Skip Header

Contribute Send feedback
Read comments (?) or add your own

P60523 (HBA_CHRBR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene names
Name:HBA
OrganismChrysocyon brachyurus (Maned wolf)
Taxonomic identifier68728 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Chrysocyon

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxygen transport from the lung to the various peripheral tissues.

Subunit structure

Heterotetramer of two alpha chains and two beta chains.

Tissue specificity

Red blood cells.

Miscellaneous

The sequence shown is one of two non-allelic alpha chains from dog.

Sequence similarities

Belongs to the globin family.

Ontologies

Keywords
   Biological processOxygen transport
Transport
   LigandHeme
Iron
Metal-binding
   PTMAcetylation
   Technical term3D-structure
Gene Ontology (GO)
   Cellular_componenthemoglobin complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionheme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

oxygen binding

Inferred from electronic annotation. Source: InterPro

oxygen transporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 141141Hemoglobin subunit alpha
PRO_0000052601

Sites

Metal binding581Iron (heme distal ligand)
Metal binding871Iron (heme proximal ligand)

Amino acid modifications

Modified residue161N6-acetyllysine By similarity

Secondary structure

1 ................... 141
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P60523 [UniParc].

Last modified March 1, 2004. Version 1.
Checksum: 548EB13A1AEBA3E4

FASTA14115,247
        10         20         30         40         50         60 
VLSPADKTNI KSTWDKIGGH AGDYGGEALD RTFQSFPTTK TYFPHFDLSP GSAQVKAHGK 

        70         80         90        100        110        120 
KVADALTTAV AHLDDLPGAL SALSDLHAYK LRVDPVNFKL LSHCLLVTLA CHHPTEFTPA 

       130        140 
VHASLDKFFT AVSTVLTSKY R

« Hide

References

[1]"Crystal structure of hemoglobin from the maned wolf (Chrysocyon brachyurus) using synchrotron radiation."
Fadel V., Canduri F., Olivieri J.R., Smarra A.L., Colombo M.F., Bonilla-Rodriguez G.O., de Azevedo W.F. Jr.
Protein Pept. Lett. 10:551-559(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FHJX-ray1.80A/C1-141[»]
2B7HX-ray2.20A/C1-141[»]
ProteinModelPortalP60523.
SMRP60523. Positions 1-141.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009709.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR018331. Haemoglobin_alpha_chain.
IPR002339. Haemoglobin_pi.
[Graphical view]
PANTHERPTHR11442:SF14. PTHR11442:SF14. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMSSF46458. Globin_like. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP60523.

Entry information

Entry nameHBA_CHRBR
AccessionPrimary (citable) accession number: P60523
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: March 6, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents