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P60656

- SPEB_SALTY

UniProt

P60656 - SPEB_SALTY

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Protein
Agmatinase
Gene
speB, STM3078
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine By similarity.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Manganese By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261Manganese By similarity
Metal bindingi149 – 1491Manganese By similarity
Metal bindingi151 – 1511Manganese By similarity
Metal bindingi153 – 1531Manganese By similarity
Metal bindingi230 – 2301Manganese By similarity
Metal bindingi232 – 2321Manganese By similarity

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3098-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
Ordered Locus Names:STM3078
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306AgmatinaseUniRule annotation
PRO_0000173742Add
BLAST

Proteomic databases

PRIDEiP60656.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM3078.

Structurei

3D structure databases

ProteinModelPortaliP60656.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000204320.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.
PhylomeDBiP60656.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60656-1 [UniParc]FASTAAdd to Basket

« Hide

MSTLGHQYDN SLVSNAFGFL RLPMNFQPYD SDADWVITGV PFDMATSGRA    50
GGRHGPAAIR QVSTNLAWEH HRFPWNFDMR ERLNVVDCGD LVYAFGDARE 100
MSEKLQAHAE KLLSAGKRML SFGGDHFVTL PLLRAHAKHF GKMALVHFDA 150
HTDTYANGCE FDHGTMFYTA PKEGLIDPHH SVQIGIRTEF DKDNGFTVLD 200
ACQVNDRGVD DILAQVKQIV GDMPVYLTFD IDCLDPAFAP GTGTPVIGGL 250
TSDRAIKLVR GLKDLNIVGM DVVEVAPAYD QSEITALAAA TLALEMLYIQ 300
AAKKGE 306
Length:306
Mass (Da):33,603
Last modified:March 29, 2004 - v1
Checksum:i6C26A30691F2C3D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL21953.1.
RefSeqiNP_461994.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21953; AAL21953; STM3078.
GeneIDi1254601.
KEGGistm:STM3078.
PATRICi32384905. VBISalEnt20916_3261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006468 Genomic DNA. Translation: AAL21953.1 .
RefSeqi NP_461994.1. NC_003197.1.

3D structure databases

ProteinModelPortali P60656.
ModBasei Search...

Protein-protein interaction databases

STRINGi 99287.STM3078.

Proteomic databases

PRIDEi P60656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL21953 ; AAL21953 ; STM3078 .
GeneIDi 1254601.
KEGGi stm:STM3078.
PATRICi 32384905. VBISalEnt20916_3261.

Phylogenomic databases

HOGENOMi HOG000204320.
KOi K01480.
OMAi KPDYSLY.
OrthoDBi EOG6R2GW5.
PhylomeDBi P60656.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .
BioCyci SENT99287:GCTI-3098-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
HAMAPi MF_01418. SpeB.
InterProi IPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiSPEB_SALTY
AccessioniPrimary (citable) accession number: P60656
Secondary accession number(s): Q8XG05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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