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Protein

Cortexin-1

Gene

CTXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cortexin-1
Gene namesi
Name:CTXN1
Synonyms:CTXN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:31108. CTXN1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944051.

Polymorphism and mutation databases

DMDMi45476804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8282Cortexin-1PRO_0000079500Add
BLAST

Proteomic databases

MaxQBiP60606.
PaxDbiP60606.
PRIDEiP60606.

PTM databases

iPTMnetiP60606.
PhosphoSiteiP60606.
SwissPalmiP60606.

Expressioni

Gene expression databases

BgeeiP60606.
CleanExiHS_CTXN1.
GenevisibleiP60606. HS.

Organism-specific databases

HPAiHPA016669.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313226.

Structurei

3D structure databases

ProteinModelPortaliP60606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cortexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3U7. Eukaryota.
ENOG41129SJ. LUCA.
GeneTreeiENSGT00390000018468.
HOGENOMiHOG000273868.
HOVERGENiHBG054879.
InParanoidiP60606.
OMAiMSTTWTL.
OrthoDBiEOG7CCBVK.
PhylomeDBiP60606.
TreeFamiTF333403.

Family and domain databases

InterProiIPR020066. Cortexin.
[Graphical view]
PfamiPF11057. Cortexin. 1 hit.
[Graphical view]
ProDomiPD054489. Cortexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P60606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATWTLSPE PLPPSTGPPV GAGLDAEQRT VFAFVLCLLV VLVLLMVRCV
60 70 80
RILLDPYSRM PASSWTDHKE ALERGQFDYA LV
Length:82
Mass (Da):9,045
Last modified:March 15, 2004 - v1
Checksum:iBEEA6DBEDA10F0D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062702 mRNA. Translation: AAH62702.1.
CCDSiCCDS12191.1.
RefSeqiNP_996664.1. NM_206833.3.
UniGeneiHs.657978.

Genome annotation databases

EnsembliENST00000318978; ENSP00000313226; ENSG00000178531.
GeneIDi404217.
KEGGihsa:404217.
UCSCiuc002miy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062702 mRNA. Translation: AAH62702.1.
CCDSiCCDS12191.1.
RefSeqiNP_996664.1. NM_206833.3.
UniGeneiHs.657978.

3D structure databases

ProteinModelPortaliP60606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000313226.

PTM databases

iPTMnetiP60606.
PhosphoSiteiP60606.
SwissPalmiP60606.

Polymorphism and mutation databases

DMDMi45476804.

Proteomic databases

MaxQBiP60606.
PaxDbiP60606.
PRIDEiP60606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318978; ENSP00000313226; ENSG00000178531.
GeneIDi404217.
KEGGihsa:404217.
UCSCiuc002miy.5. human.

Organism-specific databases

CTDi404217.
GeneCardsiCTXN1.
HGNCiHGNC:31108. CTXN1.
HPAiHPA016669.
MIMi600135. gene.
neXtProtiNX_P60606.
PharmGKBiPA134944051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3U7. Eukaryota.
ENOG41129SJ. LUCA.
GeneTreeiENSGT00390000018468.
HOGENOMiHOG000273868.
HOVERGENiHBG054879.
InParanoidiP60606.
OMAiMSTTWTL.
OrthoDBiEOG7CCBVK.
PhylomeDBiP60606.
TreeFamiTF333403.

Miscellaneous databases

GenomeRNAii404217.
NextBioi107833.
PROiP60606.
SOURCEiSearch...

Gene expression databases

BgeeiP60606.
CleanExiHS_CTXN1.
GenevisibleiP60606. HS.

Family and domain databases

InterProiIPR020066. Cortexin.
[Graphical view]
PfamiPF11057. Cortexin. 1 hit.
[Graphical view]
ProDomiPD054489. Cortexin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCTXN1_HUMAN
AccessioniPrimary (citable) accession number: P60606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.