SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P60619

- RL37A_HALMA

UniProt

P60619 - RL37A_HALMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
50S ribosomal protein L37Ae
Gene
rpl37ae, rrnAC1669
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit Inferred.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Zinc Reviewed prediction
Metal bindingi42 – 421Zinc Reviewed prediction
Metal bindingi57 – 571Zinc Reviewed prediction
Metal bindingi60 – 601Zinc Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 6022C4-type Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, RNA-binding, rRNA-binding, Zinc

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1522-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L37Ae
Alternative name(s):
Ribosomal protein L43e
Gene namesi
Name:rpl37ae
Ordered Locus Names:rrnAC1669
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 929250S ribosomal protein L37AeUniRule annotation
PRO_0000139841Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Contacts protein L2.9 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1669.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 144
Helixi20 – 3415
Beta strandi37 – 393
Beta strandi40 – 423
Beta strandi45 – 517
Beta strandi54 – 574
Turni58 – 603
Beta strandi63 – 653
Beta strandi68 – 725
Helixi74 – 818

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40W12-19[»]
1JJ2X-ray2.40Y49-79[»]
1K73X-ray3.01149-79[»]
1K8AX-ray3.00149-79[»]
1K9MX-ray3.00149-79[»]
1KC8X-ray3.01149-79[»]
1KD1X-ray3.00149-79[»]
1KQSX-ray3.10Y49-79[»]
1M1KX-ray3.20149-79[»]
1M90X-ray2.80149-79[»]
1N8RX-ray3.00149-79[»]
1NJIX-ray3.00149-79[»]
1Q7YX-ray3.20149-79[»]
1Q81X-ray2.95149-79[»]
1Q82X-ray2.98149-79[»]
1Q86X-ray3.00149-79[»]
1QVFX-ray3.10Y49-79[»]
1QVGX-ray2.90Y49-79[»]
1S72X-ray2.40Z11-82[»]
1VQ4X-ray2.70Z11-92[»]
1VQ5X-ray2.60Z11-92[»]
1VQ6X-ray2.70Z11-92[»]
1VQ7X-ray2.50Z11-92[»]
1VQ8X-ray2.20Z11-92[»]
1VQ9X-ray2.40Z11-92[»]
1VQKX-ray2.30Z11-92[»]
1VQLX-ray2.30Z11-92[»]
1VQMX-ray2.30Z11-92[»]
1VQNX-ray2.40Z11-92[»]
1VQOX-ray2.20Z11-92[»]
1VQPX-ray2.25Z11-92[»]
1W2BX-ray3.50Y49-79[»]
1YHQX-ray2.40Z11-92[»]
1YI2X-ray2.65Z11-92[»]
1YIJX-ray2.60Z11-92[»]
1YITX-ray2.80Z11-92[»]
1YJ9X-ray2.90Z11-92[»]
1YJNX-ray3.00Z11-92[»]
1YJWX-ray2.90Z11-92[»]
2OTJX-ray2.90Z11-82[»]
2OTLX-ray2.70Z11-82[»]
2QA4X-ray3.00Z1-92[»]
2QEXX-ray2.90Z11-82[»]
3CC2X-ray2.40Z1-92[»]
3CC4X-ray2.70Z1-92[»]
3CC7X-ray2.70Z1-92[»]
3CCEX-ray2.75Z1-92[»]
3CCJX-ray2.70Z1-92[»]
3CCLX-ray2.90Z1-92[»]
3CCMX-ray2.55Z1-92[»]
3CCQX-ray2.90Z1-92[»]
3CCRX-ray3.00Z1-92[»]
3CCSX-ray2.95Z1-92[»]
3CCUX-ray2.80Z1-92[»]
3CCVX-ray2.90Z1-92[»]
3CD6X-ray2.75Z1-92[»]
3CMAX-ray2.80Z1-92[»]
3CMEX-ray2.95Z1-92[»]
3CPWX-ray2.70Y1-92[»]
3G4SX-ray3.20Z10-82[»]
3G6EX-ray2.70Z10-82[»]
3G71X-ray2.85Z10-82[»]
3I55X-ray3.11Z1-92[»]
3I56X-ray2.90Z1-92[»]
4ADXelectron microscopy6.60Z1-92[»]
4HUBX-ray2.40Z1-92[»]
ProteinModelPortaliP60619.
SMRiP60619. Positions 10-82.

Miscellaneous databases

EvolutionaryTraceiP60619.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1997.
HOGENOMiHOG000229493.
KOiK02921.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00327. Ribosomal_L37Ae.
InterProiIPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01780. Ribosomal_L37ae. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR00280. L37a. 1 hit.

Sequencei

Sequence statusi: Complete.

