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P60492

- RL21_THET8

UniProt

P60492 - RL21_THET8

Protein

50S ribosomal protein L21

Gene

rplU

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein binds to 23S rRNA in the presence of protein L20 By similarity. Found on the solvent side of the large subunit.UniRule annotation

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-1825-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L21UniRule annotation
    Gene namesi
    Name:rplUUniRule annotation
    Ordered Locus Names:TTHA1783
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10110150S ribosomal protein L21PRO_0000181018Add
    BLAST

    Interactioni

    Subunit structurei

    Contacts protein L20 By similarity. Part of the 50S ribosomal subunit.By similarity

    Protein-protein interaction databases

    STRINGi300852.TTHA1783.

    Structurei

    Secondary structure

    1
    101
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 76
    Beta strandi10 – 145
    Beta strandi19 – 235
    Beta strandi29 – 313
    Beta strandi32 – 354
    Beta strandi37 – 448
    Beta strandi49 – 513
    Helixi52 – 543
    Beta strandi57 – 6610
    Beta strandi70 – 767
    Turni77 – 804
    Beta strandi81 – 877
    Beta strandi90 – 9910

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YL3X-ray5.5021-101[»]
    2HGJX-ray5.00U1-101[»]
    2HGQX-ray5.50U1-101[»]
    2HGUX-ray4.51U1-101[»]
    2J01X-ray2.80V1-101[»]
    2J03X-ray2.80V1-101[»]
    2V47X-ray3.80V1-101[»]
    2V49X-ray3.80V1-101[»]
    2WDIX-ray3.30V1-101[»]
    2WDJX-ray3.30V1-101[»]
    2WDLX-ray3.50V1-101[»]
    2WDNX-ray3.50V1-101[»]
    2WH2X-ray3.45V1-101[»]
    2WH4X-ray3.45V1-101[»]
    2WRJX-ray3.60V1-101[»]
    2WRLX-ray3.60V1-101[»]
    2WROX-ray3.60V1-101[»]
    2WRRX-ray3.60V1-101[»]
    2X9SX-ray3.10V1-101[»]
    2X9UX-ray3.10V1-101[»]
    2XG0X-ray3.20V1-101[»]
    2XG2X-ray3.20V1-101[»]
    2XQEX-ray3.10V1-101[»]
    2XTGelectron microscopy7.80V1-101[»]
    2XUXelectron microscopy7.60V1-101[»]
    2Y0VX-ray3.10V1-101[»]
    2Y0XX-ray3.10V1-101[»]
    2Y0ZX-ray3.10V1-101[»]
    2Y11X-ray3.10V1-101[»]
    2Y13X-ray3.10V1-101[»]
    2Y15X-ray3.10V1-101[»]
    2Y17X-ray3.10V1-101[»]
    2Y19X-ray3.10V1-101[»]
    3FINelectron microscopy6.40V1-101[»]
    3HUXX-ray3.10V1-101[»]
    3HUZX-ray3.10V1-101[»]
    3I8FX-ray3.1021-101[»]
    3I8IX-ray3.1021-101[»]
    3I9CX-ray3.5021-101[»]
    3I9EX-ray3.5021-101[»]
    3KIRX-ray3.30V1-101[»]
    3KITX-ray3.30V1-101[»]
    3KIWX-ray3.60V1-101[»]
    3KIYX-ray3.60V1-101[»]
    3KNIX-ray3.00V1-101[»]
    3KNKX-ray3.00V1-101[»]
    3KNMX-ray3.45V1-101[»]
    3KNOX-ray3.45V1-101[»]
    3TVEX-ray3.1021-101[»]
    3TVHX-ray3.1021-101[»]
    3UXQX-ray3.20V1-101[»]
    3UXRX-ray3.20V1-101[»]
    3UYEX-ray3.0021-101[»]
    3UYGX-ray3.0021-101[»]
    3UZ1X-ray3.3021-101[»]
    3UZ2X-ray3.3021-101[»]
    3UZ8X-ray3.0021-101[»]
    3UZ9X-ray3.0021-101[»]
    3UZFX-ray3.3021-101[»]
    3UZHX-ray3.3021-101[»]
    3UZKX-ray3.3021-101[»]
    3UZNX-ray3.3021-101[»]
    3V23X-ray3.00V1-101[»]
    3V25X-ray3.00V1-101[»]
    3V27X-ray3.10V1-101[»]
    3V29X-ray3.10V1-101[»]
    3V2DX-ray2.70V1-101[»]
    3V2FX-ray2.70V1-101[»]
    3V6WX-ray3.90V1-101[»]
    3V6XX-ray3.90V1-101[»]
    3ZN9X-ray3.10V1-101[»]
    3ZNEX-ray3.10V1-101[»]
    3ZVPX-ray3.80V1-101[»]
    4ABSX-ray3.10V1-101[»]
    4B8GX-ray3.70V1-101[»]
    4B8IX-ray3.70V1-101[»]
    4BTDX-ray2.95V1-101[»]
    4BYCX-ray3.35V1-101[»]
    4BYEX-ray3.35V1-101[»]
    4DHAX-ray3.20V1-101[»]
    4DHCX-ray3.20V1-101[»]
    4EJBX-ray3.52V1-101[»]
    4EJCX-ray3.52V1-101[»]
    4G5LX-ray3.3021-101[»]
    4G5NX-ray3.3021-101[»]
    4G5UX-ray3.1021-101[»]
    4G5WX-ray3.1021-101[»]
    4JUXX-ray2.86V1-101[»]
    4K0MX-ray3.30V1-101[»]
    4K0QX-ray3.30V1-101[»]
    4NVVX-ray3.00V1-101[»]
    4NVXX-ray3.00V1-101[»]
    4NVZX-ray3.10V1-101[»]
    4NW1X-ray3.10V1-101[»]
    ProteinModelPortaliP60492.
    SMRiP60492. Positions 1-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP60492.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L21P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0261.
    HOGENOMiHOG000036265.
    KOiK02888.
    OMAiQGRGDKV.
    OrthoDBiEOG6TJ84X.
    PhylomeDBiP60492.

