Reviewed,
UniProtKB/Swiss-Prot P60540 (HIS3_BACAN)
Last modified
January 19, 2010.
Version 45.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphoribosyl-AMP cyclohydrolase Short name=PRA-CH EC=3.5.4.19 | ||||
| Gene names |
| ||||
| Organism | Bacillus anthracis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1392 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 101 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021 |
| Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_01021. |
| Sequence similarities | Belongs to the PRA-CH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Histidine biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 101 | 101 | Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021 | PRO_0000136458 | |||
Sequences
References
| [1] | "The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria." Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J. Fraser C.M.Nature 423:81-86(2003) [PubMed: 12721629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames / isolate Porton. |
| [2] | "Bacillus anthracis comparative genomics." Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ames ancestor. |
| [3] | "Complete genome sequence of Bacillus anthracis Sterne." Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sterne. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016879 Genomic DNA. No translation available. AE017334 Genomic DNA. No translation available. AE017225 Genomic DNA. Translation: AAT53642.1. |
| RefSeq | YP_027591.1. |
3D structure databases | |
| SMR | P60540. Positions 2-100. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2850620. |
| GenomeReviews | Gene locus GBAA_1431.1 in contig AE016879_GR. Gene locus BAS1322 in contig AE017225_GR. Gene locus GBAA_1431.1 in contig AE017334_GR. |
| KEGG | bat:BAS1322. |
| TIGR | BA_1431.1. GBAA_1431.1. |
Phylogenomic databases | |
| HOGENOM | HBG294308. |
Enzyme and pathway databases | |
| BioCyc | BANT260799:BAS1322-MONOMER. |
| BRENDA | 3.5.4.19. 267517. |
Family and domain databases | |
| HAMAP | MF_01021. HisI. [Tree] |
| InterPro | IPR002496. PRA_CycHdrlase. [Graphical view] |
| Pfam | PF01502. PRA-CH. 1 hit. [Graphical view] |
| ProDom | PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | HIS3_BACAN | ||||||||
| Accession | Primary (citable) accession number: P60540 Secondary accession number(s): Q6I1E0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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