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Protein

Profilin-3

Gene

PFN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns4P). May be involved in spermatogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-3
Alternative name(s):
Profilin III
Gene namesi
Name:PFN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000196570.2.
HGNCiHGNC:18627. PFN3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196570.
PharmGKBiPA142671182.

Polymorphism and mutation databases

BioMutaiPFN3.
DMDMi48474309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995791 – 137Profilin-3Add BLAST137

Proteomic databases

MaxQBiP60673.
PaxDbiP60673.
PeptideAtlasiP60673.
PRIDEiP60673.

PTM databases

iPTMnetiP60673.
PhosphoSitePlusiP60673.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000196570.
CleanExiHS_PFN3.

Interactioni

Subunit structurei

Interacts with ACTRT3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131350. 7 interactors.
STRINGi9606.ENSP00000351379.

Structurei

3D structure databases

ProteinModelPortaliP60673.
SMRiP60673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiENOG410IW5Z. Eukaryota.
ENOG410YRK9. LUCA.
GeneTreeiENSGT00390000010143.
HOGENOMiHOG000171592.
HOVERGENiHBG053683.
InParanoidiP60673.
KOiK05759.
OMAiRRCCVIR.
OrthoDBiEOG091G0TWH.
PhylomeDBiP60673.
TreeFamiTF331744.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiView protein in InterPro
IPR005455. PFN.
IPR029893. PFN3.
IPR036140. PFN_sf.
IPR005454. Profilin1/2/3_vertebrate.
PANTHERiPTHR13936:SF2. PTHR13936:SF2. 1 hit.
PfamiView protein in Pfam
PF00235. Profilin. 1 hit.
PRINTSiPR01639. PROFILINMAML.
SMARTiView protein in SMART
SM00392. PROF. 1 hit.
SUPFAMiSSF55770. SSF55770. 1 hit.

Sequencei

Sequence statusi: Complete.

P60673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWKVYISA VLRDQRIDDV AIVGHADNSC VWASRPGGLL AAISPQEVGV
60 70 80 90 100
LTGPDRHTFL QAGLSVGGRR CCVIRDHLLA EGDGVLDART KGLDARAVCV
110 120 130
GRAPRALLVL MGRRGVHGGI LNKTVHELIR GLRMQGA
Length:137
Mass (Da):14,596
Last modified:March 29, 2004 - v1
Checksum:i9D1456E89AE6F1C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090063 Genomic DNA. No translation available.
CH471195 Genomic DNA. Translation: EAW85006.1.
BC132952 mRNA. Translation: AAI32953.1.
BC132954 mRNA. Translation: AAI32955.1.
CCDSiCCDS34301.1.
RefSeqiNP_001025057.1. NM_001029886.2.
UniGeneiHs.130196.

Genome annotation databases

EnsembliENST00000358571; ENSP00000351379; ENSG00000196570.
GeneIDi345456.
KEGGihsa:345456.
UCSCiuc003mgl.2. human.

Similar proteinsi

Entry informationi

Entry nameiPROF3_HUMAN
AccessioniPrimary (citable) accession number: P60673
Secondary accession number(s): A2RUL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families