Reviewed, UniProtKB/Swiss-Prot P60490 (RL19_THET8)

Names and origin

Protein names

Recommended name:
    50S ribosomal protein L19

Gene names

Name:	rplS
Ordered Locus Names:	TTHA1031

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Complete proteome] [HAMAP]

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Contacts the 16S rRNA of the 30S subunit (part of bridge B6), connecting the 2 subunits. HAMAP MF_00402
Subunit structure	Part of the 50S risobomal subunit. Contacts protein L14. Forms a bridge to the 30S subunit in the 70S ribosome, contacting the 16S rRNA. Ref.5
Sequence similarities	Belongs to the ribosomal protein L19P family.
Mass spectrometry	Molecular mass is 17152 Da from positions 1 - 146. Determined by MALDI. Ref.3

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 146

146

50S ribosomal protein L19 HAMAP MF_00402

PRO_0000163558

Secondary structure

1

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146

Helix Strand Turn

Details...

Helix

2 – 15

14

Beta strand

16 – 20

5

Beta strand

29 – 34

6

Turn

39 – 41

3

Beta strand

46 – 52

7

Beta strand

55 – 81

27

Beta strand

85 – 90

6

Helix

104 – 108

5

Helix

111 – 116

6

Sequences

	Sequence		Length	Mass (Da)
	P60490-1 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: 119CC349889AF6A7	FASTA	146	17,152
	10 20 30 40 50 60 MNRGALIKLV ESRYVRTDLP EFRPGDTVRV SYKVKEGNRT RIQDFEGIVI RIRRNGFNTT 70 80 90 100 110 120 FTVRKVSYGV GVERIFPLHS PLIQKIDIVQ RGRARRAKLY FIRNLSDREI RRKLRADRKR 130 140 IDQDRAAERA AKEEAQKAQE PKASQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus." Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T. Biol. Chem. 381:1079-1087(2000) [PubMed: 11154066] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-29.
[3]	"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry." Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A. Proteomics 5:4818-4831(2005) [PubMed: 16287167] [Abstract] Cited for: MASS SPECTROMETRY.
[4]	"The path of messenger RNA through the ribosome." Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F. Cell 106:233-241(2001) [PubMed: 11511350] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[5]	"Crystal structure of the ribosome at 5.5 A resolution." Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F. Science 292:883-896(2001) [PubMed: 11283358] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME, INTERSUBUNIT BRIDGE FORMATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AP008226 Genomic DNA. Translation: BAD70854.1.

RefSeq

YP_144297.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GIY	X-ray	5.50	R	1-146	[»]
1YL3	X-ray	5.50	R	1-146	[»]
2HGJ	X-ray	5.00	S	1-146	[»]
2HGQ	X-ray	5.50	S	1-146	[»]
2HGU	X-ray	4.51	S	1-146	[»]
2J01	X-ray	2.80	T	1-146	[»]
2J03	X-ray	2.80	T	1-146	[»]
2V47	X-ray	3.80	T	1-146	[»]
2V49	X-ray	3.80	T	1-146	[»]
2WDI	X-ray	3.30	T	1-146	[»]
2WDJ	X-ray	3.30	T	1-146	[»]
2WDL	X-ray	3.50	T	1-146	[»]
2WDN	X-ray	3.50	T	1-146	[»]
2WH2	X-ray	3.45	T	1-146	[»]
2WH4	X-ray	3.45	T	1-146	[»]
3FIN	electron microscopy	6.40	T	1-138	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

P60490.

Genome annotation databases

GeneID

3168297.

GenomeReviews

Gene locus TTHA1031 in contig AP008226_GR.

KEGG

ttj:TTHA1031.

NMPDR

fig|300852.3.peg.1168.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

P60490.

OMA

GVVISKR.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA1031-MON.

Family and domain databases

HAMAP

MF_00402.
[Tree]

InterPro

IPR001857. Ribosomal_L19.
IPR018257. Ribosomal_L19_CS.
[Graphical view]

PANTHER

PTHR15680. Ribosomal_L19. 1 hit.

Pfam

PF01245. Ribosomal_L19. 1 hit.
[Graphical view]

PRINTS

PR00061. RIBOSOMALL19.

ProDom

PD002979. Ribosomal_L19. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR01024. rplS_bact. 1 hit.

PROSITE

PS01015. RIBOSOMAL_L19. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RL19_THET8

Accession

Primary (citable) accession number: P60490
Secondary accession number(s): Q5SJH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 29, 2005
Last modified:	November 3, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)