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P60486

- DAZP2_RAT

UniProt

P60486 - DAZP2_RAT

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Protein

DAZ-associated protein 2

Gene

Dazap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
DAZ-associated protein 2
Alternative name(s):
Deleted in azoospermia-associated protein 2
Gene namesi
Name:Dazap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1307407. Dazap2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108DAZ-associated protein 2PRO_0000079790Add
BLAST

Post-translational modificationi

Ubiquitinated by SMURF2, leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Expressioni

Gene expression databases

GenevestigatoriP60486.

Interactioni

Subunit structurei

Interacts with SOX6. Interacts with DAZ and DAZL (By similarity). Interacts with IL17RB (By similarity). May interact with FAM168B (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006239.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 705Poly-Pro

Phylogenomic databases

eggNOGiNOG43279.
GeneTreeiENSGT00390000000685.
HOGENOMiHOG000007683.
HOVERGENiHBG051300.
InParanoidiP60486.
OMAiMNNKGSY.
OrthoDBiEOG77HDG0.
PhylomeDBiP60486.

Family and domain databases

InterProiIPR022730. DAZ_assoc-2.
[Graphical view]
PfamiPF11029. DAZAP2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60486-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSAVLVEGGY
60 70 80 90 100
DAGARFGAGA TTGSIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG

SDGGYTIW
Length:108
Mass (Da):10,775
Last modified:March 1, 2004 - v1
Checksum:iF197E40EA23A925D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062052 mRNA. Translation: AAH62052.1.
RefSeqiNP_001013125.1. NM_001013107.1.
UniGeneiRn.107901.

Genome annotation databases

EnsembliENSRNOT00000006239; ENSRNOP00000006239; ENSRNOG00000004628.
GeneIDi300235.
KEGGirno:300235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062052 mRNA. Translation: AAH62052.1 .
RefSeqi NP_001013125.1. NM_001013107.1.
UniGenei Rn.107901.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006239 ; ENSRNOP00000006239 ; ENSRNOG00000004628 .
GeneIDi 300235.
KEGGi rno:300235.

Organism-specific databases

CTDi 9802.
RGDi 1307407. Dazap2.

Phylogenomic databases

eggNOGi NOG43279.
GeneTreei ENSGT00390000000685.
HOGENOMi HOG000007683.
HOVERGENi HBG051300.
InParanoidi P60486.
OMAi MNNKGSY.
OrthoDBi EOG77HDG0.
PhylomeDBi P60486.

Miscellaneous databases

NextBioi 646601.

Gene expression databases

Genevestigatori P60486.

Family and domain databases

InterProi IPR022730. DAZ_assoc-2.
[Graphical view ]
Pfami PF11029. DAZAP2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiDAZP2_RAT
AccessioniPrimary (citable) accession number: P60486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3