; D=1-201. DR PDB; 6PC5; EM; 2.70 A; M=1-201. DR PDB; 6PC6; EM; 2.50 A; M=1-201. DR PDB; 6PC7; EM; 2.50 A; M=1-201. DR PDB; 6PC8; EM; 2.90 A; M=1-201. DR PDB; 6PCH; EM; 2.90 A; M=1-201. DR PDB; 6PCQ; EM; 2.60 A; M=1-201. DR PDB; 6PCR; EM; 2.50 A; M=1-201. DR PDB; 6PCS; EM; 2.80 A; M=1-201. DR PDB; 6PCT; EM; 2.80 A; M=1-201. DR PDB; 6PJ6; EM; 2.20 A; M=1-201. DR PDB; 6Q97; EM; 3.90 A; D=1-201. DR PDB; 6Q98; EM; 4.30 A; D=1-201. DR PDB; 6Q9A; EM; 3.70 A; D=1-201. DR PDB; 6QDW; EM; 2.83 A; e=1-201. DR PDB; 6QUL; EM; 3.00 A; E=1-201. DR PDB; 6S0K; EM; 3.10 A; E=1-201. DR PDB; 6SZS; EM; 3.06 A; E=1-201. DR PDB; 6TBV; EM; 2.70 A; L041=1-201. DR PDB; 6TC3; EM; 2.70 A; L041=1-201. DR PDB; 6U48; EM; 2.87 A; CE=1-201. DR PDB; 6VU3; EM; 3.70 A; l=1-201. DR PDB; 6VWL; EM; 3.10 A; C=1-201. DR PDB; 6VWM; EM; 3.40 A; C=1-201. DR PDB; 6VWN; EM; 3.40 A; C=1-201. DR PDB; 6VYQ; EM; 3.70 A; l=1-201. DR PDB; 6VYR; EM; 3.80 A; l=1-201. DR PDB; 6VYS; EM; 3.70 A; l=1-201. DR PDB; 6VYT; EM; 14.00 A; l=1-201. DR PDB; 6VYU; EM; 7.00 A; l=1-201. DR PDB; 6VYW; EM; 7.00 A; l=1-201. DR PDB; 6VYX; EM; 9.90 A; l=1-201. DR PDB; 6VYY; EM; 9.90 A; l=1-201. DR PDB; 6VYZ; EM; 9.90 A; l=1-201. DR PDB; 6VZ2; EM; 10.00 A; l=1-201. DR PDB; 6VZ3; EM; 8.90 A; l=1-201. DR PDB; 6VZ5; EM; 8.90 A; l=1-201. DR PDB; 6VZ7; EM; 7.00 A; l=1-201. DR PDB; 6VZJ; EM; 4.10 A; l=1-201. DR PDB; 6WD0; EM; 3.00 A; d=1-201. DR PDB; 6WD1; EM; 3.30 A; d=1-201. DR PDB; 6WD2; EM; 3.60 A; d=1-201. DR PDB; 6WD3; EM; 3.60 A; d=1-201. DR PDB; 6WD4; EM; 3.70 A; d=1-201. DR PDB; 6WD5; EM; 3.60 A; d=1-201. DR PDB; 6WD6; EM; 3.70 A; d=1-201. DR PDB; 6WD7; EM; 3.90 A; d=1-201. DR PDB; 6WD8; EM; 3.70 A; d=1-201. DR PDB; 6WD9; EM; 3.70 A; d=1-201. DR PDB; 6WDA; EM; 3.80 A; d=1-201. DR PDB; 6WDB; EM; 4.00 A; d=1-201. DR PDB; 6WDC; EM; 4.20 A; d=1-201. DR PDB; 6WDD; EM; 3.20 A; d=1-201. DR PDB; 6WDE; EM; 3.00 A; d=1-201. DR PDB; 6WDF; EM; 3.30 A; d=1-201. DR PDB; 6WDG; EM; 3.30 A; d=1-201. DR PDB; 6WDH; EM; 4.30 A; d=1-201. DR PDB; 6WDI; EM; 4.00 A; d=1-201. DR PDB; 6WDJ; EM; 3.70 A; d=1-201. DR PDB; 6WDK; EM; 3.60 A; d=1-201. DR PDB; 6WDL; EM; 3.70 A; d=1-201. DR PDB; 6WDM; EM; 3.60 A; d=1-201. DR PDB; 6WNT; EM; 3.10 A; d=1-201. DR PDB; 6WNV; EM; 3.50 A; d=1-201. DR PDB; 6WNW; EM; 3.20 A; d=1-201. DR PDB; 6WYV; EM; 2.75 A; M=1-201. DR PDB; 6X6T; EM; 3.20 A; l=1-201. DR PDB; 6X7F; EM; 3.50 A; l=1-201. DR PDB; 6X7K; EM; 3.10 A; l=1-201. DR PDB; 6X9Q; EM; 4.80 A; l=1-201. DR PDB; 6XDQ; EM; 3.70 A; l=1-201. DR PDB; 6XDR; EM; 4.70 A; l=1-201. DR PDB; 6XGF; EM; 5.00 A; l=1-201. DR PDB; 6XII; EM; 7.00 A; l=1-201. DR PDB; 6XIJ; EM; 8.00 A; l=1-201. DR PDB; 6XZ7; EM; 2.10 A; E=1-201. DR PDB; 6XZA; EM; 2.66 A; E2=1-201. DR PDB; 6XZB; EM; 2.54 A; E2=1-201. DR PDB; 6Y69; EM; 2.86 A; E=1-201. DR PDB; 6YS3; EM; 2.58 A; e=1-201. DR PDB; 6YSR; EM; 3.10 A; E=1-201. DR PDB; 6YSS; EM; 2.60 A; E=1-201. DR PDB; 6YST; EM; 3.20 A; E=1-201. DR PDB; 6YSU; EM; 3.70 A; E=1-201. DR PDB; 6ZTJ; EM; 3.40 A; BE=1-201. DR PDB; 6ZTL; EM; 3.50 A; BE=1-201. DR PDB; 6ZTM; EM; 3.30 A; BE=1-201. DR PDB; 6ZTN; EM; 3.90 A; BE=1-201. DR PDB; 6ZTO; EM; 3.00 A; BE=1-201. DR PDB; 6ZTP; EM; 3.00 A; BE=1-201. DR PDB; 6ZU1; EM; 3.00 A; BE=1-201. DR PDB; 7ABZ; EM; 3.21 A; D=1-201. DR PDB; 7AC7; EM; 3.08 A; D=1-201. DR PDB; 7ACJ; EM; 3.20 A; D=1-201. DR PDB; 7ACR; EM; 3.44 A; D=1-201. DR PDB; 7B5K; EM; 2.90 A; E=1-201. DR PDB; 7BL2; EM; 3.70 A; E=1-201. DR PDB; 7BL3; EM; 3.50 A; E=1-201. DR PDB; 7BL4; EM; 2.40 A; E=1-201. DR PDB; 7BL5; EM; 3.30 A; E=1-201. DR PDB; 7BL6; EM; 4.00 A; E=1-201. DR PDB; 7BV8; EM; 3.14 A; E=1-201. DR