Ubiquitin-conjugating enzyme E2 G2 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot P60605 (UB2G2_MOUSE)

Last modified October 13, 2009. Version 58. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Ubiquitin-conjugating enzyme E2 G2
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase G2
    Ubiquitin carrier protein G2

Gene names

Name:

Ube2g2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins. Involved in endoplasmic reticulum-associated degradation (ERAD) By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

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Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	ER-associated protein catabolic process Ref.1 Inferred from direct assay. Source: MGI post-translational protein modification Inferred from electronic annotation. Source: InterPro regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Ref.1 Inferred from direct assay. Source: MGI endoplasmic reticulum Ref.1 Inferred from direct assay. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: UniProtKB ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 165

165

Ubiquitin-conjugating enzyme E2 G2

PRO_0000082484

Sites

Active site

Glycyl thioester intermediate By similarity

Secondary structure

165

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P60605-1 [UniParc].

Last modified March 15, 2004. Version 1.
Checksum: 74DEC732A79575E3
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FASTA

165

18,566

        10         20         30         40         50         60 
MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE FGVFPAILSF 

        70         80         90        100        110        120 
PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP MGYESSAERW SPVQSVEKIL 

       130        140        150        160 
LSVVSMLAEP NDESGANVDA SKMWRDDREQ FYKIAKQIVQ KSLGL

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)." Tiwari S., Weissman A.M. J. Biol. Chem. 276:16193-16200(2001) [PubMed: 11278356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Fetus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AF296657 mRNA. Translation: AAK52608.1.
BC010321 mRNA. Translation: AAH10321.1.

IPI

IPI00153094.

RefSeq

NP_062777.2.

UniGene

Mm.458125

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FSH	X-ray	2.76	A/B	1-165	[»]

SMR

P60605. Positions 1-165.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:29061N.

STRING

P60605.

Proteomic databases

PRIDE

P60605.

Genome annotation databases

Ensembl

ENSMUST00000009437; ENSMUSP00000009437; ENSMUSG00000009293; Mus musculus. [Genome view]

GeneID

22213.

KEGG

mmu:22213.

UCSC

uc007fwa.1. mouse.

Organism-specific databases

CTD

22213.

MGI

MGI:1343188. Ube2g2.

Phylogenomic databases

HOVERGEN

P60605.

Enzyme and pathway databases

BRENDA

6.3.2.19. 244.

Gene expression databases

ArrayExpress

P60605.

Bgee

P60605.

CleanEx

MM_UBE2G2.

Genevestigator

P60605.

GermOnline

ENSMUSG00000009293. Mus musculus.

Family and domain databases

InterPro

IPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]

Gene3D

G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.

Pfam

PF00179. UQ_con. 1 hit.
[Graphical view]

ProDom

PD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00212. UBCc. 1 hit.
[Graphical view]

PROSITE

PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

302209.

SOURCE

Search...

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Entry information

Entry name

UB2G2_MOUSE

Accession

Primary (citable) accession number: P60605
Secondary accession number(s): P56554

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	March 15, 2004
Last modified:	October 13, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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