P60486 (DAZP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DAZ-associated protein 2

Alternative name(s):
Deleted in azoospermia-associated protein 2

Gene names

Name:

Dazap2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure	Interacts with SOX6. Interacts with DAZ and DAZL By similarity. Interacts with IL17RB By similarity. May interact with FAM168B By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm By similarity.
Post-translational modification	Ubiquitinated by SMURF2, leading to proteasomal degradation By similarity.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 108	108	DAZ-associated protein 2		PRO_0000079790
Regions
	Compositional bias	66 – 70	5	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	P60486 [UniParc]. Last modified March 1, 2004. Version 1. Checksum: F197E40EA23A925D	FASTA	108	10,775
	10 20 30 40 50 60 MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSAVLVEGGY DAGARFGAGA 70 80 90 100 TTGSIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC062052 mRNA. Translation: AAH62052.1.
IPI	IPI00373009.
RefSeq	NP_001013125.1. NM_001013107.1.
UniGene	Rn.107901.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000006239.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000006239; ENSRNOP00000006239; ENSRNOG00000004628.
GeneID	300235.
KEGG	rno:300235.
Organism-specific databases
CTD	9802.
RGD	1307407. Dazap2.
Phylogenomic databases
eggNOG	NOG43279.
GeneTree	ENSGT00390000000685.
HOGENOM	HOG000007683.
HOVERGEN	HBG051300.
InParanoid	P60486.
OrthoDB	EOG46MBKZ.
Gene expression databases
Genevestigator	P60486.
GermOnline	ENSRNOG00000004628. Rattus norvegicus.
Family and domain databases
InterPro	IPR022730. DAZ_assoc-2. [Graphical view]
Pfam	PF11029. DAZAP2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	646601.

Entry information

Entry name

DAZP2_RAT

Accession

Primary (citable) accession number: P60486

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program