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P60605

- UB2G2_MOUSE

UniProt

P60605 - UB2G2_MOUSE

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Protein
Ubiquitin-conjugating enzyme E2 G2
Gene
Ube2g2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD) By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. protein binding Source: UniProtKB
  4. ubiquitin-protein transferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: MGI
  2. protein K48-linked ubiquitination Source: UniProtKB
  3. protein N-linked glycosylation via asparagine Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 G2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein G2
Ubiquitin-protein ligase G2
Gene namesi
Name:Ube2g2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1343188. Ube2g2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. endoplasmic reticulum Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Ubiquitin-conjugating enzyme E2 G2
PRO_0000082484Add
BLAST

Proteomic databases

PaxDbiP60605.
PRIDEiP60605.

PTM databases

PhosphoSiteiP60605.

Expressioni

Gene expression databases

ArrayExpressiP60605.
BgeeiP60605.
CleanExiMM_UBE2G2.
GenevestigatoriP60605.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself11EBI-9108745,EBI-9108745

Protein-protein interaction databases

BioGridi204416. 6 interactions.
DIPiDIP-29061N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 1818
Beta strandi24 – 307
Beta strandi36 – 427
Turni48 – 514
Beta strandi53 – 597
Turni62 – 654
Beta strandi70 – 756
Beta strandi86 – 883
Helixi91 – 933
Helixi116 – 12813
Helixi132 – 1343
Helixi138 – 1458
Helixi148 – 16215

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FSHX-ray2.76A/B1-165[»]
ProteinModelPortaliP60605.
SMRiP60605. Positions 2-165.

Miscellaneous databases

EvolutionaryTraceiP60605.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
HOVERGENiHBG063308.
InParanoidiP60605.
KOiK04555.
OMAiDMFHPNI.
OrthoDBiEOG7VB2HT.
TreeFamiTF101118.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60605-1 [UniParc]FASTAAdd to Basket

« Hide

MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE    50
FGVFPAILSF PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP 100
MGYESSAERW SPVQSVEKIL LSVVSMLAEP NDESGANVDA SKMWRDDREQ 150
FYKIAKQIVQ KSLGL 165
Length:165
Mass (Da):18,566
Last modified:March 15, 2004 - v1
Checksum:i74DEC732A79575E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF296657 mRNA. Translation: AAK52608.1.
BC010321 mRNA. Translation: AAH10321.1.
CCDSiCCDS56722.1.
RefSeqiNP_062777.2. NM_019803.3.
UniGeneiMm.458125.

Genome annotation databases

EnsembliENSMUST00000174510; ENSMUSP00000133515; ENSMUSG00000009293.
GeneIDi22213.
KEGGimmu:22213.
UCSCiuc007fwa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF296657 mRNA. Translation: AAK52608.1 .
BC010321 mRNA. Translation: AAH10321.1 .
CCDSi CCDS56722.1.
RefSeqi NP_062777.2. NM_019803.3.
UniGenei Mm.458125.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3FSH X-ray 2.76 A/B 1-165 [» ]
ProteinModelPortali P60605.
SMRi P60605. Positions 2-165.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204416. 6 interactions.
DIPi DIP-29061N.

PTM databases

PhosphoSitei P60605.

Proteomic databases

PaxDbi P60605.
PRIDEi P60605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000174510 ; ENSMUSP00000133515 ; ENSMUSG00000009293 .
GeneIDi 22213.
KEGGi mmu:22213.
UCSCi uc007fwa.1. mouse.

Organism-specific databases

CTDi 7327.
MGIi MGI:1343188. Ube2g2.

Phylogenomic databases

eggNOGi COG5078.
HOVERGENi HBG063308.
InParanoidi P60605.
KOi K04555.
OMAi DMFHPNI.
OrthoDBi EOG7VB2HT.
TreeFami TF101118.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi UBE2G2. mouse.
EvolutionaryTracei P60605.
NextBioi 28670.
PROi P60605.
SOURCEi Search...

Gene expression databases

ArrayExpressi P60605.
Bgeei P60605.
CleanExi MM_UBE2G2.
Genevestigatori P60605.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)."
    Tiwari S., Weissman A.M.
    J. Biol. Chem. 276:16193-16200(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fetus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUB2G2_MOUSE
AccessioniPrimary (citable) accession number: P60605
Secondary accession number(s): P56554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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