Reviewed, UniProtKB/Swiss-Prot P60521 (GBRL2_MOUSE)

Names and origin

Protein names

Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 2
Alternative name(s):
    GABA(A) receptor-associated protein-like 2
    Golgi-associated ATPase enhancer of 16 kDa
      Short name=GATE-16

Gene names

Name:

Gabarapl2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 By similarity.
Subunit structure	Monomer. Interacts with GABRG2, ULK1, NSF, GOSR1 and beta-tubulin By similarity.
Subcellular location	Golgi apparatusBy similarity.
Tissue specificity	Ubiquitous. A high level expression is seen in brain, thymus, lung, heart, liver and kidney.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	Golgi membrane Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 117	117	Gamma-aminobutyric acid receptor-associated protein-like 2
Regions
	Region	1 – 22	22	Interaction with beta-tubulin By similarity
	Region	36 – 68	33	Interaction with GABRG2 Potential
Amino acid modifications
	Modified residue	10	1	Phosphoserine By similarity
	Modified residue	39	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	83	1	T → A in BAB22217. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P60521-1 [UniParc]. Last modified March 1, 2004. Version 1. Checksum: 17ACB540FD5B975B	FASTA	117	13,667
	10 20 30 40 50 60 MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF 70 80 90 100 110 MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein." Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S. Genomics 74:408-413(2001) [PubMed: 11414770] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hippocampus and Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Brain and Mammary gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF190644 mRNA. Translation: AAK16238.1. AK002596 mRNA. Translation: BAB22217.1. AK049819 mRNA. Translation: BAC33933.1. BC026798 mRNA. Translation: AAH26798.1. BC081436 mRNA. Translation: AAH81436.1.
RefSeq	NP_080969.2.
UniGene	Mm.371666
3D structure databases
SMR	P60521. Positions 1-117.
ModBase	Search...
PTM databases
PhosphoSite	P60521.
Genome annotation databases
Ensembl	ENSMUSG00000031950. Mus musculus. [Contig view]
GeneID	93739.
KEGG	mmu:93739.
Organism-specific databases
MGI	MGI:1890602. Gabarapl2.
Phylogenomic databases
HOGENOM	P60521.
HOVERGEN	P60521.
Gene expression databases
ArrayExpress	P60521.
GermOnline	ENSMUSG00000031950. Mus musculus.
Family and domain databases
InterPro	IPR004241. MAP1_LC3. [Graphical view]
PANTHER	PTHR10969. MAP1_LC3. 1 hit.
Pfam	PF02991. MAP1_LC3. 1 hit. [Graphical view]
ProDom	P60521. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

GBRL2_MOUSE

Accession

Primary (citable) accession number: P60521
Secondary accession number(s): O08765, Q9DCP8, Q9UQF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	September 2, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)