Skip Header

Contribute Send feedback
Read comments (?) or add your own

P60619 (RL37A_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L37Ae
Gene names
Name:rpl37ae
Ordered Locus Names:rrnAC1669
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula ›

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the 23S rRNA. HAMAP-Rule MF_00327

Cofactor

Binds 1 zinc ion per subunit Probable.

Subunit structure

Part of the 50S ribosomal subunit. Contacts protein L2. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9

Sequence similarities

Belongs to the ribosomal protein L37Ae family. Putative zinc-binding subfamily.

Sequence caution

The sequence AAV46581.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 929250S ribosomal protein L37Ae HAMAP-Rule MF_00327
PRO_0000139841

Regions

Zinc finger39 – 6022C4-type Potential

Sites

Metal binding391Zinc Potential
Metal binding421Zinc Potential
Metal binding571Zinc Potential
Metal binding601Zinc Potential

Secondary structure

1 ................... 92
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P60619 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: 89E52AFE761E9837

FASTA9210,172
        10         20         30         40         50         60 
MASKSGKTGS SGRFGARYGR VSRRRVAEIE SEMNEDHACP NCGEDRVDRQ GTGIWQCSYC 

        70         80         90 
DYKFTGGSYK PETPGGKTVR RSIRAALSED EE

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[2]"The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[3]"The structural basis of ribosome activity in peptide bond synthesis."
Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[4]"A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[5]"The kink-turn: a new RNA secondary structure motif."
Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[6]"The structures of four macrolide antibiotics bound to the large ribosomal subunit."
Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[7]"Structural insights into peptide bond formation."
Hansen J.L., Schmeing T.M., Moore P.B., Steitz T.A.
Proc. Natl. Acad. Sci. U.S.A. 99:11670-11675(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[8]"Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
Hansen J.L., Moore P.B., Steitz T.A.
J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[9]"Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
Schmeing T.M., Moore P.B., Steitz T.A.
RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY596297 Genomic DNA. Translation: AAV46581.1. Different initiation.
RefSeqYP_136287.1. NC_006396.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40W12-19[»]
1JJ2X-ray2.40Y51-73[»]
1K73X-ray3.01151-73[»]
1K8AX-ray3.00151-73[»]
1K9MX-ray3.00151-73[»]
1KC8X-ray3.01151-73[»]
1KD1X-ray3.00151-73[»]
1KQSX-ray3.10Y51-73[»]
1M1KX-ray3.20151-73[»]
1M90X-ray2.80151-73[»]
1N8RX-ray3.00151-73[»]
1NJIX-ray3.00151-73[»]
1Q7YX-ray3.20151-73[»]
1Q81X-ray2.95151-73[»]
1Q82X-ray2.98151-73[»]
1Q86X-ray3.00151-73[»]
1QVFX-ray3.10Y51-73[»]
1QVGX-ray2.90Y51-73[»]
1S72X-ray2.40Z11-82[»]
1VQ4X-ray2.70Z11-92[»]
1VQ5X-ray2.60Z11-92[»]
1VQ6X-ray2.70Z11-92[»]
1VQ7X-ray2.50Z11-92[»]
1VQ8X-ray2.20Z11-92[»]
1VQ9X-ray2.40Z11-92[»]
1VQKX-ray2.30Z11-92[»]
1VQLX-ray2.30Z11-92[»]
1VQMX-ray2.30Z11-92[»]
1VQNX-ray2.40Z11-92[»]
1VQOX-ray2.20Z11-92[»]
1VQPX-ray2.25Z11-92[»]
1W2BX-ray3.50Y51-73[»]
1YHQX-ray2.40Z11-92[»]
1YI2X-ray2.65Z11-92[»]
1YIJX-ray2.60Z11-92[»]
1YITX-ray2.80Z11-92[»]
1YJ9X-ray2.90Z11-92[»]
1YJNX-ray3.00Z11-92[»]
1YJWX-ray2.90Z11-92[»]
2OTJX-ray2.90Z11-82[»]
2OTLX-ray2.70Z11-82[»]
2QA4X-ray3.00Z1-92[»]
2QEXX-ray2.90Z11-82[»]
3CC2X-ray2.40Z1-92[»]
3CC4X-ray2.70Z1-92[»]
3CC7X-ray2.70Z1-92[»]
3CCEX-ray2.75Z1-92[»]
3CCJX-ray2.70Z1-92[»]
3CCLX-ray2.90Z1-92[»]
3CCMX-ray2.55Z1-92[»]
3CCQX-ray2.90Z1-92[»]
3CCRX-ray3.00Z1-92[»]
3CCSX-ray2.95Z1-92[»]
3CCUX-ray2.80Z1-92[»]
3CCVX-ray2.90Z1-92[»]
3CD6X-ray2.75Z1-92[»]
3CMAX-ray2.80Z1-92[»]
3CMEX-ray2.95Z1-92[»]
3CPWX-ray2.70Y1-92[»]
3G4SX-ray3.20Z10-82[»]
3G6EX-ray2.70Z10-82[»]
3G71X-ray2.85Z10-82[»]
3I55X-ray3.11Z1-92[»]
3I56X-ray2.90Z1-92[»]
ProteinModelPortalP60619.
SMRP60619. Positions 10-82.
ModBaseSearch...

Protein-protein interaction databases

STRING272569.rrnAC1669.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV46581; AAV46581; rrnAC1669.
GeneID3128391.
KEGGhma:rrnAC1669.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1997.
HOGENOMHOG000229493.
KOK02921.
ProtClustDBPRK03976.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-1522-MONOMER.

Family and domain databases

Gene3D2.20.25.30. 1 hit.
HAMAPMF_00327. Ribosomal_L37Ae.
InterProIPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR022945. Ribosomal_L37ae_arc.
IPR011332. Ribosomal_zn-bd_dom.
[Graphical view]
PfamPF01780. Ribosomal_L37ae. 1 hit.
[Graphical view]
SUPFAMSSF57829. Ribosomal_zn-bd. 1 hit.
TIGRFAMsTIGR00280. L37a. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP60619.

Entry information

Entry nameRL37A_HALMA
AccessionPrimary (citable) accession number: P60619
Secondary accession number(s): Q5V1M1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 4, 2005
Last modified: May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents