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Reviewed, UniProtKB/Swiss-Prot P60520 (GBRL2_HUMAN)

Last modified November 3, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Gamma-aminobutyric acid receptor-associated protein-like 2
Alternative name(s):
    GABA(A) receptor-associated protein-like 2
    Golgi-associated ATPase enhancer of 16 kDa
      Short name=GATE-16
    General protein transport factor p16
    Ganglioside expression factor 2
      Short name=GEF-2
    MAP1 light chain 3-related protein
Gene names
Name: GABARAPL2
Synonyms: FLC3A, GEF2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 By similarity.

Subunit structure

Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin By similarity. Interacts with ULK1.

Subcellular location

Golgi apparatus By similarity.

Tissue specificity

Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. Ref.1 Ref.2

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.6 Ref.7

Sequence similarities

Belongs to the MAP1 LC3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 117117Gamma-aminobutyric acid receptor-associated protein-like 2
PRO_0000212373

Regions

Region1 – 2222Interaction with beta-tubulin By similarity
Region36 – 6833Interaction with GABRG2 Potential

Amino acid modifications

Modified residue101Phosphoserine Ref.6
Modified residue241N6-acetyllysine Ref.9
Modified residue391Phosphoserine Ref.7

Natural variations

Natural variant511V → A: dbSNP rs11556291.
VAR_049756

Experimental info

Sequence conflict291V → F in AAD27779. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P60520-1 [UniParc].

Last modified March 1, 2004. Version 1.
Checksum: 17ACB540FD5B975B

FASTA11713,667
        10         20         30         40         50         60 
MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF 

        70         80         90        100        110 
MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF 

« Hide

References

« Hide 'large scale' references
[1]"Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation."
Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., Koga H., Muramatsu M.-A.
Brain Res. Mol. Brain Res. 85:1-12(2000) [PubMed: 11146101] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ULK1.
Tissue: Frontal cortex.
[2]"Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein."
Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R., Zhao S.
Genomics 74:408-413(2001) [PubMed: 11414770] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[3]Storch S., Braulke T.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Human GEF2 homolog gene."
Song H., Peng Y., Yu Y., Fu G., Mao M., Zhang Q., Zhu H., Li G., Luo M., Chen J., Hu R.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pituitary.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[6]"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry."
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, MASS SPECTROMETRY.
[7]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, MASS SPECTROMETRY.
[8]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-24, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AB030710 mRNA. Translation: BAB21548.1.
AF087848 mRNA. Translation: AAK20400.1.
AJ010569 mRNA. Translation: CAA09249.1.
AF077046 mRNA. Translation: AAD27779.1.
BC005985 mRNA. Translation: AAH05985.1.
BC014594 mRNA. Translation: AAH14594.1.
BC029601 mRNA. Translation: AAH29601.1.
IPIIPI00026358.
RefSeqNP_009216.1.
UniGeneHs.461379

3D structure databases

SMRP60520. Positions 1-117.
ModBaseSearch...

Protein-protein interaction databases

IntActP60520. 56 interactions.
STRINGP60520.

PTM databases

PhosphoSiteP60520.

Proteomic databases

PRIDEP60520.

Genome annotation databases

EnsemblENST00000037243; ENSP00000037243; ENSG00000034713; Homo sapiens. [Genome view]
GeneID11345.
KEGGhsa:11345.
UCSCuc002fen.1. human.

Organism-specific databases

CTD11345.
GeneCardsGC16P074157.
H-InvDBHIX0013248.
HGNCHGNC:13291. GABARAPL2.
MIM607452. gene.
PharmGKBPA28482.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP60520.
HOVERGENP60520.
OMAVICEKVE.

Gene expression databases

ArrayExpressP60520.
BgeeP60520.
CleanExHS_GABARAPL2.
GenevestigatorP60520.
GermOnlineENSG00000034713. Homo sapiens.

Family and domain databases

InterProIPR004241. MAP1_LC3.
[Graphical view]
PANTHERPTHR10969. MAP1_LC3. 1 hit.
PfamPF02991. MAP1_LC3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio43116.
PMAP-CutDBP60520.
SOURCESearch...

Entry information

Entry nameGBRL2_HUMAN
AccessionPrimary (citable) accession number: P60520
Secondary accession number(s): O08765, Q9DCP8, Q9UQF7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents