Reviewed, UniProtKB/Swiss-Prot P60487 (PLPP_MOUSE)

Names and origin

Protein names

Recommended name:
    Pyridoxal phosphate phosphatase
      Short name=PLP phosphatase
    EC=3.1.3.74

Gene names

Name:	Pdxp
Synonyms:	Plp, Plpp

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and Pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP By similarity.
Catalytic activity	Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
Cofactor	Divalent ions. Magnesium is the most effective By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAD-like hydrolase superfamily.

Ontologies

Keywords
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Pyridoxal phosphate phosphatase		PRO_0000068838
Sites
	Active site	25	1	Nucleophile By similarity
	Active site	27	1	Proton donor By similarity
	Metal binding	25	1	Magnesium By similarity
	Metal binding	27	1	Magnesium By similarity
	Metal binding	234	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P60487-1 [UniParc]. Last modified March 1, 2004. Version 1. Checksum: B5F1B2C7E71A585D	FASTA	292	31,512
	10 20 30 40 50 60 MARCERLRGA ALRDVLGQAQ GVLFDCDGVL WNGERIVPGA PELLQRLARA GKNTLFVSNN 70 80 90 100 110 120 SRRARPELAL RFARLGFAGL RAEQLFSSAL CAARLLRQRL SGPPDASGAV FVLGGEGLRA 130 140 150 160 170 180 ELRAAGLRLA GDPGEDPRVR AVLVGYDEQF SFSRLTEACA HLRDPDCLLV ATDRDPWHPL 190 200 210 220 230 240 SDGSRTPGTG SLAAAVETAS GRQALVVGKP SPYMFQCITE DFSVDPARTL MVGDRLETDI 250 260 270 280 290 LFGHRCGMTT VLTLTGVSSL EEAQAYLTAG QRDLVPHYYV ESIADLMEGL ED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution." Jang Y.M., Kim D.W., Kang T.-C., Won M.H., Baek N.-I., Moon B.J., Choi S.Y., Kwon O.-S. J. Biol. Chem. 278:50040-50046(2003) [PubMed: 14522954] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss. Tissue: Brain.
[2]	Lubec G., Klug S. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 100-119 AND 141-154, MASS SPECTROMETRY. Tissue: Hippocampus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-292. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY366300 mRNA. Translation: AAR12209.1. BC058388 mRNA. Translation: AAH58388.1.
IPI	IPI00118654.
RefSeq	NP_064667.2.
UniGene	Mm.263169
3D structure databases
SMR	P60487. Positions 2-290.
ModBase	Search...
2-D gel databases
REPRODUCTION-2DPAGE	P60487.
Proteomic databases
PRIDE	P60487.
Genome annotation databases
Ensembl	ENSMUSG00000068221. Mus musculus. [Contig view]
GeneID	57028.
KEGG	mmu:57028.
Organism-specific databases
MGI	MGI:1919282. Pdxp.
Phylogenomic databases
HOGENOM	P60487.
HOVERGEN	P60487.
OMA	P60487. WNGERAV.
Enzyme and pathway databases
BRENDA	3.1.3.74. 244.
Gene expression databases
ArrayExpress	P60487.
Bgee	P60487.
CleanEx	MM_PDXP.
GermOnline	ENSMUSG00000068221. Mus musculus.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006357. HAD-SF_hydro_IIA. IPR006349. PGP_euk. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01460. HAD-SF-IIA. 1 hit. TIGR01452. PGP_euk. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	313473.
SOURCE	Search...

Entry information

Entry name

PLPP_MOUSE

Accession

Primary (citable) accession number: P60487

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)