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Protein

Guanylate kinase

Gene

gmk

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:Bd1568
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
ProteomesiUP000008080 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Guanylate kinasePRO_0000170502Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264462.Bd1568.

Structurei

3D structure databases

ProteinModelPortaliP60549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 181179Guanylate kinase-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation
Contains 1 guanylate kinase-like domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTRMIIVAA PSGAGKSSFV ERITREDSRL VDIVTFTTRS IRQGETPGLQ
60 70 80 90 100
YNFIDHADFE QKIKEGFFVE WAKVHTNFYG TSYSSLETAW NQGKTAIMDI
110 120 130 140 150
DIQGVATFKS KFPDAKTVFI HPPSIDELRR RIEKRDGKVP ADIEVRMANA
160 170 180
EKEIREASKF DYQIVNDVFE KSYGEFKKIV EDLLA
Length:185
Mass (Da):21,180
Last modified:March 15, 2004 - v1
Checksum:iF17BF3E8B2E54B9E
GO

Sequence cautioni

The sequence CAE79446.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842650 Genomic DNA. Translation: CAE79446.1. Different initiation.
RefSeqiNP_968453.1. NC_005363.1.

Genome annotation databases

EnsemblBacteriaiCAE79446; CAE79446; Bd1568.
KEGGibba:Bd1568.
PATRICi21077688. VBIBdeBac73187_1420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842650 Genomic DNA. Translation: CAE79446.1. Different initiation.
RefSeqiNP_968453.1. NC_005363.1.

3D structure databases

ProteinModelPortaliP60549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264462.Bd1568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE79446; CAE79446; Bd1568.
KEGGibba:Bd1568.
PATRICi21077688. VBIBdeBac73187_1420.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037638.
KOiK00942.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
    Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
    Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

Entry informationi

Entry nameiKGUA_BDEBA
AccessioniPrimary (citable) accession number: P60549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: May 27, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.