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P60605

- UB2G2_MOUSE

UniProt

P60605 - UB2G2_MOUSE

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Protein

Ubiquitin-conjugating enzyme E2 G2

Gene

Ube2g2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD) (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. identical protein binding Source: IntAct
  4. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: MGI
  2. protein K48-linked ubiquitination Source: UniProtKB
  3. protein N-linked glycosylation via asparagine Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 G2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein G2
Ubiquitin-protein ligase G2
Gene namesi
Name:Ube2g2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1343188. Ube2g2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. endoplasmic reticulum Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Ubiquitin-conjugating enzyme E2 G2PRO_0000082484Add
BLAST

Proteomic databases

MaxQBiP60605.
PaxDbiP60605.
PRIDEiP60605.

PTM databases

PhosphoSiteiP60605.

Expressioni

Gene expression databases

BgeeiP60605.
CleanExiMM_UBE2G2.
ExpressionAtlasiP60605. baseline and differential.
GenevestigatoriP60605.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself11EBI-9108745,EBI-9108745

Protein-protein interaction databases

BioGridi204416. 7 interactions.
DIPiDIP-29061N.

Structurei

Secondary structure

165
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 1818Combined sources
Beta strandi24 – 307Combined sources
Beta strandi36 – 427Combined sources
Turni48 – 514Combined sources
Beta strandi53 – 597Combined sources
Turni62 – 654Combined sources
Beta strandi70 – 756Combined sources
Beta strandi86 – 883Combined sources
Helixi91 – 933Combined sources
Helixi116 – 12813Combined sources
Helixi132 – 1343Combined sources
Helixi138 – 1458Combined sources
Helixi148 – 16215Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FSHX-ray2.76A/B1-165[»]
ProteinModelPortaliP60605.
SMRiP60605. Positions 2-165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60605.

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOVERGENiHBG063308.
InParanoidiP60605.
KOiK04555.
OMAiDMFHPNI.
OrthoDBiEOG7VB2HT.
TreeFamiTF101118.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60605-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE
60 70 80 90 100
FGVFPAILSF PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP
110 120 130 140 150
MGYESSAERW SPVQSVEKIL LSVVSMLAEP NDESGANVDA SKMWRDDREQ
160
FYKIAKQIVQ KSLGL
Length:165
Mass (Da):18,566
Last modified:March 15, 2004 - v1
Checksum:i74DEC732A79575E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296657 mRNA. Translation: AAK52608.1.
BC010321 mRNA. Translation: AAH10321.1.
CCDSiCCDS56722.1.
RefSeqiNP_062777.2. NM_019803.3.
UniGeneiMm.458125.

Genome annotation databases

EnsembliENSMUST00000174510; ENSMUSP00000133515; ENSMUSG00000009293.
GeneIDi22213.
KEGGimmu:22213.
UCSCiuc007fwa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296657 mRNA. Translation: AAK52608.1 .
BC010321 mRNA. Translation: AAH10321.1 .
CCDSi CCDS56722.1.
RefSeqi NP_062777.2. NM_019803.3.
UniGenei Mm.458125.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3FSH X-ray 2.76 A/B 1-165 [» ]
ProteinModelPortali P60605.
SMRi P60605. Positions 2-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204416. 7 interactions.
DIPi DIP-29061N.

PTM databases

PhosphoSitei P60605.

Proteomic databases

MaxQBi P60605.
PaxDbi P60605.
PRIDEi P60605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000174510 ; ENSMUSP00000133515 ; ENSMUSG00000009293 .
GeneIDi 22213.
KEGGi mmu:22213.
UCSCi uc007fwa.1. mouse.

Organism-specific databases

CTDi 7327.
MGIi MGI:1343188. Ube2g2.

Phylogenomic databases

eggNOGi COG5078.
HOVERGENi HBG063308.
InParanoidi P60605.
KOi K04555.
OMAi DMFHPNI.
OrthoDBi EOG7VB2HT.
TreeFami TF101118.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

EvolutionaryTracei P60605.
NextBioi 28670.
PROi P60605.
SOURCEi Search...

Gene expression databases

Bgeei P60605.
CleanExi MM_UBE2G2.
ExpressionAtlasi P60605. baseline and differential.
Genevestigatori P60605.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)."
    Tiwari S., Weissman A.M.
    J. Biol. Chem. 276:16193-16200(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fetus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUB2G2_MOUSE
AccessioniPrimary (citable) accession number: P60605
Secondary accession number(s): P56554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3