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P60569

- IL2_HYLLA

UniProt

P60569 - IL2_HYLLA

Protein

Interleukin-2

Gene

IL2

Organism
Hylobates lar (Common gibbon) (White-handed gibbon)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

    GO - Biological processi

    1. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-2
    Short name:
    IL-2
    Alternative name(s):
    T-cell growth factor
    Short name:
    TCGF
    Gene namesi
    Name:IL2
    OrganismiHylobates lar (Common gibbon) (White-handed gibbon)
    Taxonomic identifieri9580 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHylobatidaeHylobates

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 153133Interleukin-2PRO_0000015485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231O-linked (GalNAc...)By similarity
    Disulfide bondi78 ↔ 125By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP60569.
    SMRiP60569. Positions 25-153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG007496.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000779. IL-2.
    [Graphical view]
    PANTHERiPTHR11443. PTHR11443. 1 hit.
    PfamiPF00715. IL2. 1 hit.
    [Graphical view]
    PRINTSiPR00265. INTERLEUKIN2.
    ProDomiPD003649. Interleukin-2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00189. IL2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60569-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN    50
    YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL 100
    RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS 150
    TLT 153
    Length:153
    Mass (Da):17,628
    Last modified:July 21, 1986 - v1
    Checksum:i59E2F40F25860F84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K03174 mRNA. Translation: AAA35453.1.
    M11144 mRNA. Translation: AAA35454.1.
    PIRiA94067. ICGI2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K03174 mRNA. Translation: AAA35453.1 .
    M11144 mRNA. Translation: AAA35454.1 .
    PIRi A94067. ICGI2.

    3D structure databases

    ProteinModelPortali P60569.
    SMRi P60569. Positions 25-153.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB00041. Aldesleukin.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG007496.

    Miscellaneous databases

    NextBioi 13896.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000779. IL-2.
    [Graphical view ]
    PANTHERi PTHR11443. PTHR11443. 1 hit.
    Pfami PF00715. IL2. 1 hit.
    [Graphical view ]
    PRINTSi PR00265. INTERLEUKIN2.
    ProDomi PD003649. Interleukin-2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00189. IL2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2."
      Chen S.J., Holbrook N.J., Mitchell K.F., Vallone C.A., Greengard J.S., Crabtree G.R., Lin Y.
      Proc. Natl. Acad. Sci. U.S.A. 82:7284-7288(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiIL2_HYLLA
    AccessioniPrimary (citable) accession number: P60569
    Secondary accession number(s): P01585
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3