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Protein

Reactive oxygen species modulator 1

Gene

Romo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity).By similarity
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Reactive oxygen species modulator 1
Short name:
ROS modulator 1
Alternative name(s):
Protein MGR2 homolog
Gene namesi
Name:Romo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914317. Romo1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 44HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000794342 – 79Reactive oxygen species modulator 1Add BLAST78

Proteomic databases

EPDiP60603.
MaxQBiP60603.
PaxDbiP60603.
PeptideAtlasiP60603.
PRIDEiP60603.

Expressioni

Tissue specificityi

Detected in brain, liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000067847.
GenevisibleiP60603. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085981.

Structurei

3D structure databases

ProteinModelPortaliP60603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 60Sufficient for antibacterial activityBy similarityAdd BLAST19

Sequence similaritiesi

Belongs to the MGR2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4096. Eukaryota.
ENOG411279J. LUCA.
GeneTreeiENSGT00390000005315.
HOVERGENiHBG051169.
InParanoidiP60603.
OMAiKMGFTIG.
OrthoDBiEOG091G17TT.
PhylomeDBiP60603.
TreeFamiTF300273.

Family and domain databases

InterProiIPR018450. Romo1/Mgr2.
[Graphical view]
PfamiPF10247. Romo1. 1 hit.
[Graphical view]
SMARTiSM01378. Romo1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR
60 70
ELMGGIGKTM MQSGGTFGTF MAIGMGIRC
Length:79
Mass (Da):8,183
Last modified:March 15, 2004 - v1
Checksum:iAD959C88C89EF80A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028425 mRNA. Translation: AAK18748.1.
AK003488 mRNA. Translation: BAB22816.1.
AK008300 mRNA. Translation: BAB25585.1.
BX649640 Genomic DNA. Translation: CAM13495.1.
BC028749 mRNA. Translation: AAH28749.1.
CCDSiCCDS38296.1.
RefSeqiNP_001157688.1. NM_001164216.1.
NP_001157689.1. NM_001164217.2.
NP_080222.1. NM_025946.6.
UniGeneiMm.371623.

Genome annotation databases

EnsembliENSMUST00000088610; ENSMUSP00000085981; ENSMUSG00000067847.
ENSMUST00000109597; ENSMUSP00000105226; ENSMUSG00000067847.
ENSMUST00000109598; ENSMUSP00000105227; ENSMUSG00000067847.
ENSMUST00000119950; ENSMUSP00000113943; ENSMUSG00000067847.
GeneIDi67067.
KEGGimmu:67067.
UCSCiuc008nmm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028425 mRNA. Translation: AAK18748.1.
AK003488 mRNA. Translation: BAB22816.1.
AK008300 mRNA. Translation: BAB25585.1.
BX649640 Genomic DNA. Translation: CAM13495.1.
BC028749 mRNA. Translation: AAH28749.1.
CCDSiCCDS38296.1.
RefSeqiNP_001157688.1. NM_001164216.1.
NP_001157689.1. NM_001164217.2.
NP_080222.1. NM_025946.6.
UniGeneiMm.371623.

3D structure databases

ProteinModelPortaliP60603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085981.

Proteomic databases

EPDiP60603.
MaxQBiP60603.
PaxDbiP60603.
PeptideAtlasiP60603.
PRIDEiP60603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088610; ENSMUSP00000085981; ENSMUSG00000067847.
ENSMUST00000109597; ENSMUSP00000105226; ENSMUSG00000067847.
ENSMUST00000109598; ENSMUSP00000105227; ENSMUSG00000067847.
ENSMUST00000119950; ENSMUSP00000113943; ENSMUSG00000067847.
GeneIDi67067.
KEGGimmu:67067.
UCSCiuc008nmm.2. mouse.

Organism-specific databases

CTDi140823.
MGIiMGI:1914317. Romo1.

Phylogenomic databases

eggNOGiKOG4096. Eukaryota.
ENOG411279J. LUCA.
GeneTreeiENSGT00390000005315.
HOVERGENiHBG051169.
InParanoidiP60603.
OMAiKMGFTIG.
OrthoDBiEOG091G17TT.
PhylomeDBiP60603.
TreeFamiTF300273.

Miscellaneous databases

PROiP60603.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067847.
GenevisibleiP60603. MM.

Family and domain databases

InterProiIPR018450. Romo1/Mgr2.
[Graphical view]
PfamiPF10247. Romo1. 1 hit.
[Graphical view]
SMARTiSM01378. Romo1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROMO1_MOUSE
AccessioniPrimary (citable) accession number: P60603
Secondary accession number(s): A2BHV9, Q9CQ98, Q9H1N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.