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Protein

Pannexin-1

Gene

Panx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions and the hemichannels. May play a role as a Ca2+-leak channel to regulate ER Ca2+ homeostasis (By similarity).By similarity

GO - Molecular functioni

  • calcium channel activity Source: UniProtKB
  • gap junction channel activity Source: RGD
  • gap junction hemi-channel activity Source: UniProtKB
  • ion channel binding Source: RGD
  • leak channel activity Source: UniProtKB
  • protease binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • scaffold protein binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-112303. Electric Transmission Across Gap Junctions.
R-RNO-844456. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-1
Gene namesi
Name:Panx1
Synonyms:Px1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi735204. Panx1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini62 – 10645ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini128 – 21689CytoplasmicSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini238 – 27740ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini299 – 426128CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Pannexin-1PRO_0000208487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401S-nitrosocysteineBy similarity
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence analysis
Modified residuei346 – 3461S-nitrosocysteineBy similarity

Post-translational modificationi

S-nitrosylation inhibits channel currents and ATP release.By similarity

Keywords - PTMi

Glycoprotein, S-nitrosylation

Proteomic databases

PaxDbiP60570.
PRIDEiP60570.

Expressioni

Tissue specificityi

Expressed in the eye, thyroid, prostate, kidney and liver. Abundantly expressed in the CNS, including hippocampus, olfactory bulb, cortex, cerebellum and white matter.1 Publication

Gene expression databases

ExpressionAtlasiP60570. baseline and differential.
GenevisibleiP60570. RN.

Interactioni

Subunit structurei

Homohexamer (By similarity). Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes.By similarity1 Publication

GO - Molecular functioni

  • ion channel binding Source: RGD
  • protease binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • scaffold protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013577.

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5X. Eukaryota.
ENOG410YA5H. LUCA.
GeneTreeiENSGT00390000009703.
HOGENOMiHOG000063721.
HOVERGENiHBG053497.
InParanoidiP60570.
KOiK03443.
OMAiVPFRQKT.
OrthoDBiEOG74N5G9.
PhylomeDBiP60570.
TreeFamiTF333142.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIAHLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI
60 70 80 90 100
SLAFAQEISI GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN
110 120 130 140 150
LPLWLHKFFP YILLLFAILL YLPALFWRFA AAPHLCSDLK FIMEELDKVY
160 170 180 190 200
NRAIKAAKSA RDLDLRDGPG PPGVTENVGQ SLWEISESHF KYPIVEQYLK
210 220 230 240 250
TKKNSSHLIM KYISCRLVTF AVVLLACIYL SYYFSLSSLS DEFLCSIKSG
260 270 280 290 300
VLRNDSTIPD SFQCKLIAVG IFQLLSLINL LVYALLVPVV IYTLFVPFRQ
310 320 330 340 350
KTDVLKVYEI LPTFDVLHFK SEGYNDLSLY NLFLEENISE LKSYKCLKVL
360 370 380 390 400
ENIKSNGQGI DPMLLLTNLG MIKMDVIDGK VPMSLQTKGE DQGSQRMDFK
410 420
DLDLSSETAA NNGEKNSRQR LLNSSC
Length:426
Mass (Da):48,073
Last modified:March 15, 2004 - v1
Checksum:i1C2AF8FF058323B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ557015 mRNA. Translation: CAD89522.1.
RefSeqiNP_955429.1. NM_199397.2.
UniGeneiRn.204521.

Genome annotation databases

EnsembliENSRNOT00000013577; ENSRNOP00000013577; ENSRNOG00000010060.
GeneIDi315435.
KEGGirno:315435.
UCSCiRGD:735204. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ557015 mRNA. Translation: CAD89522.1.
RefSeqiNP_955429.1. NM_199397.2.
UniGeneiRn.204521.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013577.

Proteomic databases

PaxDbiP60570.
PRIDEiP60570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013577; ENSRNOP00000013577; ENSRNOG00000010060.
GeneIDi315435.
KEGGirno:315435.
UCSCiRGD:735204. rat.

Organism-specific databases

CTDi24145.
RGDi735204. Panx1.

Phylogenomic databases

eggNOGiENOG410II5X. Eukaryota.
ENOG410YA5H. LUCA.
GeneTreeiENSGT00390000009703.
HOGENOMiHOG000063721.
HOVERGENiHBG053497.
InParanoidiP60570.
KOiK03443.
OMAiVPFRQKT.
OrthoDBiEOG74N5G9.
PhylomeDBiP60570.
TreeFamiTF333142.

Enzyme and pathway databases

ReactomeiR-RNO-112303. Electric Transmission Across Gap Junctions.
R-RNO-844456. The NLRP3 inflammasome.

Miscellaneous databases

PROiP60570.

Gene expression databases

ExpressionAtlasiP60570. baseline and differential.
GenevisibleiP60570. RN.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pannexins, a family of gap junction proteins expressed in brain."
    Bruzzone R., Hormuzdi S.G., Barbe M., Herb A., Monyer H.
    Proc. Natl. Acad. Sci. U.S.A. 100:13644-13649(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBUNIT.
    Strain: Wistar.
    Tissue: Hippocampus.

Entry informationi

Entry nameiPANX1_RAT
AccessioniPrimary (citable) accession number: P60570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.