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Protein

Pannexin-1

Gene

Panx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of the gap junctions and the hemichannels. May play a role as a Ca2+-leak channel to regulate ER Ca2+ homeostasis (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: RGD
  • actin filament binding Source: RGD
  • calcium channel activity Source: UniProtKB
  • channel activity Source: RGD
  • gap junction channel activity Source: RGD
  • gap junction hemi-channel activity Source: UniProtKB
  • ion channel binding Source: RGD
  • leak channel activity Source: UniProtKB
  • protease binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • receptor binding Source: RGD
  • scaffold protein binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-RNO-112303 Electric Transmission Across Gap Junctions
R-RNO-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-1
Gene namesi
Name:Panx1
Synonyms:Px1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi735204 Panx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini62 – 106ExtracellularSequence analysisAdd BLAST45
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini128 – 216CytoplasmicSequence analysisAdd BLAST89
Transmembranei217 – 237HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini238 – 277ExtracellularSequence analysisAdd BLAST40
Transmembranei278 – 298HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini299 – 426CytoplasmicSequence analysisAdd BLAST128

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002084871 – 426Pannexin-1Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40S-nitrosocysteineBy similarity1
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei346S-nitrosocysteineBy similarity1

Post-translational modificationi

S-nitrosylation inhibits channel currents and ATP release.By similarity

Keywords - PTMi

Glycoprotein, S-nitrosylation

Proteomic databases

PaxDbiP60570
PRIDEiP60570

PTM databases

iPTMnetiP60570
PhosphoSitePlusiP60570

Expressioni

Tissue specificityi

Expressed in the eye, thyroid, prostate, kidney and liver. Abundantly expressed in the CNS, including hippocampus, olfactory bulb, cortex, cerebellum and white matter.1 Publication

Gene expression databases

BgeeiENSRNOG00000010060
ExpressionAtlasiP60570 baseline and differential
GenevisibleiP60570 RN

Interactioni

Subunit structurei

Homohexamer (By similarity). Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: RGD
  • actin filament binding Source: RGD
  • ion channel binding Source: RGD
  • protease binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • receptor binding Source: RGD
  • scaffold protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013577

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5X Eukaryota
ENOG410YA5H LUCA
GeneTreeiENSGT00390000009703
HOGENOMiHOG000063721
HOVERGENiHBG053497
InParanoidiP60570
KOiK03443
OMAiKMVTCIA
OrthoDBiEOG091G086D
PhylomeDBiP60570
TreeFamiTF333142

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P60570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIAHLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI
60 70 80 90 100
SLAFAQEISI GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN
110 120 130 140 150
LPLWLHKFFP YILLLFAILL YLPALFWRFA AAPHLCSDLK FIMEELDKVY
160 170 180 190 200
NRAIKAAKSA RDLDLRDGPG PPGVTENVGQ SLWEISESHF KYPIVEQYLK
210 220 230 240 250
TKKNSSHLIM KYISCRLVTF AVVLLACIYL SYYFSLSSLS DEFLCSIKSG
260 270 280 290 300
VLRNDSTIPD SFQCKLIAVG IFQLLSLINL LVYALLVPVV IYTLFVPFRQ
310 320 330 340 350
KTDVLKVYEI LPTFDVLHFK SEGYNDLSLY NLFLEENISE LKSYKCLKVL
360 370 380 390 400
ENIKSNGQGI DPMLLLTNLG MIKMDVIDGK VPMSLQTKGE DQGSQRMDFK
410 420
DLDLSSETAA NNGEKNSRQR LLNSSC
Length:426
Mass (Da):48,073
Last modified:March 15, 2004 - v1
Checksum:i1C2AF8FF058323B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ557015 mRNA Translation: CAD89522.1
RefSeqiNP_955429.1, NM_199397.2
UniGeneiRn.204521

Genome annotation databases

EnsembliENSRNOT00000013577; ENSRNOP00000013577; ENSRNOG00000010060
GeneIDi315435
KEGGirno:315435
UCSCiRGD:735204 rat

Similar proteinsi

Entry informationi

Entry nameiPANX1_RAT
AccessioniPrimary (citable) accession number: P60570
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health