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P60618

- RL15E_HALMA

UniProt

P60618 - RL15E_HALMA

Protein

50S ribosomal protein L15e

Gene

rpl15e

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-1864-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L15e
    Alternative name(s):
    50S ribosomal protein LC12
    Gene namesi
    Name:rpl15e
    Ordered Locus Names:rrnAC2065
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 19619550S ribosomal protein L15ePRO_0000127570Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Interacts with protein L7Ae and weakly with L44e.2 Publications

    Protein-protein interaction databases

    STRINGi272569.rrnAC2065.

    Structurei

    Secondary structure

    1
    196
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 127
    Helixi19 – 3214
    Beta strandi33 – 353
    Beta strandi37 – 437
    Helixi47 – 537
    Beta strandi61 – 699
    Helixi84 – 863
    Beta strandi89 – 913
    Helixi98 – 10912
    Beta strandi114 – 12411
    Beta strandi127 – 1359
    Helixi140 – 1434
    Turni146 – 1483
    Helixi149 – 1524
    Helixi154 – 1563
    Helixi159 – 1624
    Helixi166 – 1716
    Turni182 – 1843
    Turni188 – 1925

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40I37-194[»]
    1JJ2X-ray2.40L2-194[»]
    1K73X-ray3.01N2-194[»]
    1K8AX-ray3.00N2-194[»]
    1K9MX-ray3.00N2-194[»]
    1KC8X-ray3.01N2-194[»]
    1KD1X-ray3.00N2-194[»]
    1KQSX-ray3.10L2-194[»]
    1M1KX-ray3.20N2-194[»]
    1M90X-ray2.80N2-194[»]
    1N8RX-ray3.00N2-194[»]
    1NJIX-ray3.00N2-194[»]
    1Q7YX-ray3.20N2-194[»]
    1Q81X-ray2.95N2-194[»]
    1Q82X-ray2.98N2-194[»]
    1Q86X-ray3.00N2-194[»]
    1QVFX-ray3.10L2-194[»]
    1QVGX-ray2.90L2-194[»]
    1S72X-ray2.40M2-194[»]
    1VQ4X-ray2.70M2-194[»]
    1VQ5X-ray2.60M2-194[»]
    1VQ6X-ray2.70M2-194[»]
    1VQ7X-ray2.50M2-194[»]
    1VQ8X-ray2.20M2-194[»]
    1VQ9X-ray2.40M1-194[»]
    1VQKX-ray2.30M1-194[»]
    1VQLX-ray2.30M1-194[»]
    1VQMX-ray2.30M1-194[»]
    1VQNX-ray2.40M2-194[»]
    1VQOX-ray2.20M1-194[»]
    1VQPX-ray2.25M1-194[»]
    1W2BX-ray3.50L2-194[»]
    1YHQX-ray2.40M2-195[»]
    1YI2X-ray2.65M1-195[»]
    1YIJX-ray2.60M1-195[»]
    1YITX-ray2.80M1-195[»]
    1YJ9X-ray2.90M1-195[»]
    1YJNX-ray3.00M1-195[»]
    1YJWX-ray2.90M1-195[»]
    2OTJX-ray2.90M2-194[»]
    2OTLX-ray2.70M2-194[»]
    2QA4X-ray3.00M1-194[»]
    2QEXX-ray2.90M1-194[»]
    3CC2X-ray2.40M1-196[»]
    3CC4X-ray2.70M1-196[»]
    3CC7X-ray2.70M1-196[»]
    3CCEX-ray2.75M1-196[»]
    3CCJX-ray2.70M1-196[»]
    3CCLX-ray2.90M1-196[»]
    3CCMX-ray2.55M1-196[»]
    3CCQX-ray2.90M1-196[»]
    3CCRX-ray3.00M1-196[»]
    3CCSX-ray2.95M1-196[»]
    3CCUX-ray2.80M1-196[»]
    3CCVX-ray2.90M1-196[»]
    3CD6X-ray2.75M1-196[»]
    3CMAX-ray2.80M1-196[»]
    3CMEX-ray2.95M1-196[»]
    3CPWX-ray2.70L1-196[»]
    3G4SX-ray3.20M2-195[»]
    3G6EX-ray2.70M2-195[»]
    3G71X-ray2.85M2-195[»]
    3I55X-ray3.11M2-194[»]
    3I56X-ray2.90M2-194[»]
    4ADXelectron microscopy6.60M1-196[»]
    4HUBX-ray2.40M1-196[»]
    ProteinModelPortaliP60618.
    SMRiP60618. Positions 2-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60618.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L15e family.Curated

