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Protein

Isoprenyl transferase

Gene

uppS

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331UniRule annotation
Metal bindingi33 – 331MagnesiumUniRule annotation
Binding sitei38 – 381SubstrateUniRule annotation
Binding sitei46 – 461SubstrateUniRule annotation
Binding sitei50 – 501SubstrateUniRule annotation
Active sitei81 – 811Proton acceptorUniRule annotation
Binding sitei82 – 821SubstrateUniRule annotation
Binding sitei84 – 841SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Metal bindingi220 – 2201MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1163-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:SA1103
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Isoprenyl transferasePRO_0000123673Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

Secondary structure

1
256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Helixi35 – 417Combined sources
Helixi46 – 6722Combined sources
Beta strandi70 – 789Combined sources
Helixi81 – 833Combined sources
Helixi86 – 10924Combined sources
Beta strandi113 – 1186Combined sources
Helixi120 – 1223Combined sources
Helixi125 – 13713Combined sources
Turni138 – 1403Combined sources
Beta strandi145 – 1528Combined sources
Helixi154 – 17118Combined sources
Helixi176 – 1783Combined sources
Helixi181 – 1855Combined sources
Turni189 – 1924Combined sources
Beta strandi197 – 2015Combined sources
Turni213 – 2186Combined sources
Beta strandi220 – 2234Combined sources
Helixi228 – 2303Combined sources
Helixi233 – 24513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H8EX-ray1.30A1-256[»]
4U82X-ray1.66A1-256[»]
ProteinModelPortaliP60477.
SMRiP60477. Positions 24-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 374Substrate bindingUniRule annotation
Regioni78 – 803Substrate bindingUniRule annotation
Regioni207 – 2093Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000006054.
OMAiWNRPKLE.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P60477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKLINKKN TINNYNEELD SSNIPEHIAI IMDGNGRWAK KRKMPRIKGH
60 70 80 90 100
YEGMQTIKKI TRIASDIGVK YLTLYAFSTE NWSRPESEVN YIMNLPVNFL
110 120 130 140 150
KTFLPELIEK NVKVETIGFT DKLPKSTIEA INNAKEKTAN NTGLKLIFAI
160 170 180 190 200
NYGGRAELVH SIKNMFDELH QQGLNSDIID ETYINNHLMT KDYPDPELLI
210 220 230 240 250
RTSGEQRISN FLIWQVSYSE FIFNQKLWPD FDEDELIKCI KIYQSRQRRF

GGLSEE
Length:256
Mass (Da):29,862
Last modified:February 16, 2004 - v1
Checksum:i051AE0C3457D0305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42355.1.
PIRiG89899.
RefSeqiWP_000473699.1. NC_002745.2.

Genome annotation databases

EnsemblBacteriaiBAB42355; BAB42355; BAB42355.
PATRICi19574426. VBIStaAur116463_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA. Translation: BAB42355.1.
PIRiG89899.
RefSeqiWP_000473699.1. NC_002745.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4H8EX-ray1.30A1-256[»]
4U82X-ray1.66A1-256[»]
ProteinModelPortaliP60477.
SMRiP60477. Positions 24-246.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB42355; BAB42355; BAB42355.
PATRICi19574426. VBIStaAur116463_1182.

Phylogenomic databases

HOGENOMiHOG000006054.
OMAiWNRPKLE.
OrthoDBiEOG68H89T.

Enzyme and pathway databases

BioCyciSAUR158879:GJCB-1163-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: N315.

Entry informationi

Entry nameiISPT_STAAN
AccessioniPrimary (citable) accession number: P60477
Secondary accession number(s): Q99UL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.