Reviewed,
UniProtKB/Swiss-Prot P60605 (UB2G2_MOUSE)
Last modified
October 13, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 G2 EC=6.3.2.19 Alternative name(s): Ubiquitin-protein ligase G2 Ubiquitin carrier protein G2 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 165 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. Involved in endoplasmic reticulum-associated degradation (ERAD) By similarity. |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | ER-associated protein catabolic process Ref.1 Inferred from direct assay. Source: MGI post-translational protein modificationInferred from electronic annotation. Source: InterPro regulation of protein metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytosol Ref.1 Inferred from direct assay. Source: MGI endoplasmic reticulum Ref.1Inferred from direct assay. Source: MGI |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: UniProtKB ubiquitin-protein ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 165 | 165 | Ubiquitin-conjugating enzyme E2 G2 | PRO_0000082484 | |||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||
| Active site | 89 | 1 | Glycyl thioester intermediate By similarity | ||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||
| Helix | 5 – 18 | 14 | |||||||||||||||||||||||||
| Beta strand | 36 – 41 | 6 | |||||||||||||||||||||||||
| Beta strand | 54 – 59 | 6 | |||||||||||||||||||||||||
| Turn | 62 – 65 | 4 | |||||||||||||||||||||||||
| Beta strand | 70 – 75 | 6 | |||||||||||||||||||||||||
| Helix | 91 – 93 | 3 | |||||||||||||||||||||||||
| Helix | 116 – 128 | 13 | |||||||||||||||||||||||||
| Helix | 138 – 145 | 8 | |||||||||||||||||||||||||
| Helix | 148 – 162 | 15 | |||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)." Tiwari S., Weissman A.M. J. Biol. Chem. 276:16193-16200(2001) [PubMed: 11278356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Fetus. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF296657 mRNA. Translation: AAK52608.1. BC010321 mRNA. Translation: AAH10321.1. | |||||||||||||
| IPI | IPI00153094. | ||||||||||||
| RefSeq | NP_062777.2. | ||||||||||||
| UniGene | Mm.458125 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| SMR | P60605. Positions 1-165. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP:29061N. | ||||||||||||
| STRING | P60605. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P60605. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSMUST00000009437; ENSMUSP00000009437; ENSMUSG00000009293; Mus musculus. [Genome view] | ||||||||||||
| GeneID | 22213. | ||||||||||||
| KEGG | mmu:22213. | ||||||||||||
| UCSC | uc007fwa.1. mouse. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 22213. | ||||||||||||
| MGI | MGI:1343188. Ube2g2. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOVERGEN | P60605. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 6.3.2.19. 244. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P60605. | ||||||||||||
| Bgee | P60605. | ||||||||||||
| CleanEx | MM_UBE2G2. | ||||||||||||
| Genevestigator | P60605. | ||||||||||||
| GermOnline | ENSMUSG00000009293. Mus musculus. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. | ||||||||||||
| Pfam | PF00179. UQ_con. 1 hit. [Graphical view] | ||||||||||||
| ProDom | PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| SMART | SM00212. UBCc. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 302209. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | UB2G2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P60605 Secondary accession number(s): P56554 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


