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Protein

Pannexin-2

Gene

Panx2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions and the hemichannels.

GO - Molecular functioni

  • gap junction channel activity Source: RGD
  • gap junction hemi-channel activity Source: UniProtKB
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • cell-cell signaling Source: RGD
  • ion transport Source: UniProtKB-KW
  • protein hexamerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-2
Gene namesi
Name:Panx2
Synonyms:Px2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735191. Panx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini11 – 5343CytoplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini75 – 12551ExtracellularSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini147 – 23084CytoplasmicSequence analysisAdd
BLAST
Transmembranei231 – 25121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini252 – 29544ExtracellularSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini317 – 674358CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Pannexin-2PRO_0000208490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Modified residuei590 – 5901PhosphoserineBy similarity
Modified residuei601 – 6011PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP60571.
PRIDEiP60571.

Expressioni

Tissue specificityi

Expressed in the eye, thyroid, prostate, kidney and liver. Abundantly expressed in the CNS, including hippocampus, olfactory bulb, cortex, cerebellum. Not detected in the white matter.1 Publication

Interactioni

Subunit structurei

Forms PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes. Does not form homomeric channels.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047054.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGKS. Eukaryota.
ENOG4110P9D. LUCA.
HOGENOMiHOG000082414.
HOVERGENiHBG053498.
InParanoidiP60571.
KOiK03443.
OrthoDBiEOG74N5G9.
PhylomeDBiP60571.
TreeFamiTF333142.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHLLEQSAD MATALLAGEK LRELILPGSQ DDKAGALAAL LLQLKLELPF
60 70 80 90 100
DRVVTIGTVL VPILLVTLVF TKNFAEEPIY CYTPHNFTRD QALYARGYCW
110 120 130 140 150
TELRDALPGV DASLWPSLFE HKFLPYALLA FAAIMYVPAL GWEFLASTRL
160 170 180 190 200
TSELNFLLQE IDNCYHRAAE GRAPKIEKQI QSKGPGITER EKREIIENAE
210 220 230 240 250
KEKSPEQNLF EKYLERRGRS NFLAKLYLAR HVLILLLSVV PISYLCTYYA
260 270 280 290 300
TQKQNEFTCA LGASPDGPVG SAGPTVRVSC KLPSVQLQRI IAGVDIVLLC
310 320 330 340 350
FMNLIILVNL IHLFIFRKSN FIFDKLHKVG IKTRRQWRRS QFCDINILAM
360 370 380 390 400
FCNENRDHIK SLNRLDFITN ESDLMYDNVV RQLLAALAQS NHDTTPTVRD
410 420 430 440 450
SGIQTVDPSI NPAEPEGSAE PPVVKRPRKK MKWIPTSNPL PQPFKEQLAI
460 470 480 490 500
MRVENSKTEK PKPVRRKTAT DTLIAPLLDA GARAAHHYKG SGGDTGPSSA
510 520 530 540 550
PPAASEKKHT RHFSLDVHPY ILGSKKAKTE AVPPALPASR SQEGGFLSQT
560 570 580 590 600
EECGLGLAAA PTKDAPLPEK EIPYPTESAL PSGGPFHVCS PPTASAAASL
610 620 630 640 650
SPSSLGKADP LTILSRNATH PLLHISTLYE AREEEEGGPC APSDMGDLLS
660 670
IPPPQQILIA TFEEPRTVVS TVEF
Length:674
Mass (Da):74,434
Last modified:May 18, 2010 - v2
Checksum:i9E8C82865CDA4751
GO

Sequence cautioni

The sequence CAD89523.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ557016 mRNA. Translation: CAD89523.1. Different initiation.
RefSeqiNP_955441.2. NM_199409.2.
UniGeneiRn.229333.

Genome annotation databases

GeneIDi362979.
KEGGirno:362979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ557016 mRNA. Translation: CAD89523.1. Different initiation.
RefSeqiNP_955441.2. NM_199409.2.
UniGeneiRn.229333.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047054.

Proteomic databases

PaxDbiP60571.
PRIDEiP60571.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362979.
KEGGirno:362979.

Organism-specific databases

CTDi56666.
RGDi735191. Panx2.

Phylogenomic databases

eggNOGiENOG410IGKS. Eukaryota.
ENOG4110P9D. LUCA.
HOGENOMiHOG000082414.
HOVERGENiHBG053498.
InParanoidiP60571.
KOiK03443.
OrthoDBiEOG74N5G9.
PhylomeDBiP60571.
TreeFamiTF333142.

Miscellaneous databases

PROiP60571.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pannexins, a family of gap junction proteins expressed in brain."
    Bruzzone R., Hormuzdi S.G., Barbe M., Herb A., Monyer H.
    Proc. Natl. Acad. Sci. U.S.A. 100:13644-13649(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBUNIT.
    Strain: Wistar.
    Tissue: Hippocampus.

Entry informationi

Entry nameiPANX2_RAT
AccessioniPrimary (citable) accession number: P60571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.