P60653 (SPEB_NEIMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Agmatinase
EC=3.5.3.11

Alternative name(s):
Agmatine ureohydrolase
Short name=AUH

Gene names

Name:	speB
Ordered Locus Names:	NMA2016

Organism

Neisseria meningitidis serogroup A / serotype 4A (strain Z2491) [Complete proteome] [HAMAP]

Taxonomic identifier

122587 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria meningitidis › Neisseria meningitidis serogroup A

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of putrescine from agmatine By similarity. HAMAP-Rule MF_01418
Catalytic activity	Agmatine + H2O = putrescine + urea. HAMAP-Rule MF_01418
Cofactor	Manganese By similarity.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. HAMAP-Rule MF_01418
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	putrescine biosynthetic process from arginine Inferred from electronic annotation. Source: UniProtKB-UniPathway spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	agmatinase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Agmatinase HAMAP-Rule MF_01418		PRO_0000173735
Sites
	Metal binding	128	1	Manganese By similarity
	Metal binding	151	1	Manganese By similarity
	Metal binding	153	1	Manganese By similarity
	Metal binding	155	1	Manganese By similarity
	Metal binding	232	1	Manganese By similarity
	Metal binding	234	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	P60653 [UniParc]. Last modified March 29, 2004. Version 1. Checksum: 1B5013800B47E4BF	FASTA	307	33,905
	10 20 30 40 50 60 MQYSTLAGQT DNSLVSNNFG FLRLPLNFMP YESHADWVIT GVPYDMAVSG RSGARFGPEA 70 80 90 100 110 120 IRRASVNLAW EHRRFPWTFD VRERLNIIDC GDLVFSFGDS RDFVEKMEAH AGKLLSSGKR 130 140 150 160 170 180 CLSLGGDHFI TLPLLRAHAR YFGKLALIHF DAHTDTYDNG SEYDHGTMFY TAPKEGLIDP 190 200 210 220 230 240 SRSVQIGIRT EHSKKLPFTV LSAPKVNEDS VEETVRKIKE TVGNMPVYLT FDIDCLDPSF 250 260 270 280 290 300 APGTGTPVCG GLSSDRALKI LRGLTDLDIV GMDVVEVAPS YDQSDITALA GATIALEMLY LQGAKKD

References

[1]

"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491." Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M., Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M., Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K., Leather S. , Moule S., Mungall K.L., Quail M.A., Rajandream M.A., Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G., Barrell B.G. Nature 404:502-506(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Z2491.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157959 Genomic DNA. Translation: CAM09121.1.
PIR	B81196.
RefSeq	YP_002343279.1. NC_003116.1.
3D structure databases
ProteinModelPortal	P60653.
ModBase	Search...
Protein-protein interaction databases
STRING	122587.NMA2016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAM09121; CAM09121; NMA2016.
GeneID	907424.
KEGG	nma:NMA2016.
PATRIC	20365424. VBINeiMen132687_2398.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0010.
HOGENOM	HOG000204320.
KO	K01480.
OMA	MRRKYTK.
ProtClustDB	PRK02190.
Enzyme and pathway databases
BioCyc	NMEN122587:GI3Q-1791-MONOMER.
UniPathway	UPA00534; UER00287.
Family and domain databases
Gene3D	3.40.800.10. 1 hit.
HAMAP	MF_01418. SpeB.
InterPro	IPR023694. Agmatinase. IPR005925. Agmatinase-rel. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
PANTHER	PTHR11358. PTHR11358. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
TIGRFAMs	TIGR01230. agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEB_NEIMA

Accession

Primary (citable) accession number: P60653
Secondary accession number(s): A1ITK4, Q9JRG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	March 29, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program