Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isoprenyl transferase

Gene

uppS

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33UniRule annotation1
Metal bindingi33MagnesiumUniRule annotation1
Binding sitei38SubstrateUniRule annotation1
Binding sitei46SubstrateUniRule annotation1
Binding sitei50SubstrateUniRule annotation1
Active sitei81Proton acceptorUniRule annotation1
Binding sitei82SubstrateUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei201SubstrateUniRule annotation1
Metal bindingi220MagnesiumUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:SA1103
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001236731 – 256Isoprenyl transferaseAdd BLAST256

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 31Combined sources6
Helixi35 – 41Combined sources7
Helixi46 – 67Combined sources22
Beta strandi70 – 78Combined sources9
Helixi81 – 83Combined sources3
Helixi86 – 109Combined sources24
Beta strandi113 – 118Combined sources6
Helixi120 – 122Combined sources3
Helixi125 – 137Combined sources13
Turni138 – 140Combined sources3
Beta strandi145 – 152Combined sources8
Helixi154 – 171Combined sources18
Helixi176 – 178Combined sources3
Helixi181 – 185Combined sources5
Turni189 – 192Combined sources4
Beta strandi197 – 201Combined sources5
Turni213 – 218Combined sources6
Beta strandi220 – 223Combined sources4
Helixi228 – 230Combined sources3
Helixi233 – 245Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H8EX-ray1.30A1-256[»]
4U82X-ray1.66A1-256[»]
ProteinModelPortaliP60477.
SMRiP60477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni78 – 80Substrate bindingUniRule annotation3
Regioni207 – 209Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000006054.
KOiK00806.
OMAiWNRPKLE.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKLINKKN TINNYNEELD SSNIPEHIAI IMDGNGRWAK KRKMPRIKGH
60 70 80 90 100
YEGMQTIKKI TRIASDIGVK YLTLYAFSTE NWSRPESEVN YIMNLPVNFL
110 120 130 140 150
KTFLPELIEK NVKVETIGFT DKLPKSTIEA INNAKEKTAN NTGLKLIFAI
160 170 180 190 200
NYGGRAELVH SIKNMFDELH QQGLNSDIID ETYINNHLMT KDYPDPELLI
210 220 230 240 250
RTSGEQRISN FLIWQVSYSE FIFNQKLWPD FDEDELIKCI KIYQSRQRRF

GGLSEE
Length:256
Mass (Da):29,862
Last modified:February 16, 2004 - v1
Checksum:i051AE0C3457D0305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42355.1.
PIRiG89899.
RefSeqiWP_000473699.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42355; BAB42355; BAB42355.
KEGGisau:SA1103.
PATRICi19574426. VBIStaAur116463_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42355.1.
PIRiG89899.
RefSeqiWP_000473699.1. NC_002745.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H8EX-ray1.30A1-256[»]
4U82X-ray1.66A1-256[»]
ProteinModelPortaliP60477.
SMRiP60477.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB42355; BAB42355; BAB42355.
KEGGisau:SA1103.
PATRICi19574426. VBIStaAur116463_1182.

Phylogenomic databases

HOGENOMiHOG000006054.
KOiK00806.
OMAiWNRPKLE.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISPT_STAAN
AccessioniPrimary (citable) accession number: P60477
Secondary accession number(s): Q99UL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.