ID RL37A_HALMA Reviewed; 92 AA. AC P60619; Q5V1M1; DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot. DT 04-JAN-2005, sequence version 2. DT 24-JAN-2024, entry version 126. DE RecName: Full=Large ribosomal subunit protein eL43 {ECO:0000255|HAMAP-Rule:MF_00327}; DE AltName: Full=50S ribosomal protein L37Ae {ECO:0000305}; DE AltName: Full=Ribosomal protein L43e {ECO:0000255|HAMAP-Rule:MF_00327}; GN Name=rpl37ae {ECO:0000255|HAMAP-Rule:MF_00327}; GN OrderedLocusNames=rrnAC1669; OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM OS B-1809) (Halobacterium marismortui). OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales; OC Haloarculaceae; Haloarcula. OX NCBI_TaxID=272569; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=15520287; DOI=10.1101/gr.2700304; RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., RA Hood L., Ng W.V.; RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the RT Dead Sea."; RL Genome Res. 14:2221-2234(2004). RN [2] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=10937989; DOI=10.1126/science.289.5481.905; RA Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.; RT "The complete atomic structure of the large ribosomal subunit at 2.4 A RT resolution."; RL Science 289:905-920(2000). RN [3] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=10937990; DOI=10.1126/science.289.5481.920; RA Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.; RT "The structural basis of ribosome activity in peptide bond synthesis."; RL Science 289:920-930(2000). RN [4] RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=11828326; DOI=10.1038/nsb758; RA Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., RA Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.; RT "A pre-translocational intermediate in protein synthesis observed in RT crystals of enzymatically active 50S subunits."; RL Nat. Struct. Biol. 9:225-230(2002). RN [5] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=11483524; DOI=10.1093/emboj/20.15.4214; RA Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.; RT "The kink-turn: a new RNA secondary structure motif."; RL EMBO J. 20:4214-4221(2001). RN [6] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH RP FOUR MACROLIDE ANTIBIOTICS. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=12150912; DOI=10.1016/s1097-2765(02)00570-1; RA Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.; RT "The structures of four macrolide antibiotics bound to the large ribosomal RT subunit."; RL Mol. Cell 10:117-128(2002). RN [7] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=12185246; DOI=10.1073/pnas.172404099; RA Hansen J.L., Schmeing T.M., Moore P.B., Steitz T.A.; RT "Structural insights into peptide bond formation."; RL Proc. Natl. Acad. Sci. U.S.A. 99:11670-11675(2002). RN [8] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH RP FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER. RC STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; RX PubMed=12860128; DOI=10.1016/s0022-2836(03)00668-5; RA Hansen J.L., Moore P.B., Steitz T.A.; RT "Structures of five antibiotics bound at the peptidyl transferase center of RT the large ribosomal subunit."; RL J. Mol. Biol. 330:1061-1075(2003). RN [9] RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT RP E SITE SUBSTRATES. RX PubMed=14561884; DOI=10.1261/rna.5120503; RA Schmeing T.M., Moore P.B., Steitz T.A.; RT "Structures of deacylated tRNA mimics bound to the E site of the large RT ribosomal subunit."; RL RNA 9:1345-1352(2003). RN [10] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT. RX PubMed=23695244; DOI=10.1107/s0907444913004745; RA Gabdulkhakov A., Nikonov S., Garber M.; RT "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."; RL Acta Crystallogr. D 69:997-1004(2013). CC -!