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P60492

- RL21_THET8

UniProt

P60492 - RL21_THET8

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Protein

50S ribosomal protein L21

Gene

rplU

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein binds to 23S rRNA in the presence of protein L20 (By similarity). Found on the solvent side of the large subunit.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1825-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L21UniRule annotation
Gene namesi
Name:rplUUniRule annotation
Ordered Locus Names:TTHA1783
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10110150S ribosomal protein L21PRO_0000181018Add
BLAST

Interactioni

Subunit structurei

Contacts protein L20 (By similarity). Part of the 50S ribosomal subunit.By similarity

Protein-protein interaction databases

STRINGi300852.TTHA1783.

Structurei

Secondary structure

1
101
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Beta strandi10 – 145Combined sources
Beta strandi19 – 235Combined sources
Beta strandi29 – 313Combined sources
Beta strandi32 – 354Combined sources
Beta strandi37 – 448Combined sources
Beta strandi49 – 513Combined sources
Helixi52 – 543Combined sources
Beta strandi57 – 6610Combined sources
Beta strandi70 – 767Combined sources
Turni77 – 804Combined sources
Beta strandi81 – 877Combined sources
Beta strandi90 – 9910Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VVMX-ray3.22V1-101[»]
1VVOX-ray3.22V1-101[»]
1VVQX-ray3.90V1-101[»]
1VVSX-ray3.90V1-101[»]
1VVUX-ray3.90V1-101[»]
1VVWX-ray3.90V1-101[»]
1VVYX-ray3.92V1-101[»]
1VW0X-ray3.92V1-101[»]
1VX9X-ray2.94V1-101[»]
1VXJX-ray2.94V1-101[»]
1VXLX-ray3.48V1-101[»]
1VXNX-ray3.48V1-101[»]
1VXQX-ray3.14V1-101[»]
1VXTX-ray3.14V1-101[»]
1VY1X-ray3.68V1-101[»]
1VY3X-ray3.68V1-101[»]
1YL3X-ray5.5021-101[»]
2HGJX-ray5.00U1-101[»]
2HGQX-ray5.50U1-101[»]
2HGUX-ray4.51U1-101[»]
2J01X-ray2.80V1-101[»]
2J03X-ray2.80V1-101[»]
2V47X-ray3.80V1-101[»]
2V49X-ray3.80V1-101[»]
2WDIX-ray3.30V1-101[»]
2WDJX-ray3.30V1-101[»]
2WDLX-ray3.50V1-101[»]
2WDNX-ray3.50V1-101[»]
2WH2X-ray3.45V1-101[»]
2WH4X-ray3.45V1-101[»]
2WRJX-ray3.60V1-101[»]
2WRLX-ray3.60V1-101[»]
2WROX-ray3.60V1-101[»]
2WRRX-ray3.60V1-101[»]
2X9SX-ray3.10V1-101[»]
2X9UX-ray3.10V1-101[»]
2XG0X-ray3.20V1-101[»]
2XG2X-ray3.20V1-101[»]
2XQEX-ray3.10V1-101[»]
2XTGelectron microscopy7.80V1-101[»]
2XUXelectron microscopy7.60V1-101[»]
2Y0VX-ray3.10V1-101[»]
2Y0XX-ray3.10V1-101[»]
2Y0ZX-ray3.10V1-101[»]
2Y11X-ray3.10V1-101[»]
2Y13X-ray3.10V1-101[»]
2Y15X-ray3.10V1-101[»]
2Y17X-ray3.10V1-101[»]
2Y19X-ray3.10V1-101[»]
3FINelectron microscopy6.40V1-101[»]
3HUXX-ray3.10V1-101[»]
3HUZX-ray3.10V1-101[»]
3I8FX-ray3.1021-101[»]
3I8IX-ray3.1021-101[»]
3I9CX-ray3.5021-101[»]
3I9EX-ray3.5021-101[»]
3KIRX-ray3.30V1-101[»]
3KITX-ray3.30V1-101[»]
3KIWX-ray3.60V1-101[»]
3KIYX-ray3.60V1-101[»]
3KNIX-ray3.00V1-101[»]
3KNKX-ray3.00V1-101[»]
3KNMX-ray3.45V1-101[»]
3KNOX-ray3.45V1-101[»]
3TVEX-ray3.1021-101[»]
3TVHX-ray3.1021-101[»]
3UXQX-ray3.20V1-101[»]
3UXRX-ray3.20V1-101[»]
3UYEX-ray3.0021-101[»]
3UYGX-ray3.0021-101[»]
3UZ1X-ray3.3021-101[»]
3UZ2X-ray3.3021-101[»]
3UZ8X-ray3.0021-101[»]
3UZ9X-ray3.0021-101[»]
3UZFX-ray3.3021-101[»]
3UZHX-ray3.3021-101[»]
3UZKX-ray3.3021-101[»]
3UZNX-ray3.3021-101[»]
3V23X-ray3.00V1-101[»]
3V25X-ray3.00V1-101[»]
3V27X-ray3.10V1-101[»]
3V29X-ray3.10V1-101[»]
3V2DX-ray2.70V1-101[»]
3V2FX-ray2.70V1-101[»]
3V6WX-ray3.90V1-101[»]
3V6XX-ray3.90V1-101[»]
3ZN9X-ray3.10V1-101[»]
3ZNEX-ray3.10V1-101[»]
3ZVPX-ray3.80V1-101[»]
4ABSX-ray3.10V1-101[»]
4B8GX-ray3.70V1-101[»]
4B8IX-ray3.70V1-101[»]
4BTDX-ray2.95V1-101[»]
4BYCX-ray3.35V1-101[»]
4BYEX-ray3.35V1-101[»]
4DHAX-ray3.20V1-101[»]
4DHCX-ray3.20V1-101[»]
4EJBX-ray3.52V1-101[»]
4EJCX-ray3.52V1-101[»]
4G5LX-ray3.3021-101[»]
4G5NX-ray3.3021-101[»]
4G5UX-ray3.1021-101[»]
4G5WX-ray3.1021-101[»]
4JUXX-ray2.86V1-101[»]
4K0MX-ray3.30V1-101[»]
4K0QX-ray3.30V1-101[»]
4KX0X-ray3.44V1-101[»]
4KX2X-ray3.44V1-101[»]
4NVVX-ray3.00V1-101[»]
4NVXX-ray3.00V1-101[»]
4NVZX-ray3.10V1-101[»]
4NW1X-ray3.10V1-101[»]
4QCNX-ray2.60V1-101[»]
4QCPX-ray2.60V1-101[»]
4QCRX-ray2.55V1-101[»]
4QCTX-ray2.55V1-101[»]
4QCVX-ray2.90V1-101[»]
4QCXX-ray2.90V1-101[»]
4QCZX-ray2.80V1-101[»]
4QD1X-ray2.80V1-101[»]
ProteinModelPortaliP60492.
SMRiP60492. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60492.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L21P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0261.
HOGENOMiHOG000036265.
KOiK02888.
OMAiQGRGDKV.
OrthoDBiEOG6TJ84X.
PhylomeDBiP60492.

