P60522 (GBRL2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 2

Alternative name(s):
GABA(A) receptor-associated protein-like 2
Ganglioside expression factor 2
Short name=GEF-2
Golgi-associated ATPase enhancer of 16 kDa
Short name=GATE-16

Gene names

Name:	Gabarapl2
Synonyms:	Gef2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 By similarity.
Subunit structure	Monomer. Interacts with GABRG2, ULK1, NSF, GOSR1 and beta-tubulin By similarity.
Subcellular location	Golgi apparatus By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Gamma-aminobutyric acid receptor-associated protein-like 2		PRO_0000212375
Regions
	Region	1 – 22	22	Interaction with beta-tubulin By similarity
	Region	36 – 68	33	Interaction with GABRG2 Potential
Amino acid modifications
	Modified residue	10	1	Phosphoserine By similarity
	Modified residue	24	1	N6-acetyllysine By similarity
	Modified residue	39	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P60522 [UniParc]. Last modified March 1, 2004. Version 1. Checksum: 17ACB540FD5B975B	FASTA	117	13,667
	10 20 30 40 50 60 MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF 70 80 90 100 110 MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of a cDNA encoding a ganglioside expression factor-2 (GEF-2)." Ogura K. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver and Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB003515 mRNA. Translation: BAA19975.1. BC058145 mRNA. Translation: AAH58145.1. BC088139 mRNA. Translation: AAH88139.1.
IPI	IPI00195649.
RefSeq	NP_073197.1. NM_022706.2. XP_002729993.1. XM_002729947.1.
UniGene	Rn.120952. Rn.64537.
3D structure databases
ProteinModelPortal	P60522.
SMR	P60522. Positions 1-117.
ModBase	Search...
Protein-protein interaction databases
STRING	P60522.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000048998; ENSRNOP00000040067; ENSRNOG00000019425.
GeneID	100359937. 64670.
KEGG	rno:100359937. rno:64670.
UCSC	NM_022706. rat.
Organism-specific databases
CTD	11345.
RGD	620510. Gabarapl2.
Phylogenomic databases
eggNOG	maNOG20050.
GeneTree	ENSGT00390000012937.
HOVERGEN	HBG051706.
InParanoid	P60522.
OrthoDB	EOG4V4394.
PhylomeDB	P60522.
Gene expression databases
ArrayExpress	P60522.
Genevestigator	P60522.
GermOnline	ENSRNOG00000019425. Rattus norvegicus. ENSRNOG00000033345. Rattus norvegicus.
Family and domain databases
InterPro	IPR004241. Atg8_ubiquitin-like. [Graphical view]
KO	K08341.
PANTHER	PTHR10969. MAP1_LC3. 1 hit.
Pfam	PF02991. Atg8. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	613665.

Entry information

Entry name

GBRL2_RAT

Accession

Primary (citable) accession number: P60522
Secondary accession number(s): O08765, Q9DCP8, Q9UQF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program