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P60655

- SPEB_SALTI

UniProt

P60655 - SPEB_SALTI

Protein

Agmatinase

Gene

speB

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (29 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of putrescine from agmatine.UniRule annotation

    Catalytic activityi

    Agmatine + H2O = putrescine + urea.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi126 – 1261ManganeseUniRule annotation
    Metal bindingi149 – 1491ManganeseUniRule annotation
    Metal bindingi151 – 1511ManganeseUniRule annotation
    Metal bindingi153 – 1531ManganeseUniRule annotation
    Metal bindingi230 – 2301ManganeseUniRule annotation
    Metal bindingi232 – 2321ManganeseUniRule annotation

    GO - Molecular functioni

    1. agmatinase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: InterPro

    GO - Biological processi

    1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00534; UER00287.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
    Alternative name(s):
    Agmatine ureohydrolaseUniRule annotation
    Short name:
    AUHUniRule annotation
    Gene namesi
    Name:speBUniRule annotation
    Ordered Locus Names:STY3238, t2998
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306AgmatinasePRO_0000173741Add
    BLAST

    Proteomic databases

    PRIDEiP60655.

    Interactioni

    Protein-protein interaction databases

    STRINGi220341.STY3238.

    Structurei

    3D structure databases

    ProteinModelPortaliP60655.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000204320.
    KOiK01480.
    OMAiKPDYSLY.
    OrthoDBiEOG6R2GW5.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    HAMAPiMF_01418. SpeB.
    InterProiIPR023694. Agmatinase.
    IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    TIGRFAMsiTIGR01230. agmatinase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60655-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTLGHQYDN SLVSNAFGFL RLPMNFQPYD SDADWVITGV PFDMATSGRA    50
    GGRHGPAAIR QVSTNLAWEH HRFPWNFDMR ERLNVVDCGD LVYAFGDARE 100
    MSEKLQAHAE KLLSAGKRML SFGGDHFVTL PLLRAHAKHF GKMALVHFDA 150
    HTDTYANGCE FDHGTMFYTA PKEGLIDPHH SVQIGIRTEF DKDNGFTVLD 200
    ACQVNDRGVD DILAQVKQIV GDMPVYLTFD IDCLDPAFAP GTGTPVIGGL 250
    TSDRAIKLVR GLKDLNIVGM DVVEVAPAYD QSEITALAAA TLALEMLYIQ 300
    AAKKGE 306
    Length:306
    Mass (Da):33,603
    Last modified:March 29, 2004 - v1
    Checksum:i6C26A30691F2C3D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014613 Genomic DNA. Translation: AAO70550.1.
    AL513382 Genomic DNA. Translation: CAD02910.1.
    RefSeqiNP_457478.1. NC_003198.1.
    NP_806690.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO70550; AAO70550; t2998.
    CAD02910; CAD02910; CAD02910.
    GeneIDi1249521.
    KEGGisty:STY3238.
    PATRICi18544550. VBISalEnt120419_3301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014613 Genomic DNA. Translation: AAO70550.1 .
    AL513382 Genomic DNA. Translation: CAD02910.1 .
    RefSeqi NP_457478.1. NC_003198.1.
    NP_806690.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali P60655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY3238.

    Proteomic databases

    PRIDEi P60655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO70550 ; AAO70550 ; t2998 .
    CAD02910 ; CAD02910 ; CAD02910 .
    GeneIDi 1249521.
    KEGGi sty:STY3238.
    PATRICi 18544550. VBISalEnt120419_3301.

    Phylogenomic databases

    HOGENOMi HOG000204320.
    KOi K01480.
    OMAi KPDYSLY.
    OrthoDBi EOG6R2GW5.

    Enzyme and pathway databases

    UniPathwayi UPA00534 ; UER00287 .

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    HAMAPi MF_01418. SpeB.
    InterProi IPR023694. Agmatinase.
    IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    TIGRFAMsi TIGR01230. agmatinase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.

    Entry informationi

    Entry nameiSPEB_SALTI
    AccessioniPrimary (citable) accession number: P60655
    Secondary accession number(s): Q8XG05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: March 29, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3