Family and domain databases

HAMAPiMF_01363. Ribosomal_L21.
InterProiIPR028909. L21p-like.
IPR001787. Ribosomal_L21.
[Graphical view]
PfamiPF00829. Ribosomal_L21p. 1 hit.
[Graphical view]
SUPFAMiSSF141091. SSF141091. 1 hit.
TIGRFAMsiTIGR00061. L21. 1 hit.

Sequencei

Sequence statusi: Complete.

P60492-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAIVKTGGK QYRVEPGLKL RVEKLDAEPG ATVELPVLLL GGEKTVVGTP
60 70 80 90 100
VVEGASVVAE VLGHGRGKKI LVSKFKAKVQ YRRKKGHRQP YTELLIKEIR

G
Length:101
Mass (Da):11,047
Last modified:March 29, 2005 - v2
Checksum:i3117549029950A0C
GO

Mass spectrometryi

Molecular mass is 11048 Da from positions 1 - 101. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71606.1.
RefSeqiYP_145049.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71606; BAD71606; BAD71606.
GeneIDi3169471.
KEGGittj:TTHA1783.
PATRICi23958527. VBITheThe93045_1753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71606.1 .
RefSeqi YP_145049.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VVM X-ray 3.22 V 1-101 [» ]
1VVO X-ray 3.22 V 1-101 [» ]
1VVQ X-ray 3.90 V 1-101 [» ]
1VVS X-ray 3.90 V 1-101 [» ]
1VVU X-ray 3.90 V 1-101 [» ]
1VVW X-ray 3.90 V 1-101 [» ]
1VVY X-ray 3.92 V 1-101 [» ]
1VW0 X-ray 3.92 V 1-101 [» ]
1VX9 X-ray 2.94 V 1-101 [» ]
1VXJ X-ray 2.94 V 1-101 [» ]
1VXL X-ray 3.48 V 1-101 [» ]
1VXN X-ray 3.48 V 1-101 [» ]
1VXQ X-ray 3.14 V 1-101 [» ]
1VXT X-ray 3.14 V 1-101 [» ]
1VY1 X-ray 3.68 V 1-101 [» ]
1VY3 X-ray 3.68 V 1-101 [» ]
1YL3 X-ray 5.50 2 1-101 [» ]
2HGJ X-ray 5.00 U 1-101 [» ]
2HGQ X-ray 5.50 U 1-101 [» ]
2HGU X-ray 4.51 U 1-101 [» ]
2J01 X-ray 2.80 V 1-101 [» ]
2J03 X-ray 2.80 V 1-101 [» ]
2V47 X-ray 3.80 V 1-101 [» ]
2V49 X-ray 3.80 V 1-101 [» ]
2WDI X-ray 3.30 V 1-101 [» ]
2WDJ X-ray 3.30 V 1-101 [» ]
2WDL X-ray 3.50 V 1-101 [» ]
2WDN X-ray 3.50 V 1-101 [» ]
2WH2 X-ray 3.45 V 1-101 [» ]
2WH4 X-ray 3.45 V 1-101 [» ]
2WRJ X-ray 3.60 V 1-101 [» ]
2WRL X-ray 3.60 V 1-101 [» ]
2WRO X-ray 3.60 V 1-101 [» ]
2WRR X-ray 3.60 V 1-101 [» ]
2X9S X-ray 3.10 V 1-101 [» ]
2X9U X-ray 3.10 V 1-101 [» ]
2XG0 X-ray 3.20 V 1-101 [» ]
2XG2 X-ray 3.20 V 1-101 [» ]
2XQE X-ray 3.10 V 1-101 [» ]
2XTG electron microscopy 7.80 V 1-101 [» ]
2XUX electron microscopy 7.60 V 1-101 [» ]
2Y0V X-ray 3.10 V 1-101 [» ]
2Y0X X-ray 3.10 V 1-101 [» ]
2Y0Z X-ray 3.10 V 1-101 [» ]
2Y11 X-ray 3.10 V 1-101 [» ]
2Y13 X-ray 3.10 V 1-101 [» ]
2Y15 X-ray 3.10 V 1-101 [» ]
