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Protein

Protein FixA

Gene

fixA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for anaerobic carnitine reduction. May bring reductant to CaiA.1 Publication

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

  • carnitine catabolic process Source: EcoCyc
  • carnitine metabolic process Source: EcoliWiki
  • oxidation-reduction process Source: GO_Central

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11562-MONOMER
UniPathwayiUPA00117

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FixA
Gene namesi
Name:fixA
Synonyms:yaaQ
Ordered Locus Names:b0041, JW0040
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11562 fixA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001678921 – 256Protein FixAAdd BLAST256

Proteomic databases

PaxDbiP60566
PRIDEiP60566

Interactioni

Subunit structurei

Heterodimer of FixA and FixB.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
ybhFP0A9U13EBI-1113126,EBI-547696

Protein-protein interaction databases

BioGridi4262207, 10 interactors
IntActiP60566, 8 interactors
STRINGi316385.ECDH10B_0042

Structurei

3D structure databases

ProteinModelPortaliP60566
SMRiP60566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETF beta-subunit/FixA family.Curated

Phylogenomic databases

eggNOGiENOG4105BZJ Bacteria
COG2086 LUCA
HOGENOMiHOG000247880
InParanoidiP60566
KOiK03521
OMAiMYEPESE
PhylomeDBiP60566

Family and domain databases

CDDicd01714 ETF_beta, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_01055 FixA, 1 hit
InterProiView protein in InterPro
IPR000049 ET-Flavoprotein_bsu_CS
IPR014730 ETF_a/b_N
IPR012255 ETF_b
IPR033948 ETF_beta_N
IPR023463 FixA
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21294 PTHR21294, 1 hit
PfamiView protein in Pfam
PF01012 ETF, 1 hit
PIRSFiPIRSF000090 Beta-ETF, 1 hit
SMARTiView protein in SMART
SM00893 ETF, 1 hit
PROSITEiView protein in PROSITE
PS01065 ETF_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P60566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIITCYKCV PDEQDIAVNN ADGSLDFSKA DAKISQYDLN AIEAACQLKQ
60 70 80 90 100
QAAEAQVTAL SVGGKALTNA KGRKDVLSRG PDELIVVIDD QFEQALPQQT
110 120 130 140 150
ASALAAAAQK AGFDLILCGD GSSDLYAQQV GLLVGEILNI PAVNGVSKII
160 170 180 190 200
SLTADTLTVE RELEDETETL SIPLPAVVAV STDINSPQIP SMKAILGAAK
210 220 230 240 250
KPVQVWSAAD IGFNAEAAWS EQQVAAPKQR ERQRIVIEGD GEEQIAAFAE

NLRKVI
Length:256
Mass (Da):27,144
Last modified:March 15, 2004 - v1
Checksum:i1954E0469748D310
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216 – 217EA → VD in CAA50797 (PubMed:7473063).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71977 Genomic DNA Translation: CAA50797.1
U00096 Genomic DNA Translation: AAC73152.2
AP009048 Genomic DNA Translation: BAB96610.2
PIRiA64725
RefSeqiNP_414583.2, NC_000913.3
WP_000692204.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73152; AAC73152; b0041
BAB96610; BAB96610; BAB96610
GeneIDi947316
KEGGiecj:JW0040
eco:b0041
PATRICifig|1411691.4.peg.2242

Similar proteinsi

Entry informationi

Entry nameiFIXA_ECOLI
AccessioniPrimary (citable) accession number: P60566
Secondary accession number(s): P31573
, P75625, P76901, Q8XA29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health