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P60617

- RL10E_HALMA

UniProt

P60617 - RL10E_HALMA

Protein

50S ribosomal protein L10e

Gene

rpl10e

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    This is 1 of 5 proteins that mediate the attachment of the 5S rRNA onto the large ribosomal subunit, stabilizing the orientation of adjacent RNA domains. Modeling places the A and P site tRNAs in close proximity to this protein.

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro
    3. tRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding, tRNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-2126-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L10eUniRule annotation
    Gene namesi
    Name:rpl10eUniRule annotation
    Ordered Locus Names:rrnAC2357
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17717750S ribosomal protein L10ePRO_0000147132Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Weakly binds 5S rRNA. Probably binds the A and P site tRNAs.2 Publications

    Protein-protein interaction databases

    STRINGi272569.rrnAC2357.

    Structurei

    Secondary structure

    1
    177
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Turni20 – 223
    Beta strandi34 – 374
    Beta strandi40 – 423
    Helixi43 – 453
    Beta strandi47 – 5610
    Beta strandi58 – 614
    Helixi62 – 8019
    Turni81 – 833
    Beta strandi87 – 904
    Beta strandi96 – 1005
    Beta strandi116 – 1183
    Beta strandi122 – 1309
    Beta strandi135 – 1417
    Turni143 – 1453
    Helixi146 – 15611
    Helixi157 – 1593
    Beta strandi160 – 1623
    Beta strandi164 – 1663
    Turni172 – 1743

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40F14-129[»]
    1JJ2X-ray2.40H14-130[»]
    1K73X-ray3.01J14-130[»]
    1K8AX-ray3.00J14-130[»]
    1K9MX-ray3.00J14-130[»]
    1KC8X-ray3.01J14-130[»]
    1KD1X-ray3.00J14-130[»]
    1KQSX-ray3.10H14-130[»]
    1M1KX-ray3.20J14-130[»]
    1M90X-ray2.80J14-130[»]
    1N8RX-ray3.00J14-130[»]
    1NJIX-ray3.00J14-130[»]
    1Q7YX-ray3.20J14-130[»]
    1Q81X-ray2.95J14-130[»]
    1Q82X-ray2.98J14-130[»]
    1Q86X-ray3.00J14-130[»]
    1QVFX-ray3.10H14-130[»]
    1QVGX-ray2.90H14-130[»]
    1S72X-ray2.40H4-166[»]
    1VQ4X-ray2.70H4-166[»]
    1VQ5X-ray2.60H4-166[»]
    1VQ6X-ray2.70H4-166[»]
    1VQ7X-ray2.50H4-166[»]
    1VQ8X-ray2.20H4-166[»]
    1VQ9X-ray2.40H4-166[»]
    1VQKX-ray2.30H4-166[»]
    1VQLX-ray2.30H4-166[»]
    1VQMX-ray2.30H4-166[»]
    1VQNX-ray2.40H4-166[»]
    1VQOX-ray2.20H4-166[»]
    1VQPX-ray2.25H4-166[»]
    1W2BX-ray3.50H14-130[»]
    1YHQX-ray2.40H1-177[»]
    1YI2X-ray2.65H1-177[»]
    1YIJX-ray2.60H1-177[»]
    1YITX-ray2.80H1-177[»]
    1YJ9X-ray2.90H1-177[»]
    1YJNX-ray3.00H1-177[»]
    1YJWX-ray2.90H1-177[»]
    2OTJX-ray2.90H4-166[»]
    2OTLX-ray2.70H4-166[»]
    2QA4X-ray3.00H4-177[»]
    2QEXX-ray2.90H1-177[»]
    3CC2X-ray2.40H1-177[»]
    3CC4X-ray2.70H1-177[»]
    3CC7X-ray2.70H1-177[»]
    3CCEX-ray2.75H1-177[»]
    3CCJX-ray2.70H1-177[»]
    3CCLX-ray2.90H1-177[»]
    3CCMX-ray2.55H1-177[»]
    3CCQX-ray2.90H1-177[»]
    3CCRX-ray3.00H1-177[»]
    3CCSX-ray2.95H1-177[»]
    3CCUX-ray2.80H1-177[»]
    3CCVX-ray2.90H1-177[»]
    3CD6X-ray2.75H1-177[»]
    3CMAX-ray2.80H1-177[»]
    3CMEX-ray2.95H1-177[»]
    3CPWX-ray2.70H1-177[»]
    3G4SX-ray3.20H1-177[»]
    3G6EX-ray2.70H1-177[»]
    3G71X-ray2.85H1-177[»]
    3I55X-ray3.11H1-166[»]
    3I56X-ray2.90H1-166[»]
    4ADXelectron microscopy6.60H1-177[»]
    4HUBX-ray2.40H1-177[»]
    ProteinModelPortaliP60617.
    SMRiP60617. Positions 4-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60617.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L10e family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0197.
    HOGENOMiHOG000223755.
    KOiK02866.
    OMAiNAGENNY.