PDB; 7D6Z; EM; 3.40 A; E=1-201. DR PDB; 7D80; EM; 4.10 A; d=1-201. DR PDB; 7JSS; EM; 3.70 A; d=1-201. DR PDB; 7JSW; EM; 3.80 A; d=1-201. DR PDB; 7JSZ; EM; 3.70 A; d=1-201. DR PDB; 7JT1; EM; 3.30 A; d=1-201. DR PDB; 7JT2; EM; 3.50 A; d=1-201. DR PDB; 7JT3; EM; 3.70 A; d=1-201. DR PDB; 7K00; EM; 1.98 A; e=1-201. DR PDB; 7K50; EM; 3.40 A; d=1-201. DR PDB; 7K51; EM; 3.50 A; d=1-201. DR PDB; 7K52; EM; 3.40 A; d=1-201. DR PDB; 7K53; EM; 3.20 A; d=1-201. DR PDB; 7K54; EM; 3.20 A; d=1-201. DR PDB; 7K55; EM; 3.30 A; d=1-201. DR PDB; 7LV0; EM; 3.20 A; d=1-201. DR PDB; 7LVK; EM; 2.20 A; M=1-201. DR PDB; 7M5D; EM; 2.80 A; D=1-201. DR PDB; 7N1P; EM; 2.33 A; LD=1-201. DR PDB; 7N2C; EM; 2.72 A; LD=1-201. DR PDB; 7N2U; EM; 2.53 A; LD=1-201. DR PDB; 7N2V; EM; 2.54 A; LD=1-201. DR PDB; 7N30; EM; 2.66 A; LD=1-201. DR PDB; 7N31; EM; 2.69 A; LD=1-201. DR PDB; 7NBU; EM; 3.11 A; e=1-201. DR PDB; 7NSO; EM; 2.90 A; E=1-201. DR PDB; 7NSP; EM; 3.50 A; E=1-201. DR PDB; 7NSQ; EM; 3.10 A; E=1-201. DR PDB; 7NWT; EM; 2.66 A; D=1-201. DR PDB; 7NWW; EM; 3.05 A; E=1-201. DR PDB; 7O19; EM; 2.90 A; BE=1-201. DR PDB; 7O1A; EM; 2.40 A; BE=1-201. DR PDB; 7O1C; EM; 2.60 A; BE=1-201. DR PDB; 7ODE; EM; 2.84 A; M=1-201. DR PDB; 7OIF; EM; 3.00 A; E=1-201. DR PDB; 7OIG; EM; 3.20 A; E=1-201. DR PDB; 7OII; EM; 3.00 A; E=1-201. DR PDB; 7OIZ; EM; 2.90 A; e=1-201. DR PDB; 7OJ0; EM; 3.50 A; e=1-201. DR PDB; 7OT5; EM; 2.90 A; E=1-201. DR PDB; 7P3K; EM; 2.90 A; e=1-201. DR PDB; 7PJS; EM; 2.35 A; E=1-201. DR PDB; 7PJT; EM; 6.00 A; E=1-201. DR PDB; 7PJV; EM; 3.10 A; E=1-201. DR PDB; 7PJW; EM; 4.00 A; E=1-201. DR PDB; 7PJX; EM; 6.50 A; E=1-201. DR PDB; 7PJY; EM; 3.10 A; E=1-201. DR PDB; 7PJZ; EM; 6.00 A; E=1-201. DR PDB; 7Q4K; EM; 3.00 A; BE=1-201. DR PDB; 7QG8; EM; 3.97 A; R=1-201. DR PDB; 7QGH; EM; 4.48 A; R=1-201. DR PDB; 7QGN; EM; 3.37 A; R=1-201. DR PDB; 7QGR; EM; 5.70 A; R=1-201. DR PDB; 7QQ3; EM; 2.10 A; M=1-201. DR PDB; 7S1G; EM; 2.48 A; M=1-201. DR PDB; 7S1H; EM; 2.35 A; M=1-201. DR PDB; 7S1I; EM; 2.48 A; M=1-201. DR PDB; 7S1J; EM; 2.47 A; M=1-201. DR PDB; 7S1K; EM; 2.42 A; M=1-201. DR PDB; 7SA4; EM; 2.55 A; D=1-201. DR PDB; 7SS9; EM; 3.90 A; d=1-201. DR PDB; 7SSD; EM; 3.30 A; d=1-201. DR PDB; 7SSL; EM; 3.80 A; d=1-201. DR PDB; 7SSN; EM; 3.20 A; d=1-201. DR PDB; 7SSO; EM; 3.20 A; d=1-201. DR PDB; 7SSW; EM; 3.80 A; d=1-201. DR PDB; 7ST2; EM; 2.90 A; d=1-201. DR PDB; 7ST6; EM; 3.00 A; d=1-201. DR PDB; 7ST7; EM; 3.20 A; d=1-201. DR PDB; 7TOS; EM; 2.90 A; L04=1-201. DR PDB; 7UG7; EM; 2.58 A; LD=1-201. DR PDB; 7UPH; EM; 4.18 A; M=1-201. DR PDB; 7Y7C; EM; 2.51 A; e=1-201. DR PDB; 7Y7D; EM; 2.58 A; e=1-201. DR PDB; 7Y7E; EM; 2.41 A; e=1-201. DR PDB; 7Y7F; EM; 2.43 A; e=1-201. DR PDB; 7Y7G; EM; 2.34 A; e=1-201. DR PDB; 7Y7H; EM; 2.51 A; e=1-201. DR PDB; 7YLA; EM; 2.52 A; M=1-201. DR PDB; 7Z20; EM; 2.29 A; e=1-201. DR PDB; 7ZOD; EM; 2.56 A; e=1-201. DR PDB; 7ZP8; EM; 2.20 A; e=1-201. DR PDB; 7ZQ5; EM; 2.70 A; e=1-201. DR PDB; 7ZQ6; EM; 2.75 A; e=1-201. DR PDB; 7ZTA; EM; 2.70 A; L041=1-201. DR PDB; 8A3L; EM; 3.42 A; e=1-201. DR PDB; 8AKN; EM; 2.30 A; e=1-201. DR PDB; 8AM9; EM; 2.80 A; e=1-201. DR PDB; 8ANA; EM; 2.10 A; e=1-201. DR PDB; 8AP4; EM; 3.00 A; e=1-201. DR PDB; 8AYE; EM; 1.96 A; e=1-201. DR PDB; 8B0X; EM; 1.55 A; e=1-201. DR PDB; 8B7Y; EM; 3.00 A; M=1-201. DR PDB; 8BF7; EM; 2.33 A; C=1-201. DR PDB; 8BGE; EM; 2.11 A; C=1-201. DR PDB; 8BGH; EM; 2.88 A; C=1-201. DR PDB; 8BH4; EM; 2.62 A; C=1-201. DR PDB; 8BHJ; EM; 2.81 A; C=1-201. DR PDB; 8BHL; EM; 2.21 A; C=1-201. DR PDB; 8BHN; EM; 2.85 A; C=1-201. DR PDB; 8BHP; EM; 2.37 A; C=1-201. DR PDB; 