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Protein

DAZ-associated protein 2

Gene

Dazap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
DAZ-associated protein 2
Alternative name(s):
Deleted in azoospermia-associated protein 2
Gene namesi
Name:Dazap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307407. Dazap2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108DAZ-associated protein 2PRO_0000079790Add
BLAST

Post-translational modificationi

Ubiquitinated by SMURF2, leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Expressioni

Gene expression databases

GenevestigatoriP60486.

Interactioni

Subunit structurei

Interacts with SOX6. Interacts with DAZ and DAZL (By similarity). Interacts with IL17RB (By similarity). May interact with FAM168B (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006239.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 705Poly-Pro

Phylogenomic databases

eggNOGiNOG43279.
GeneTreeiENSGT00390000000685.
HOGENOMiHOG000007683.
HOVERGENiHBG051300.
InParanoidiP60486.
OMAiAYSEIYQ.
OrthoDBiEOG77HDG0.
PhylomeDBiP60486.

Family and domain databases

InterProiIPR022730. DAZ_assoc-2.
[Graphical view]
PfamiPF11029. DAZAP2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSAVLVEGGY
60 70 80 90 100
DAGARFGAGA TTGSIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG

SDGGYTIW
Length:108
Mass (Da):10,775
Last modified:March 1, 2004 - v1
Checksum:iF197E40EA23A925D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062052 mRNA. Translation: AAH62052.1.
RefSeqiNP_001013125.1. NM_001013107.1.
UniGeneiRn.107901.

Genome annotation databases

EnsembliENSRNOT00000006239; ENSRNOP00000006239; ENSRNOG00000004628.
GeneIDi300235.
KEGGirno:300235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062052 mRNA. Translation: AAH62052.1.
RefSeqiNP_001013125.1. NM_001013107.1.
UniGeneiRn.107901.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006239; ENSRNOP00000006239; ENSRNOG00000004628.
GeneIDi300235.
KEGGirno:300235.

Organism-specific databases

CTDi9802.
RGDi1307407. Dazap2.

Phylogenomic databases

eggNOGiNOG43279.
GeneTreeiENSGT00390000000685.
HOGENOMiHOG000007683.
HOVERGENiHBG051300.
InParanoidiP60486.
OMAiAYSEIYQ.
OrthoDBiEOG77HDG0.
PhylomeDBiP60486.

Miscellaneous databases

NextBioi646601.
PROiP60486.

Gene expression databases

GenevestigatoriP60486.

Family and domain databases

InterProiIPR022730. DAZ_assoc-2.
[Graphical view]
PfamiPF11029. DAZAP2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiDAZP2_RAT
AccessioniPrimary (citable) accession number: P60486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: April 29, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.