2Y17 X-ray 3.10 V 1-101 [» ]
2Y19 X-ray 3.10 V 1-101 [» ]
3FIN electron microscopy 6.40 V 1-101 [» ]
3HUX X-ray 3.10 V 1-101 [» ]
3HUZ X-ray 3.10 V 1-101 [» ]
3I8F X-ray 3.10 2 1-101 [» ]
3I8I X-ray 3.10 2 1-101 [» ]
3I9C X-ray 3.50 2 1-101 [» ]
3I9E X-ray 3.50 2 1-101 [» ]
3KIR X-ray 3.30 V 1-101 [» ]
3KIT X-ray 3.30 V 1-101 [» ]
3KIW X-ray 3.60 V 1-101 [» ]
3KIY X-ray 3.60 V 1-101 [» ]
3KNI X-ray 3.00 V 1-101 [» ]
3KNK X-ray 3.00 V 1-101 [» ]
3KNM X-ray 3.45 V 1-101 [» ]
3KNO X-ray 3.45 V 1-101 [» ]
3TVE X-ray 3.10 2 1-101 [» ]
3TVH X-ray 3.10 2 1-101 [» ]
3UXQ X-ray 3.20 V 1-101 [» ]
3UXR X-ray 3.20 V 1-101 [» ]
3UYE X-ray 3.00 2 1-101 [» ]
3UYG X-ray 3.00 2 1-101 [» ]
3UZ1 X-ray 3.30 2 1-101 [» ]
3UZ2 X-ray 3.30 2 1-101 [» ]
3UZ8 X-ray 3.00 2 1-101 [» ]
3UZ9 X-ray 3.00 2 1-101 [» ]
3UZF X-ray 3.30 2 1-101 [» ]
3UZH X-ray 3.30 2 1-101 [» ]
3UZK X-ray 3.30 2 1-101 [» ]
3UZN X-ray 3.30 2 1-101 [» ]
3V23 X-ray 3.00 V 1-101 [» ]
3V25 X-ray 3.00 V 1-101 [» ]
3V27 X-ray 3.10 V 1-101 [» ]
3V29 X-ray 3.10 V 1-101 [» ]
3V2D X-ray 2.70 V 1-101 [» ]
3V2F X-ray 2.70 V 1-101 [» ]
3V6W X-ray 3.90 V 1-101 [» ]
3V6X X-ray 3.90 V 1-101 [» ]
3ZN9 X-ray 3.10 V 1-101 [» ]
3ZNE X-ray 3.10 V 1-101 [» ]
3ZVP X-ray 3.80 V 1-101 [» ]
4ABS X-ray 3.10 V 1-101 [» ]
4B8G X-ray 3.70 V 1-101 [» ]
4B8I X-ray 3.70 V 1-101 [» ]
4BTD X-ray 2.95 V 1-101 [» ]
4BYC X-ray 3.35 V 1-101 [» ]
4BYE X-ray 3.35 V 1-101 [» ]
4DHA X-ray 3.20 V 1-101 [» ]
4DHC X-ray 3.20 V 1-101 [» ]
4EJB X-ray 3.52 V 1-101 [» ]
4EJC X-ray 3.52 V 1-101 [» ]
4G5L X-ray 3.30 2 1-101 [» ]
4G5N X-ray 3.30 2 1-101 [» ]
4G5U X-ray 3.10 2 1-101 [» ]
4G5W X-ray 3.10 2 1-101 [» ]
4JUX X-ray 2.86 V 1-101 [» ]
4K0M X-ray 3.30 V 1-101 [» ]
4K0Q X-ray 3.30 V 1-101 [» ]
4KX0 X-ray 3.44 V 1-101 [» ]
4KX2 X-ray 3.44 V 1-101 [» ]
4NVV X-ray 3.00 V 1-101 [» ]
4NVX X-ray 3.00 V 1-101 [» ]
4NVZ X-ray 3.10 V 1-101 [» ]
4NW1 X-ray 3.10 V 1-101 [» ]
4QCN X-ray 2.60 V 1-101 [» ]
4QCP X-ray 2.60 V 1-101 [» ]
4QCR X-ray 2.55 V 1-101 [» ]
4QCT X-ray 2.55 V 1-101 [» ]
4QCV X-ray 2.90 V 1-101 [» ]
4QCX X-ray 2.90 V 1-101 [» ]
4QCZ X-ray 2.80 V 1-101 [» ]
4QD1 X-ray 2.80 V 1-101 [» ]
ProteinModelPortali P60492.
SMRi P60492. Positions 1-101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1783.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71606 ; BAD71606 ; BAD71606 .
GeneIDi 3169471.
KEGGi ttj:TTHA1783.
PATRICi 23958527. VBITheThe93045_1753.

