P60538 (HIS21_RHOPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase 1
Short name=PRA-PH 1
EC=3.6.1.31

Gene names

Name:	hisE1
Ordered Locus Names:	RPA0314

Organism

Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) [Complete proteome] [HAMAP]

Taxonomic identifier

258594 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Phosphoribosyl-ATP pyrophosphatase 1 HAMAP MF_01020		PRO_0000136384

Sequences

	Sequence		Length	Mass (Da)
	P60538 [UniParc]. Last modified March 15, 2004. Version 1. Checksum: E92D2557CFCC8ED2	FASTA	107	11,670
	10 20 30 40 50 60 MARFTLHDLA ATVDARAASG GESSYTKKLL DKGPEHCAKK FGEEAVEMVI AAVENDRGHL 70 80 90 100 ISETADVLFH MLVLLKSRGV KLEEVEAALA QRTSMSGLEE KASRKRD

References

[1]

"Complete genome sequence of the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris." Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L., Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R., Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C., Harrison F.H., Gibson J., Harwood C.S. Nat. Biotechnol. 22:55-61(2004) [PubMed: 14704707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-98 / CGA009.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX572593 Genomic DNA. Translation: CAE25758.1.
RefSeq	NP_945667.1. NC_005296.1.
3D structure databases
ProteinModelPortal	P60538.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2693116.
GenomeReviews	Gene locus RPA0314 in contig BX571963_GR.
KEGG	rpa:RPA0314.
NMPDR	fig|258594.1.peg.311.
PATRIC	23284763. VBIRhoPal84835_0331.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646527.
OMA	ETVMAAK.
ProtClustDB	PRK00400.
Enzyme and pathway databases
BioCyc	RPAL258594:RPA0314-MONOMER.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. [Graphical view]
KO	K01523.
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS21_RHOPA

Accession

Primary (citable) accession number: P60538

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	March 15, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program