P60569 (IL2_HYLLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-2
Short name=IL-2

Alternative name(s):
T-cell growth factor
Short name=TCGF

Gene names

Name:

IL2

Organism

Hylobates lar (Common gibbon) (White-handed gibbon)

Taxonomic identifier

9580 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hylobatidae › Hylobates

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-2 family.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 153	133	Interleukin-2		PRO_0000015485
Amino acid modifications
	Glycosylation	23	1	O-linked (GalNAc...) By similarity
	Disulfide bond	78 ↔ 125		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P60569 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 59E2F40F25860F84	FASTA	153	17,628
	10 20 30 40 50 60 MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML 70 80 90 100 110 120 TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE 130 140 150 TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT

References

[1]

"A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2." Chen S.J., Holbrook N.J., Mitchell K.F., Vallone C.A., Greengard J.S., Crabtree G.R., Lin Y. Proc. Natl. Acad. Sci. U.S.A. 82:7284-7288(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	K03174 mRNA. Translation: AAA35453.1. M11144 mRNA. Translation: AAA35454.1.
PIR	ICGI2. A94067.
3D structure databases
ProteinModelPortal	P60569.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG007496.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR000779. Interleukin-2. [Graphical view]
PANTHER	PTHR11443. PTHR11443. 1 hit.
Pfam	PF00715. IL2. 1 hit. [Graphical view]
PRINTS	PR00265. INTERLEUKIN2.
ProDom	PD003649. Interleukin-2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00189. IL2. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00424. INTERLEUKIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00041. Aldesleukin.
NextBio	13896.

Entry information

Entry name

IL2_HYLLA

Accession

Primary (citable) accession number: P60569
Secondary accession number(s): P01585

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program