Reviewed,
UniProtKB/Swiss-Prot P60519 (GBRL2_BOVIN)
Last modified
June 16, 2009.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Gamma-aminobutyric acid receptor-associated protein-like 2 Alternative name(s): GABA(A) receptor-associated protein-like 2 Golgi-associated ATPase enhancer of 16 kDa Short name=GATE-16 General protein transport factor p16 Ganglioside expression factor 2 Short name=GEF-2 MAP1 light chain 3-related protein | ||||
| Gene names |
| ||||
| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 117 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. Ref.1 |
| Subunit structure | Interacts with GABRG2, ULK1 and beta-tubulin By similarity. Monomer. Interacts with NSF and GOSR1. |
| Subcellular location | |
| Post-translational modification | Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. |
| Sequence similarities | Belongs to the MAP1 LC3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Golgi apparatus |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | intra-Golgi vesicle-mediated transport Ref.1 Inferred from direct assay. Source: UniProtKB positive regulation of ATPase activity Ref.1Inferred from direct assay. Source: UniProtKB protein transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | Golgi membrane Ref.1 Inferred from direct assay. Source: UniProtKB cytosolInferred from direct assay. Source: UniProtKB |
| Molecular function | ATPase binding Ref.1 Inferred from direct assay. Source: UniProtKB SNARE binding Ref.1Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 117 | 117 | Gamma-aminobutyric acid receptor-associated protein-like 2 | PRO_0000212372 | |||||||||||||||||||||
Regions | |||||||||||||||||||||||||
| Region | 1 – 22 | 22 | Interaction with beta-tubulin By similarity | ||||||||||||||||||||||
| Region | 36 – 68 | 33 | Interaction with GABRG2 Potential | ||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||
| Modified residue | 10 | 1 | Phosphoserine By similarity | ||||||||||||||||||||||
| Modified residue | 39 | 1 | Phosphoserine By similarity | ||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||
| Helix | 4 – 8 | 5 | |||||||||||||||||||||||
| Helix | 11 – 24 | 14 | |||||||||||||||||||||||
| Beta strand | 28 – 35 | 8 | |||||||||||||||||||||||
| Beta strand | 48 – 52 | 5 | |||||||||||||||||||||||
| Helix | 57 – 68 | 12 | |||||||||||||||||||||||
| Beta strand | 77 – 80 | 4 | |||||||||||||||||||||||
| Helix | 91 – 98 | 8 | |||||||||||||||||||||||
| Beta strand | 105 – 110 | 6 | |||||||||||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28." Sagiv Y., Legesse-Miller A., Porat A., Elazar Z. EMBO J. 19:1494-1504(2000) [PubMed: 10747018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-47; 55-65; 69-74 AND 107-116, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NSF AND GOSR1. Tissue: Brain. |
| [2] | "Cellular sequences in pestivirus genomes encoding gamma-aminobutyric acid (A) receptor-associated protein and Golgi-associated ATPase enhancer of 16 kilodaltons." Becher P., Thiel H.-J., Collins M., Brownlie J., Orlich M. J. Virol. 76:13069-13076(2002) [PubMed: 12438634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney. |
| [3] | "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus. |
| [5] | "Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p." Paz Y., Elazar Z., Fass D. J. Biol. Chem. 275:25445-25450(2000) [PubMed: 10856287] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF020262 mRNA. Translation: AAD20720.1. AY117147 mRNA. Translation: AAM77036.1. BT020958 mRNA. Translation: AAX08975.1. BC102902 mRNA. Translation: AAI02903.2. | |||||||||||||
| IPI | IPI00715504. | ||||||||||||
| RefSeq | NP_777100.1. | ||||||||||||
| UniGene | Bt.41007 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSBTAG00000006550. Bos taurus. [Contig view] | ||||||||||||
| GeneID | 282531. | ||||||||||||
| KEGG | bta:282531. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOVERGEN | P60519. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR004241. MAP1_LC3. [Graphical view] | ||||||||||||
| PANTHER | PTHR10969. MAP1_LC3. 1 hit. | ||||||||||||
| Pfam | PF02991. MAP1_LC3. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Entry information
| Entry name | GBRL2_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P60519 Secondary accession number(s): O08765 Q9UQF7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