8BIL; EM; 2.04 A; C=1-201. DR PDB; 8BIM; EM; 2.04 A; C=1-201. DR PDB; 8C8X; EM; 3.93 A; E=1-201. DR PDB; 8C8Y; EM; 3.03 A; E=1-201. DR PDB; 8C8Z; EM; 3.12 A; E=1-201. DR PDB; 8C90; EM; 3.15 A; E=1-201. DR PDB; 8C91; EM; 4.19 A; E=1-201. DR PDB; 8C92; EM; 3.79 A; E=1-201. DR PDB; 8C93; EM; 4.17 A; E=1-201. DR PDB; 8C94; EM; 3.80 A; E=1-201. DR PDB; 8C95; EM; 4.92 A; E=1-201. DR PDB; 8C96; EM; 4.43 A; E=1-201. DR PDB; 8C97; EM; 4.07 A; E=1-201. DR PDB; 8C98; EM; 3.66 A; E=1-201. DR PDB; 8C99; EM; 3.29 A; E=1-201. DR PDB; 8C9A; EM; 4.86 A; E=1-201. DR PDB; 8C9B; EM; 5.90 A; E=1-201. DR PDB; 8CAM; EM; 1.86 A; e=1-201. DR PDB; 8CEU; EM; 1.83 A; e=1-201. DR PDB; 8CGD; EM; 1.98 A; e=1-201. DR PDB; 8CGK; EM; 1.64 A; e=1-201. DR PDB; 8CGV; EM; 1.66 A; e=1-201. DR PDB; 8E30; EM; 1.91 A; M=1-201. DR PDB; 8E32; EM; 2.35 A; M=1-201. DR PDB; 8E33; EM; 2.23 A; M=1-201. DR PDB; 8E35; EM; 2.27 A; M=1-201. DR PDB; 8E36; EM; 2.38 A; M=1-201. DR PDB; 8E3L; EM; 2.35 A; M=1-201. DR PDB; 8E3M; EM; 2.25 A; M=1-201. DR PDB; 8E3O; EM; 1.99 A; M=1-201. DR PDB; 8E41; EM; 2.13 A; M=1-201. DR PDB; 8E42; EM; 2.29 A; M=1-201. DR PDB; 8E43; EM; 2.09 A; M=1-201. DR PDB; 8E44; EM; 2.53 A; M=1-201. DR PDB; 8E45; EM; 2.30 A; M=1-201. DR PDB; 8E46; EM; 2.32 A; M=1-201. DR PDB; 8E47; EM; 2.32 A; M=1-201. DR PDB; 8E48; EM; 2.27 A; M=1-201. DR PDB; 8E49; EM; 2.05 A; M=1-201. DR PDB; 8EIU; EM; 2.24 A; e=1-201. DR PDB; 8EKC; EM; 2.70 A; E=1-201. DR PDB; 8EMM; EM; 2.10 A; e=1-201. DR PDB; 8FIZ; EM; 3.80 A; BF=1-201. DR PDB; 8G6W; EM; 2.02 A; e=1-201. DR PDB; 8G6X; EM; 2.31 A; e=1-201. DR PDB; 8G6Y; EM; 2.09 A; e=1-201. DR PDB; 8PVA; EM; 4.50 A; e=1-201. DR PDBsum; 2J28; -. DR PDBsum; 2RDO; -. DR PDBsum; 3BBX; -. DR PDBsum; 3J5L; -. DR PDBsum; 3J7Z; -. DR PDBsum; 3J8G; -. DR PDBsum; 3J9Y; -. DR PDBsum; 3J9Z; -. DR PDBsum; 3JA1; -. DR PDBsum; 3JBU; -. DR PDBsum; 3JBV; -. DR PDBsum; 3JCD; -. DR PDBsum; 3JCE; -. DR PDBsum; 3JCJ; -. DR PDBsum; 3JCN; -. DR PDBsum; 4CSU; -. DR PDBsum; 4U1U; -. DR PDBsum; 4U1V; -. DR PDBsum; 4U20; -. DR PDBsum; 4U24; -. DR PDBsum; 4U25; -. DR PDBsum; 4U26; -. DR PDBsum; 4U27; -. DR PDBsum; 4UY8; -. DR PDBsum; 4V47; -. DR PDBsum; 4V48; -. DR PDBsum; 4V4H; -. DR PDBsum; 4V4Q; -. DR PDBsum; 4V4V; -. DR PDBsum; 4V4W; -. DR PDBsum; 4V50; -. DR PDBsum; 4V52; -. DR PDBsum; 4V53; -. DR PDBsum; 4V54; -. DR PDBsum; 4V55; -. DR PDBsum; 4V56; -. DR PDBsum; 4V57; -. DR PDBsum; 4V5B; -. DR PDBsum; 4V5H; -. DR PDBsum; 4V5Y; -. DR PDBsum; 4V64; -. DR PDBsum; 4V65; -. DR PDBsum; 4V66; -. DR PDBsum; 4V69; -. DR PDBsum; 4V6C; -. DR PDBsum; 4V6D; -. DR PDBsum; 4V6E; -. DR PDBsum; 4V6K; -. DR PDBsum; 4V6L; -. DR PDBsum; 4V6M; -. DR PDBsum; 4V6N; -. DR PDBsum; 4V6O; -. DR PDBsum; 4V6P; -. DR PDBsum; 4V6Q; -. DR PDBsum; 4V6R; -. DR PDBsum; 4V6S; -. DR PDBsum; 4V6T; -. DR PDBsum; 4V6V; -. DR PDBsum; 4V6Y; -. DR PDBsum; 4V6Z; -. DR PDBsum; 4V70; -. DR PDBsum; 4V71; -. DR PDBsum; 4V72; -. DR PDBsum; 4V73; -. DR PDBsum; 4V74; -. DR PDBsum; 4V75; -. DR PDBsum; 4V76; -. DR PDBsum; 4V77; -. DR PDBsum; 4V78; -. DR PDBsum; 4V79; -. DR PDBsum; 4V7A; -. DR PDBsum; 4V7B; -. DR PDBsum; 4V7C; -. DR PDBsum; 4V7D; -. DR PDBsum; 4V7I; -. DR PDBsum; 4V7S; -. DR PDBsum; 4V7T; -. DR PDBsum; 4V7U; -. DR PDBsum; 4V7V; -. DR PDBsum; 4V85; -. DR PDBsum; 4V89; -. DR PDBsum; 4V9C; -. DR PDBsum; 4V9D; -. DR PDBsum; 4V9O; -. DR PDBsum; 4V9P; -. DR PDBsum; 4WF1; -. DR PDBsum; 4WOI; -. DR PDBsum; 4WWW; -. DR PDBsum; 4YBB; -. DR PDBsum; 5ADY; -. DR PDBsum; 5AFI; -. DR PDBsum; 5AKA; -. DR PDBsum; 5GAD; -. DR PDBsum; 5GAE; -. DR PDBsum; 5GAF; -. DR PDBsum; 5GAG; -. DR PDBsum; 