    Family and domain databases

    Gene3Di3.90.1170.10. 1 hit.
    HAMAPiMF_00448. Ribosomal_L10e.
    InterProiIPR001197. Ribosomal_L10e.
    IPR016180. Ribosomal_L10e/L16.
    IPR022981. Ribosomal_L10e_arc.
    IPR018255. Ribosomal_L10e_CS.
    [Graphical view]
    PfamiPF00252. Ribosomal_L16. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005590. Ribosomal_L10. 1 hit.
    SUPFAMiSSF54686. SSF54686. 1 hit.
    PROSITEiPS01257. RIBOSOMAL_L10E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P60617-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKPASMYR DIDKPAYTRR EYITGIPGSK IAQHKMGRKQ KDADDYPVQI    50
    SLIVEETVQL RHGSLEASRL SANRHLIKEL GEEGDYKMTL RKFPHQVLRE 100
    NKQATGAGAD RVSDGMRAAF GKIVGTAARV QAGEQLFTAY CNVEDAEHVK 150
    EAFRRAYNKI TPSCRIKVER GEELLIA 177
    Length:177
    Mass (Da):19,908
    Last modified:January 4, 2005 - v2
    Checksum:iE7A72FE3683D2BDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV47175.1.
    RefSeqiYP_136882.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV47175; AAV47175; rrnAC2357.
    GeneIDi3130436.
    KEGGihma:rrnAC2357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV47175.1 .
    RefSeqi YP_136882.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 F 14-129 [» ]
    1JJ2 X-ray 2.40 H 14-130 [» ]
    1K73 X-ray 3.01 J 14-130 [» ]
    1K8A X-ray 3.00 J 14-130 [» ]
    1K9M X-ray 3.00 J 14-130 [» ]
    1KC8 X-ray 3.01 J 14-130 [» ]
    1KD1 X-ray 3.00 J 14-130 [» ]
    1KQS X-ray 3.10 H 14-130 [» ]
    1M1K X-ray 3.20 J 14-130 [» ]
    1M90 X-ray 2.80 J 14-130 [» ]
    1N8R X-ray 3.00 J 14-130 [» ]
    1NJI X-ray 3.00 J 14-130 [» ]
    1Q7Y X-ray 3.20 J 14-130 [» ]
    1Q81 X-ray 2.95 J 14-130 [» ]
    1Q82 X-ray 2.98 J 14-130 [» ]
    1Q86 X-ray 3.00 J 14-130 [» ]
    1QVF X-ray 3.10 H 14-130 [» ]
    1QVG X-ray 2.90 H 14-130 [» ]
    1S72 X-ray 2.40 H 4-166 [» ]
    1VQ4 X-ray 2.70 H 4-166 [» ]
    1VQ5 X-ray 2.60 H 4-166 [» ]
    1VQ6 X-ray 2.70 H 4-166 [» ]
    1VQ7 X-ray 2.50 H 4-166 [» ]
    1VQ8 X-ray 2.20 H 4-166 [» ]
    1VQ9 X-ray 2.40 H 4-166 [» ]
    1VQK X-ray 2.30 H 4-166 [» ]
    1VQL X-ray 2.30 H 4-166 [» ]
    1VQM X-ray 2.30 H 4-166 [» ]
    1VQN X-ray 2.40 H 4-166 [» ]
    1VQO X-ray 2.20 H 4-166 [» ]
    1VQP X-ray 2.25 H 4-166 [» ]
    1W2B X-ray 3.50 H 14-130 [» ]
    1YHQ X-ray 2.40 H 1-177 [» ]
    1YI2 X-ray 2.65 H 1-177 [» ]
    1YIJ X-ray 2.60 H 1-177 [» ]
