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P60520

- GBRL2_HUMAN

UniProt

P60520 - GBRL2_HUMAN

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Protein
Gamma-aminobutyric acid receptor-associated protein-like 2
Gene
GABARAPL2, FLC3A, GEF2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 By similarity. Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei116 – 1172Cleavage; by ATG4

GO - Molecular functioni

  1. ATPase binding Source: UniProtKB
  2. GABA receptor binding Source: UniProtKB
  3. SNARE binding Source: UniProtKB
  4. beta-tubulin binding Source: UniProtKB
  5. microtubule binding Source: UniProtKB
  6. phosphatidylethanolamine binding Source: RefGenome
  7. protein binding Source: UniProtKB

GO - Biological processi

  1. CVT pathway Source: RefGenome
  2. autophagic vacuole assembly Source: RefGenome
  3. autophagy Source: UniProtKB
  4. cellular response to nitrogen starvation Source: RefGenome
  5. intra-Golgi vesicle-mediated transport Source: UniProtKB
  6. late nucleophagy Source: RefGenome
  7. mitochondrion degradation Source: RefGenome
  8. negative regulation of proteasomal protein catabolic process Source: BHF-UCL
  9. piecemeal microautophagy of nucleus Source: RefGenome
  10. positive regulation of ATPase activity Source: UniProtKB
  11. protein targeting to vacuole involved in autophagy Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 2
Alternative name(s):
GABA(A) receptor-associated protein-like 2
Ganglioside expression factor 2
Short name:
GEF-2
General protein transport factor p16
Golgi-associated ATPase enhancer of 16 kDa
Short name:
GATE-16
MAP1 light chain 3-related protein
Gene namesi
Synonyms:FLC3A, GEF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:13291. GABARAPL2.

Subcellular locationi

Golgi apparatus By similarity. Cytoplasmic vesicleautophagosome 5 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB
  3. autophagic vacuole Source: UniProtKB
  4. autophagic vacuole membrane Source: UniProtKB
  5. cytoplasm Source: BHF-UCL
  6. cytoplasmic vesicle Source: UniProtKB-KW
  7. cytosol Source: UniProtKB
  8. intracellular Source: LIFEdb
  9. pre-autophagosomal structure Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi116 – 1161G → A: Impairs localization at the autophagosomal membrane. 1 Publication

Organism-specific databases

PharmGKBiPA28482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Gamma-aminobutyric acid receptor-associated protein-like 2
PRO_0000212373Add
BLAST
Propeptidei117 – 1171Removed in mature form
PRO_0000423070

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241N6-acetyllysine1 Publication
Modified residuei39 – 391Phosphoserine1 Publication
Lipidationi116 – 1161Phosphatidylethanolamine amidated glycine1 Publication

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.1 Publication
The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine By similarity.

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiP60520.
PaxDbiP60520.
PRIDEiP60520.

2D gel databases

UCD-2DPAGEP60520.

PTM databases

PhosphoSiteiP60520.

Miscellaneous databases

PMAP-CutDBP60520.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.2 Publications

Gene expression databases

ArrayExpressiP60520.
BgeeiP60520.
CleanExiHS_GABARAPL2.
GenevestigatoriP60520.

Organism-specific databases

HPAiHPA036726.

Interactioni

Subunit structurei

Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin By similarity. Interacts with ATG3, ATG7, ATG13 and ULK1. Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3. Interacts with TECPR2 and PCM1.13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKFY1Q9P2R32EBI-720116,EBI-2513908
ATG13O751433EBI-720116,EBI-2798775
ATG16L1Q676U52EBI-720116,EBI-535909
ATG2AQ2TAZ02EBI-720116,EBI-2514077
ATG3Q9NT625EBI-720116,EBI-988094
ATG4BQ9Y4P17EBI-720116,EBI-712014
ATG7O953527EBI-720116,EBI-987834
Bnip3lQ9Z2F72EBI-720116,EBI-1774669From a different organism.
DYX1C1Q8WXU22EBI-720116,EBI-2946907
EGFRP005332EBI-720116,EBI-297353
FYCO1Q9BQS82EBI-720116,EBI-2869338
GBASO753236EBI-720116,EBI-307133
HADHAP409394EBI-720116,EBI-356720
IPO5O004105EBI-720116,EBI-356424
KBTBD6Q86V972EBI-720116,EBI-2514778
KBTBD7Q8WVZ93EBI-720116,EBI-473695
NBR1Q1459611EBI-720116,EBI-742698
NEDD4P469346EBI-720116,EBI-726944
NEK9Q8TD197EBI-720116,EBI-1044009
RASSF1Q9NS232EBI-720116,EBI-367363
RASSF5Q8WWW02EBI-720116,EBI-367390
RCN2Q142573EBI-720116,EBI-356710
SQSTM1Q1350112EBI-720116,EBI-307104
STBD1O952105EBI-720116,EBI-2947137
STK3Q131882EBI-720116,EBI-992580
STK4Q130432EBI-720116,EBI-367376
TBC1D15Q8TC072EBI-720116,EBI-1048247
TBC1D2BQ9UPU73EBI-720116,EBI-2947180
TECPR2O150402EBI-720116,EBI-2946991
UBA5Q9GZZ910EBI-720116,EBI-747805
ULK1O753853EBI-720116,EBI-908831

Protein-protein interaction databases

BioGridi116473. 61 interactions.
DIPiDIP-35051N.
IntActiP60520. 494 interactions.
MINTiMINT-1414121.
STRINGi9606.ENSP00000037243.

Structurei

3D structure databases

ProteinModelPortaliP60520.
SMRiP60520. Positions 1-117.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2222Interaction with beta-tubulin By similarity
Add
BLAST
Regioni36 – 6833Interaction with GABRG2 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the ATG8 family.

Phylogenomic databases

eggNOGiNOG249730.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiP60520.
KOiK08341.
OMAiHALEHRC.
OrthoDBiEOG70KGRK.
PhylomeDBiP60520.
TreeFamiTF312964.

Family and domain databases

InterProiIPR004241. Atg8_like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiPF02991. Atg8. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60520-1 [UniParc]FASTAAdd to Basket

« Hide

MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL    50
VPSDITVAQF MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD 100
EDGFLYVAYS GENTFGF 117
Length:117
Mass (Da):13,667
Last modified:March 1, 2004 - v1
Checksum:i17ACB540FD5B975B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511V → A.
Corresponds to variant rs11556291 [ dbSNP | Ensembl ].
VAR_049756

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291V → F in AAD27779. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030710 mRNA. Translation: BAB21548.1.
AF087848 mRNA. Translation: AAK20400.1.
AJ010569 mRNA. Translation: CAA09249.1.
AF077046 mRNA. Translation: AAD27779.1.
CR542217 mRNA. Translation: CAG47013.1.
AK289788 mRNA. Translation: BAF82477.1.
CH471114 Genomic DNA. Translation: EAW95630.1.
BC005985 mRNA. Translation: AAH05985.1.
BC014594 mRNA. Translation: AAH14594.1.
BC029601 mRNA. Translation: AAH29601.1.
CCDSiCCDS10921.1.
RefSeqiNP_009216.1. NM_007285.6.
UniGeneiHs.461379.

Genome annotation databases

EnsembliENST00000037243; ENSP00000037243; ENSG00000034713.
GeneIDi11345.
KEGGihsa:11345.
UCSCiuc002fen.3. human.

Polymorphism databases

DMDMi44888808.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030710 mRNA. Translation: BAB21548.1 .
AF087848 mRNA. Translation: AAK20400.1 .
AJ010569 mRNA. Translation: CAA09249.1 .
AF077046 mRNA. Translation: AAD27779.1 .
CR542217 mRNA. Translation: CAG47013.1 .
AK289788 mRNA. Translation: BAF82477.1 .
CH471114 Genomic DNA. Translation: EAW95630.1 .
BC005985 mRNA. Translation: AAH05985.1 .
BC014594 mRNA. Translation: AAH14594.1 .
BC029601 mRNA. Translation: AAH29601.1 .
CCDSi CCDS10921.1.
RefSeqi NP_009216.1. NM_007285.6.
UniGenei Hs.461379.

3D structure databases

ProteinModelPortali P60520.
SMRi P60520. Positions 1-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116473. 61 interactions.
DIPi DIP-35051N.
IntActi P60520. 494 interactions.
MINTi MINT-1414121.
STRINGi 9606.ENSP00000037243.

PTM databases

PhosphoSitei P60520.

Polymorphism databases

DMDMi 44888808.

2D gel databases

UCD-2DPAGE P60520.

Proteomic databases

MaxQBi P60520.
PaxDbi P60520.
PRIDEi P60520.

Protocols and materials databases

DNASUi 11345.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000037243 ; ENSP00000037243 ; ENSG00000034713 .
GeneIDi 11345.
KEGGi hsa:11345.
UCSCi uc002fen.3. human.

Organism-specific databases

CTDi 11345.
GeneCardsi GC16P075600.
HGNCi HGNC:13291. GABARAPL2.
HPAi HPA036726.
MIMi 607452. gene.
neXtProti NX_P60520.
PharmGKBi PA28482.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249730.
HOGENOMi HOG000232034.
HOVERGENi HBG051706.
InParanoidi P60520.
KOi K08341.
OMAi HALEHRC.
OrthoDBi EOG70KGRK.
PhylomeDBi P60520.
TreeFami TF312964.

Miscellaneous databases

ChiTaRSi GABARAPL2. human.
GeneWikii GABARAPL2.
GenomeRNAii 11345.
NextBioi 43116.
PMAP-CutDB P60520.
PROi P60520.
SOURCEi Search...

Gene expression databases

ArrayExpressi P60520.
Bgeei P60520.
CleanExi HS_GABARAPL2.
Genevestigatori P60520.

Family and domain databases

InterProi IPR004241. Atg8_like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10969. PTHR10969. 1 hit.
Pfami PF02991. Atg8. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."
    Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., Koga H., Muramatsu M.-A.
    Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ULK1.
    Tissue: Frontal cortex.
  2. "Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein."
    Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S.
    Genomics 74:408-413(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. Storch S., Braulke T.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Human GEF2 homolog gene."
    Song H., Peng Y., Yu Y., Fu G., Mao M., Zhang Q., Zhu H., Li G., Luo M., Chen J., Hu R.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  9. "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
    Tanida I., Tanida-Miyake E., Ueno T., Kominami E.
    J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG7.
  10. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
    Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E.
    J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG3.
  11. "GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3."
    Tanida I., Komatsu M., Ueno T., Kominami E.
    Biochem. Biophys. Res. Commun. 300:637-644(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIPIDATION AT GLY-116, INTERACTION WITH ATG3 AND ATG7, SUBCELLULAR LOCATION.
  12. "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation."
    Kabeya Y., Mizushima N., Yamamoto A., Oshitani-Okamoto S., Ohsumi Y., Yoshimori T.
    J. Cell Sci. 117:2805-2812(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-116.
  13. "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
    Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H., Overvatn A., Bjorkoy G., Johansen T.
    J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  15. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TP53INP2.
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis."
    Weidberg H., Shvets E., Shpilka T., Shimron F., Shinder V., Elazar Z.
    EMBO J. 29:1792-1802(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  18. "Network organization of the human autophagy system."
    Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
    Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TECPR2.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."
    Itoh T., Kanno E., Uemura T., Waguri S., Fukuda M.
    J. Cell Biol. 192:839-853(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TBC1D25.
  21. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
    Tang Z., Lin M.G., Stowe T.R., Chen S., Zhu M., Stearns T., Franco B., Zhong Q.
    Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION PCM1.
  22. "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
    Seillier M., Peuget S., Gayet O., Gauthier C., N'guessan P., Monte M., Carrier A., Iovanna J.L., Dusetti N.J.
    Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53INP1.
  23. "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."
    Alemu E.A., Lamark T., Torgersen K.M., Birgisdottir A.B., Larsen K.B., Jain A., Olsvik H., Overvatn A., Kirkin V., Johansen T.
    J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG13 AND ULK1.
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  25. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
    Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
    PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53INP1 AND TP53INP2.
  26. "Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."
    Zhu Y., Massen S., Terenzio M., Lang V., Chen-Lindner S., Eils R., Novak I., Dikic I., Hamacher-Brady A., Brady N.R.
    J. Biol. Chem. 288:1099-1113(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BNIP3, FUNCTION.

Entry informationi

Entry nameiGBRL2_HUMAN
AccessioniPrimary (citable) accession number: P60520
Secondary accession number(s): O08765
, Q6FG91, Q9DCP8, Q9UQF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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