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Protein

Interleukin-2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

  • carbohydrate binding Source: Ensembl
  • cytokine activity Source: MGI
  • glycosphingolipid binding Source: Ensembl
  • growth factor activity Source: UniProtKB
  • interleukin-2 receptor binding Source: MGI
  • kappa-type opioid receptor binding Source: Ensembl
  • kinase activator activity Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP60568
SIGNORiP60568

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
INN: Aldesleukin
Gene namesi
Name:IL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109471.4
HGNCiHGNC:6001 IL2
MIMi147680 gene
neXtProtiNX_P60568

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.1 Publication

Pharmaceutical usei

Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi3558
OpenTargetsiENSG00000109471
PharmGKBiPA195

Chemistry databases

ChEMBLiCHEMBL5880
DrugBankiDB03455 (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid
DB04278 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide
DB05676 Apremilast
DB05299 keyhole limpet hemocyanin
DB00852 Pseudoephedrine
DB03957 SP2456
DB02555 SP4160
DB05304 WX-G250

Polymorphism and mutation databases

BioMutaiIL2
DMDMi45593462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001548421 – 153Interleukin-2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_00005123O-linked (GalNAc...) threonine2 Publications1
Disulfide bondi78 ↔ 1252 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP60568
PeptideAtlasiP60568
PRIDEiP60568

PTM databases

GlyConnecti225
297
298
299
300
iPTMnetiP60568
PhosphoSitePlusiP60568
UniCarbKBiP60568

Expressioni

Gene expression databases

BgeeiENSG00000109471
CleanExiHS_IL2
ExpressionAtlasiP60568 baseline and differential
GenevisibleiP60568 HS

Organism-specific databases

HPAiCAB010310

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: UniProtKB
  • interleukin-2 receptor binding Source: MGI
  • kappa-type opioid receptor binding Source: Ensembl
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome

Protein-protein interaction databases

BioGridi109773, 2 interactors
CORUMiP60568
DIPiDIP-475N
IntActiP60568, 3 interactors
STRINGi9606.ENSP00000226730

Chemistry databases

BindingDBiP60568

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 49Combined sources25
Helixi53 – 59Combined sources7
Helixi60 – 62Combined sources3
Beta strandi64 – 68Combined sources5
Helixi73 – 76Combined sources4
Helixi77 – 93Combined sources17
Turni95 – 97Combined sources3
Beta strandi98 – 100Combined sources3
Helixi105 – 117Combined sources13
Helixi120 – 122Combined sources3
Beta strandi127 – 132Combined sources6
Helixi134 – 149Combined sources16
Turni150 – 152Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-226-153[»]
1ILNmodel-226-153[»]
1IRLNMR-A21-153[»]
1M47X-ray1.99A21-153[»]
1M48X-ray1.95A/B21-153[»]
1M49X-ray2.00A/B21-153[»]
1M4AX-ray2.18A21-153[»]
1M4BX-ray2.15A21-153[»]
1M4CX-ray2.40A/B21-153[»]
1NBPX-ray2.20A21-153[»]
1PW6X-ray2.60A/B21-153[»]
1PY2X-ray2.80A/B/C/D21-152[»]
1QVNX-ray2.70A/B/C/D21-152[»]
1Z92X-ray2.80A21-153[»]
2B5IX-ray2.30A21-153[»]
2ERJX-ray3.00D/H21-153[»]
3INKX-ray2.50C/D21-153[»]
3QAZX-ray3.80A/D/G/J/M/P/S/V/Y/b/e/h21-153[»]
3QB1X-ray3.10A/B/C/D/E/F/G/H21-153[»]
4NEJX-ray1.92A24-153[»]
4NEMX-ray1.93A24-153[»]
5LQBX-ray1.95A22-153[»]
5M5EX-ray2.30D8-153[»]
ProteinModelPortaliP60568
SMRiP60568
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60568

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
GeneTreeiENSGT00390000003555
HOVERGENiHBG007496
InParanoidiP60568
KOiK05429
OMAiKWITFCQ
OrthoDBiEOG091G0VTZ
PhylomeDBiP60568
TreeFamiTF338200

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS

TLT
Length:153
Mass (Da):17,628
Last modified:July 21, 1986 - v1
Checksum:i59E2F40F25860F84
GO

Sequence cautioni

The sequence AAA59140 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00396721Missing in FT-IL2-A and FT-IL2-B. 1
Natural variantiVAR_00396822Missing in FT-IL2-B. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00695 Genomic DNA Translation: CAA25292.1
V00564 mRNA Translation: CAA23827.1
X01586 mRNA Translation: CAA25742.1
J00264 Genomic DNA Translation: AAD48509.1
K02056 Genomic DNA Translation: AAA98792.1
S77834 mRNA Translation: AAD14263.2
S82692 mRNA Translation: AAB46883.1
AF359939 Genomic DNA Translation: AAK26665.1
BC066255 mRNA Translation: AAH66255.1
BC066257 mRNA Translation: AAH66257.1
BC070338 mRNA Translation: AAH70338.1
M33199 Genomic DNA Translation: AAA59139.1
M13879 Genomic DNA Translation: AAA59141.1
M22005 Genomic DNA Translation: AAA59140.1 Different initiation.
CCDSiCCDS3726.1
PIRiA01849 ICHU2
RefSeqiNP_000577.2, NM_000586.3
UniGeneiHs.89679

Genome annotation databases

EnsembliENST00000226730; ENSP00000226730; ENSG00000109471
GeneIDi3558
KEGGihsa:3558

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiIL2_HUMAN
AccessioniPrimary (citable) accession number: P60568
Secondary accession number(s): P01585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

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