    1YIT X-ray 2.80 H 1-177 [» ]
    1YJ9 X-ray 2.90 H 1-177 [» ]
    1YJN X-ray 3.00 H 1-177 [» ]
    1YJW X-ray 2.90 H 1-177 [» ]
    2OTJ X-ray 2.90 H 4-166 [» ]
    2OTL X-ray 2.70 H 4-166 [» ]
    2QA4 X-ray 3.00 H 4-177 [» ]
    2QEX X-ray 2.90 H 1-177 [» ]
    3CC2 X-ray 2.40 H 1-177 [» ]
    3CC4 X-ray 2.70 H 1-177 [» ]
    3CC7 X-ray 2.70 H 1-177 [» ]
    3CCE X-ray 2.75 H 1-177 [» ]
    3CCJ X-ray 2.70 H 1-177 [» ]
    3CCL X-ray 2.90 H 1-177 [» ]
    3CCM X-ray 2.55 H 1-177 [» ]
    3CCQ X-ray 2.90 H 1-177 [» ]
    3CCR X-ray 3.00 H 1-177 [» ]
    3CCS X-ray 2.95 H 1-177 [» ]
    3CCU X-ray 2.80 H 1-177 [» ]
    3CCV X-ray 2.90 H 1-177 [» ]
    3CD6 X-ray 2.75 H 1-177 [» ]
    3CMA X-ray 2.80 H 1-177 [» ]
    3CME X-ray 2.95 H 1-177 [» ]
    3CPW X-ray 2.70 H 1-177 [» ]
    3G4S X-ray 3.20 H 1-177 [» ]
    3G6E X-ray 2.70 H 1-177 [» ]
    3G71 X-ray 2.85 H 1-177 [» ]
    3I55 X-ray 3.11 H 1-166 [» ]
    3I56 X-ray 2.90 H 1-166 [» ]
    4ADX electron microscopy 6.60 H 1-177 [» ]
    4HUB X-ray 2.40 H 1-177 [» ]
    ProteinModelPortali P60617.
    SMRi P60617. Positions 4-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC2357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV47175 ; AAV47175 ; rrnAC2357 .
    GeneIDi 3130436.
    KEGGi hma:rrnAC2357.

    Phylogenomic databases

    eggNOGi COG0197.
    HOGENOMi HOG000223755.
    KOi K02866.
    OMAi NAGENNY.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-2126-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P60617.

    Family and domain databases

    Gene3Di 3.90.1170.10. 1 hit.
    HAMAPi MF_00448. Ribosomal_L10e.
    InterProi IPR001197. Ribosomal_L10e.
    IPR016180. Ribosomal_L10e/L16.
    IPR022981. Ribosomal_L10e_arc.
    IPR018255. Ribosomal_L10e_CS.
    [Graphical view ]
    Pfami PF00252. Ribosomal_L16. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005590. Ribosomal_L10. 1 hit.
    SUPFAMi SSF54686. SSF54686. 1 hit.
    PROSITEi PS01257. RIBOSOMAL_L10E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    2. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    3. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    10. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL10E_HALMA
    AccessioniPrimary (citable) accession number: P60617
    Secondary accession number(s): Q5UZX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3