Gamma-aminobutyric acid receptor-associated protein-like 2

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P60519 (GBRL2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 64. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 2

Alternative name(s):
GABA(A) receptor-associated protein-like 2
Ganglioside expression factor 2
Short name=GEF-2
General protein transport factor p16
Golgi-associated ATPase enhancer of 16 kDa
Short name=GATE-16
MAP1 light chain 3-related protein

Gene names

Name:	GABARAPL2
Synonyms:	GEF2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Ref.1
Subunit structure	Interacts with GABRG2, ULK1 and beta-tubulin By similarity. Monomer. Interacts with NSF and GOSR1. Ref.1 Ref.5
Subcellular location	Golgi apparatus Ref.1.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	intra-Golgi vesicle-mediated transport Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of ATPase activity Inferred from direct assay Ref.1. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi membrane Inferred from direct assay Ref.1. Source: UniProtKB cytosol Inferred from direct assay. Source: UniProtKB
Molecular function	ATPase binding Inferred from direct assay Ref.1. Source: UniProtKB SNARE binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 117

117

Gamma-aminobutyric acid receptor-associated protein-like 2

PRO_0000212372

Regions

Region

1 – 22

Interaction with beta-tubulin By similarity

Region

36 – 68

Interaction with GABRG2 Potential

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

Phosphoserine By similarity

Secondary structure

117

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P60519 [UniParc].

Last modified March 1, 2004. Version 1.
Checksum: 17ACB540FD5B975B
Show »

FASTA

117

13,667

        10         20         30         40         50         60 
MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF 

        70         80         90        100        110 
MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28." Sagiv Y., Legesse-Miller A., Porat A., Elazar Z. EMBO J. 19:1494-1504(2000) [PubMed: 10747018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-47; 55-65; 69-74 AND 107-116, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NSF AND GOSR1. Tissue: Brain.
[2]	"Cellular sequences in pestivirus genomes encoding gamma-aminobutyric acid (A) receptor-associated protein and Golgi-associated ATPase enhancer of 16 kilodaltons." Becher P., Thiel H.-J., Collins M., Brownlie J., Orlich M. J. Virol. 76:13069-13076(2002) [PubMed: 12438634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[3]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.
[5]	"Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p." Paz Y., Elazar Z., Fass D. J. Biol. Chem. 275:25445-25450(2000) [PubMed: 10856287] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF020262 mRNA. Translation: AAD20720.1.
AY117147 mRNA. Translation: AAM77036.1.
BT020958 mRNA. Translation: AAX08975.1.
BC102902 mRNA. Translation: AAI02903.2.

IPI

IPI00715504.

RefSeq

NP_777100.1. NM_174675.2.

UniGene

Bt.41007.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EO6	X-ray	1.80	A/B	1-117	[»]

ProteinModelPortal

P60519.

SMR

P60519. Positions 1-117.

ModBase

Search...

Protein-protein interaction databases

STRING

P60519.

Proteomic databases

PRIDE

P60519.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

282531.

KEGG

bta:282531.

Organism-specific databases

CTD

11345.

Phylogenomic databases

eggNOG

maNOG20050.

GeneTree

ENSGT00390000012937.

HOVERGEN

HBG051706.

InParanoid

P60519.

OrthoDB

EOG4V4394.

PhylomeDB

P60519.

Family and domain databases

InterPro

IPR004241. Atg8_ubiquitin-like.
[Graphical view]

K08341.

PANTHER

PTHR10969. MAP1_LC3. 1 hit.

Pfam

PF02991. Atg8. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

GBRL2_BOVIN

Accession

Primary (citable) accession number: P60519
Secondary accession number(s): O08765

Q9UQF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents