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Protein

Reactive oxygen species modulator 1

Gene

ROMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

Miscellaneous

Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cellular response to reactive oxygen species Source: UniProtKB
  • cytolysis in other organism Source: UniProtKB
  • defense response to bacterium Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of reactive oxygen species metabolic process Source: UniProtKB
  • replicative cell aging Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Protein family/group databases

TCDBi9.B.181.1.1. the reactive oxygen species modulator 1 (romo1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Reactive oxygen species modulator 1
Short name:
ROS modulator 1
Alternative name(s):
Epididymis tissue protein Li 175
Glyrichin
Mitochondrial targeting GxxxG motif protein
Short name:
MTGM
Protein MGR2 homolog
Gene namesi
Name:ROMO1
Synonyms:C20orf52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125995.15.
HGNCiHGNC:16185. ROMO1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 44HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi140823.
OpenTargetsiENSG00000125995.
PharmGKBiPA164725540.

Polymorphism and mutation databases

BioMutaiROMO1.
DMDMi45593159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000794332 – 79Reactive oxygen species modulator 1Add BLAST78

Proteomic databases

EPDiP60602.
MaxQBiP60602.
PaxDbiP60602.
PeptideAtlasiP60602.
PRIDEiP60602.
TopDownProteomicsiP60602-1. [P60602-1]

Expressioni

Tissue specificityi

Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.2 Publications

Developmental stagei

Expression increases in senescent cells.1 Publication

Inductioni

By the anticancer drug fluorouracil (5FU).1 Publication

Gene expression databases

BgeeiENSG00000125995.
CleanExiHS_ROMO1.
GenevisibleiP60602. HS.

Organism-specific databases

HPAiHPA012782.

Interactioni

Protein-protein interaction databases

BioGridi126718. 7 interactors.
IntActiP60602. 1 interactor.
STRINGi9606.ENSP00000338293.

Structurei

3D structure databases

ProteinModelPortaliP60602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 60Sufficient for antibacterial activityAdd BLAST19

Sequence similaritiesi

Belongs to the MGR2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4096. Eukaryota.
ENOG411279J. LUCA.
GeneTreeiENSGT00390000005315.
HOVERGENiHBG051169.
InParanoidiP60602.
OMAiLKMGAMM.
OrthoDBiEOG091G17TT.
PhylomeDBiP60602.
TreeFamiTF300273.

Family and domain databases

InterProiView protein in InterPro
IPR018450. Romo1/Mgr2.
PANTHERiPTHR28525. PTHR28525. 1 hit.
PfamiView protein in Pfam
PF10247. Romo1. 1 hit.
SMARTiView protein in SMART
SM01378. Romo1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P60602-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR
60 70
ELMGGIGKTM MQSGGTFGTF MAIGMGIRC
Length:79
Mass (Da):8,183
Last modified:March 15, 2004 - v1
Checksum:iAD959C88C89EF80A
GO
Isoform 2 (identifier: P60602-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-79: RIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC → SSILVSSSGSECGVES

Note: Gene prediction based on EST data.
Show »
Length:59
Mass (Da):5,900
Checksum:i22C898C2946D76C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01412728A → P. Corresponds to variant dbSNP:rs1044521Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03648644 – 79RIGMR…MGIRC → SSILVSSSGSECGVES in isoform 2. CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM397244 mRNA. Translation: CAL37002.1.
AM397245 mRNA. Translation: CAL37003.1.
AM397246 mRNA. Translation: CAL37004.1.
GU727625 mRNA. Translation: ADU87627.1.
AL357374 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW76168.1.
CH471077 Genomic DNA. Translation: EAW76169.1.
BC008488 mRNA. Translation: AAH08488.1.
BC105281 mRNA. Translation: AAI05282.1.
CCDSiCCDS13264.1. [P60602-1]
RefSeqiNP_542786.1. NM_080748.2. [P60602-1]
XP_016883167.1. XM_017027678.1. [P60602-1]
UniGeneiHs.472564.

Genome annotation databases

EnsembliENST00000336695; ENSP00000338293; ENSG00000125995. [P60602-1]
ENST00000374072; ENSP00000363185; ENSG00000125995. [P60602-2]
ENST00000374077; ENSP00000363190; ENSG00000125995. [P60602-1]
ENST00000374078; ENSP00000363191; ENSG00000125995. [P60602-1]
ENST00000397416; ENSP00000380561; ENSG00000125995. [P60602-1]
GeneIDi140823.
KEGGihsa:140823.
UCSCiuc002xdy.4. human. [P60602-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiROMO1_HUMAN
AccessioniPrimary (citable) accession number: P60602
Secondary accession number(s): A7M872
, E1P5R9, E9KL28, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families