Reviewed,
UniProtKB/Swiss-Prot P60520 (GBRL2_HUMAN)
Last modified
July 22, 2008.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Gamma-aminobutyric acid receptor-associated protein-like 2 Alternative name(s): GABA(A) receptor-associated protein-like 2 Golgi-associated ATPase enhancer of 16 kDa Short name=GATE-16 General protein transport factor p16 Ganglioside expression factor 2 Short name=GEF-2 MAP1 light chain 3-related protein | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 117 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 By similarity. |
| Subunit structure | Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin By similarity. Interacts with ULK1. |
| Subcellular location | Golgi apparatusBy similarity. |
| Tissue specificity | Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Sequence similarities | Belongs to the MAP1 LC3 family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ATG3 | Q9NT62 | 1 | EBI-720116,EBI-988094 | |
| ATG4B | Q9Y4P1 | 1 | EBI-720116,EBI-712014 | |
| EIF4G1 | Q04637 | 1 | EBI-720116,EBI-73711 | |
| HBG1 | P69891 | 1 | EBI-720116,EBI-1056789 | |
| IRGQ | Q8WZA9 | 1 | EBI-720116,EBI-1055331 | |
| LRPPRC | P42704 | 1 | EBI-720116,EBI-1050853 | |
| NEK9 | Q8TD19 | 1 | EBI-720116,EBI-1044009 | |
| VDAC1 | P21796 | 1 | EBI-720116,EBI-354158 | |
| VIL2 | P15311 | 1 | EBI-720116,EBI-1056902 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 117 | 117 | Gamma-aminobutyric acid receptor-associated protein-like 2 | |||||
Regions | ||||||||
| Region | 1 – 22 | 22 | Interaction with beta-tubulin By similarity | |||||
| Region | 36 – 68 | 33 | Interaction with GABRG2 Potential | |||||
Amino acid modifications | ||||||||
| Modified residue | 10 | 1 | Phosphoserine | |||||
| Modified residue | 39 | 1 | Phosphoserine | |||||
Experimental info | ||||||||
| Sequence conflict | 29 | 1 | V → F in AAD27779. Ref.4 | |||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation." Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., Koga H., Muramatsu M.-A. Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed: 11146101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ULK1. Tissue: Frontal cortex. |
| [2] | "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein." Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S. Genomics 74:408-413(2001) [PubMed: 11414770] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [3] | Storch S., Braulke T. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Human GEF2 homolog gene." Song H., Peng Y., Yu Y., Fu G., Mao M., Zhang Q., Zhu H., Li G., Luo M., Chen J., Hu R. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Testis. |
| [6] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, MASS SPECTROMETRY. |
| [7] | "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AB030710 mRNA. Translation: BAB21548.1. AF087848 mRNA. Translation: AAK20400.1. AJ010569 mRNA. Translation: CAA09249.1. AF077046 mRNA. Translation: AAD27779.1. BC005985 mRNA. Translation: AAH05985.1. BC014594 mRNA. Translation: AAH14594.1. BC029601 mRNA. Translation: AAH29601.1. | |
| RefSeq | NP_009216.1. |
| UniGene | Hs.461379 |
3D structure databases | |
| SMR | P60520. Positions 1-117. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P60520. |
PTM databases | |
| PhosphoSite | P60520. |
Genome annotation databases | |
| Ensembl | ENSG00000034713. Homo sapiens. [Contig view] |
| GeneID | 11345. |
| KEGG | hsa:11345. |
Organism-specific databases | |
| H-InvDB | HIX0013248. |
| HGNC | HGNC:13291. GABARAPL2. |
| MIM | 607452. gene. |
| PharmGKB | PA28482. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P60520. |
| HOVERGEN | P60520. |
Gene expression databases | |
| ArrayExpress | P60520. |
| CleanEx | HS_GABARAPL2. |
| GermOnline | ENSG00000034713. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004241. MAP1_LC3. [Graphical view] |
| PANTHER | PTHR10969. MAP1_LC3. 1 hit. |
| Pfam | PF02991. MAP1_LC3. 1 hit. [Graphical view] |
| ProDom | P60520. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | GBRL2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P60520 Secondary accession number(s): O08765, Q9DCP8, Q9UQF7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


