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P60620

- COX1_ARATH

UniProt

P60620 - COX1_ARATH

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, COXI, AtMg01360
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand) Inferred
Metal bindingi243 – 2431Copper B Inferred
Metal bindingi247 – 2471Copper B Inferred
Metal bindingi292 – 2921Copper B Inferred
Metal bindingi293 – 2931Copper B Inferred
Metal bindingi378 – 3781Iron (heme A3 axial ligand) Inferred
Metal bindingi380 – 3801Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:ATMG01360-MONOMER.
MetaCyc:ATMG01360-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COXI
Ordered Locus Names:AtMg01360
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Mitochondrion

Organism-specific databases

TAIRiATMG01360.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Reviewed prediction
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Transmembranei148 – 16821Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei312 – 33221Helical; Reviewed prediction
Add
BLAST
Transmembranei340 – 36021Helical; Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Transmembranei458 – 47821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Cytochrome c oxidase subunit 1
PRO_0000183286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Proteomic databases

PaxDbiP60620.
PRIDEiP60620.

Expressioni

Gene expression databases

GenevestigatoriP60620.

Structurei

3D structure databases

ProteinModelPortaliP60620.
SMRiP60620. Positions 6-515.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02256.
OMAiMGMTRRV.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60620-1 [UniParc]FASTAAdd to Basket

« Hide

MKNLVRWLFS TNHKDIGTLY FIFGAIAGVM GTCFSVLIRM ELARPGDQIL    50
GGNHQLYNVL ITAHAFLMIF FMVMPAMIGG FGNWFVPILI GAPDMAFPRL 100
NNISFWLLPP SLLLLLSSAL VEVGSGTGWT VYPPLSGITS HSGGAVDLAI 150
FSLHLSGVSS ILGSINFITT IFNMRGPGMT MHRLPLFVWS VLVTAFLLLL 200
SLPVLAGAIT MLLTDRNFNT TFFDPAGGGD PILYQHLFWF FGHPEVYILI 250
LPGFGIISHI VSTFSGKPVF GYLGMVYAMI SIGVLGFLVW AHHMFTVGLD 300
VDTRAYFTAA TMIIAVPTGI KIFSWIATMW GGSIQYKTPM LFAVGFIFLF 350
TIGGLTGIVL ANSGLDIALH DTYYVVAHFH YVLSMGAVFA LFAGFYYWVG 400
KIFGRTYPET LGQIHFWITF FGVNLTFFPM HFLGLSGMPR RIPDYPDAYA 450
GWNALSSFGS YISVVGICCF FVVVTITLSS GNNKRCAPSP WALELNSTTL 500
EWMVQSPPAF HTFGELPAIK ETKSYVK 527
Length:527
Mass (Da):57,996
Last modified:March 15, 2004 - v1
Checksum:i69509955882FDE9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69785.1.
RefSeqiNP_085587.1. NC_001284.2.

Genome annotation databases

EnsemblPlantsiATMG01360.1; ATMG01360.1; ATMG01360.
GeneIDi814620.
KEGGiath:ArthMp109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69785.1 .
RefSeqi NP_085587.1. NC_001284.2.

3D structure databases

ProteinModelPortali P60620.
SMRi P60620. Positions 6-515.
ModBasei Search...

Proteomic databases

PaxDbi P60620.
PRIDEi P60620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi ATMG01360.1 ; ATMG01360.1 ; ATMG01360 .
GeneIDi 814620.
KEGGi ath:ArthMp109.

Organism-specific databases

TAIRi ATMG01360.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02256.
OMAi MGMTRRV.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci ARA:ATMG01360-MONOMER.
MetaCyc:ATMG01360-MONOMER.

Miscellaneous databases

PROi P60620.

Gene expression databases

Genevestigatori P60620.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
    Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
    Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiCOX1_ARATH
AccessioniPrimary (citable) accession number: P60620
Secondary accession number(s): Q07063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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