Reviewed,
UniProtKB/Swiss-Prot P60605 (UB2G2_MOUSE)
Last modified
November 25, 2008.
Version 50.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 G2 EC=6.3.2.19 Alternative name(s): Ubiquitin-protein ligase G2 Ubiquitin carrier protein G2 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 165 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. Involved in endoplasmic reticulum-associated degradation (ERAD) By similarity. |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Molecular function | Ligase |
Gene Ontology (GO) | |
| Biological process | ER-associated protein catabolic process Ref.1 Inferred from direct assay. Source: MGI post-translational protein modificationInferred from electronic annotation. Source: InterPro regulation of protein metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytosol Ref.1 Inferred from direct assay. Source: MGI endoplasmic reticulum Ref.1Inferred from direct assay. Source: MGI |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB ubiquitin-protein ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)." Tiwari S., Weissman A.M. J. Biol. Chem. 276:16193-16200(2001) [PubMed: 11278356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Fetus. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF296657 mRNA. Translation: AAK52608.1. BC010321 mRNA. Translation: AAH10321.1. | |
| RefSeq | NP_062777.2. |
| UniGene | Mm.458125 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2UCZ based on UniProtKB Q02159. |
| SMR | P60605. Positions 1-165. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:29061N. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000009293. Mus musculus. [Contig view] |
| GeneID | 22213. |
| KEGG | mmu:22213. |
Organism-specific databases | |
| MGI | MGI:1343188. Ube2g2. |
Phylogenomic databases | |
| HOVERGEN | P60605. |
Gene expression databases | |
| ArrayExpress | P60605. |
| CleanEx | MM_UBE2G2. |
| GermOnline | ENSMUSG00000009293. Mus musculus. |
Family and domain databases | |
| InterPro | IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view] |
| Gene3D | G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. |
| PANTHER | PTHR11621. UBQ-conjugat_E2. 1 hit. |
| Pfam | PF00179. UQ_con. 1 hit. [Graphical view] |
| ProDom | PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00212. UBCc. 1 hit. [Graphical view] |
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 302209. |
| SOURCE | Search... |
Entry information
| Entry name | UB2G2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P60605 Secondary accession number(s): P56554 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


