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Protein

Myosin light polypeptide 6

Gene

MYL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  • actin-dependent ATPase activity Source: HGNC
  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

  • muscle contraction Source: HGNC
  • muscle filament sliding Source: HGNC
  • skeletal muscle tissue development Source: UniProtKB

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-445355 Smooth Muscle Contraction
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light polypeptide 6
Alternative name(s):
17 kDa myosin light chain
Short name:
LC17
Myosin light chain 3
Short name:
MLC-3
Myosin light chain alkali 3
Short name:
Myosin light chain A3
Smooth muscle and nonmuscle myosin light chain alkali 6
Gene namesi
Name:MYL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000092841.18
HGNCiHGNC:7587 MYL6
MIMi609931 gene
neXtProtiNX_P60660

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4637
OpenTargetsiENSG00000092841
PharmGKBiPA31384

Polymorphism and mutation databases

BioMutaiMYL6
DMDMi47606436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001986902 – 151Myosin light polypeptide 6Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Isoform Smooth muscle (identifier: P60660-2)
Modified residuei135PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP60660
MaxQBiP60660
PaxDbiP60660
PeptideAtlasiP60660
PRIDEiP60660
TopDownProteomicsiP60660-1 [P60660-1]
P60660-2 [P60660-2]

2D gel databases

DOSAC-COBS-2DPAGEiP60660
SWISS-2DPAGEiP60660

PTM databases

iPTMnetiP60660
PhosphoSitePlusiP60660
SwissPalmiP60660

Expressioni

Gene expression databases

BgeeiENSG00000092841
CleanExiHS_MYL6
ExpressionAtlasiP60660 baseline and differential
GenevisibleiP60660 HS

Organism-specific databases

HPAiHPA046859
HPA063034

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110721, 74 interactors
CORUMiP60660
IntActiP60660, 47 interactors
MINTiP60660
STRINGi9606.ENSP00000446714

Structurei

3D structure databases

ProteinModelPortaliP60660
SMRiP60660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini84 – 119EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini119 – 151EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOVERGENiHBG012180
InParanoidiP60660
KOiK12751
PhylomeDBiP60660
TreeFamiTF351553

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Non-muscle (identifier: P60660-1) [UniParc]FASTAAdd to basket
Also known as: MLC3nm, LC17A, LC17-nm

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK
60 70 80 90 100
VLGNPKSDEM NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG
110 120 130 140 150
NGTVMGAEIR HVLVTLGEKM TEEEVEMLVA GHEDSNGCIN YEAFVRHILS

G
Length:151
Mass (Da):16,930
Last modified:January 23, 2007 - v2
Checksum:iA2B7B4F41179523D
GO
Isoform Smooth muscle (identifier: P60660-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: MLC3sm, LC17B, LC17-sm

The sequence of this isoform differs from the canonical sequence as follows:
     143-151: AFVRHILSG → ELVRMVLNG

Show »
Length:151
Mass (Da):16,961
Checksum:i25B244E686095233
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → ADLIPST in AAA20643 (PubMed:8188229).Curated1
Sequence conflicti45N → D in AAA59853 (PubMed:2304459).Curated1
Sequence conflicti76T → R in AAA20643 (PubMed:8188229).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05045785T → I. Corresponds to variant dbSNP:rs11553509Ensembl.1
Natural variantiVAR_034118103T → P. Corresponds to variant dbSNP:rs1050470Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009735143 – 151AFVRHILSG → ELVRMVLNG in isoform Smooth muscle. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22918 mRNA Translation: AAA36347.1
M22919 Genomic DNA Translation: AAA59892.1
M22919 Genomic DNA Translation: AAA59893.1
M22920 mRNA Translation: AAA36348.1
M31212 mRNA Translation: AAA59853.1
U02629 mRNA Translation: AAA20643.1
AB046613 mRNA Translation: BAB62402.1
CR457014 mRNA Translation: CAG33295.1
BC006781 mRNA Translation: AAH06781.2
BC017455 mRNA Translation: AAH17455.1
BC071661 mRNA Translation: AAH71661.1
BC093066 mRNA Translation: AAH93066.1
CCDSiCCDS31834.1 [P60660-2]
CCDS8906.1
PIRiA33709 MOHU6N
A49620 MOHU6E
B33709 MOHU6M
RefSeqiNP_066299.2, NM_021019.4 [P60660-1]
NP_524147.2, NM_079423.3 [P60660-2]
UniGeneiHs.632717

Genome annotation databases

EnsembliENST00000547649; ENSP00000446714; ENSG00000092841 [P60660-2]
ENST00000548293; ENSP00000448101; ENSG00000092841 [P60660-1]
ENST00000550697; ENSP00000446955; ENSG00000092841 [P60660-1]
GeneIDi4637
KEGGihsa:4637
UCSCiuc001sjw.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYL6_HUMAN
AccessioniPrimary (citable) accession number: P60660
Secondary accession number(s): P16475
, P24572, P24573, Q12790, Q561V9, Q6IAZ0, Q6IPY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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