5GAH; -. DR PDBsum; 5H5U; -. DR PDBsum; 5IQR; -. DR PDBsum; 5IT8; -. DR PDBsum; 5J5B; -. DR PDBsum; 5J7L; -. DR PDBsum; 5J88; -. DR PDBsum; 5J8A; -. DR PDBsum; 5J91; -. DR PDBsum; 5JC9; -. DR PDBsum; 5JTE; -. DR PDBsum; 5JU8; -. DR PDBsum; 5KCR; -. DR PDBsum; 5KCS; -. DR PDBsum; 5KPS; -. DR PDBsum; 5KPV; -. DR PDBsum; 5KPW; -. DR PDBsum; 5KPX; -. DR PDBsum; 5L3P; -. DR PDBsum; 5LZA; -. DR PDBsum; 5LZB; -. DR PDBsum; 5LZC; -. DR PDBsum; 5LZD; -. DR PDBsum; 5LZE; -. DR PDBsum; 5LZF; -. DR PDBsum; 5MDV; -. DR PDBsum; 5MDW; -. DR PDBsum; 5MDY; -. DR PDBsum; 5MDZ; -. DR PDBsum; 5MGP; -. DR PDBsum; 5NCO; -. DR PDBsum; 5NP6; -. DR PDBsum; 5NWY; -. DR PDBsum; 5O2R; -. DR PDBsum; 5U4I; -. DR PDBsum; 5U9F; -. DR PDBsum; 5U9G; -. DR PDBsum; 5UYK; -. DR PDBsum; 5UYL; -. DR PDBsum; 5UYM; -. DR PDBsum; 5UYN; -. DR PDBsum; 5UYP; -. DR PDBsum; 5UYQ; -. DR PDBsum; 5WDT; -. DR PDBsum; 5WE4; -. DR PDBsum; 5WE6; -. DR PDBsum; 5WF0; -. DR PDBsum; 5WFK; -. DR PDBsum; 5WFS; -. DR PDBsum; 6BU8; -. DR PDBsum; 6BY1; -. DR PDBsum; 6C4I; -. DR PDBsum; 6DNC; -. DR PDBsum; 6ENF; -. DR PDBsum; 6ENJ; -. DR PDBsum; 6ENU; -. DR PDBsum; 6GBZ; -. DR PDBsum; 6GC0; -. DR PDBsum; 6GC4; -. DR PDBsum; 6GC6; -. DR PDBsum; 6GC7; -. DR PDBsum; 6GC8; -. DR PDBsum; 6GWT; -. DR PDBsum; 6GXM; -. DR PDBsum; 6GXN; -. DR PDBsum; 6GXO; -. DR PDBsum; 6GXP; -. DR PDBsum; 6H4N; -. DR PDBsum; 6H58; -. DR PDBsum; 6HRM; -. DR PDBsum; 6I0Y; -. DR PDBsum; 6I7V; -. DR PDBsum; 6O9J; -. DR PDBsum; 6O9K; -. DR PDBsum; 6OFX; -. DR PDBsum; 6OG7; -. DR PDBsum; 6OGF; -. DR PDBsum; 6OGG; -. DR PDBsum; 6OGI; -. DR PDBsum; 6OM6; -. DR PDBsum; 6ORE; -. DR PDBsum; 6ORL; -. DR PDBsum; 6OSK; -. DR PDBsum; 6OSQ; -. DR PDBsum; 6OST; -. DR PDBsum; 6OT3; -. DR PDBsum; 6OUO; -. DR PDBsum; 6PC5; -. DR PDBsum; 6PC6; -. DR PDBsum; 6PC7; -. DR PDBsum; 6PC8; -. DR PDBsum; 6PCH; -. DR PDBsum; 6PCQ; -. DR PDBsum; 6PCR; -. DR PDBsum; 6PCS; -. DR PDBsum; 6PCT; -. DR PDBsum; 6PJ6; -. DR PDBsum; 6Q97; -. DR PDBsum; 6Q98; -. DR PDBsum; 6Q9A; -. DR PDBsum; 6QDW; -. DR PDBsum; 6QUL; -. DR PDBsum; 6S0K; -. DR PDBsum; 6SZS; -. DR PDBsum; 6TBV; -. DR PDBsum; 6TC3; -. DR PDBsum; 6U48; -. DR PDBsum; 6VU3; -. DR PDBsum; 6VWL; -. DR PDBsum; 6VWM; -. DR PDBsum; 6VWN; -. DR PDBsum; 6VYQ; -. DR PDBsum; 6VYR; -. DR PDBsum; 6VYS; -. DR PDBsum; 6VYT; -. DR PDBsum; 6VYU; -. DR PDBsum; 6VYW; -. DR PDBsum; 6VYX; -. DR PDBsum; 6VYY; -. DR PDBsum; 6VYZ; -. DR PDBsum; 6VZ2; -. DR PDBsum; 6VZ3; -. DR PDBsum; 6VZ5; -. DR PDBsum; 6VZ7; -. DR PDBsum; 6VZJ; -. DR PDBsum; 6WD0; -. DR PDBsum; 6WD1; -. DR PDBsum; 6WD2; -. DR PDBsum; 6WD3; -. DR PDBsum; 6WD4; -. DR PDBsum; 6WD5; -. DR PDBsum; 6WD6; -. DR PDBsum; 6WD7; -. DR PDBsum; 6WD8; -. DR PDBsum; 6WD9; -. DR PDBsum; 6WDA; -. DR PDBsum; 6WDB; -. DR PDBsum; 6WDC; -. DR PDBsum; 6WDD; -. DR PDBsum; 6WDE; -. DR PDBsum; 6WDF; -. DR PDBsum; 6WDG; -. DR PDBsum; 6WDH; -. DR PDBsum; 6WDI; -. DR PDBsum; 6WDJ; -. DR PDBsum; 6WDK; -. DR PDBsum; 6WDL; -. DR PDBsum; 6WDM; -. DR PDBsum; 6WNT; -. DR PDBsum; 6WNV; -. DR PDBsum; 6WNW; -. DR PDBsum; 6WYV; -. DR PDBsum; 6X6T; -. DR PDBsum; 6X7F; -. DR PDBsum; 6X7K; -. DR PDBsum; 6X9Q; -. DR PDBsum; 6XDQ; -. DR PDBsum; 6XDR; -. DR PDBsum; 6XGF; -. DR PDBsum; 6XII; -. DR PDBsum; 6XIJ; -. DR PDBsum; 6XZ7; -. DR PDBsum; 6XZA; -. DR PDBsum; 6XZB; -. DR PDBsum; 6Y69; -. DR PDBsum; 6YS3; -. DR PDBsum; 6YSR; -. DR PDBsum; 6YSS; -. DR PDBsum; 6YST; -. DR PDBsum; 6YSU; -. DR PDBsum; 6ZTJ; -. DR PDBsum; 6ZTL; -. DR PDBsum; 6ZTM; -. DR PDBsum; 6ZTN; -. DR PDBsum; 6ZTO; -. DR PDBsum; 6ZTP; -. DR PDBsum; 6ZU1; -. DR PDBsum; 7ABZ; -. DR PDBsum; 7AC7; -. DR PDBsum; 7ACJ; -. DR PDBsum; 7ACR; -. DR PDBsum; 7B5K; -. DR PDBsum; 7BL2; -. DR PDBsum; 7BL3; -. DR PDBsum; 7BL4; -. DR PDBsum; 7BL5; -. DR PDBsum; 7BL6; -. DR PDBsum; 7BV8; -. DR PDBsum; 7D6Z; -. DR PDBsum; 7D80; -. DR PDBsum; 7JSS; -. DR PDBsum; 7JSW; -. DR PDBsum; 7JSZ; -. DR PDBsum; 7JT1; -. DR PDBsum; 7JT2; -. DR PDBsum; 7JT3; -. DR PDBsum; 7K00; -. DR PDBsum; 7K50; -. DR PDBsum; 7K51; -. DR PDBsum; 7K52; -. DR PDBsum; 7K53; -. DR PDBsum; 7K54; -. DR PDBsum; 7K55; -. DR PDBsum; 7LV0; -. DR PDBsum; 7LVK; -. DR PDBsum; 7M5D; -. DR PDBsum; 7N1P; -. DR PDBsum; 7N2C; -. DR PDBsum; 7N2U; -. DR PDBsum; 7N2V; -. DR PDBsum; 7N30; -. DR PDBsum; 7N31; -. DR PDBsum; 7NBU; -. DR PDBsum; 7NSO; -. DR PDBsum; 7NSP; -. DR PDBsum; 7NSQ; -. DR PDBsum; 7NWT; -. DR PDBsum; 7NWW; -. DR PDBsum; 7O19; -. DR PDBsum; 7O1A; -. DR PDBsum; 7O1C; -. DR PDBsum; 7ODE; -. DR PDBsum; 7OIF; -. DR PDBsum; 7OIG; -. DR PDBsum; 7OII; -. DR PDBsum; 7OIZ; -. DR PDBsum; 7OJ0; -. DR PDBsum; 7OT5; -. DR PDBsum; 7P3K; -. DR PDBsum; 7PJS; -. DR PDBsum; 7PJT; -. DR PDBsum; 7PJV; -. DR PDBsum; 7PJW; -. DR PDBsum; 7PJX; -. DR PDBsum; 7PJY; -. DR PDBsum; 7PJZ; -. DR PDBsum; 7Q4K; -. DR PDBsum; 7QG8; -. DR PDBsum; 7QGH; -. DR PDBsum; 7QGN; -. DR PDBsum; 7QGR; -. DR PDBsum; 7QQ3; -. DR PDBsum; 7S1G; -. DR PDBsum; 7S1H; -. DR PDBsum; 7S1I; -. DR PDBsum; 7S1J; -. DR PDBsum; 7S1K; -. DR PDBsum; 7SA4; -. DR PDBsum; 7SS9; -. DR PDBsum; 7SSD; -. DR PDBsum; 7SSL; -. DR PDBsum; 7SSN; -. DR PDBsum; 7SSO; -. DR PDBsum; 7SSW; -. DR PDBsum; 7ST2; -. DR PDBsum; 7ST6; -. DR PDBsum; 7ST7; -. DR PDBsum; 7TOS; -. DR PDBsum; 7UG7; -. DR PDBsum; 7UPH; -. DR PDBsum; 7Y7C; -. DR PDBsum; 7Y7D; -. DR PDBsum; 7Y7E; -. DR PDBsum; 7Y7F; -. DR PDBsum; 7Y7G; -. DR PDBsum; 7Y7H; -. DR PDBsum; 7YLA; -. DR PDBsum; 7Z20; -. DR PDBsum; 7ZOD; -. DR PDBsum; 7ZP8; -. DR PDBsum; 7ZQ5; -. DR PDBsum; 7ZQ6; -. DR PDBsum; 7ZTA; -. DR PDBsum; 8A3L; -. DR PDBsum; 8AKN; -. DR PDBsum; 8AM9; -. DR PDBsum; 8ANA; -. DR PDBsum; 8AP4; -. DR PDBsum; 8AYE; -. DR PDBsum; 8B0X; -. DR PDBsum; 8B7Y; -. DR PDBsum; 8BF7; -. DR PDBsum; 8BGE; -. DR PDBsum; 8BGH; -. DR PDBsum; 8BH4; -. DR PDBsum; 8BHJ; -. DR PDBsum; 8BHL; -. DR PDBsum; 8BHN; -. DR PDBsum; 8BHP; -. DR PDBsum; 8BIL; -. DR PDBsum; 8BIM; -. DR PDBsum; 8C8X; -. DR PDBsum; 8C8Y; -. DR PDBsum; 8C8Z; -. DR PDBsum; 8C90; -. DR PDBsum; 8C91; -. DR PDBsum; 8C92; -. DR PDBsum; 8C93; -. DR PDBsum; 8C94; -. DR PDBsum; 8C95; -. DR PDBsum; 8C96; -. DR PDBsum; 8C97; -. DR PDBsum; 8C98; -. DR PDBsum; 8C99; -. DR PDBsum; 8C9A; -. DR PDBsum; 8C9B; -. DR PDBsum; 8CAM; -. DR PDBsum; 8CEU; -. DR PDBsum; 8CGD; -. DR PDBsum; 8CGK; -. DR PDBsum; 8CGV; -. DR PDBsum; 8E30; -. DR PDBsum; 8E32; -. DR PDBsum; 8E33; -. DR PDBsum; 8E35; -. DR PDBsum; 8E36; -. DR PDBsum; 8E3L; -. DR PDBsum; 8E3M; -. DR PDBsum; 8E3O; -. DR PDBsum; 8E41; -. DR PDBsum; 8E42; -. DR PDBsum; 8E43; -. DR PDBsum; 8E44; -. DR PDBsum; 8E45; -. DR PDBsum; 8E46; -. DR PDBsum; 8E47; -. DR PDBsum; 8E48; -. DR PDBsum; 8E49; -. DR PDBsum; 8EIU; -. DR PDBsum; 8EKC; -. DR PDBsum; 8EMM; -. DR PDBsum; 8FIZ; -. DR PDBsum; 8G6W; -. DR PDBsum; 8G6X; -. DR PDBsum; 8G6Y; -. DR PDBsum; 8PVA; -. DR AlphaFoldDB; P60723; -. DR EMDB; EMD-0076; -. DR EMDB; EMD-0080; -. DR EMDB; EMD-0081; -. DR EMDB; EMD-0082; -. DR EMDB; EMD-0083; -. DR EMDB; EMD-0137; -. DR EMDB; EMD-0139; -. DR EMDB; EMD-0261; -. DR EMDB; EMD-0322; -. DR EMDB; EMD-0661; -. DR EMDB; EMD-0662; -. DR EMDB; EMD-10073; -. DR EMDB; EMD-10353; -. DR EMDB; EMD-10453; -. DR EMDB; EMD-10458; -. DR EMDB; EMD-10655; -. DR EMDB; EMD-10656; -. DR