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Protein

Pleckstrin homology domain-containing family A member 4

Gene

Plekha4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 4
Short name:
PH domain-containing family A member 4
Alternative name(s):
Phosphoinositol 3-phosphate-binding protein 1
Short name:
PEPP-1
Gene namesi
Name:Plekha4
Synonyms:Pepp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi735133. Plekha4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Pleckstrin homology domain-containing family A member 4PRO_0000053882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei164 – 1641PhosphoserineBy similarity
Modified residuei562 – 5621PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP60669.
PRIDEiP60669.

PTM databases

iPTMnetiP60669.
PhosphoSiteiP60669.

Expressioni

Gene expression databases

GenevisibleiP60669. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028423.

Structurei

3D structure databases

ProteinModelPortaliP60669.
SMRiP60669. Positions 47-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 153100PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 356195Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFZ8. Eukaryota.
ENOG410YAHN. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115553.
HOVERGENiHBG082146.
InParanoidiP60669.
OMAiTEASQWH.
OrthoDBiEOG7K6PTJ.
PhylomeDBiP60669.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQGRPRSSL SLTSSASTVS SLSSLSAKKP TRVVHKVHAF GKRNNALRRD
60 70 80 90 100
PNLPVHIRGW LHKQDSSGLR LWKRRWFVLS GHCLFYYKDS REESVLGSVL
110 120 130 140 150
LPSYSVRPDG PGAPRGRRFT FTAEHPGMRT YVLAADTLED LRGWLRALGK
160 170 180 190 200
ASRAEGEDCG LPRSPARPRP GEGPGGPGGP PEVNRREEGR TSESPEVAPL
210 220 230 240 250
SRGPGRHEMH APGSSADLQP DTWSRRTRSP EPFSPLSRPP SPLSLPRPRS
260 270 280 290 300
APVRRPPLSA GDISFPARPH TPLSRIDVRP PLDWGPQRQT LSRPPIPRRG
310 320 330 340 350
PFSEAGGGRP PRSPQLRTPE HRTQSTQVSS GSSTYLQLPP RPPGTQASMI
360 370 380 390 400
LLPGPPVDST LHQSLETDTL LTKLCGQDRL LRQLQEDLDK RQEEKEQLEA
410 420 430 440 450
ALELTRQQLG QATREAAASG KAWGRQRLLQ DRLVNVRAAL CHLTQERERV
460 470 480 490 500
WDTYSGLEQD LGTLRETLEY LLHLGSPQDR ASAQQQLWMV EDTLAGLGGP
510 520 530 540 550
QKQPPHTEPK SPSPAPQREE SSERESLSES LELSSPQSPE VDWGQPPGGD
560 570 580 590 600
RALSSSQSGV GSPRVSRASS PECRQQSSPL LRTKAPLARP RMSAQEQLER
610 620 630 640 650
MRRNQACGLS LPRPTSPRLL TLGRTLSPVP RQPDMEQRPI VGAAKWLRSS
660 670 680 690 700
GSWSSPRHST TYSPVSGGHR ERVLSLSQAL ATEASQWHRL MTASPERNLD
710 720 730 740 750
TRGDCLQPSP QPPSEELPQV TSSPTSHKAN SATTGFSCQG SGRGLAPWEP
760 770
RWDPGKAPPA LAQEEGAWPL RVTLLQSSF
Length:779
Mass (Da):85,642
Last modified:March 29, 2004 - v1
Checksum:i091A4BC54096447C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061738 mRNA. Translation: AAH61738.1.
RefSeqiNP_954532.1. NM_199101.1.
UniGeneiRn.99114.

Genome annotation databases

EnsembliENSRNOT00000028423; ENSRNOP00000028423; ENSRNOG00000020942.
GeneIDi308584.
KEGGirno:308584.
UCSCiRGD:735133. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061738 mRNA. Translation: AAH61738.1.
RefSeqiNP_954532.1. NM_199101.1.
UniGeneiRn.99114.

3D structure databases

ProteinModelPortaliP60669.
SMRiP60669. Positions 47-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028423.

PTM databases

iPTMnetiP60669.
PhosphoSiteiP60669.

Proteomic databases

PaxDbiP60669.
PRIDEiP60669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028423; ENSRNOP00000028423; ENSRNOG00000020942.
GeneIDi308584.
KEGGirno:308584.
UCSCiRGD:735133. rat.

Organism-specific databases

CTDi57664.
RGDi735133. Plekha4.

Phylogenomic databases

eggNOGiENOG410IFZ8. Eukaryota.
ENOG410YAHN. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000115553.
HOVERGENiHBG082146.
InParanoidiP60669.
OMAiTEASQWH.
OrthoDBiEOG7K6PTJ.
PhylomeDBiP60669.

Miscellaneous databases

PROiP60669.

Gene expression databases

GenevisibleiP60669. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiPKHA4_RAT
AccessioniPrimary (citable) accession number: P60669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.