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Protein

Cysteine-rich venom protein

Gene
N/A
Organism
Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffein-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity).By similarity

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich venom protein
Short name:
CRVP
Alternative name(s):
Cysteine-rich secretory protein
Stecrisp
OrganismiTrimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri)
Taxonomic identifieri39682 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeTrimeresurus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 12Sequence analysisAdd BLAST›12
ChainiPRO_000000629013 – 233Cysteine-rich venom proteinAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 146PROSITE-ProRule annotation1 Publication
Disulfide bondi85 ↔ 160PROSITE-ProRule annotation1 Publication
Disulfide bondi141 ↔ 157PROSITE-ProRule annotation1 Publication
Disulfide bondi179 ↔ 186PROSITE-ProRule annotation1 Publication
Disulfide bondi182 ↔ 191PROSITE-ProRule annotation1 Publication
Disulfide bondi195 ↔ 228PROSITE-ProRule annotation1 Publication
Disulfide bondi204 ↔ 222PROSITE-ProRule annotation1 Publication
Disulfide bondi213 ↔ 226PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 19Combined sources3
Helixi24 – 39Combined sources16
Beta strandi45 – 47Combined sources3
Helixi55 – 65Combined sources11
Turni66 – 68Combined sources3
Helixi75 – 78Combined sources4
Beta strandi86 – 94Combined sources9
Helixi98 – 106Combined sources9
Helixi107 – 111Combined sources5
Turni114 – 116Combined sources3
Beta strandi117 – 120Combined sources4
Helixi126 – 131Combined sources6
Beta strandi138 – 145Combined sources8
Beta strandi149 – 161Combined sources13
Beta strandi175 – 177Combined sources3
Turni178 – 181Combined sources4
Beta strandi185 – 187Combined sources3
Helixi204 – 209Combined sources6
Helixi216 – 221Combined sources6
Helixi223 – 227Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RC9X-ray1.60A13-233[»]
ProteinModelPortaliP60623.
SMRiP60623.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60623.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 159SCPAdd BLAST129
Domaini195 – 228ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004184.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PILAAVLQQS SGNVDFDSES PRKPEIQNEI VDLHNSLRRS VNPTASNMLR
60 70 80 90 100
MEWYPEAADN AERWAYRCIE SHSSYESRVI EGIKCGENIY MSPYPMKWTD
110 120 130 140 150
IIHAWHDEYK DFKYGVGADP PNAVTGHYTQ IVWYKSYRIG CAAAYCPSSP
160 170 180 190 200
YSYFFVCQYC PAGNFIGKTA TPYTSGTPCG DCPSDCDNGL CTNPCTRENK
210 220 230
FTNCNTMVQQ SSCQDNYMKT NCPASCFCQN KII
Length:233
Mass (Da):26,294
Last modified:March 15, 2004 - v1
Checksum:iA9E326F5242DD249
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423708 mRNA. Translation: AAQ98964.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423708 mRNA. Translation: AAQ98964.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RC9X-ray1.60A13-233[»]
ProteinModelPortaliP60623.
SMRiP60623.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004184.

Miscellaneous databases

EvolutionaryTraceiP60623.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRVP_TRIST
AccessioniPrimary (citable) accession number: P60623
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.