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P60520

- GBRL2_HUMAN

UniProt

P60520 - GBRL2_HUMAN

Protein

Gamma-aminobutyric acid receptor-associated protein-like 2

Gene

GABARAPL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 By similarity. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.By similarity2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei116 – 1172Cleavage; by ATG4

    GO - Molecular functioni

    1. ATPase binding Source: UniProtKB
    2. beta-tubulin binding Source: UniProtKB
    3. GABA receptor binding Source: UniProtKB
    4. microtubule binding Source: UniProtKB
    5. protein binding Source: UniProtKB
    6. SNARE binding Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB
    2. intra-Golgi vesicle-mediated transport Source: UniProtKB
    3. negative regulation of proteasomal protein catabolic process Source: BHF-UCL
    4. positive regulation of ATPase activity Source: UniProtKB
    5. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 2
    Alternative name(s):
    GABA(A) receptor-associated protein-like 2
    Ganglioside expression factor 2
    Short name:
    GEF-2
    General protein transport factor p16
    Golgi-associated ATPase enhancer of 16 kDa
    Short name:
    GATE-16
    MAP1 light chain 3-related protein
    Gene namesi
    Name:GABARAPL2
    Synonyms:FLC3A, GEF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:13291. GABARAPL2.

    Subcellular locationi

    Golgi apparatus By similarity. Cytoplasmic vesicleautophagosome 5 Publications

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB
    2. autophagic vacuole membrane Source: UniProtKB
    3. cytoplasm Source: BHF-UCL
    4. cytoplasmic vesicle Source: UniProtKB-KW
    5. cytosol Source: UniProtKB
    6. Golgi apparatus Source: UniProtKB
    7. Golgi membrane Source: UniProtKB
    8. intracellular Source: LIFEdb

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi116 – 1161G → A: Impairs localization at the autophagosomal membrane. 1 Publication

    Organism-specific databases

    PharmGKBiPA28482.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116Gamma-aminobutyric acid receptor-associated protein-like 2PRO_0000212373Add
    BLAST
    Propeptidei117 – 1171Removed in mature formPRO_0000423070

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241N6-acetyllysine1 Publication
    Modified residuei39 – 391Phosphoserine1 Publication
    Lipidationi116 – 1161Phosphatidylethanolamine amidated glycine1 Publication

    Post-translational modificationi

    The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.1 Publication
    The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.By similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP60520.
    PaxDbiP60520.
    PRIDEiP60520.

    2D gel databases

    UCD-2DPAGEP60520.

    PTM databases

    PhosphoSiteiP60520.

    Miscellaneous databases

    PMAP-CutDBP60520.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.2 Publications

    Gene expression databases

    ArrayExpressiP60520.
    BgeeiP60520.
    CleanExiHS_GABARAPL2.
    GenevestigatoriP60520.

    Organism-specific databases

    HPAiHPA036726.

    Interactioni

    Subunit structurei

    Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin By similarity. Interacts with ATG3, ATG7, ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3. Interacts with TECPR2 and PCM1.By similarity13 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ANKFY1Q9P2R32EBI-720116,EBI-2513908
    ATG13O751433EBI-720116,EBI-2798775
    ATG16L1Q676U52EBI-720116,EBI-535909
    ATG2AQ2TAZ02EBI-720116,EBI-2514077
    ATG3Q9NT625EBI-720116,EBI-988094
    ATG4BQ9Y4P17EBI-720116,EBI-712014
    ATG7O953527EBI-720116,EBI-987834
    Bnip3lQ9Z2F72EBI-720116,EBI-1774669From a different organism.
    DYX1C1Q8WXU22EBI-720116,EBI-2946907
    EGFRP005332EBI-720116,EBI-297353
    FYCO1Q9BQS82EBI-720116,EBI-2869338
    GBASO753236EBI-720116,EBI-307133
    HADHAP409394EBI-720116,EBI-356720
    IPO5O004105EBI-720116,EBI-356424
    KBTBD6Q86V972EBI-720116,EBI-2514778
    KBTBD7Q8WVZ93EBI-720116,EBI-473695
    NBR1Q1459611EBI-720116,EBI-742698
    NEDD4P469346EBI-720116,EBI-726944
    NEK9Q8TD197EBI-720116,EBI-1044009
    RASSF1Q9NS232EBI-720116,EBI-367363
    RASSF5Q8WWW02EBI-720116,EBI-367390
    RCN2Q142573EBI-720116,EBI-356710
    SQSTM1Q1350112EBI-720116,EBI-307104
    STBD1O952105EBI-720116,EBI-2947137
    STK3Q131882EBI-720116,EBI-992580
    STK4Q130432EBI-720116,EBI-367376
    TBC1D15Q8TC072EBI-720116,EBI-1048247
    TBC1D2BQ9UPU73EBI-720116,EBI-2947180
    TECPR2O150402EBI-720116,EBI-2946991
    UBA5Q9GZZ910EBI-720116,EBI-747805
    ULK1O753853EBI-720116,EBI-908831

    Protein-protein interaction databases

    BioGridi116473. 61 interactions.
    DIPiDIP-35051N.
    IntActiP60520. 494 interactions.
    MINTiMINT-1414121.
    STRINGi9606.ENSP00000037243.

    Structurei

    3D structure databases

    ProteinModelPortaliP60520.
    SMRiP60520. Positions 1-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2222Interaction with beta-tubulinBy similarityAdd
    BLAST
    Regioni36 – 6833Interaction with GABRG2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATG8 family.Curated

    Phylogenomic databases

    eggNOGiNOG249730.
    HOGENOMiHOG000232034.
    HOVERGENiHBG051706.
    InParanoidiP60520.
    KOiK08341.
    OMAiHALEHRC.
    OrthoDBiEOG70KGRK.
    PhylomeDBiP60520.
    TreeFamiTF312964.

    Family and domain databases

    InterProiIPR004241. Atg8_like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10969. PTHR10969. 1 hit.
    PfamiPF02991. Atg8. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P60520-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL    50
    VPSDITVAQF MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD 100
    EDGFLYVAYS GENTFGF 117
    Length:117
    Mass (Da):13,667
    Last modified:March 1, 2004 - v1
    Checksum:i17ACB540FD5B975B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291V → F in AAD27779. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511V → A.
    Corresponds to variant rs11556291 [ dbSNP | Ensembl ].
    VAR_049756

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030710 mRNA. Translation: BAB21548.1.
    AF087848 mRNA. Translation: AAK20400.1.
    AJ010569 mRNA. Translation: CAA09249.1.
    AF077046 mRNA. Translation: AAD27779.1.
    CR542217 mRNA. Translation: CAG47013.1.
    AK289788 mRNA. Translation: BAF82477.1.
    CH471114 Genomic DNA. Translation: EAW95630.1.
    BC005985 mRNA. Translation: AAH05985.1.
    BC014594 mRNA. Translation: AAH14594.1.
    BC029601 mRNA. Translation: AAH29601.1.
    CCDSiCCDS10921.1.
    RefSeqiNP_009216.1. NM_007285.6.
    UniGeneiHs.461379.

    Genome annotation databases

    EnsembliENST00000037243; ENSP00000037243; ENSG00000034713.
    GeneIDi11345.
    KEGGihsa:11345.
    UCSCiuc002fen.3. human.

    Polymorphism databases

    DMDMi44888808.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030710 mRNA. Translation: BAB21548.1 .
    AF087848 mRNA. Translation: AAK20400.1 .
    AJ010569 mRNA. Translation: CAA09249.1 .
    AF077046 mRNA. Translation: AAD27779.1 .
    CR542217 mRNA. Translation: CAG47013.1 .
    AK289788 mRNA. Translation: BAF82477.1 .
    CH471114 Genomic DNA. Translation: EAW95630.1 .
    BC005985 mRNA. Translation: AAH05985.1 .
    BC014594 mRNA. Translation: AAH14594.1 .
    BC029601 mRNA. Translation: AAH29601.1 .
    CCDSi CCDS10921.1.
    RefSeqi NP_009216.1. NM_007285.6.
    UniGenei Hs.461379.

    3D structure databases

    ProteinModelPortali P60520.
    SMRi P60520. Positions 1-117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116473. 61 interactions.
    DIPi DIP-35051N.
    IntActi P60520. 494 interactions.
    MINTi MINT-1414121.
    STRINGi 9606.ENSP00000037243.

    PTM databases

    PhosphoSitei P60520.

    Polymorphism databases

    DMDMi 44888808.