    Family and domain databases

    HAMAPiMF_01363. Ribosomal_L21.
    InterProiIPR028909. L21p-like.
    IPR001787. Ribosomal_L21.
    [Graphical view]
    PfamiPF00829. Ribosomal_L21p. 1 hit.
    [Graphical view]
    SUPFAMiSSF141091. SSF141091. 1 hit.
    TIGRFAMsiTIGR00061. L21. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P60492-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAIVKTGGK QYRVEPGLKL RVEKLDAEPG ATVELPVLLL GGEKTVVGTP    50
    VVEGASVVAE VLGHGRGKKI LVSKFKAKVQ YRRKKGHRQP YTELLIKEIR 100
    G 101
    Length:101
    Mass (Da):11,047
    Last modified:March 29, 2005 - v2
    Checksum:i3117549029950A0C
    GO

    Mass spectrometryi

    Molecular mass is 11048 Da from positions 1 - 101. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71606.1.
    RefSeqiYP_145049.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD71606; BAD71606; BAD71606.
    GeneIDi3169471.
    KEGGittj:TTHA1783.
    PATRICi23958527. VBITheThe93045_1753.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71606.1 .
    RefSeqi YP_145049.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YL3 X-ray 5.50 2 1-101 [» ]
    2HGJ X-ray 5.00 U 1-101 [» ]
    2HGQ X-ray 5.50 U 1-101 [» ]
    2HGU X-ray 4.51 U 1-101 [» ]
    2J01 X-ray 2.80 V 1-101 [» ]
    2J03 X-ray 2.80 V 1-101 [» ]
    2V47 X-ray 3.80 V 1-101 [» ]
    2V49 X-ray 3.80 V 1-101 [» ]
    2WDI X-ray 3.30 V 1-101 [» ]
    2WDJ X-ray 3.30 V 1-101 [» ]
    2WDL X-ray 3.50 V 1-101 [» ]
    2WDN X-ray 3.50 V 1-101 [» ]
    2WH2 X-ray 3.45 V 1-101 [» ]
    2WH4 X-ray 3.45 V 1-101 [» ]
    2WRJ X-ray 3.60 V 1-101 [» ]
    2WRL X-ray 3.60 V 1-101 [» ]
    2WRO X-ray 3.60 V 1-101 [» ]
    2WRR X-ray 3.60 V 1-101 [» ]
    2X9S X-ray 3.10 V 1-101 [» ]
    2X9U X-ray 3.10 V 1-101 [» ]
    2XG0 X-ray 3.20 V 1-101 [» ]
    2XG2 X-ray 3.20 V 1-101 [» ]
    2XQE X-ray 3.10 V 1-101 [» ]
    2XTG electron microscopy 7.80 V 1-101 [» ]
    2XUX electron microscopy 7.60 V 1-101 [» ]
    2Y0V X-ray 3.10 V 1-101 [» ]
    2Y0X X-ray 3.10 V 1-101 [» ]
    2Y0Z X-ray 3.10 V 1-101 [» ]
    2Y11 X-ray 3.10 V 1-101 [» ]
    2Y13 X-ray 3.10 V 1-101 [» ]
    2Y15 X-ray 3.10 V 1-101 [» ]
    2Y17 X-ray 3.10 V 1-101 [» ]
    2Y19 X-ray 3.10 V 1-101 [» ]
    3FIN electron microscopy 6.40 V 1-101 [» ]
    3HUX X-ray 3.10 V 1-101 [» ]
    3HUZ X-ray 3.10 V 1-101 [» ]
    3I8F X-ray 3.10 2 1-101 [» ]
    3I8I X-ray 3.10 2 1-101 [» ]
    3I9C X-ray 3.50 2 1-101 [» ]
    3I9E X-ray 3.50 2 1-101 [» ]
    3KIR X-ray 3.30 V 1-101 [» ]
    3KIT X-ray 3.30 V 1-101 [» ]
    3KIW X-ray 3.60 V 1-101 [» ]
    3KIY X-ray 3.60 V 1-101 [» ]
    3KNI X-ray 3.00 V 1-101 [» ]
    3KNK X-ray 3.00 V 1-101 [» ]
    3KNM X-ray 3.45 V 1-101 [» ]
    3KNO X-ray 3.45 V 1-101 [» ]
    3TVE X-ray 3.10 2 1-101 [» ]
    3TVH X-ray 3.10 2 1-101 [» ]
    3UXQ X-ray 3.20 V 1-101 [» ]
    3UXR X-ray 3.20 V 1-101 [» ]
    3UYE X-ray 3.00 2 1-101 [» ]
    3UYG X-ray 3.00 2 1-101 [» ]
    3UZ1 X-ray 3.30 2 1-101 [» ]
    3UZ2 X-ray 3.30 2 1-101 [» ]
    3UZ8 X-ray 3.00 2 1-101 [» ]
    3UZ9 X-ray 3.00 2 1-101 [» ]