EMDB; EMD-10657; -. DR EMDB; EMD-10705; -. DR EMDB; EMD-10891; -. DR EMDB; EMD-10905; -. DR EMDB; EMD-10906; -. DR EMDB; EMD-10907; -. DR EMDB; EMD-10908; -. DR EMDB; EMD-11418; -. DR EMDB; EMD-11419; -. DR EMDB; EMD-11420; -. DR EMDB; EMD-11421; -. DR EMDB; EMD-11422; -. DR EMDB; EMD-11423; -. DR EMDB; EMD-11426; -. DR EMDB; EMD-11710; -. DR EMDB; EMD-11713; -. DR EMDB; EMD-11717; -. DR EMDB; EMD-11718; -. DR EMDB; EMD-12035; -. DR EMDB; EMD-12215; -. DR EMDB; EMD-12216; -. DR EMDB; EMD-12217; -. DR EMDB; EMD-12218; -. DR EMDB; EMD-12219; -. DR EMDB; EMD-12261; -. DR EMDB; EMD-12573; -. DR EMDB; EMD-12574; -. DR EMDB; EMD-12575; -. DR EMDB; EMD-12635; -. DR EMDB; EMD-12636; -. DR EMDB; EMD-12693; -. DR EMDB; EMD-12694; -. DR EMDB; EMD-12695; -. DR EMDB; EMD-12826; -. DR EMDB; EMD-12928; -. DR EMDB; EMD-12929; -. DR EMDB; EMD-12930; -. DR EMDB; EMD-12936; -. DR EMDB; EMD-12937; -. DR EMDB; EMD-13055; -. DR EMDB; EMD-13180; -. DR EMDB; EMD-13458; -. DR EMDB; EMD-13459; -. DR EMDB; EMD-13461; -. DR EMDB; EMD-13462; -. DR EMDB; EMD-13463; -. DR EMDB; EMD-13464; -. DR EMDB; EMD-13465; -. DR EMDB; EMD-13805; -. DR EMDB; EMD-13952; -. DR EMDB; EMD-13955; -. DR EMDB; EMD-13956; -. DR EMDB; EMD-13958; -. DR EMDB; EMD-14121; -. DR EMDB; EMD-14454; -. DR EMDB; EMD-14846; -. DR EMDB; EMD-14850; -. DR EMDB; EMD-14864; -. DR EMDB; EMD-14865; -. DR EMDB; EMD-14956; -. DR EMDB; EMD-15116; -. DR EMDB; EMD-15558; -. DR EMDB; EMD-15793; -. DR EMDB; EMD-15905; -. DR EMDB; EMD-16015; -. DR EMDB; EMD-16029; -. DR EMDB; EMD-16031; -. DR EMDB; EMD-16047; -. DR EMDB; EMD-16057; -. DR EMDB; EMD-16059; -. DR EMDB; EMD-16062; -. DR EMDB; EMD-16065; -. DR EMDB; EMD-16081; -. DR EMDB; EMD-16082; -. DR EMDB; EMD-16530; -. DR EMDB; EMD-16613; -. DR EMDB; EMD-16641; -. DR EMDB; EMD-16646; -. DR EMDB; EMD-16652; -. DR EMDB; EMD-17959; -. DR EMDB; EMD-20048; -. DR EMDB; EMD-20052; -. DR EMDB; EMD-20173; -. DR EMDB; EMD-20174; -. DR EMDB; EMD-20188; -. DR EMDB; EMD-20193; -. DR EMDB; EMD-20204; -. DR EMDB; EMD-20296; -. DR EMDB; EMD-20297; -. DR EMDB; EMD-20298; -. DR EMDB; EMD-20299; -. DR EMDB; EMD-20300; -. DR EMDB; EMD-20304; -. DR EMDB; EMD-20305; -. DR EMDB; EMD-20306; -. DR EMDB; EMD-20307; -. DR EMDB; EMD-21420; -. DR EMDB; EMD-21421; -. DR EMDB; EMD-21422; -. DR EMDB; EMD-21625; -. DR EMDB; EMD-21630; -. DR EMDB; EMD-21631; -. DR EMDB; EMD-21632; -. DR EMDB; EMD-21633; -. DR EMDB; EMD-21634; -. DR EMDB; EMD-21635; -. DR EMDB; EMD-21636; -. DR EMDB; EMD-21637; -. DR EMDB; EMD-21638; -. DR EMDB; EMD-21639; -. DR EMDB; EMD-21640; -. DR EMDB; EMD-21641; -. DR EMDB; EMD-21856; -. DR EMDB; EMD-21857; -. DR EMDB; EMD-21858; -. DR EMDB; EMD-21969; -. DR EMDB; EMD-22459; -. DR EMDB; EMD-22461; -. DR EMDB; EMD-22464; -. DR EMDB; EMD-22466; -. DR EMDB; EMD-22469; -. DR EMDB; EMD-22472; -. DR EMDB; EMD-22669; -. DR EMDB; EMD-22670; -. DR EMDB; EMD-22671; -. DR EMDB; EMD-22672; -. DR EMDB; EMD-22673; -. DR EMDB; EMD-22674; -. DR EMDB; EMD-23528; -. DR EMDB; EMD-24120; -. DR EMDB; EMD-24132; -. DR EMDB; EMD-24133; -. DR EMDB; EMD-24134; -. DR EMDB; EMD-24135; -. DR EMDB; EMD-24136; -. DR EMDB; EMD-25405; -. DR EMDB; EMD-25407; -. DR EMDB; EMD-25409; -. DR EMDB; EMD-25410; -. DR EMDB; EMD-25411; -. DR EMDB; EMD-25415; -. DR EMDB; EMD-25418; -. DR EMDB; EMD-25420; -. DR EMDB; EMD-25421; -. DR EMDB; EMD-30215; -. DR EMDB; EMD-30598; -. DR EMDB; EMD-30611; -. DR EMDB; EMD-33660; -. DR EMDB; EMD-33661; -. DR EMDB; EMD-33662; -. DR EMDB; EMD-33663; -. DR EMDB; EMD-33664; -. DR EMDB; EMD-33665; -. DR EMDB; EMD-3489; -. DR EMDB; EMD-3490; -. DR