- FUNCTION: Binds to the 23S rRNA. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305}; CC Note=Binds 1 zinc ion per subunit. {ECO:0000305}; CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Contacts protein L2. CC {ECO:0000255|HAMAP-Rule:MF_00327, ECO:0000269|PubMed:12150912, CC ECO:0000269|PubMed:12860128}. CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL43 family. CC Putative zinc-binding subfamily. {ECO:0000255|HAMAP-Rule:MF_00327}. CC -!- SEQUENCE CAUTION: CC Sequence=AAV46581.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY596297; AAV46581.1; ALT_INIT; Genomic_DNA. DR PDB; 1FFK; X-ray; 2.40 A; W=12-19. DR PDB; 1JJ2; X-ray; 2.40 A; Y=49-79. DR PDB; 1K73; X-ray; 3.01 A; 1=49-79. DR PDB; 1K8A; X-ray; 3.00 A; 1=49-79. DR PDB; 1K9M; X-ray; 3.00 A; 1=49-79. DR PDB; 1KC8; X-ray; 3.01 A; 1=49-79. DR PDB; 1KD1; X-ray; 3.00 A; 1=49-79. DR PDB; 1KQS; X-ray; 3.10 A; Y=49-79. DR PDB; 1M1K; X-ray; 3.20 A; 1=49-79. DR PDB; 1M90; X-ray; 2.80 A; 1=49-79. DR PDB; 1N8R; X-ray; 3.00 A; 1=49-79. DR PDB; 1NJI; X-ray; 3.00 A; 1=49-79. DR PDB; 1Q7Y; X-ray; 3.20 A; 1=49-79. DR PDB; 1Q81; X-ray; 2.95 A; 1=49-79. DR PDB; 1Q82; X-ray; 2.98 A; 1=49-79. DR PDB; 1Q86; X-ray; 3.00 A; 1=49-79. DR PDB; 1QVF; X-ray; 3.10 A; Y=49-79. DR PDB; 1QVG; X-ray; 2.90 A; Y=49-79. DR PDB; 1S72; X-ray; 2.40 A; Z=11-82. DR PDB; 1VQ4; X-ray; 2.70 A; Z=11-92. DR PDB; 1VQ5; X-ray; 2.60 A; Z=11-92. DR PDB; 1VQ6; X-ray; 2.70 A; Z=11-92. DR PDB; 1VQ7; X-ray; 2.50 A; Z=11-92. DR PDB; 1VQ8; X-ray; 2.20 A; Z=11-92. DR PDB; 1VQ9; X-ray; 2.40 A; Z=11-92. DR PDB; 1VQK; X-ray; 2.30 A; Z=11-92. DR PDB; 1VQL; X-ray; 2.30 A; Z=11-92. DR PDB; 1VQM; X-ray; 2.30 A; Z=11-92. DR PDB; 1VQN; X-ray; 2.40 A; Z=11-92. DR PDB; 1VQO; X-ray; 2.20 A; Z=11-92. DR PDB; 1VQP; X-ray; 2.25 A; Z=11-92. DR PDB; 1W2B; X-ray; 3.50 A; Y=49-79. DR PDB; 1YHQ; X-ray; 2.40 A; Z=11-92. DR PDB; 1YI2; X-ray; 2.65 A; Z=11-92. DR PDB; 1YIJ; X-ray; 2.60 A; Z=11-92. DR PDB; 1YIT; X-ray; 2.80 A; Z=11-92. DR PDB; 1YJ9; X-ray; 2.90 A; Z=11-92. DR PDB; 1YJN; X-ray; 3.00 A; Z=11-92. DR PDB; 1YJW; X-ray; 2.90 A; Z=11-92. DR PDB; 2OTJ; X-ray; 2.90 A; Z=11-82. DR PDB; 2OTL; X-ray; 2.70 A; Z=11-82. DR PDB; 2QA4; X-ray; 3.00 A; Z=1-92. DR PDB; 2QEX; X-ray; 2.90 A; Z=11-82. DR PDB; 3CC2; X-ray; 2.40 A; Z=1-92. DR PDB; 3CC4; X-ray; 2.70 A; Z=1-92. DR PDB; 3CC7; X-ray; 2.70 A; Z=1-92. DR PDB; 3CCE; X-ray; 2.75 A; Z=1-92. DR PDB; 3CCJ; X-ray; 2.70 A; Z=1-92. DR PDB; 3CCL; X-ray; 2.90 A; Z=1-92. DR PDB; 3CCM; X-ray; 2.55 A; Z=1-92. DR PDB; 3CCQ; X-ray; 2.90 A; Z=1-92. DR PDB; 3CCR; X-ray; 3.00 A; Z=1-92. DR PDB; 3CCS; X-ray; 2.95 A; Z=1-92. DR PDB; 3CCU; X-ray; 2.80 A; Z=1-92. DR PDB; 3CCV; X-ray; 2.90 A; Z=1-92. DR PDB; 3CD6; X-ray; 2.75 A; Z=1-92. DR PDB; 3CMA; X-ray; 2.80 A; Z=1-92. DR PDB; 3CME; X-ray; 2.95 A; Z=1-92. DR PDB; 3CPW; X-ray; 2.70 A; Y=1-92. DR PDB; 3G4S; X-ray; 3.20 A; Z=10-82. DR PDB; 3G6E; X-ray; 2.70 A; Z=10-82. DR PDB; 3G71; X-ray; 2.85 A; Z=10-82. DR PDB; 3I55; X-ray; 3.11 A; Z=1-92. DR PDB; 3I56; X-ray; 2.90 A; Z=1-92. DR PDB; 4ADX; EM; 6.60 A; Z=1-92. DR PDB; 4V9F; X-ray; 2.40 A; Z=1-92. DR PDBsum; 1FFK; -. DR PDBsum; 1JJ2; -. DR PDBsum; 1K73; -. DR PDBsum; 1K8A; -. DR PDBsum; 1K9M; -. DR PDBsum; 1KC8; -. DR PDBsum; 1KD1; -. DR