    3UZF X-ray 3.30 2 1-101 [» ]
    3UZH X-ray 3.30 2 1-101 [» ]
    3UZK X-ray 3.30 2 1-101 [» ]
    3UZN X-ray 3.30 2 1-101 [» ]
    3V23 X-ray 3.00 V 1-101 [» ]
    3V25 X-ray 3.00 V 1-101 [» ]
    3V27 X-ray 3.10 V 1-101 [» ]
    3V29 X-ray 3.10 V 1-101 [» ]
    3V2D X-ray 2.70 V 1-101 [» ]
    3V2F X-ray 2.70 V 1-101 [» ]
    3V6W X-ray 3.90 V 1-101 [» ]
    3V6X X-ray 3.90 V 1-101 [» ]
    3ZN9 X-ray 3.10 V 1-101 [» ]
    3ZNE X-ray 3.10 V 1-101 [» ]
    3ZVP X-ray 3.80 V 1-101 [» ]
    4ABS X-ray 3.10 V 1-101 [» ]
    4B8G X-ray 3.70 V 1-101 [» ]
    4B8I X-ray 3.70 V 1-101 [» ]
    4BTD X-ray 2.95 V 1-101 [» ]
    4BYC X-ray 3.35 V 1-101 [» ]
    4BYE X-ray 3.35 V 1-101 [» ]
    4DHA X-ray 3.20 V 1-101 [» ]
    4DHC X-ray 3.20 V 1-101 [» ]
    4EJB X-ray 3.52 V 1-101 [» ]
    4EJC X-ray 3.52 V 1-101 [» ]
    4G5L X-ray 3.30 2 1-101 [» ]
    4G5N X-ray 3.30 2 1-101 [» ]
    4G5U X-ray 3.10 2 1-101 [» ]
    4G5W X-ray 3.10 2 1-101 [» ]
    4JUX X-ray 2.86 V 1-101 [» ]
    4K0M X-ray 3.30 V 1-101 [» ]
    4K0Q X-ray 3.30 V 1-101 [» ]
    4NVV X-ray 3.00 V 1-101 [» ]
    4NVX X-ray 3.00 V 1-101 [» ]
    4NVZ X-ray 3.10 V 1-101 [» ]
    4NW1 X-ray 3.10 V 1-101 [» ]
    ProteinModelPortali P60492.
    SMRi P60492. Positions 1-101.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA1783.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD71606 ; BAD71606 ; BAD71606 .
    GeneIDi 3169471.
    KEGGi ttj:TTHA1783.
    PATRICi 23958527. VBITheThe93045_1753.

    Phylogenomic databases

    eggNOGi COG0261.
    HOGENOMi HOG000036265.
    KOi K02888.
    OMAi QGRGDKV.
    OrthoDBi EOG6TJ84X.
    PhylomeDBi P60492.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-1825-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P60492.

    Family and domain databases

    HAMAPi MF_01363. Ribosomal_L21.
    InterProi IPR028909. L21p-like.
    IPR001787. Ribosomal_L21.
    [Graphical view ]
    Pfami PF00829. Ribosomal_L21p. 1 hit.
    [Graphical view ]
    SUPFAMi SSF141091. SSF141091. 1 hit.
    TIGRFAMsi TIGR00061. L21. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    2. "Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
      Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
      Biol. Chem. 381:1079-1087(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-18.
    3. "Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
      Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
      Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
    4. Cited for: STRUCTURE OF THE RIBOSOME.
    5. "Translational operator of mRNA on the ribosome: how repressor proteins exclude ribosome binding."
      Jenner L., Romby P., Rees B., Schulze-Briese C., Springer M., Ehresmann C., Ehresmann B., Moras D., Yusupova G., Yusupov M.
      Science 308:120-123(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-101 OF THE RIBOSOME.

    Entry informationi

    Entry nameiRL21_THET8
    AccessioniPrimary (citable) accession number: P60492
    Secondary accession number(s): Q5SHE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3