Reviewed, UniProtKB/Swiss-Prot P60588 (LPP1_PIG)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphohydrolase 1
    EC=3.1.3.4
Alternative name(s):
    Phosphatidic acid phosphatase 2a
    PAP2-alpha
      Short name=PAP-2a
      Short name=PAP2a
    Phosphatidate phosphohydrolase type 2a

Gene names

Name:	PPAP2A
Synonyms:	LPP1

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	15 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P).
Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›15	›15	Lipid phosphate phosphohydrolase 1		PRO_0000220907
Experimental info
	Non-terminal residue	15	1

Sequences

	Sequence		Length	Mass (Da)
	P60588-1 [UniParc]. Last modified March 15, 2004. Version 1. Checksum: 390910FBDEC05A7E	FASTA	15	1,781
	10 MFDKTRLPYV ALDVL

References

[1]	"Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (type 2) bound to plasma membranes." Kai M., Wada I., Imai S., Sakane F., Kanoh H. J. Biol. Chem. 271:18931-18938(1996) [PubMed: 8702556] [Abstract] Cited for: PROTEIN SEQUENCE, SYNTHESIS OF 1-15.
[2]	"Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes." Kanoh H., Imai S., Yamada K., Sakane F. J. Biol. Chem. 267:25309-25314(1992) [PubMed: 1334090] [Abstract] Cited for: CHARACTERIZATION. Tissue: Thymus.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P60588.
Enzyme and pathway databases
BRENDA	3.1.3.4. 249.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

LPP1_PIG

Accession

Primary (citable) accession number: P60588

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	March 15, 2004
Last modified:	October 13, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)