PDBsum; 1KQS; -. DR PDBsum; 1M1K; -. DR PDBsum; 1M90; -. DR PDBsum; 1N8R; -. DR PDBsum; 1NJI; -. DR PDBsum; 1Q7Y; -. DR PDBsum; 1Q81; -. DR PDBsum; 1Q82; -. DR PDBsum; 1Q86; -. DR PDBsum; 1QVF; -. DR PDBsum; 1QVG; -. DR PDBsum; 1S72; -. DR PDBsum; 1VQ4; -. DR PDBsum; 1VQ5; -. DR PDBsum; 1VQ6; -. DR PDBsum; 1VQ7; -. DR PDBsum; 1VQ8; -. DR PDBsum; 1VQ9; -. DR PDBsum; 1VQK; -. DR PDBsum; 1VQL; -. DR PDBsum; 1VQM; -. DR PDBsum; 1VQN; -. DR PDBsum; 1VQO; -. DR PDBsum; 1VQP; -. DR PDBsum; 1W2B; -. DR PDBsum; 1YHQ; -. DR PDBsum; 1YI2; -. DR PDBsum; 1YIJ; -. DR PDBsum; 1YIT; -. DR PDBsum; 1YJ9; -. DR PDBsum; 1YJN; -. DR PDBsum; 1YJW; -. DR PDBsum; 2OTJ; -. DR PDBsum; 2OTL; -. DR PDBsum; 2QA4; -. DR PDBsum; 2QEX; -. DR PDBsum; 3CC2; -. DR PDBsum; 3CC4; -. DR PDBsum; 3CC7; -. DR PDBsum; 3CCE; -. DR PDBsum; 3CCJ; -. DR PDBsum; 3CCL; -. DR PDBsum; 3CCM; -. DR PDBsum; 3CCQ; -. DR PDBsum; 3CCR; -. DR PDBsum; 3CCS; -. DR PDBsum; 3CCU; -. DR PDBsum; 3CCV; -. DR PDBsum; 3CD6; -. DR PDBsum; 3CMA; -. DR PDBsum; 3CME; -. DR PDBsum; 3CPW; -. DR PDBsum; 3G4S; -. DR PDBsum; 3G6E; -. DR PDBsum; 3G71; -. DR PDBsum; 3I55; -. DR PDBsum; 3I56; -. DR PDBsum; 4ADX; -. DR PDBsum; 4V9F; -. DR AlphaFoldDB; P60619; -. DR SMR; P60619; -. DR IntAct; P60619; 2. DR STRING; 272569.rrnAC1669; -. DR PaxDb; 272569-rrnAC1669; -. DR EnsemblBacteria; AAV46581; AAV46581; rrnAC1669. DR KEGG; hma:rrnAC1669; -. DR PATRIC; fig|272569.17.peg.2356; -. DR eggNOG; arCOG04208; Archaea. DR HOGENOM; CLU_141199_2_0_2; -. DR EvolutionaryTrace; P60619; -. DR Proteomes; UP000001169; Chromosome I. DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW. DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW. DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule. DR Gene3D; 2.20.25.30; -; 1. DR HAMAP; MF_00327; Ribosomal_eL43; 1. DR InterPro; IPR011331; Ribosomal_eL37/eL43. DR InterPro; IPR002674; Ribosomal_eL43. DR InterPro; IPR011332; Ribosomal_zn-bd. DR NCBIfam; TIGR00280; eL43_euk_arch; 1. DR PANTHER; PTHR48129; 60S RIBOSOMAL PROTEIN L37A; 1. DR PANTHER; PTHR48129:SF1; 60S RIBOSOMAL PROTEIN L37A; 1. DR Pfam; PF01780; Ribosomal_L37ae; 1. DR SUPFAM; SSF57829; Zn-binding ribosomal proteins; 1. PE 1: Evidence at protein level; KW 3D-structure; Metal-binding; Reference proteome; Ribonucleoprotein; KW Ribosomal protein; RNA-binding; rRNA-binding; Zinc; Zinc-finger. FT CHAIN 1..92 FT /note="Large ribosomal subunit protein eL43" FT /id="PRO_0000139841" FT ZN_FING 39..60 FT /note="C4-type" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327" FT BINDING 39 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327" FT BINDING 42 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327" FT BINDING 57 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327" FT BINDING 60 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00327" FT HELIX 11..14 FT /evidence="ECO:0007829|PDB:1VQ8" FT HELIX 20..34 FT /evidence="ECO:0007829|PDB:1VQ8" FT STRAND 37..39 FT /evidence="ECO:0007829|PDB:3CCJ" FT STRAND 40..42 FT /evidence="ECO:0007829|PDB:1VQ8" FT STRAND 45..51 FT /evidence="ECO:0007829|PDB:1VQ8" FT STRAND 54..57 FT /evidence="ECO:0007829|PDB:1VQ8" FT TURN 58..60 FT /evidence="ECO:0007829|PDB:1VQ8" FT STRAND 63..65 FT /evidence="ECO:0007829|PDB:1VQ8" FT STRAND 68..72 FT /evidence="ECO:0007829|PDB:1VQ8" FT HELIX 74..81 FT /evidence="ECO:0007829|PDB:1VQ8" SQ SEQUENCE 92 AA; 10172 MW; 89E52AFE761E9837 CRC64; MASKSGKTGS SGRFGARYGR VSRRRVAEIE SEMNEDHACP NCGEDRVDRQ GTGIWQCSYC DYKFTGGSYK PETPGGKTVR RSIRAALSED EE //