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P60722

- LIPB_ECOL6

UniProt

P60722 - LIPB_ECOL6

Protein

Octanoyltransferase

Gene

lipB

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (26 Apr 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.UniRule annotation

    Catalytic activityi

    Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei135 – 1351Lowers pKa of active site CysUniRule annotation
    Active sitei169 – 1691Acyl-thioester intermediateUniRule annotation

    GO - Molecular functioni

    1. lipoyl(octanoyl) transferase activity Source: UniProtKB-EC
    2. octanoyltransferase activity Source: InterPro

    GO - Biological processi

    1. cellular protein modification process Source: InterPro
    2. lipoate biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciECOL199310:C0720-MONOMER.
    UniPathwayiUPA00538; UER00592.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OctanoyltransferaseUniRule annotation (EC:2.3.1.181UniRule annotation)
    Alternative name(s):
    Lipoate-protein ligase BUniRule annotation
    Lipoyl/octanoyl transferaseUniRule annotation
    Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferaseUniRule annotation
    Gene namesi
    Name:lipBUniRule annotation
    Ordered Locus Names:c0720
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213OctanoyltransferasePRO_0000062836Add
    BLAST

    Proteomic databases

    PRIDEiP60722.

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c0720.

    Structurei

    3D structure databases

    ProteinModelPortaliP60722.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni71 – 788Substrate bindingUniRule annotation
    Regioni138 – 1403Substrate bindingUniRule annotation
    Regioni151 – 1533Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the LipB family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000194321.
    KOiK03801.
    OMAiIWLVEHD.
    OrthoDBiEOG6XM7G6.

    Family and domain databases

    HAMAPiMF_00013. LipB.
    InterProiIPR004143. BPL_LipA_LipB.
    IPR000544. Octanoyltransferase.
    IPR020605. Octanoyltransferase_CS.
    [Graphical view]
    PfamiPF03099. BPL_LplA_LipB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016262. LPLase. 1 hit.
    TIGRFAMsiTIGR00214. lipB. 1 hit.
    PROSITEiPS01313. LIPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60722-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQDKILVRQ LGLQPYEPIS QAMHEFTDTR DDSTLDEIWL VEHYPVFTQG    50
    QAGKAEHILM PGDIPVIQSD RGGQVTYHGP GQQVMYVLLN LKRRKLGVRE 100
    LVTLLEQTVV NTLAELGIEA HPRADAPGVY VGEKKICSLG LRIRRGCSFH 150
    GLALNVNMDL SPFLRINPCG YAGMEMAKIS QWKPEATTNN IAPRLLENIL 200
    ALLNNPDFEY ITA 213
    Length:213
    Mass (Da):23,883
    Last modified:April 26, 2004 - v1
    Checksum:i56EE2BB105F99EAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79193.1.
    RefSeqiNP_752650.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN79193; AAN79193; c0720.
    GeneIDi1036853.
    KEGGiecc:c0720.
    PATRICi18279479. VBIEscCol75197_0683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN79193.1 .
    RefSeqi NP_752650.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P60722.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c0720.

    Proteomic databases

    PRIDEi P60722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN79193 ; AAN79193 ; c0720 .
    GeneIDi 1036853.
    KEGGi ecc:c0720.
    PATRICi 18279479. VBIEscCol75197_0683.

    Phylogenomic databases

    HOGENOMi HOG000194321.
    KOi K03801.
    OMAi IWLVEHD.
    OrthoDBi EOG6XM7G6.

    Enzyme and pathway databases

    UniPathwayi UPA00538 ; UER00592 .
    BioCyci ECOL199310:C0720-MONOMER.

    Family and domain databases

    HAMAPi MF_00013. LipB.
    InterProi IPR004143. BPL_LipA_LipB.
    IPR000544. Octanoyltransferase.
    IPR020605. Octanoyltransferase_CS.
    [Graphical view ]
    Pfami PF03099. BPL_LplA_LipB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016262. LPLase. 1 hit.
    TIGRFAMsi TIGR00214. lipB. 1 hit.
    PROSITEi PS01313. LIPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiLIPB_ECOL6
    AccessioniPrimary (citable) accession number: P60722
    Secondary accession number(s): P30976, P77684, Q8XBQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 26, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3