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Protein

Reactive oxygen species modulator 1

Gene

Romo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity).By similarity
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Reactive oxygen species modulator 1
Short name:
ROS modulator 1
Alternative name(s):
Protein MGR2 homolog
Gene namesi
Name:Romo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914317 Romo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 44HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794341 – 79Reactive oxygen species modulator 1Add BLAST79

Proteomic databases

EPDiP60603
MaxQBiP60603
PaxDbiP60603
PeptideAtlasiP60603
PRIDEiP60603

PTM databases

iPTMnetiP60603

Expressioni

Tissue specificityi

Detected in brain, liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000067847
GenevisibleiP60603 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085981

Structurei

3D structure databases

ProteinModelPortaliP60603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 60Sufficient for antibacterial activityBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the MGR2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4096 Eukaryota
ENOG411279J LUCA
GeneTreeiENSGT00390000005315
HOVERGENiHBG051169
InParanoidiP60603
OMAiLKMGAMM
OrthoDBiEOG091G17TT
PhylomeDBiP60603
TreeFamiTF300273

Family and domain databases

InterProiView protein in InterPro
IPR018450 Romo1/Mgr2
PANTHERiPTHR28525 PTHR28525, 1 hit
PfamiView protein in Pfam
PF10247 Romo1, 1 hit
SMARTiView protein in SMART
SM01378 Romo1, 1 hit

Sequencei

Sequence statusi: Complete.

P60603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR
60 70
ELMGGIGKTM MQSGGTFGTF MAIGMGIRC
Length:79
Mass (Da):8,183
Last modified:March 15, 2004 - v1
Checksum:iAD959C88C89EF80A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028425 mRNA Translation: AAK18748.1
AK003488 mRNA Translation: BAB22816.1
AK008300 mRNA Translation: BAB25585.1
BX649640 Genomic DNA No translation available.
BC028749 mRNA Translation: AAH28749.1
CCDSiCCDS38296.1
RefSeqiNP_001157688.1, NM_001164216.1
NP_001157689.1, NM_001164217.2
NP_080222.1, NM_025946.6
UniGeneiMm.371623

Genome annotation databases

EnsembliENSMUST00000088610; ENSMUSP00000085981; ENSMUSG00000067847
ENSMUST00000109597; ENSMUSP00000105226; ENSMUSG00000067847
ENSMUST00000109598; ENSMUSP00000105227; ENSMUSG00000067847
ENSMUST00000119950; ENSMUSP00000113943; ENSMUSG00000067847
GeneIDi67067
KEGGimmu:67067
UCSCiuc008nmm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiROMO1_MOUSE
AccessioniPrimary (citable) accession number: P60603
Secondary accession number(s): A2BHV9, Q9CQ98, Q9H1N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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