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P60569 (IL2_HYLLA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-2

Short name=IL-2
Alternative name(s):
T-cell growth factor
Short name=TCGF
Gene names
Name:IL2
OrganismHylobates lar (Common gibbon) (White-handed gibbon)
Taxonomic identifier9580 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeHylobates

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-2 family.

Ontologies

Keywords
   Biological processAdaptive immunity
Immunity
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processimmune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 153133Interleukin-2
PRO_0000015485

Amino acid modifications

Glycosylation231O-linked (GalNAc...) By similarity
Disulfide bond78 ↔ 125 By similarity

Sequences

Sequence LengthMass (Da)Tools
P60569 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 59E2F40F25860F84

FASTA15317,628
        10         20         30         40         50         60 
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML 

        70         80         90        100        110        120 
TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE 

       130        140        150 
TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT 

« Hide

References

[1]"A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2."
Chen S.J., Holbrook N.J., Mitchell K.F., Vallone C.A., Greengard J.S., Crabtree G.R., Lin Y.
Proc. Natl. Acad. Sci. U.S.A. 82:7284-7288(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K03174 mRNA. Translation: AAA35453.1.
M11144 mRNA. Translation: AAA35454.1.
PIRICGI2. A94067.

3D structure databases

ProteinModelPortalP60569.
SMRP60569. Positions 25-153.
ModBaseSearch...
MobiDBSearch...

Chemistry

DrugBankDB00041. Aldesleukin.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG007496.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERPTHR11443. PTHR11443. 1 hit.
PfamPF00715. IL2. 1 hit.
[Graphical view]
PRINTSPR00265. INTERLEUKIN2.
ProDomPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13896.

Entry information

Entry nameIL2_HYLLA
AccessionPrimary (citable) accession number: P60569
Secondary accession number(s): P01585
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 11, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families