Phylogenomic databases

eggNOGi COG0261.
HOGENOMi HOG000036265.
KOi K02888.
OMAi QGRGDKV.
OrthoDBi EOG6TJ84X.
PhylomeDBi P60492.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1825-MONOMER.

Miscellaneous databases

EvolutionaryTracei P60492.

Family and domain databases

HAMAPi MF_01363. Ribosomal_L21.
InterProi IPR028909. L21p-like.
IPR001787. Ribosomal_L21.
[Graphical view ]
Pfami PF00829. Ribosomal_L21p. 1 hit.
[Graphical view ]
SUPFAMi SSF141091. SSF141091. 1 hit.
TIGRFAMsi TIGR00061. L21. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
    Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
    Biol. Chem. 381:1079-1087(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-18.
  3. "Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
    Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
    Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
  4. Cited for: STRUCTURE OF THE RIBOSOME.
  5. "Translational operator of mRNA on the ribosome: how repressor proteins exclude ribosome binding."
    Jenner L., Romby P., Rees B., Schulze-Briese C., Springer M., Ehresmann C., Ehresmann B., Moras D., Yusupova G., Yusupov M.
    Science 308:120-123(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-101 OF THE RIBOSOME.

Entry informationi

Entry nameiRL21_THET8
AccessioniPrimary (citable) accession number: P60492
Secondary accession number(s): Q5SHE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 29, 2005
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3