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P60619

- RL37A_HALMA

UniProt

P60619 - RL37A_HALMA

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Protein

50S ribosomal protein L37Ae

Gene

rpl37ae

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.

Cofactori

Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391ZincUniRule annotation
Metal bindingi42 – 421ZincUniRule annotation
Metal bindingi57 – 571ZincUniRule annotation
Metal bindingi60 – 601ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 6022C4-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, RNA-binding, rRNA-binding, Zinc

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1522-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L37AeUniRule annotation
Alternative name(s):
Ribosomal protein L43eUniRule annotation
Gene namesi
Name:rpl37aeUniRule annotation
Ordered Locus Names:rrnAC1669
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 929250S ribosomal protein L37AePRO_0000139841Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Contacts protein L2.2 PublicationsUniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC1669.

Structurei

Secondary structure

1
92
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 144Combined sources
Helixi20 – 3415Combined sources
Beta strandi37 – 393Combined sources
Beta strandi40 – 423Combined sources
Beta strandi45 – 517Combined sources
Beta strandi54 – 574Combined sources
Turni58 – 603Combined sources
Beta strandi63 – 653Combined sources
Beta strandi68 – 725Combined sources
Helixi74 – 818Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40W12-19[»]
1JJ2X-ray2.40Y49-79[»]
1K73X-ray3.01149-79[»]
1K8AX-ray3.00149-79[»]
1K9MX-ray3.00149-79[»]
1KC8X-ray3.01149-79[»]
1KD1X-ray3.00149-79[»]
1KQSX-ray3.10Y49-79[»]
1M1KX-ray3.20149-79[»]
1M90X-ray2.80149-79[»]
1N8RX-ray3.00149-79[»]
1NJIX-ray3.00149-79[»]
1Q7YX-ray3.20149-79[»]
1Q81X-ray2.95149-79[»]
1Q82X-ray2.98149-79[»]
1Q86X-ray3.00149-79[»]
1QVFX-ray3.10Y49-79[»]
1QVGX-ray2.90Y49-79[»]
1S72X-ray2.40Z11-82[»]
1VQ4X-ray2.70Z11-92[»]
1VQ5X-ray2.60Z11-92[»]
1VQ6X-ray2.70Z11-92[»]
1VQ7X-ray2.50Z11-92[»]
1VQ8X-ray2.20Z11-92[»]
1VQ9X-ray2.40Z11-92[»]
1VQKX-ray2.30Z11-92[»]
1VQLX-ray2.30Z11-92[»]
1VQMX-ray2.30Z11-92[»]
1VQNX-ray2.40Z11-92[»]
1VQOX-ray2.20Z11-92[»]
1VQPX-ray2.25Z11-92[»]
1W2BX-ray3.50Y49-79[»]
1YHQX-ray2.40Z11-92[»]
1YI2X-ray2.65Z11-92[»]
1YIJX-ray2.60Z11-92[»]
1YITX-ray2.80Z11-92[»]
1YJ9X-ray2.90Z11-92[»]
1YJNX-ray3.00Z11-92[»]
1YJWX-ray2.90Z11-92[»]
2OTJX-ray2.90Z11-82[»]
2OTLX-ray2.70Z11-82[»]
2QA4X-ray3.00Z1-92[»]
2QEXX-ray2.90Z11-82[»]
3CC2X-ray2.40Z1-92[»]
3CC4X-ray2.70Z1-92[»]
3CC7X-ray2.70Z1-92[»]
3CCEX-ray2.75Z1-92[»]
3CCJX-ray2.70Z1-92[»]
3CCLX-ray2.90Z1-92[»]
3CCMX-ray2.55Z1-92[»]
3CCQX-ray2.90Z1-92[»]
3CCRX-ray3.00Z1-92[»]
3CCSX-ray2.95Z1-92[»]
3CCUX-ray2.80Z1-92[»]
3CCVX-ray2.90Z1-92[»]
3CD6X-ray2.75Z1-92[»]
3CMAX-ray2.80Z1-92[»]
3CMEX-ray2.95Z1-92[»]
3CPWX-ray2.70Y1-92[»]
3G4SX-ray3.20Z10-82[»]
3G6EX-ray2.70Z10-82[»]
3G71X-ray2.85Z10-82[»]
3I55X-ray3.11Z1-92[»]
3I56X-ray2.90Z1-92[»]
4ADXelectron microscopy6.60Z1-92[»]
4HUBX-ray2.40Z1-92[»]
ProteinModelPortaliP60619.
SMRiP60619. Positions 10-82.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60619.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L37Ae family. Putative zinc-binding subfamily.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 6022C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1997.
HOGENOMiHOG000229493.
KOiK02921.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00327. Ribosomal_L37Ae.
InterProiIPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01780. Ribosomal_L37ae. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR00280. L37a. 1 hit.

Sequencei

Sequence statusi: Complete.

P60619-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKSGKTGS SGRFGARYGR VSRRRVAEIE SEMNEDHACP NCGEDRVDRQ
60 70 80 90
GTGIWQCSYC DYKFTGGSYK PETPGGKTVR RSIRAALSED EE
Length:92
Mass (Da):10,172
Last modified:January 4, 2005 - v2
Checksum:i89E52AFE761E9837
GO

Sequence cautioni

The sequence AAV46581.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV46581.1. Different initiation.
RefSeqiYP_136287.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46581; AAV46581; rrnAC1669.
GeneIDi3128391.
KEGGihma:rrnAC1669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV46581.1 . Different initiation.
RefSeqi YP_136287.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 W 12-19 [» ]
1JJ2 X-ray 2.40 Y 49-79 [» ]
1K73 X-ray 3.01 1 49-79 [» ]
1K8A X-ray 3.00 1 49-79 [» ]
1K9M X-ray 3.00 1 49-79 [» ]
1KC8 X-ray 3.01 1 49-79 [» ]
1KD1 X-ray 3.00 1 49-79 [» ]
1KQS X-ray 3.10 Y 49-79 [» ]
1M1K X-ray 3.20 1 49-79 [» ]
1M90 X-ray 2.80 1 49-79 [» ]
1N8R X-ray 3.00 1 49-79 [» ]
1NJI X-ray 3.00 1 49-79 [» ]
1Q7Y X-ray 3.20 1 49-79 [» ]
1Q81 X-ray 2.95 1 49-79 [» ]
1Q82 X-ray 2.98 1 49-79 [» ]
1Q86 X-ray 3.00 1 49-79 [» ]
1QVF X-ray 3.10 Y 49-79 [» ]
1QVG X-ray 2.90 Y 49-79 [» ]
1S72 X-ray 2.40 Z 11-82 [» ]
1VQ4 X-ray 2.70 Z 11-92 [» ]
1VQ5 X-ray 2.60 Z 11-92 [» ]
1VQ6 X-ray 2.70 Z 11-92 [» ]
1VQ7 X-ray 2.50 Z 11-92 [» ]
1VQ8 X-ray 2.20 Z 11-92 [» ]
1VQ9 X-ray 2.40 Z 11-92 [» ]
1VQK X-ray 2.30 Z 11-92 [» ]
1VQL X-ray 2.30 Z 11-92 [» ]
1VQM X-ray 2.30 Z 11-92 [» ]
1VQN X-ray 2.40 Z 11-92 [» ]
1VQO X-ray 2.20 Z 11-92 [» ]
1VQP X-ray 2.25 Z 11-92 [» ]
1W2B X-ray 3.50 Y 49-79 [» ]
1YHQ X-ray 2.40 Z 11-92 [» ]
1YI2 X-ray 2.65 Z 11-92 [» ]
1YIJ X-ray 2.60 Z 11-92 [» ]
1YIT X-ray 2.80 Z 11-92 [» ]
1YJ9 X-ray 2.90 Z 11-92 [» ]
1YJN X-ray 3.00 Z 11-92 [» ]
1YJW X-ray 2.90 Z 11-92 [» ]
2OTJ X-ray 2.90 Z 11-82 [» ]
2OTL X-ray 2.70 Z 11-82 [» ]
2QA4 X-ray 3.00 Z 1-92 [» ]
2QEX X-ray 2.90 Z 11-82 [» ]
3CC2 X-ray 2.40 Z 1-92 [» ]
3CC4 X-ray 2.70 Z 1-92 [» ]
3CC7 X-ray 2.70 Z 1-92 [» ]
3CCE X-ray 2.75 Z 1-92 [» ]
3CCJ X-ray 2.70 Z 1-92 [» ]
3CCL X-ray 2.90 Z 1-92 [» ]
3CCM X-ray 2.55 Z 1-92 [» ]
3CCQ X-ray 2.90 Z 1-92 [» ]
3CCR X-ray 3.00 Z 1-92 [» ]
3CCS X-ray 2.95 Z 1-92 [» ]
3CCU X-ray 2.80 Z 1-92 [» ]
3CCV X-ray 2.90 Z 1-92 [» ]
3CD6 X-ray 2.75 Z 1-92 [» ]
3CMA X-ray 2.80 Z 1-92 [» ]
3CME X-ray 2.95 Z 1-92 [» ]
3CPW X-ray 2.70 Y 1-92 [» ]
3G4S X-ray 3.20 Z 10-82 [» ]
3G6E X-ray 2.70 Z 10-82 [» ]
3G71 X-ray 2.85 Z 10-82 [» ]
3I55 X-ray 3.11 Z 1-92 [» ]
3I56 X-ray 2.90 Z 1-92 [» ]
4ADX electron microscopy 6.60 Z 1-92 [» ]
4HUB X-ray 2.40 Z 1-92 [» ]
ProteinModelPortali P60619.
SMRi P60619. Positions 10-82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46581 ; AAV46581 ; rrnAC1669 .
GeneIDi 3128391.
KEGGi hma:rrnAC1669.

Phylogenomic databases

eggNOGi COG1997.
HOGENOMi HOG000229493.
KOi K02921.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1522-MONOMER.

Miscellaneous databases

EvolutionaryTracei P60619.

Family and domain databases

Gene3Di 2.20.25.30. 1 hit.
HAMAPi MF_00327. Ribosomal_L37Ae.
InterProi IPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
[Graphical view ]
Pfami PF01780. Ribosomal_L37ae. 1 hit.
[Graphical view ]
SUPFAMi SSF57829. SSF57829. 1 hit.
TIGRFAMsi TIGR00280. L37a. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  2. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  10. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL37A_HALMA
AccessioniPrimary (citable) accession number: P60619
Secondary accession number(s): Q5V1M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3