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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Chrysocyon brachyurus (Maned wolf)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

The sequence shown is one of two non-allelic alpha chains from dog.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)1
Metal bindingi87Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiChrysocyon brachyurus (Maned wolf)
Taxonomic identifieri68728 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeChrysocyon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000526011 – 141Hemoglobin subunit alphaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1
Modified residuei7N6-succinyllysineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei11N6-succinyllysineBy similarity1
Modified residuei16N6-acetyllysine; alternateBy similarity1
Modified residuei16N6-succinyllysine; alternateBy similarity1
Modified residuei24PhosphotyrosineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei40N6-succinyllysineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei108PhosphothreonineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Modified residuei134PhosphothreonineBy similarity1
Modified residuei137PhosphothreonineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP60523

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 17Combined sources14
Helixi18 – 20Combined sources3
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi53 – 71Combined sources19
Turni72 – 74Combined sources3
Helixi76 – 89Combined sources14
Helixi96 – 112Combined sources17
Turni114 – 116Combined sources3
Helixi119 – 136Combined sources18
Turni137 – 139Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FHJX-ray1.80A/C1-141[»]
2B7HX-ray2.20A/C1-141[»]
ProteinModelPortaliP60523
SMRiP60523
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60523

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P60523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSPADKTNI KSTWDKIGGH AGDYGGEALD RTFQSFPTTK TYFPHFDLSP
60 70 80 90 100
GSAQVKAHGK KVADALTTAV AHLDDLPGAL SALSDLHAYK LRVDPVNFKL
110 120 130 140
LSHCLLVTLA CHHPTEFTPA VHASLDKFFT AVSTVLTSKY R
Length:141
Mass (Da):15,247
Last modified:March 1, 2004 - v1
Checksum:i548EB13A1AEBA3E4
GO

Similar proteinsi

Entry informationi

Entry nameiHBA_CHRBR
AccessioniPrimary (citable) accession number: P60523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health