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Protein

Pi-theraphotoxin-Pc1a

Gene
N/A
Organism
Psalmopoeus cambridgei (Trinidad chevron tarantula)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potently and selectively blocks the acid-sensing ion channel ASIC1a/ACCN2. The blockade is rapid and reversible. Psalmotoxin 1 loses its capacity to block ASIC1a/ACCN2 as soon as this subunit is associated with another member of the family (ASIC2a/ACCN1 or ASIC3/ACCN3). The toxin can distinguish between the two ASIC1/ACCN2 splice variants ASIC1a/ACCN2 and ASIC1b/ACCN2.1 Publication

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Protein family/group databases

TCDBi8.B.10.1.1. the psalmotoxin-1 (pctx1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Pi-theraphotoxin-Pc1a
Short name:
Pi-TRTX-Pc1a
Alternative name(s):
PcTx1
Psalmotoxin-1
OrganismiPsalmopoeus cambridgei (Trinidad chevron tarantula)
Taxonomic identifieri179874 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaePsalmopoeus

Organism-specific databases

ArachnoServeriAS000400. pi-theraphotoxin-Pc1a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449651 – 40Pi-theraphotoxin-Pc1aAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 181 Publication
Disulfide bondi10 ↔ 231 Publication
Disulfide bondi17 ↔ 331 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

DIPiDIP-59909N.

Structurei

Secondary structure

140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Beta strandi6 – 8Combined sources3
Turni11 – 14Combined sources4
Beta strandi18 – 20Combined sources3
Beta strandi21 – 24Combined sources4
Beta strandi27 – 29Combined sources3
Beta strandi32 – 35Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LMMNMR-A1-40[»]
2KNINMR-A1-40[»]
3S3XX-ray2.99D/E/F2-38[»]
4FZ0X-ray2.80M/N/O1-40[»]
4FZ1X-ray3.36D1-40[»]
ProteinModelPortaliP60514.
SMRiP60514.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60514.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords - Domaini

Knottin

Sequencei

Sequence statusi: Complete.

P60514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
EDCIPKWKGC VNRHGDCCEG LECWKRRRSF EVCVPKTPKT
Length:40
Mass (Da):4,695
Last modified:March 1, 2004 - v1
Checksum:iA52DC98962D9598C
GO

Mass spectrometryi

Molecular mass is 4689.25 Da from positions 1 - 40. Determined by MALDI. 1 Publication
Molecular mass is 4690 Da from positions 1 - 40. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LMMNMR-A1-40[»]
2KNINMR-A1-40[»]
3S3XX-ray2.99D/E/F2-38[»]
4FZ0X-ray2.80M/N/O1-40[»]
4FZ1X-ray3.36D1-40[»]
ProteinModelPortaliP60514.
SMRiP60514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59909N.

Protein family/group databases

TCDBi8.B.10.1.1. the psalmotoxin-1 (pctx1) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000400. pi-theraphotoxin-Pc1a.

Miscellaneous databases

EvolutionaryTraceiP60514.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTXP1_PSACA
AccessioniPrimary (citable) accession number: P60514
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.