P60619-1 [UniParc]FASTAAdd to Basket

« Hide

MASKSGKTGS SGRFGARYGR VSRRRVAEIE SEMNEDHACP NCGEDRVDRQ   50
GTGIWQCSYC DYKFTGGSYK PETPGGKTVR RSIRAALSED EE 92
Length:92
Mass (Da):10,172
Last modified:January 4, 2005 - v2
Checksum:i89E52AFE761E9837
GO

Sequence cautioni

The sequence AAV46581.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV46581.1. Different initiation.
RefSeqiYP_136287.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46581; AAV46581; rrnAC1669.
GeneIDi3128391.
KEGGihma:rrnAC1669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV46581.1 . Different initiation.
RefSeqi YP_136287.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 W 12-19 [» ]
1JJ2 X-ray 2.40 Y 49-79 [» ]
1K73 X-ray 3.01 1 49-79 [» ]
1K8A X-ray 3.00 1 49-79 [» ]
1K9M X-ray 3.00 1 49-79 [» ]
1KC8 X-ray 3.01 1 49-79 [» ]
1KD1 X-ray 3.00 1 49-79 [» ]
1KQS X-ray 3.10 Y 49-79 [» ]
1M1K X-ray 3.20 1 49-79 [» ]
1M90 X-ray 2.80 1 49-79 [» ]
1N8R X-ray 3.00 1 49-79 [» ]
1NJI X-ray 3.00 1 49-79 [» ]
1Q7Y X-ray 3.20 1 49-79 [» ]
1Q81 X-ray 2.95 1 49-79 [» ]
1Q82 X-ray 2.98 1 49-79 [» ]
1Q86 X-ray 3.00 1 49-79 [» ]
1QVF X-ray 3.10 Y 49-79 [» ]
1QVG X-ray 2.90 Y 49-79 [» ]
1S72 X-ray 2.40 Z 11-82 [» ]
1VQ4 X-ray 2.70 Z 11-92 [» ]
1VQ5 X-ray 2.60 Z 11-92 [» ]
1VQ6 X-ray 2.70 Z 11-92 [» ]
1VQ7 X-ray 2.50 Z 11-92 [» ]
1VQ8 X-ray 2.20 Z 11-92 [» ]
1VQ9 X-ray 2.40 Z 11-92 [» ]
1VQK X-ray 2.30 Z 11-92 [» ]
1VQL X-ray 2.30 Z 11-92 [» ]
1VQM X-ray 2.30 Z 11-92 [» ]
1VQN X-ray 2.40 Z 11-92 [» ]
1VQO X-ray 2.20 Z 11-92 [» ]
1VQP X-ray 2.25 Z 11-92 [» ]
1W2B X-ray 3.50 Y 49-79 [» ]
1YHQ X-ray 2.40 Z 11-92 [» ]
1YI2 X-ray 2.65 Z 11-92 [» ]
1YIJ X-ray 2.60 Z 11-92 [» ]
1YIT X-ray 2.80 Z 11-92 [» ]
1YJ9 X-ray 2.90 Z 11-92 [» ]
1YJN X-ray 3.00 Z 11-92 [» ]
1YJW X-ray 2.90 Z 11-92 [» ]
2OTJ X-ray 2.90 Z 11-82 [» ]
2OTL X-ray 2.70 Z 11-82 [» ]
2QA4 X-ray 3.00 Z 1-92 [» ]
2QEX X-ray 2.90 Z 11-82 [» ]
3CC2 X-ray 2.40 Z 1-92 [» ]
3CC4 X-ray 2.70 Z 1-92 [» ]
3CC7 X-ray 2.70 Z 1-92 [» ]
3CCE X-ray 2.75 Z 1-92 [» ]
3CCJ X-ray 2.70 Z 1-92 [» ]
3CCL X-ray 2.90 Z 1-92 [» ]
3CCM X-ray 2.55 Z 1-92 [» ]
3CCQ X-ray 2.90 Z 1-92 [» ]
3CCR X-ray 3.00 Z 1-92 [» ]
3CCS X-ray 2.95 Z 1-92 [» ]
3CCU X-ray 2.80 Z 1-92 [» ]
3CCV X-ray 2.90 Z 1-92 [» ]
3CD6 X-ray 2.75 Z 1-92 [» ]
3CMA X-ray 2.80 Z 1-92 [» ]
3CME X-ray 2.95 Z 1-92 [» ]
3CPW X-ray 2.70 Y 1-92 [» ]
3G4S X-ray 3.20 Z 10-82 [» ]
3G6E X-ray 2.70 Z 10-82 [» ]
3G71 X-ray 2.85 Z 10-82 [» ]
3I55 X-ray 3.11 Z 1-92 [» ]
3I56 X-ray 2.90 Z 1-92 [» ]
4ADX electron microscopy 6.60 Z 1-92 [» ]
4HUB X-ray 2.40 Z 1-92 [» ]
ProteinModelPortali P60619.
SMRi P60619. Positions 10-82.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46581 ; AAV46581 ; rrnAC1669 .
GeneIDi 3128391.
KEGGi hma:rrnAC1669.

Phylogenomic databases

eggNOGi COG1997.
HOGENOMi HOG000229493.
KOi K02921.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1522-MONOMER.

Miscellaneous databases

EvolutionaryTracei P60619.

Family and domain databases

Gene3Di 2.20.25.30. 1 hit.
HAMAPi MF_00327. Ribosomal_L37Ae.
InterProi IPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
[Graphical view ]
Pfami PF01780. Ribosomal_L37ae. 1 hit.
[Graphical view ]
SUPFAMi SSF57829. SSF57829. 1 hit.
TIGRFAMsi TIGR00280. L37a. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  2. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  10. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL37A_HALMA
AccessioniPrimary (citable) accession number: P60619
Secondary accession number(s): Q5V1M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi