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P60619

- RL37A_HALMA

UniProt

P60619 - RL37A_HALMA

Protein

50S ribosomal protein L37Ae

Gene

rpl37ae

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the 23S rRNA.

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi39 – 391ZincUniRule annotation
    Metal bindingi42 – 421ZincUniRule annotation
    Metal bindingi57 – 571ZincUniRule annotation
    Metal bindingi60 – 601ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri39 – 6022C4-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    Metal-binding, RNA-binding, rRNA-binding, Zinc

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-1522-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L37AeUniRule annotation
    Alternative name(s):
    Ribosomal protein L43eUniRule annotation
    Gene namesi
    Name:rpl37aeUniRule annotation
    Ordered Locus Names:rrnAC1669
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 929250S ribosomal protein L37AePRO_0000139841Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Contacts protein L2.2 PublicationsUniRule annotation

    Protein-protein interaction databases

    STRINGi272569.rrnAC1669.

    Structurei

    Secondary structure

    1
    92
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 144
    Helixi20 – 3415
    Beta strandi37 – 393
    Beta strandi40 – 423
    Beta strandi45 – 517
    Beta strandi54 – 574
    Turni58 – 603
    Beta strandi63 – 653
    Beta strandi68 – 725
    Helixi74 – 818

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40W12-19[»]
    1JJ2X-ray2.40Y49-79[»]
    1K73X-ray3.01149-79[»]
    1K8AX-ray3.00149-79[»]
    1K9MX-ray3.00149-79[»]
    1KC8X-ray3.01149-79[»]
    1KD1X-ray3.00149-79[»]
    1KQSX-ray3.10Y49-79[»]
    1M1KX-ray3.20149-79[»]
    1M90X-ray2.80149-79[»]
    1N8RX-ray3.00149-79[»]
    1NJIX-ray3.00149-79[»]
    1Q7YX-ray3.20149-79[»]
    1Q81X-ray2.95149-79[»]
    1Q82X-ray2.98149-79[»]
    1Q86X-ray3.00149-79[»]
    1QVFX-ray3.10Y49-79[»]
    1QVGX-ray2.90Y49-79[»]
    1S72X-ray2.40Z11-82[»]
    1VQ4X-ray2.70Z11-92[»]
    1VQ5X-ray2.60Z11-92[»]
    1VQ6X-ray2.70Z11-92[»]
    1VQ7X-ray2.50Z11-92[»]
    1VQ8X-ray2.20Z11-92[»]
    1VQ9X-ray2.40Z11-92[»]
    1VQKX-ray2.30Z11-92[»]
    1VQLX-ray2.30Z11-92[»]
    1VQMX-ray2.30Z11-92[»]
    1VQNX-ray2.40Z11-92[»]
    1VQOX-ray2.20Z11-92[»]
    1VQPX-ray2.25Z11-92[»]
    1W2BX-ray3.50Y49-79[»]
    1YHQX-ray2.40Z11-92[»]
    1YI2X-ray2.65Z11-92[»]
    1YIJX-ray2.60Z11-92[»]
    1YITX-ray2.80Z11-92[»]
    1YJ9X-ray2.90Z11-92[»]
    1YJNX-ray3.00Z11-92[»]
    1YJWX-ray2.90Z11-92[»]
    2OTJX-ray2.90Z11-82[»]
    2OTLX-ray2.70Z11-82[»]
    2QA4X-ray3.00Z1-92[»]
    2QEXX-ray2.90Z11-82[»]
    3CC2X-ray2.40Z1-92[»]
    3CC4X-ray2.70Z1-92[»]
    3CC7X-ray2.70Z1-92[»]
    3CCEX-ray2.75Z1-92[»]
    3CCJX-ray2.70Z1-92[»]
    3CCLX-ray2.90Z1-92[»]
    3CCMX-ray2.55Z1-92[»]
    3CCQX-ray2.90Z1-92[»]
    3CCRX-ray3.00Z1-92[»]
    3CCSX-ray2.95Z1-92[»]
    3CCUX-ray2.80Z1-92[»]
    3CCVX-ray2.90Z1-92[»]
    3CD6X-ray2.75Z1-92[»]
    3CMAX-ray2.80Z1-92[»]
    3CMEX-ray2.95Z1-92[»]
    3CPWX-ray2.70Y1-92[»]
    3G4SX-ray3.20Z10-82[»]
    3G6EX-ray2.70Z10-82[»]
    3G71X-ray2.85Z10-82[»]
    3I55X-ray3.11Z1-92[»]
    3I56X-ray2.90Z1-92[»]
    4ADXelectron microscopy6.60Z1-92[»]
    4HUBX-ray2.40Z1-92[»]
    ProteinModelPortaliP60619.
    SMRiP60619. Positions 10-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60619.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L37Ae family. Putative zinc-binding subfamily.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri39 – 6022C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1997.
    HOGENOMiHOG000229493.
    KOiK02921.

    Family and domain databases

    Gene3Di2.20.25.30. 1 hit.
    HAMAPiMF_00327. Ribosomal_L37Ae.
    InterProiIPR002674. Ribosomal_L37ae.
    IPR011331. Ribosomal_L37ae/L37e.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PfamiPF01780. Ribosomal_L37ae. 1 hit.
    [Graphical view]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    TIGRFAMsiTIGR00280. L37a. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P60619-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKSGKTGS SGRFGARYGR VSRRRVAEIE SEMNEDHACP NCGEDRVDRQ   50
    GTGIWQCSYC DYKFTGGSYK PETPGGKTVR RSIRAALSED EE 92
    Length:92
    Mass (Da):10,172
    Last modified:January 4, 2005 - v2
    Checksum:i89E52AFE761E9837
    GO

    Sequence cautioni

    The sequence AAV46581.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV46581.1. Different initiation.
    RefSeqiYP_136287.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV46581; AAV46581; rrnAC1669.
    GeneIDi3128391.
    KEGGihma:rrnAC1669.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV46581.1 . Different initiation.
    RefSeqi YP_136287.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 W 12-19 [» ]
    1JJ2 X-ray 2.40 Y 49-79 [» ]
    1K73 X-ray 3.01 1 49-79 [» ]
    1K8A X-ray 3.00 1 49-79 [» ]
    1K9M X-ray 3.00 1 49-79 [» ]
    1KC8 X-ray 3.01 1 49-79 [» ]
    1KD1 X-ray 3.00 1 49-79 [» ]
    1KQS X-ray 3.10 Y 49-79 [» ]
    1M1K X-ray 3.20 1 49-79 [» ]
    1M90 X-ray 2.80 1 49-79 [» ]
    1N8R X-ray 3.00 1 49-79 [» ]
    1NJI X-ray 3.00 1 49-79 [» ]
    1Q7Y X-ray 3.20 1 49-79 [» ]
    1Q81 X-ray 2.95 1 49-79 [» ]
    1Q82 X-ray 2.98 1 49-79 [» ]
    1Q86 X-ray 3.00 1 49-79 [» ]
    1QVF X-ray 3.10 Y 49-79 [» ]
    1QVG X-ray 2.90 Y 49-79 [» ]
    1S72 X-ray 2.40 Z 11-82 [» ]
    1VQ4 X-ray 2.70 Z 11-92 [» ]
    1VQ5 X-ray 2.60 Z 11-92 [» ]
    1VQ6 X-ray 2.70 Z 11-92 [» ]
    1VQ7 X-ray 2.50 Z 11-92 [» ]
    1VQ8 X-ray 2.20 Z 11-92 [» ]
    1VQ9 X-ray 2.40 Z 11-92 [» ]
    1VQK X-ray 2.30 Z 11-92 [» ]
    1VQL X-ray 2.30 Z 11-92 [» ]
    1VQM X-ray 2.30 Z 11-92 [» ]
    1VQN X-ray 2.40 Z 11-92 [» ]
    1VQO X-ray 2.20 Z 11-92 [» ]
    1VQP X-ray 2.25 Z 11-92 [» ]
    1W2B X-ray 3.50 Y 49-79 [» ]
    1YHQ X-ray 2.40 Z 11-92 [» ]
    1YI2 X-ray 2.65 Z 11-92 [» ]
    1YIJ X-ray 2.60 Z 11-92 [» ]
    1YIT X-ray 2.80 Z 11-92 [» ]
    1YJ9 X-ray 2.90 Z 11-92 [» ]
    1YJN X-ray 3.00 Z 11-92 [» ]
    1YJW X-ray 2.90 Z 11-92 [» ]
    2OTJ X-ray 2.90 Z 11-82 [» ]
    2OTL X-ray 2.70 Z 11-82 [» ]
    2QA4 X-ray 3.00 Z 1-92 [» ]
    2QEX X-ray 2.90 Z 11-82 [» ]
    3CC2 X-ray 2.40 Z 1-92 [» ]
    3CC4 X-ray 2.70 Z 1-92 [» ]
    3CC7 X-ray 2.70 Z 1-92 [» ]
    3CCE X-ray 2.75 Z 1-92 [» ]
    3CCJ X-ray 2.70 Z 1-92 [» ]
    3CCL X-ray 2.90 Z 1-92 [» ]
    3CCM X-ray 2.55 Z 1-92 [» ]
    3CCQ X-ray 2.90 Z 1-92 [» ]
    3CCR X-ray 3.00 Z 1-92 [» ]
    3CCS X-ray 2.95 Z 1-92 [» ]
    3CCU X-ray 2.80 Z 1-92 [» ]
    3CCV X-ray 2.90 Z 1-92 [» ]
    3CD6 X-ray 2.75 Z 1-92 [» ]
    3CMA X-ray 2.80 Z 1-92 [» ]
    3CME X-ray 2.95 Z 1-92 [» ]
    3CPW X-ray 2.70 Y 1-92 [» ]
    3G4S X-ray 3.20 Z 10-82 [» ]
    3G6E X-ray 2.70 Z 10-82 [» ]
    3G71 X-ray 2.85 Z 10-82 [» ]
    3I55 X-ray 3.11 Z 1-92 [» ]
    3I56 X-ray 2.90 Z 1-92 [» ]
    4ADX electron microscopy 6.60 Z 1-92 [» ]
    4HUB X-ray 2.40 Z 1-92 [» ]
    ProteinModelPortali P60619.
    SMRi P60619. Positions 10-82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC1669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV46581 ; AAV46581 ; rrnAC1669 .
    GeneIDi 3128391.
    KEGGi hma:rrnAC1669.

    Phylogenomic databases

    eggNOGi COG1997.
    HOGENOMi HOG000229493.
    KOi K02921.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-1522-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P60619.

    Family and domain databases

    Gene3Di 2.20.25.30. 1 hit.
    HAMAPi MF_00327. Ribosomal_L37Ae.
    InterProi IPR002674. Ribosomal_L37ae.
    IPR011331. Ribosomal_L37ae/L37e.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    Pfami PF01780. Ribosomal_L37ae. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    TIGRFAMsi TIGR00280. L37a. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    2. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    3. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    10. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL37A_HALMA
    AccessioniPrimary (citable) accession number: P60619
    Secondary accession number(s): Q5V1M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3