    Phylogenomic databases

    eggNOGiCOG1632.
    HOGENOMiHOG000229584.
    KOiK02877.
    OMAiSHIKDAW.

    Family and domain databases

    Gene3Di3.40.1120.10. 1 hit.
    HAMAPiMF_00256. Ribosomal_L15e.
    InterProiIPR024794. Rbsml_L15e_core_dom.
    IPR000439. Ribosomal_L15e.
    IPR020926. Ribosomal_L15e_arc.
    IPR020925. Ribosomal_L15e_CS.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    [Graphical view]
    PANTHERiPTHR11847. PTHR11847. 1 hit.
    PfamiPF00827. Ribosomal_L15e. 1 hit.
    [Graphical view]
    SUPFAMiSSF54189. SSF54189. 1 hit.
    PROSITEiPS01194. RIBOSOMAL_L15E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60618-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSAYSYIR DAWKNPGDGQ LAELQWQRQQ EWRNEGAVER IERPTRLDKA    50
    RSQGYKAKQG VIVARVSVRK GSARKRRHKA GRRSKRQGVT RITRRKDIQR 100
    VAEERASRTF PNLRVLNSYS VGQDGRQKWH EVILIDPNHP AIQNDDDLSW 150
    ICADDQADRV FRGLTGAGRR NRGLSGKGKG SEKTRPSLRS NGGKGK 196
    Length:196
    Mass (Da):22,355
    Last modified:January 23, 2007 - v3
    Checksum:i502449E0A6BC23BB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131W → T AA sequence (PubMed:3196689)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV46920.1.
    PIRiH28949.
    RefSeqiYP_136626.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV46920; AAV46920; rrnAC2065.
    GeneIDi3129041.
    KEGGihma:rrnAC2065.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV46920.1 .
    PIRi H28949.
    RefSeqi YP_136626.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 I 37-194 [» ]
    1JJ2 X-ray 2.40 L 2-194 [» ]
    1K73 X-ray 3.01 N 2-194 [» ]
    1K8A X-ray 3.00 N 2-194 [» ]
    1K9M X-ray 3.00 N 2-194 [» ]
    1KC8 X-ray 3.01 N 2-194 [» ]
    1KD1 X-ray 3.00 N 2-194 [» ]
    1KQS X-ray 3.10 L 2-194 [» ]
    1M1K X-ray 3.20 N 2-194 [» ]
    1M90 X-ray 2.80 N 2-194 [» ]
    1N8R X-ray 3.00 N 2-194 [» ]
    1NJI X-ray 3.00 N 2-194 [» ]
    1Q7Y X-ray 3.20 N 2-194 [» ]
    1Q81 X-ray 2.95 N 2-194 [» ]
    1Q82 X-ray 2.98 N 2-194 [» ]
    1Q86 X-ray 3.00 N 2-194 [» ]
    1QVF X-ray 3.10 L 2-194 [» ]
    1QVG X-ray 2.90 L 2-194 [» ]
    1S72 X-ray 2.40 M 2-194 [» ]
    1VQ4 X-ray 2.70 M 2-194 [» ]
    1VQ5 X-ray 2.60 M 2-194 [» ]
    1VQ6 X-ray 2.70 M 2-194 [» ]
    1VQ7 X-ray 2.50 M 2-194 [» ]
    1VQ8 X-ray 2.20 M 2-194 [» ]
    1VQ9 X-ray 2.40 M 1-194 [» ]
    1VQK X-ray 2.30 M 1-194 [» ]
    1VQL X-ray 2.30 M 1-194 [» ]
    1VQM X-ray 2.30 M 1-194 [» ]
    1VQN X-ray 2.40 M 2-194 [» ]
    1VQO X-ray 2.20 M 1-194 [» ]
    1VQP X-ray 2.25 M 1-194 [» ]
    1W2B X-ray 3.50 L 2-194 [» ]
    1YHQ X-ray 2.40 M 2-195 [» ]
    1YI2 X-ray 2.65 M 1-195 [» ]
    1YIJ X-ray 2.60 M 1-195 [» ]
    1YIT X-ray 2.80 M 1-195 [» ]
    1YJ9 X-ray 2.90 M 1-195 [» ]
    1YJN X-ray 3.00 M 1-195 [» ]
    1YJW X-ray 2.90 M 1-195 [» ]
    2OTJ X-ray 2.90 M 2-194 [» ]
    2OTL X-ray 2.70 M 2-194 [» ]
    2QA4 X-ray 3.00 M 1-194 [» ]
    2QEX X-ray 2.90 M 1-194 [» ]
    3CC2 X-ray 2.40 M 1-196 [» ]
    3CC4 X-ray 2.70 M 1-196 [» ]
    3CC7 X-ray 2.70 M 1-196 [» ]
    3CCE X-ray 2.75 M 1-196 [» ]
    3CCJ X-ray 2.70 M 1-196 [» ]
    3CCL X-ray 2.90 M 1-196 [» ]
    3CCM X-ray 2.55 M 1-196 [» ]
    3CCQ X-ray 2.90 M 1-196 [» ]
    3CCR X-ray 3.00 M 1-196 [» ]
    3CCS X-ray 2.95 M 1-196 [» ]
    3CCU X-ray 2.80 M 1-196 [» ]
    3CCV X-ray 2.90 M 1-196 [» ]
    3CD6 X-ray 2.75 M 1-196 [» ]
    3CMA X-ray 2.80 M 1-196 [» ]
    3CME X-ray 2.95 M 1-196 [» ]
    3CPW X-ray 2.70 L 1-196 [» ]
    3G4S X-ray 3.20 M 2-195 [» ]
    3G6E X-ray 2.70 M 2-195 [» ]
    3G71 X-ray 2.85 M 2-195 [» ]
    3I55 X-ray 3.11 M 2-194 [» ]
    3I56 X-ray 2.90 M 2-194 [» ]
    4ADX electron microscopy 6.60 M 1-196 [» ]
    4HUB X-ray 2.40 M 1-196 [» ]
    ProteinModelPortali P60618.
    SMRi P60618. Positions 2-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC2065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV46920 ; AAV46920 ; rrnAC2065 .
    GeneIDi 3129041.
    KEGGi hma:rrnAC2065.

    Phylogenomic databases

    eggNOGi COG1632.
    HOGENOMi HOG000229584.
    KOi K02877.
    OMAi SHIKDAW.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-1864-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P60618.

    Family and domain databases

    Gene3Di 3.40.1120.10. 1 hit.
    HAMAPi MF_00256. Ribosomal_L15e.
    InterProi IPR024794. Rbsml_L15e_core_dom.
    IPR000439. Ribosomal_L15e.
    IPR020926. Ribosomal_L15e_arc.
    IPR020925. Ribosomal_L15e_CS.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    [Graphical view ]
    PANTHERi PTHR11847. PTHR11847. 1 hit.
    Pfami PF00827. Ribosomal_L15e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54189. SSF54189. 1 hit.
    PROSITEi PS01194. RIBOSOMAL_L15E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    2. "Extended N-terminal sequencing of proteins of archaebacterial ribosomes blotted from two-dimensional gels onto glass fiber and poly(vinylidene difluoride) membrane."
      Walsh M.J., McDougall J., Wittmann-Liebold B.
      Biochemistry 27:6867-6876(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
    3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL15E_HALMA
    AccessioniPrimary (citable) accession number: P60618
    Secondary accession number(s): P12740, Q5V0N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3