Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P60550 (KGUA_CORDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:DIP1328
OrganismCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis) [Complete proteome] [HAMAP]
Taxonomic identifier257309 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Guanylate kinase HAMAP-Rule MF_00328
PRO_0000170527

Regions

Domain8 – 188181Guanylate kinase-like
Nucleotide binding15 – 228ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P60550 [UniParc].

Last modified March 15, 2004. Version 1.
Checksum: E9FE0FDE14DCA999

FASTA19120,896
        10         20         30         40         50         60 
MSGDNPVGRL VVLAGPSAVG KSTVVHRLRE EIEDLYFSVS MTTRAPRPGE RDGVDYFFVS 

        70         80         90        100        110        120 
PEEFQSKIDA GEMLEWADIH GGLQRSGTPA GPVEAALLAG RPVLVEVDLV GARNVASLKP 

       130        140        150        160        170        180 
ESETVFLAPP SWEVLVERLT GRGTEPEDVI TRRLETAKNE LTAQHEFKHV VVNEDVEKAV 

       190 
SDIKEILVGR R 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248357 Genomic DNA. Translation: CAE49856.1.
RefSeqNP_939681.1. NC_002935.2.

3D structure databases

ProteinModelPortalP60550.
SMRP60550. Positions 7-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257309.DIP1328.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE49856; CAE49856; DIP1328.
GeneID2649882.
KEGGcdi:DIP1328.
PATRIC21483850. VBICorDip47633_1308.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037640.
KOK00942.
OMAGELLEWC.
OrthoDBEOG6CP410.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_CORDI
AccessionPrimary (citable) accession number: P60550
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families