    2D gel databases

    UCD-2DPAGE P60520.

    Proteomic databases

    MaxQBi P60520.
    PaxDbi P60520.
    PRIDEi P60520.

    Protocols and materials databases

    DNASUi 11345.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000037243 ; ENSP00000037243 ; ENSG00000034713 .
    GeneIDi 11345.
    KEGGi hsa:11345.
    UCSCi uc002fen.3. human.

    Organism-specific databases

    CTDi 11345.
    GeneCardsi GC16P075600.
    HGNCi HGNC:13291. GABARAPL2.
    HPAi HPA036726.
    MIMi 607452. gene.
    neXtProti NX_P60520.
    PharmGKBi PA28482.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249730.
    HOGENOMi HOG000232034.
    HOVERGENi HBG051706.
    InParanoidi P60520.
    KOi K08341.
    OMAi HALEHRC.
    OrthoDBi EOG70KGRK.
    PhylomeDBi P60520.
    TreeFami TF312964.

    Miscellaneous databases

    ChiTaRSi GABARAPL2. human.
    GeneWikii GABARAPL2.
    GenomeRNAii 11345.
    NextBioi 43116.
    PMAP-CutDB P60520.
    PROi P60520.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P60520.
    Bgeei P60520.
    CleanExi HS_GABARAPL2.
    Genevestigatori P60520.

    Family and domain databases

    InterProi IPR004241. Atg8_like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10969. PTHR10969. 1 hit.
    Pfami PF02991. Atg8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."
      Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., Koga H., Muramatsu M.-A.
      Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ULK1.
      Tissue: Frontal cortex.
    2. "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein."
      Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S.
      Genomics 74:408-413(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. Storch S., Braulke T.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Human GEF2 homolog gene."
      Song H., Peng Y., Yu Y., Fu G., Mao M., Zhang Q., Zhu H., Li G., Luo M., Chen J., Hu R.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.
    9. "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
      Tanida I., Tanida-Miyake E., Ueno T., Kominami E.
      J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG7.
    10. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
      Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E.
      J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG3.
    11. "GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3."
      Tanida I., Komatsu M., Ueno T., Kominami E.
      Biochem. Biophys. Res. Commun. 300:637-644(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIPIDATION AT GLY-116, INTERACTION WITH ATG3 AND ATG7, SUBCELLULAR LOCATION.
    12. "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation."
      Kabeya Y., Mizushima N., Yamamoto A., Oshitani-Okamoto S., Ohsumi Y., Yoshimori T.
      J. Cell Sci. 117:2805-2812(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-116.
    13. "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
      Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H., Overvatn A., Bjorkoy G., Johansen T.
      J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    15. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TP53INP2.
    16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis."
      Weidberg H., Shvets E., Shpilka T., Shimron F., Shinder V., Elazar Z.
      EMBO J. 29:1792-1802(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    18. "Network organization of the human autophagy system."
      Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
      Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TECPR2.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."
      Itoh T., Kanno E., Uemura T., Waguri S., Fukuda M.
      J. Cell Biol. 192:839-853(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TBC1D25.
    21. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
      Tang Z., Lin M.G., Stowe T.R., Chen S., Zhu M., Stearns T., Franco B., Zhong Q.
      Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION PCM1.
    22. "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
      Seillier M., Peuget S., Gayet O., Gauthier C., N'guessan P., Monte M., Carrier A., Iovanna J.L., Dusetti N.J.
      Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TP53INP1.
    23. "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."
      Alemu E.A., Lamark T., Torgersen K.M., Birgisdottir A.B., Larsen K.B., Jain A., Olsvik H., Overvatn A., Kirkin V., Johansen T.
      J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG13 AND ULK1.
    24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    25. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
      Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
      PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TP53INP1 AND TP53INP2.
    26. "Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."
      Zhu Y., Massen S., Terenzio M., Lang V., Chen-Lindner S., Eils R., Novak I., Dikic I., Hamacher-Brady A., Brady N.R.
      J. Biol. Chem. 288:1099-1113(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BNIP3, FUNCTION.

    Entry informationi

    Entry nameiGBRL2_HUMAN
    AccessioniPrimary (citable) accession number: P60520
    Secondary accession number(s): O08765
    , Q6FG91, Q9DCP8, Q9UQF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3