EMDB; EMD-3492; -. DR EMDB; EMD-3493; -. DR EMDB; EMD-3508; -. DR EMDB; EMD-3617; -. DR EMDB; EMD-3713; -. DR EMDB; EMD-3730; -. DR EMDB; EMD-3898; -. DR EMDB; EMD-3899; -. DR EMDB; EMD-3903; -. DR EMDB; EMD-4001; -. DR EMDB; EMD-4121; -. DR EMDB; EMD-4122; -. DR EMDB; EMD-4123; -. DR EMDB; EMD-4124; -. DR EMDB; EMD-4125; -. DR EMDB; EMD-4126; -. DR EMDB; EMD-4378; -. DR EMDB; EMD-4379; -. DR EMDB; EMD-4380; -. DR EMDB; EMD-4381; -. DR EMDB; EMD-4382; -. DR EMDB; EMD-4383; -. DR EMDB; EMD-4476; -. DR EMDB; EMD-4477; -. DR EMDB; EMD-4478; -. DR EMDB; EMD-4531; -. DR EMDB; EMD-4638; -. DR EMDB; EMD-6667; -. DR EMDB; EMD-7289; -. DR EMDB; EMD-7341; -. DR EMDB; EMD-8000; -. DR EMDB; EMD-8001; -. DR EMDB; EMD-8002; -. DR EMDB; EMD-8003; -. DR EMDB; EMD-8004; -. DR EMDB; EMD-8107; -. DR EMDB; EMD-8175; -. DR EMDB; EMD-8176; -. DR EMDB; EMD-8237; -. DR EMDB; EMD-8238; -. DR EMDB; EMD-8279; -. DR EMDB; EMD-8280; -. DR EMDB; EMD-8281; -. DR EMDB; EMD-8282; -. DR EMDB; EMD-8505; -. DR EMDB; EMD-8521; -. DR EMDB; EMD-8522; -. DR EMDB; EMD-8615; -. DR EMDB; EMD-8616; -. DR EMDB; EMD-8617; -. DR EMDB; EMD-8618; -. DR EMDB; EMD-8619; -. DR EMDB; EMD-8620; -. DR EMDB; EMD-8813; -. DR EMDB; EMD-8814; -. DR EMDB; EMD-8815; -. DR EMDB; EMD-8828; -. DR SMR; P60723; -. DR BioGRID; 4261291; 145. DR ComplexPortal; CPX-3807; 50S large ribosomal subunit. DR DIP; DIP-35791N; -. DR IntAct; P60723; 228. DR MINT; P60723; -. DR STRING; 511145.b3319; -. DR DrugBank; DB13179; Troleandomycin. DR MoonProt; P60723; -. DR jPOST; P60723; -. DR PaxDb; 511145-b3319; -. DR EnsemblBacteria; AAC76344; AAC76344; b3319. DR GeneID; 84234838; -. DR GeneID; 947818; -. DR KEGG; ecj:JW3281; -. DR KEGG; eco:b3319; -. DR PATRIC; fig|1411691.4.peg.3412; -. DR EchoBASE; EB0860; -. DR eggNOG; COG0088; Bacteria. DR HOGENOM; CLU_041575_5_2_6; -. DR InParanoid; P60723; -. DR OMA; PQVHILE; -. DR OrthoDB; 9803201at2; -. DR PhylomeDB; P60723; -. DR BioCyc; EcoCyc:EG10867-MONOMER; -. DR BioCyc; MetaCyc:EG10867-MONOMER; -. DR EvolutionaryTrace; P60723; -. DR PRO; PR:P60723; -. DR Proteomes; UP000000318; Chromosome. DR Proteomes; UP000000625; Chromosome. DR GO; GO:0005737; C:cytoplasm; IDA:ComplexPortal. DR GO; GO:0005829; C:cytosol; IDA:EcoCyc. DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:EcoCyc. DR GO; GO:0015934; C:large ribosomal subunit; IMP:CAFA. DR GO; GO:0003677; F:DNA binding; EXP:DisProt. DR GO; GO:0060698; F:endoribonuclease inhibitor activity; IDA:EcoCyc. DR GO; GO:0048027; F:mRNA 5'-UTR binding; IDA:EcoCyc. DR GO; GO:0001070; F:RNA-binding transcription regulator activity; IDA:EcoCyc. DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central. DR GO; GO:0030371; F:translation repressor activity; IDA:EcoliWiki. DR GO; GO:0002181; P:cytoplasmic translation; NAS:ComplexPortal. DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-KW. DR GO; GO:2000766; P:negative regulation of cytoplasmic translation; IMP:EcoCyc. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IMP:CAFA. DR GO; GO:0017148; P:negative regulation of translation; IMP:CAFA. DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. DR GO; GO:0042255; P:ribosome assembly; IMP:CAFA. DR GO; GO:0031555; P:transcriptional attenuation; IDA:EcoCyc. DR DisProt; DP00600; -. DR Gene3D; 3.40.1370.10; -; 1. DR HAMAP; MF_01328_B; Ribosomal_uL4_B; 1. DR InterPro; IPR002136; Ribosomal_uL4. DR InterPro; IPR013005; Ribosomal_uL4-like. DR InterPro; IPR023574; Ribosomal_uL4_dom_sf. DR NCBIfam; TIGR03953; rplD_bact; 1. DR PANTHER; PTHR10746:SF6; 39S RIBOSOMAL PROTEIN L4, MITOCHONDRIAL; 1. DR PANTHER; PTHR10746; 50S RIBOSOMAL PROTEIN L4; 1. DR Pfam; PF00573; Ribosomal_L4; 1. DR SUPFAM; SSF52166; Ribosomal protein L4; 1. PE 1: Evidence at protein level; KW 3D-structure; Antibiotic resistance; Direct protein sequencing; KW Reference proteome; Repressor; Ribonucleoprotein; Ribosomal protein; KW RNA-binding; rRNA-binding; Transcription; Transcription regulation; KW Transcription termination; Translation regulation. FT CHAIN 1..201 FT /note="Large ribosomal subunit protein uL4" FT /id="PRO_0000129215" FT REGION 44..71 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 63 FT /note="K -> E (in strain: N282; confers erythromycin FT resistance. Ribosomes bind erythromycin poorly and have FT reduced peptidyltransferase activity. 50S subunits assemble FT normally, even in the presence of drug, but assembly is FT cold-sensitive at 20 degrees Celsius)" FT /evidence="ECO:0000269|PubMed:4589347, FT ECO:0000269|PubMed:7766155, ECO:0000269|PubMed:7928988" FT MUTAGEN 40..88 FT /note="Missing: Regulates the S10 operon normally. FT Assembles into ribosomes in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT MUTAGEN 67..103 FT /note="Missing: Regulates the S10 operon normally. Does not FT assemble into ribosomes in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT MUTAGEN 93..101 FT /note="Missing: Regulates the S10 operon normally. Not FT stably associated with the ribosome in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT MUTAGEN 131 FT /note="T->I: Does not regulate the S10 operon; assembles FT into ribosomes in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT MUTAGEN 134 FT /note="L->P: Does not regulate the S10 operon in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT MUTAGEN 160 FT /note="A->V: Does not regulate the S10 operon; assembles FT into ribosomes in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT MUTAGEN 167 FT /note="V->D: Does not regulate the S10 operon in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT MUTAGEN 171..201 FT /note="DATGIDPVSLIAFDKVVMTADAVKQVEEMLA->RRSK: Loss of S10 FT operon regulation. Assembles into ribosomes in vivo." FT /evidence="ECO:0000269|PubMed:8846294" FT STRAND 2..4 FT /evidence="ECO:0007829|PDB:8CGV" FT TURN 6..8 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 11..13 FT /evidence="ECO:0007829|PDB:8CGV" FT HELIX 16..19 FT /evidence="ECO:0007829|PDB:8CGK" FT HELIX 25..38 FT /evidence="ECO:0007829|PDB:8CGK" FT TURN 49..51 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 52..54 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 62..67 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 78..81 FT /evidence="ECO:0007829|PDB:7QQ3" FT HELIX 98..114 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 118..122 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 127..129 FT /evidence="ECO:0007829|PDB:8CGK" FT HELIX 131..140 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 144..152 FT /evidence="ECO:0007829|PDB:8CGK" FT HELIX 155..161 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 167..171 FT /evidence="ECO:0007829|PDB:8CGK" FT HELIX 172..174 FT /evidence="ECO:0007829|PDB:8CGK" FT HELIX 177..182 FT /evidence="ECO:0007829|PDB:8CGK" FT STRAND 183..189 FT /evidence="ECO:0007829|PDB:8CGK" FT HELIX 190..200 FT /evidence="ECO:0007829|PDB:8CGK" SQ SEQUENCE 201 AA; 22087 MW; 3A953206B0F083B5 CRC64; MELVLKDAQS ALTVSETTFG RDFNEALVHQ VVVAYAAGAR QGTRAQKTRA EVTGSGKKPW RQKGTGRARS GSIKSPIWRS GGVTFAARPQ DHSQKVNKKM YRGALKSILS ELVRQDRLIV VEKFSVEAPK TKLLAQKLKD MALEDVLIIT GELDENLFLA ARNLHKVDVR DATGIDPVSL IAFDKVVMTA DAVKQVEEML A //