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P60605 (UB2G2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 G2

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein G2
Ubiquitin-protein ligase G2
Gene names
Name:Ube2g2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD) By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Ubiquitin-conjugating enzyme E2 G2
PRO_0000082484

Sites

Active site891Glycyl thioester intermediate By similarity

Secondary structure

.......................... 165
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P60605 [UniParc].

Last modified March 15, 2004. Version 1.
Checksum: 74DEC732A79575E3

FASTA16518,566
        10         20         30         40         50         60 
MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE FGVFPAILSF 

        70         80         90        100        110        120 
PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP MGYESSAERW SPVQSVEKIL 

       130        140        150        160 
LSVVSMLAEP NDESGANVDA SKMWRDDREQ FYKIAKQIVQ KSLGL 

« Hide

References

« Hide 'large scale' references
[1]"Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)."
Tiwari S., Weissman A.M.
J. Biol. Chem. 276:16193-16200(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Fetus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF296657 mRNA. Translation: AAK52608.1.
BC010321 mRNA. Translation: AAH10321.1.
RefSeqNP_062777.2. NM_019803.3.
UniGeneMm.458125.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3FSHX-ray2.76A/B1-165[»]
ProteinModelPortalP60605.
SMRP60605. Positions 2-165.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204416. 4 interactions.
DIPDIP-29061N.

PTM databases

PhosphoSiteP60605.

Proteomic databases

PaxDbP60605.
PRIDEP60605.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000174510; ENSMUSP00000133515; ENSMUSG00000009293.
GeneID22213.
KEGGmmu:22213.
UCSCuc007fwa.1. mouse.

Organism-specific databases

CTD7327.
MGIMGI:1343188. Ube2g2.

Phylogenomic databases

eggNOGCOG5078.
HOVERGENHBG063308.
InParanoidP60605.
KOK04555.
OMADMFHPNI.
OrthoDBEOG7VB2HT.
TreeFamTF101118.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressP60605.
BgeeP60605.
CleanExMM_UBE2G2.
GenevestigatorP60605.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUBE2G2. mouse.
EvolutionaryTraceP60605.
NextBio28670.
PROP60605.
SOURCESearch...

Entry information

Entry nameUB2G2_MOUSE
AccessionPrimary (citable) accession number: P60605
Secondary accession number(s): P56554
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot