Gamma-aminobutyric acid receptor-associated protein

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Reviewed, UniProtKB/Swiss-Prot P60517 (GBRAP_RAT)

Last modified January 19, 2010. Version 60. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor-associated protein
Alternative name(s):
GABA(A) receptor-associated protein

Gene names

Name:

Gabarap

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Ref.4
Subunit structure	Interacts with GABRG2, TUBA1 and ULK1 By similarity. Interacts with beta-tubulin, GPHN and NSF. Ref.4 Ref.1 Ref.3
Subcellular location	Endomembrane system. Cytoplasm › cytoskeleton. Golgi apparatus membrane. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules. Ref.4 Ref.1
Tissue specificity	Can be found in both somatodendritic and axonal compartment of neurons. Ref.4
Sequence similarities	Belongs to the MAP1 LC3 family.

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Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus Membrane Microtubule
Technical term	3D-structure
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
Nsf	Q9QUL6	1	EBI-925812,EBI-925794

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 117

117

Gamma-aminobutyric acid receptor-associated protein

PRO_0000212366

Regions

Region

1 – 22

Interaction with beta-tubulin

Region

36 – 117

Interaction with GPHN

Region

36 – 68

Interaction with GABRG2 Potential

Secondary structure

117

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P60517-1 [UniParc].

Last modified March 1, 2004. Version 1.
Checksum: BC0B84B8A51C1E32
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FASTA

117

13,918

        10         20         30         40         50         60 
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction." Wang H., Olsen R.W. J. Neurochem. 75:644-655(2000) [PubMed: 10899939] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH BETA-TUBULIN.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse." Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Waessle H., Olsen R.W., Betz H. Proc. Natl. Acad. Sci. U.S.A. 97:8594-8599(2000) [PubMed: 10900017] [Abstract] Cited for: INTERACTION WITH GPHN.
[4]	"The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors." Kittler J.T., Rostaing P., Schiavo G., Fritschy J.-M., Olsen R., Triller A., Moss S.J. Mol. Cell. Neurosci. 18:13-25(2001) [PubMed: 11461150] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NSF.
[5]	"Crystal structure of the GABA(A)-receptor-associated protein, GABARAP." Bavro V.N., Sola M., Bracher A., Kneussel M., Betz H., Weissenhorn W. EMBO Rep. 3:183-189(2002) [PubMed: 11818336] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF161588 mRNA. Translation: AAD47643.1.
BC058441 mRNA. Translation: AAH58441.1.

IPI

IPI00210522.

RefSeq

NP_742033.1.

UniGene

Rn.8411

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KJT	X-ray	2.00	A	1-117	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

P60517. 1 interaction.

STRING

P60517.

Genome annotation databases

Ensembl

ENSRNOT00000023724; ENSRNOP00000023724; ENSRNOG00000017417; Rattus norvegicus. [Genome view]

GeneID

58974.

KEGG

rno:58974.

UCSC

NM_172036. rat.

Organism-specific databases

CTD

58974.

RGD

61911. Gabarap.

Phylogenomic databases

eggNOG

maNOG19744.

HOVERGEN

P60517.

InParanoid

P60517.

OMA

TTMGQLY.

PhylomeDB

P60517.

Gene expression databases

ArrayExpress

P60517.

Genevestigator

P60517.

GermOnline

ENSRNOG00000017417. Rattus norvegicus.

Family and domain databases

InterPro

IPR004241. MAP1_LC3.
[Graphical view]

PANTHER

PTHR10969. MAP1_LC3. 1 hit.

Pfam

PF02991. MAP1_LC3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

611644.

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Entry information

Entry name

GBRAP_RAT

Accession

Primary (citable) accession number: P60517
Secondary accession number(s): Q9QUI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	January 19, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents